AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaHealth Care
BenzamidesPiperazinesPyrimidinesProto-Oncogene Proteins c-ablLeukemia, Myelogenous, Chronic, BCR-ABL PositiveFusion Proteins, bcr-ablProto-Oncogene Proteins c-kitAntineoplastic AgentsReceptor, Platelet-Derived Growth Factor alphaReceptor, Platelet-Derived Growth Factor betaGastrointestinal Stromal TumorsGastrointestinal NeoplasmsK562 CellsProtein-Tyrosine KinasesPyridonesDrug ApprovalReceptors, Platelet-Derived Growth FactorEnzyme InhibitorsDrug Resistance, NeoplasmCell Line, TumorApoptosisSignal TransductionPhosphorylationDose-Response Relationship, DrugCell DivisionCell ProliferationProtein Structure, TertiaryMutationCell SurvivalTreatment OutcomeCell Line
Imatinib mesylateChronicTumorsLeukemiaImatibNovartisDrugs2001PatientsEfficacyResearchersSignaling pathwayDrugMedicationsEnzymeResistanceTreatmentTherapyPharmacySide effectsCancer cellsYearsCommonSiteSprycelCancersClinical trialCancerMutationsCancerousPharmaciesGastrointestinalDrugsDosePillProteinsPregnancyDramaticallySideDiagnosisInfectionDrug calledHealth careTimeCareLess likelyHeart failureEvents
Imatinib mesylate4
  • Preliminary studies show that a vaccine made with leukemia cells may be able to reduce or eliminate the last remaining cancer cells in some chronic myeloid leukemia patients taking the drug Imatinib mesylate (Gleevec). (sciencedaily.com)
  • EAST HANOVER, NJ-Novartis has submitted a supplemental new drug application (sNDA) to the FDA seeking approval for Gleevec (imatinib mesylate) for the treatment of patients with unresectable and/or metastatic malignant gastrointestinal stromal tumors (GISTs). (cancernetwork.com)
  • Preclinical data shows improvements in response for the combination of imatinib mesylate (IM, Gleevec) and gemcitabine (GEM) therapy compared with GEM alone. (aacrjournals.org)
  • The FDA's Oncologic Drugs Advisory Committee (ODAC) unanimously recommended approval of Sprycel (dasatinib) for chronic myelogenous leukemia (CML) patients who are refractory or intolerant to Gleevec (imatinib mesylate). (patientcareonline.com)
Chronic4
  • Last May, Gleevec received FDA approval for the treatment of patients with chronic myeloid leukemia in the blast crisis, accelerated phase, or in chronic phase after failure of interferon-alfa. (cancernetwork.com)
  • In chronic phase CML patients, the Gleevec-intolerant patients had a higher response rate than Gleevec-resistant patients. (patientcareonline.com)
  • A new drug may overcome Gleevec resistance in late-stage chronic myeloid leukemia (CML) patients, according to findings reported in the February 2005 issue of the journal Cancer Cell. (ohsu.edu)
  • Gleevec is used to treat chronic myelogenous leukemia. (trnmag.com)
Tumors1
  • Generic Gleevec is used to treat certain types of leukemia (blood cancer), bone marrow disorders, and skin cancer, or certain tumors of the stomach and digestive system. (healthylifemeds.com)
Leukemia1
  • Gleevec fights leukemia by blocking a specific receptor on cancerous white blood cells, inhibiting their ability to multiply and spread, Israel said. (cheapgenericsonline.com)
Imatib1
  • This helps stop the spread of malignant growth cells.Imatib tablet is also sold under the brand name gleevec and also known as Imatinib gleevec. (onlinegenericmedicine.com)
Novartis3
  • However, as its patent expires stateside, expect profits to continue to fall, and watch as Novartis bad mouths and cannibalizes Gleevec in favor of Tasigna, its me-too drug designed to replace those enormous Gleevec profits. (lymphomainfo.net)
  • Druker originally collaborated with pharmaceutical company Novartis to develop Gleevec into a successful treatment for CML. (ohsu.edu)
  • As reported in Cancer Cell, researchers at Novartis Pharmaceuticals in Basel, Switzerland, approached the challenge of resistance by designing a more potent form of Gleevec and then worked with researchers at Dana-Farber Cancer Institute to test the compound. (ohsu.edu)
Drugs3
  • Druker and colleagues also are investigating the efficacy of AMN107 and companion drugs designed to overcome Gleevec resistance. (ohsu.edu)
  • Depending on the outcome of clinical trials, a potentially effective new therapeutic approach may be to use AMN107, Gleevec and chemically similar drugs in a cocktail to prohibit or delay the onset of acquired drug resistance in patients with advanced CML, said Druker. (ohsu.edu)
  • Drugs such as imatinib (Gleevec) and venetoclax can treat cancers caused by specific genetic changes. (cdc.gov)
20011
  • In 2001, the Food and Drug Administration (FDA) broke a record for cancer therapy approval by fast-tracking Gleevec, approving it in less than three months. (ohsu.edu)
Patients16
  • Gleevec, one of the first targeted cancer therapies with wide success in CML patients, destroys most leukemic cells in the body, but in most patients, some cancerous cells remain and are measurable with sensitive molecular tests. (sciencedaily.com)
  • The study vaccine was given to 19 CML patients with measurable cancer cells, despite taking Gleevec for at least one year. (sciencedaily.com)
  • According to the investigators, most patients with CML will need to remain on Gleevec therapy for the rest of their lives. (sciencedaily.com)
  • Gleevec also cannot be taken during pregnancy, and since one-third of CML patients are in their 20s and 30s, many patients hoping to start families would like to discontinue taking it. (sciencedaily.com)
  • Ultimately, should this vaccine approach prove to be successful, the ability to get patients off lifelong Gleevec therapy would be a significant advance," says Levitsky. (sciencedaily.com)
  • The submission is supported by data from a phase II, open-label study of 147 patients with unresectable or metastatic malignant GIST randomized to receive 400 mg or 600 mg of Gleevec daily for up to 24 months. (cancernetwork.com)
  • In patients being treated for Ph+ CML or GIST, it is not known at this time whether Gleevec will improve symptoms or help patients live longer. (directoryofdrugs.com)
  • The company submitted one phase I trial and five phase II trials for review that enrolled a total of 94 Gleevec-intolerant patients and 457 Gleevec-resistant patients. (patientcareonline.com)
  • In the data reported Sprycel demonstrated hematologic and cytogenic response in 31% to 59% of patients who were resistant or intolerant to Gleevec. (patientcareonline.com)
  • Although the company is seeking FDA approval for the Sprycel for treatment of Gleevec-resistant patients, Bristol-Myers Squibb is also conducting trials of the drug as a first-line agent. (patientcareonline.com)
  • Blood tests showed that Gleevec did reduce mast cell activity in patients, Israel said. (cheapgenericsonline.com)
  • Further, allergy challenge tests showed a decrease in airway reactivity among patients taking Gleevec, the researchers reported. (cheapgenericsonline.com)
  • If proven effective, Gleevec might provide a relatively inexpensive new treatment for asthma patients. (cheapgenericsonline.com)
  • Currently about 95 percent of these CML patients achieve a lasting response with Gleevec therapy. (ohsu.edu)
  • While relapses are relatively uncommon in newly diagnosed patients treated with Gleevec, they are the rule in patients with more advanced disease. (ohsu.edu)
  • To determine the frequency and severity of adverse effects of Gleevec in this cohort of patients as assessed by CTC. (knowcancer.com)
Efficacy1
  • This is a new prediction regarding the efficacy of Gleevec. (aimsciences.org)
Researchers1
  • The researchers showed that the device could measure how effectively the small molecule drug Gleevec blocked the ATP-receptor binding. (trnmag.com)
Signaling pathway1
  • A key conclusion associated with the study is that the new drug acts on the same molecular abnormality targeted by Gleevec, indicating that this previously identified signaling pathway is consistently central to disease pathogenesis. (ohsu.edu)
Drug4
  • Could Cancer Drug Gleevec Help With Severe Asthma? (cheapgenericsonline.com)
  • The resulting drug, AMN107, which is still in clinical trials, is approximately 20-fold stronger than Gleevec. (ohsu.edu)
  • Dynamical effects of the drug STI-571 (Gleevec) on these events are examined, and a minimal concentration for drug effectiveness is predicted by simulation. (aimsciences.org)
  • Most importantly, the model suggests that, for cells in blast crisis, cellular drug clearance mechanisms such as drug efflux pumps dramatically reduce the effectiveness of Gleevec. (aimsciences.org)
Medications2
  • Because Gleevec interacts with certain other medications, review all medications that you are taking with your doctor, including those that you take without a prescription. (directoryofdrugs.com)
  • Gleevec may affect other medications so it is important to review all medicines that you take with your doctor. (directoryofdrugs.com)
Enzyme1
  • Gleevec specifically targets the enzyme produced by the Bcr-Abl gene that causes production of excessive white blood cells. (ohsu.edu)
Resistance1
  • An equally important outcome of this work, he noted, is the demonstration of how quickly an understanding of the molecular mechanism of Gleevec resistance has translated into new treatment. (ohsu.edu)
Treatment2
  • All received top-notch asthma treatment, and were randomly assigned to take either Gleevec or a placebo pill once daily during the 6-month trial. (cheapgenericsonline.com)
  • It likely will be three to four years before Gleevec could be approved for asthma treatment, Israel estimated. (cheapgenericsonline.com)
Therapy2
  • These remaining cells are a source of relapse, according to the investigators, especially if Gleevec therapy is stopped. (sciencedaily.com)
  • Gleevec is indicated as first-line therapy for all phases of CML. (patientcareonline.com)
Pharmacy1
Side effects3
  • After 2 months on Gleevec things were wonderful, I was tolerating all side effects. (cmlc.ml)
  • What are some possible side effects of Gleevec? (directoryofdrugs.com)
  • This is NOT a complete list of side effects reported with Gleevec. (directoryofdrugs.com)
Cancer cells1
Years1
  • Diagnosed 3/2014 WBC 28 Non detectable within 3 monthsGleevec 400 mg 5/2014 one hour after dinner really improves nausea300 mg 12/15/2016200 mg and 300 mg Gleevec 2/25/2017 (after 3 years on Gleevec) For last four months taking 300 mg per day. (cmlc.ml)
Common1
  • Another common side effect of Gleevec, says Smith, is fatigue. (sciencedaily.com)
Site1
  • When you want to know Imatinib (Gleevec) capsule cost, go to an online site and click on the medicine and check price. (heptopic.com)
Sprycel1
  • Dasatinib (Sprycel) and nilotinib (Tasigna) are now considered first line treatments for CML.Imatinib (Gleevec) remains a first line treatment. (empowher.com)
Cancers3
  • Gleevec is a prescription drug used to treat certain types of cancers. (medicalnewstoday.com)
  • We were barraged with the same question: Which of the other cancers will Gleevec help? (liferaftgroup.org)
  • Drugs such as imatinib (Gleevec) and venetoclax can treat cancers caused by specific genetic changes. (cdc.gov)
Clinical trial5
  • Preliminary findings from a large clinical trial expand the potential use for Gleevec, one of a new class of cancer drugs specifically designed to block abnormal proteins that lead to tumor growth. (nih.gov)
  • In this episode of the "CURE® Talks Cancer" podcast Mel Mann discusses his participation in the clinical trial for Gleevec and how it changed the trajectory of his life. (curetoday.com)
  • In 1998, Mel Mann received his first dose of Gleevec (imatinib) in a clinical trial to treat his leukemia, which was then determined to be terminal. (curetoday.com)
  • According to a small-scale clinical trial reported by US News & World Report, leukemia drug Gleevec (imatinib) might also effectively treat severe asthma. (respiratory-therapy.com)
  • That summer, I became the second of 20 patients to enter the phase I Gleevec clinical trial at MD Anderson. (mdanderson.org)
Cancer10
  • Daily Gleevec tablets helped to prevent the return of cancer in patients with a rare form of gastrointestinal cancer. (nih.gov)
  • After surgical removal of a rare type of gastrointestinal tumor, patients who took daily Gleevec tablets were significantly less likely to have the cancer return than patients who didn't take the drug. (nih.gov)
  • Gleevec is used to treat cancer. (medicine.com)
  • Patients with cancer who take Gleevec may be at a greater risk of getting a severe health problem called tumor lysis syndrome (TLS).This may lead to death. (medicine.com)
  • The OHSU Knight Cancer Institute offers the most advanced care for leukemia, including lifesaving Gleevec and immunotherapy. (ohsu.edu)
  • Gleevec is a smart bomb, designed to kill only cancer. (theglobeandmail.com)
  • Yet it's fun to listen to their happy chatter, and easy to see why Gleevec is an inspiration for scientists around the world working on drugs that will kill cancer cells but leave healthy tissue alone. (theglobeandmail.com)
  • In those first days after FDA approval, no editor thought it worthwhile to criticize Department of Health and Human Services Secretary Tommy Thompson or Acting FDA Commissioner Bernard Schwetz for parading Gleevec in public as a drug that could well be the breakthrough drug we have all been waiting for in cancer therapy. (liferaftgroup.org)
  • The first line of treatment for the majority of CML cancer patients is a drug called Gleevec. (medindia.net)
  • A New York Times story is reporting that Paul Greengard (and his dog Alpha), who won a Nobel Prize for his work on signaling in brain cells, has found that the cancer drug Gleevec, is a new potential drug target for Alzheimer's disease and blocks gamma secretase activating protein. (addiandcassi.com)
Mutations1
  • The drug imatinib (Gleevec) is effective in treating many GIST having mutations in these genes. (nih.gov)
Cancerous1
  • Gleevec fights leukemia by blocking a specific receptor on cancerous white blood cells, inhibiting their ability to multiply and spread, Israel said. (respiratory-therapy.com)
Pharmacies2
  • Compare Gleevec prices available at Canadian and international online pharmacies with local U.S. pharmacy coupon prices. (pharmacychecker.com)
  • The lowest price on PharmacyChecker.com for Gleevec 400 mg is $6.67 per pill or unit for 90 pills or units at PharmacyChecker-accredited online pharmacies. (pharmacychecker.com)
Gastrointestinal2
  • Approval of Gleevec offers health care professionals and patients an important new therapeutic option for patients with this uncommon gastrointestinal disease," said Richard Pazdur, MD, FDA director of Oncology Drug Products, Center for Drug Evaluation and Research, in a news release. (medscape.com)
  • Very bad and sometimes deadly holes in the GI (gastrointestinal) tract have happened with Gleevec. (medicine.com)
Drugs2
  • You must check to make sure that it is safe for you to take Gleevec with all of your drugs and health problems. (medicine.com)
  • All you pay is the cost of Gleevec prescription drugs plus a shipping fee. (canada-border-pharmacy.com)
Dose1
  • If you get pregnant while taking Gleevec or within 2 weeks after your last dose, call your doctor right away. (medicine.com)
Pill1
  • Pill with imprint gleevec is Orange, Capsule/Oblong and has been identified as Gleevec 400 mg. (drugs.com)
Proteins1
  • Gleevec is ineffective in blocking these variant proteins. (nih.gov)
Pregnancy2
  • If you are able to get pregnant, a pregnancy test will be done to show that you are NOT pregnant before starting Gleevec. (medicine.com)
  • Use birth control that you can trust to prevent pregnancy while taking Gleevec and for at least 2 weeks after stopping the drug. (medicine.com)
Dramatically1
  • Most importantly, the model suggests that, for cells in blast crisis, cellular drug clearance mechanisms such as drug efflux pumps dramatically reduce the effectiveness of Gleevec. (aimsciences.org)
Side2
  • Good luck my prayers are with you stay in touch I have CML DXjust two weeks ago and Gleevec has put my WBC back to normal with no serious side effects.All people are different in repsonse to Treatments and keep a positive attitude and seek the comnfort of friends and family to give you moral support. (cancer.org)
  • I know that red & puffy eyes are a common side effect of Gleevec, but what about dry eyes, inflammation, and infection? (cmlc.ml)
Diagnosis1
  • With Gleevec, patients who once faced a life-threatening diagnosis can now often expect a normal lifespan. (ohsu.edu)
Infection1
  • Use of some vaccines with Gleevec may either raise the chance of an infection or make the vaccine not work as well. (medicine.com)
Drug called1
Health care2
  • Tell all of your health care providers that you take Gleevec. (medicine.com)
  • Keep taking Gleevec as you have been told by your doctor or other health care provider, even if you feel well. (medicine.com)
Time3
  • Take Gleevec at the same time of day. (medicine.com)
  • Also vision issues, I took my gleevec in the morning and by knock off time I felt like I was looking through a grey fog, not sure if that was from the fluid retention. (cmlc.ml)
  • With renewed hope, I returned home with my supply of Gleevec in time for Thanksgiving. (mdanderson.org)
Care1
  • If you are 65 or older, use Gleevec with care. (medicine.com)
Less likely1
  • Gleevec reduced the "twitchiness" of airways, making them less likely to reflexively constrict when exposed to an allergen or asthma trigger, said senior researcher Dr Elliot Israel. (respiratory-therapy.com)
Heart failure1
  • Heart failure has happened with Gleevec, as well as heart failure that has gotten worse in people who already have it. (medicine.com)
Events1
  • Dynamical effects of the drug STI-571 (Gleevec) on these events are examined, and a minimal concentration for drug effectiveness is predicted by simulation. (aimsciences.org)