original brand name CeeNU, now marketed as Gleostine) is an alkylating nitrosourea compound used in chemotherapy. (wikipedia.org)
Chemotherapy4
Lomustine is an alkylating chemotherapy drug that is indicated by the FDA for the treatment of patients with brain tumors (primary and metastatic), following any necessary surgery and radiation, as well as for treatment of progressive Hodgkin's lymphoma. (wikipedia.org)
Chemotherapy drugs, such as lomustine and temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (uci.edu)
The purpose of this study is to compare the efficacy and safety of eflornithine in combination with lomustine, compared to lomustine taken alone, in treating patients whose anaplastic astrocytoma has recurred/progressed after radiation and temozolomide chemotherapy. (mycancergenome.org)
Gleostine ® is an FDA-approved chemotherapeutic drug indicated for use in patients with brain tumors, primary and metastatic, following appropriate surgical and/or radiotherapeutics procedures as well with Hodgkin's lymphoma in combination with other chemotherapies, following disease progression with initial chemotherapy. (gleostine.com)
Bone marrow2
Lomustine can cause a severe decrease in the number of blood cells in your bone marrow. (medlineplus.gov)
Bone marrow suppression, notably thrombocytopenia and leukopenia, which may contribute to bleeding and overwhelming infections in an already compromised patient, is the most common and severe of the toxic effects of Gleostine® (see WARNINGS and ADVERSE REACTIONS). (gleostine.com)
Capsules3
Lomustine is available in 5 mg (yellow capsule), 10 mg (white capsule), 40 mg (white & green capsule), and 100 mg (green capsule) gel capsules, referred to as Gleostine. (wikipedia.org)
tell your doctor and pharmacist if you are allergic to lomustine, any other medications, or any of the ingredients in lomustine capsules. (medlineplus.gov)
NextSource Cares ™ provide Gleostine ® (lomustine) capsules to patients for whom a medical need is established, who cannot afford the cost of therapy and have no other reimbursement options that would enable them to purchase the Gleostine ® capsules. (nextsourcepharma.com)
Toxicity2
Lomustine causes high levels of organ toxicity, which must be taken into account when determining dosing for elderly patients. (wikipedia.org)
Lomustine use is linked to a variety of organ toxicities hepatotoxicity, nephrotoxicity, and pulmonary toxicity. (wikipedia.org)
Administered orally or1
Lomustine may be administered orally or by injection in cats and dogs. (wikipedia.org)
If you or your partner become pregnant while taking lomustine, call your doctor. (medlineplus.gov)
Fetus2
While current data is only based on animal studies, there is reason to believe that lomustine use during pregnancy can cause harm to a fetus, potentially leading to miscarriages or birth defects. (wikipedia.org)
Lomustine comes as a capsule to take by mouth. (medlineplus.gov)
Clinical2
There is insufficient clinical data surrounding the use of lomustine in pediatric populations. (wikipedia.org)
While there are no clinical studies on lomustine use in the 65+ age group, clinicians are recommended to exercise caution in prescribing this drug to geriatric patients. (wikipedia.org)
Pregnancy1
If you are female, you should use birth control to prevent pregnancy during your treatment with lomustine and for at least 2 weeks after your final dose. (medlineplus.gov)
Harm1
Patients are advised to use birth control with partners while taking lomustine due to the potential for fetal harm. (wikipedia.org)
Medications2
Lomustine is also used with other medications to treat Hodgkin's lymphoma (Hodgkin's disease) that has not improved or that has worsened after treatment with other medications. (medlineplus.gov)
However, patients on Lomustine are advised not to breastfeed during the course of treatment due to the potential for serious adverse reactions to the drug. (wikipedia.org)
A total of approximately 340 patients will be randomized in a 1:1 ratio to receive either eflornithine + lomustine or lomustine alone. (mycancergenome.org)
You should not breast-feed while taking lomustine and for 2 weeks after your final dose. (medlineplus.gov)
At the recommended dosage, courses of Gleostine® should not be given more frequently than every 6 weeks. (gleostine.com)
Dose2
If you are male, you and your female partner should use birth control during your treatment with lomustine and continue for 4 months after your final dose. (medlineplus.gov)
The median overall survival (OS) in the higher-dose subgroup was 14.4 months, which compared favorably with historical controls of a median OS of 8.4 months seen with lomustine (Gleostine) for GBM. (targetedonc.com)
Treatment4
Lomustine is approved for the treatment of brain tumors, breast cancer, lung cancer, Hodgkin's lymphoma, and melanoma by Health Canada. (wikipedia.org)
Lomustine is used as an "off-label" veterinary treatment for cancers in cats and dogs. (wikipedia.org)
Your doctor will order laboratory tests before, during, and after your treatment to check your body's response to lomustine to see if your blood cells, liver, kidneys, and lungs are affected by this medication. (medlineplus.gov)
Adding lomustine to usual treatment of temozolomide and radiation therapy may help shrink and stabilize glioblastoma. (uci.edu)
Brain2
Lomustine is used to treat certain types of brain tumors. (medlineplus.gov)
Usually, brain cancer drugs, such as Gleostine ® , work by damaging the RNA or DNA that tells the cell how to copy itself in division. (gleostine.com)
Drug2
Lomustine is also used as an anti-cancer drug in several European countries, including the United Kingdom. (wikipedia.org)
Due to the cytotoxic nature of lomustine, the drug must be dosed, administered, and disposed of with special precautions including wearing gloves to prevent dermal exposure. (wikipedia.org)
Alkylating agent2
Lomustine is a bifunctional alkylating agent, alkylates both DNA and RNA, has the ability to created interstrand cross-links (ICLs) in DNA. (wikipedia.org)
Gleostine ® is classified as an alkylating agent. (gleostine.com)
Trial1
This phase III trial compares the effect of adding lomustine to temozolomide and radiation therapy versus temozolomide and radiation therapy alone in shrinking or stabilizing newly diagnosed MGMT methylated glioblastoma. (uci.edu)
Body1
Lomustine dosing is calculated based on body surface area. (wikipedia.org)
CCNU1
Lomustine (CCNU), a nitrogen mustard and DNA alkylator used in combination with other chemotherapeutic agents. (medscape.com)
Brain tumors4
Lomustine is an alkylating chemotherapy drug that is indicated by the FDA for the treatment of patients with brain tumors (primary and metastatic), following any necessary surgery and radiation, as well as for treatment of progressive Hodgkin's lymphoma. (wikipedia.org)
Lomustine is approved for the treatment of brain tumors, breast cancer, lung cancer, Hodgkin's lymphoma, and melanoma by Health Canada. (wikipedia.org)
Lomustine is used to treat certain types of brain tumors. (medlineplus.gov)
The usual tumors against which lomustine is most commonly used are lymphoma , particularly cutaneous (skin) lymphoma, mast cell tumors , brain tumors, kidney tumors, lung tumors, and histiocytic sarcoma. (vin.com)
CeeNu1
original brand name CeeNU, now marketed as Gleostine) is an alkylating nitrosourea compound used in chemotherapy. (wikipedia.org)
Myelosuppression2
Gleostine causes myelosuppression including fatal myelosuppression. (nih.gov)
Cumulative myelosuppression from Gleostine is manifested by greater severity and longer duration of cytopenias. (nih.gov)
Liver4
Your doctor will order laboratory tests before, during, and after your treatment to check your body's response to lomustine to see if your blood cells, liver, kidneys, and lungs are affected by this medication. (medlineplus.gov)
Lomustine is harsh on the patient's liver as well. (vin.com)
In one study, 7 out of 12 dogs with lomustine-related liver disease died and the ones that recovered had experienced fewer lomustine doses. (vin.com)
No information is available regarding liver toxicity in cats on lomustine, so currently, the canine monitoring protocols are recommended for both species. (vin.com)
Drugs1
For now, let's hope that pharmaceutical companies begin to make generic versions of expensive drugs like Lomustine, and sell them at a cheaper price. (iflscience.com)
Due to the cytotoxic nature of lomustine, the drug must be dosed, administered, and disposed of with special precautions including wearing gloves to prevent dermal exposure. (wikipedia.org)
Effects1
No research currently exists on the effects of lomustine and its metabolites on breastfed infants. (wikipedia.org)
Function1
In addition to essentially tangling DNA up, lomustine generates a by-product that prevents normal DNA function. (vin.com)