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  • neuronal cells
  • In accordance, the two splice isoforms responded differently to KCl-induced depolarization that is known to trigger the secretion of neurotrophin family members in neuronal cells. (helsinki.fi)
  • protein
  • To elucidate, whether secreted proGDNF has any biological activity, the recombinant cleavage-resistant proGDNF mutant protein was expressed in mammalian CHO cells and next purified from the media. (helsinki.fi)
  • Biology
  • Before this study, we didn't know what physiological role the proNGF molecule played in the eye," said coauthor Dr. Adriana Di Polo, a professor at the Universite de Montreal Department of Pathology and Cell Biology. (medindia.net)
  • The next step for researchers is to explore whether proNGF signals can be controlled", said Frederic Lebrun-Julien, first author and a PhD student at the Universite de Montreal's Department of Pathology and Cell Biology. (medindia.net)
  • More is known about astrocytic biology than about that of other glial cell types. (frontiersin.org)
  • nuclear
  • On day 17 animals were sacrificed and neuronal nuclear antigen (NeuN) and tyrosine hydroxylase (TH) immunoreactive cells counted in the arcuate-periventricular hypothalamic region. (biomedsearch.com)
  • function
  • Our research shows that we can increase the production and maintenance of glial cells that are important for supporting neurons, providing an enriched environment for proper neuronal function. (kurzweilai.net)
  • Glial cells support the growth and function of nerve cells and their connections. (kurzweilai.net)
  • An underlying molecular mechanism was also identified when the data showed that antidepressants increase glial generation and function via increasing FGF2 signaling. (kurzweilai.net)
  • our studies demonstrate that DLX3 physically interacts with GCM1 and inhibits its transactivation activity, suggesting that DLX3 and GCM1 may form a complex to functionally regulate placental cell function through modulation of target gene expression. (nih.gov)
  • Although glial cells in the PNS have similar functions to their CNS counterparts, there are enough differences in the morphology, biochemistry, and function between PNS and CNS glia that they appear to be more analogs rather than homologs, and we need to be careful about making too many generalizations. (pubmedcentralcanada.ca)
  • 3 , 4 The purpose of gene therapy is to provide a therapeutic gene to prevent or treat diseases related to abnormal cell function. (dovepress.com)
  • These findings suggest that complex gangliosides modulate glial cell function to some extent. (gla.ac.uk)
  • microglial
  • o Investigating mechanisms by which HIV-1 induced inflammatory agents released from activated astroglial and microglial cells can precipitate psychiatric illnesses such as major depression. (nih.gov)
  • o Investigate mechanisms by which peripherally induced inflammatory agents such as cytokines and chemokines influence astroglial and microglial cells and examine the contribution of these responses to the pathogenesis evident in the central nervous system response to HIV-1 infection. (nih.gov)
  • human
  • Title: DLX3 interacts with GCM1 and inhibits its transactivation-stimulating activity in a homeodomain-dependent manner in human trophoblast-derived cells. (nih.gov)
  • The protocols described are primarily optimized with NSCs derived from human embryonic stem cells (ESC) or induced pluripotent stem cells (iPSC). (thermofisher.com)
  • Gibco Human Neural Stem Cells (H9 hESC-Derived) (Cat. (thermofisher.com)
  • normally
  • Glial cells, which normally protect neurons in the retina can also kill them, resulting in vision loss and blindness has been discovered by scientists from University of Montreal and McGill University's Montreal Neurological Institute. (medindia.net)
  • transcription
  • Co-transfection of the Drosophila SL2 cells using mGIF expression plasmid and reporter constructs having Sp1 binding sites indicated that mGIF represses transcription from a TATA-containing as well as from a TATA-less promoter. (jneurosci.org)