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  • protein
  • To elucidate, whether secreted proGDNF has any biological activity, the recombinant cleavage-resistant proGDNF mutant protein was expressed in mammalian CHO cells and next purified from the media. (helsinki.fi)
  • secretion
  • In accordance, the two splice isoforms responded differently to KCl-induced depolarization that is known to trigger the secretion of neurotrophin family members in neuronal cells. (helsinki.fi)
  • Parkinson's
  • hNPC can be genetically modified, and thereby represent a safe and powerful option for delivering growth factors to specific targets within the central nervous system for diseases such as Parkinson's. (epfl.ch)
  • It shows neuroprotective effects against 1-methyl-4-phenylpyridinium (MPP(+)) toxicity and ischemia-induced neuronal cell death and represents a potential therapeutic agent against Parkinson's disease. (bachem.com)
  • axotomy
  • The culture process imposes severe traumatic effects on the retinal grafts, such as ganglion cell axotomy, separation from the retinal vasculature and the retinal pigment epithelium (RPE). (arvojournals.org)
  • trophic factors
  • We tested whether neonatal rat hypoglossal motoneurons target retrogradely transported trophic factors to synaptic sites on their dendrites within the brainstem and subsequently transfer these trophins across the synaptic cleft to afferent synapses (transsynaptic transcytosis). (jneurosci.org)
  • Here, we report on the fate of retrogradely transported trophic factors by using quantitative electronmicroscopic autoradiography in neonatal rat hypoglossal motoneurons. (jneurosci.org)
  • therapeutic
  • 3 , 4 The purpose of gene therapy is to provide a therapeutic gene to prevent or treat diseases related to abnormal cell function. (dovepress.com)
  • It has been postulated that lack of clinical efficacy, as well as some side effects, resulted in part from the high focal levels of the therapeutic factor delivered and/or suboptimal delivery methods. (jneurosci.org)
  • Studies
  • In numerous studies, stem cell implantation has substantially improved brain function in experimental animals with brain trauma. (stem-cells-news.com)
  • growth
  • Neuronal growth factors play an important role in the development and maintenance of the nervous system. (garvan.org.au)
  • In the olfactory system, neurogenesis and synapse formation occur not only during development but throughout life and it would be expected that growth factors play a significant role in these ongoing processes. (garvan.org.au)
  • activity
  • To elucidate, whether secreted proGDNF has any biological activity, the recombinant cleavage-resistant proGDNF mutant protein was expressed in mammalian CHO cells and next purified from the media. (helsinki.fi)
  • However
  • However, to date, no trophic factor has been identified with synaptic targeting properties and transcytotic efficiencies that resemble those of tetanus toxin. (jneurosci.org)
  • loss
  • The inducible loss of DJ-1 triggers the establishment of hypoxia and the production of reactive oxygen species that stabilize the hypoxia-inducible factor-1α (HIF-1a). (pubmedcentralcanada.ca)
  • Although
  • Although some of these factors have been discovered, the regulatory mechanisms for this developmental event have not been fully elucidated. (diva-portal.org)