• Sex cord-stromal tumors are groups of tumors composed of granulosa cells, theca cells, Sertoli cells, Leydig cells, and fibroblasts of stromal origin, singly or in various combinations. (medscape.com)
  • [ 1 ] sex cord-stromal tumors are classified into the following categories. (medscape.com)
  • Sex cord-stromal tumors account for approximately 8% of all ovarian tumors. (medscape.com)
  • Although various markers have been reported to stain sex cord-stromal tumors (eg, CD99, CD56, A103, müllerian inhibiting factor, vimentin), inhibin and calretinin have proven to be the most helpful to date. (medscape.com)
  • CD56 is a sensitive marker of ovarian sex cord-stromal tumors and may also be useful in the diagnosis of this group of neoplasms, especially in cases that are inhibin or calretinin negative, and the differential diagnosis includes neoplasms that are CD56 negative. (medscape.com)
  • A worldwide database analysis revealed that younger age, smaller tumor size, early stage, and granulosa cell tumor histologic type appear to be independent prognostic factors for improved survival in patients with malignant sex cord-stromal tumors who undergo lymph node dissection. (medscape.com)
  • The volume and weight of tumors was measured and analyzing the ability of purified DU145 cells isolated from the tumors to migrate and proliferate. (jcancer.org)
  • The volume and weight of tumors were significantly higher in mice transplanted with DU145 and stromal cells from PZ. (jcancer.org)
  • The purified DU145 cells isolated from the tumors with DU145 and stromal cells in PZ had increased ability to migrate and proliferate, and had increased expression of C-Kit. (jcancer.org)
  • Effective immunotherapy of stromal-rich tumors requires simultaneous targeting of cancer cells and immunosuppressive elements of the microenvironment. (aacrjournals.org)
  • Gastrointestinal stromal tumors develop in special cells in the wall of your gastrointestinal tract. (healthline.com)
  • Gastrointestinal stromal tumors in general have a 5-year relative survival rate of 83% . (healthline.com)
  • It's called GIST, which stands for gastrointestinal stromal tumors. (bannerhealth.com)
  • Gastrointestinal stromal tumors are rare tumors that develop in the digestive tract. (bannerhealth.com)
  • Most human prostate cancers are adenocarcinomas, which originate from the epithelial cells that line the glands and ducts of prostate [ 2 ]. (jcancer.org)
  • These glands and ducts are distributed in the prostate and surrounded by stromal tissues. (jcancer.org)
  • A prostate has four distinct glandular zones: the peripheral zone (PZ), central zone, transitional zone (TZ), and anterior fibro-muscular zone. (jcancer.org)
  • Keywords: prostate swelling androgen receptor TGF-β1 laser capture microdissection Intro Benign prostatic hyperplasia (BPH) is definitely associated with proliferation of the prostatic duct and stromal component and commonly impacts older men by inducing lower urinary system symptoms. (healthweeks.com)
  • Benign prostatic hyperplasia (BPH) refers to the proliferation of the stromal and epithelial cells of the prostate gland. (mpconsulting.co.za)
  • This proliferation of cells is mainly at the transition zone of the prostate gland in the early stages, and may involve the entire gland at a later stage, leaving only a rim of normal glandular tissue beneath the capsule. (mpconsulting.co.za)
  • Prostate cells provide a glandular function in the body by generating fluid which serves several functions in reproduction. (lonza.com)
  • Lonza's Human Prostate Cells are available from epithelial, smooth muscle, and stromal tissue. (lonza.com)
  • Prostate Smooth Muscle Cells (PrSMC) are guaranteed through 10 population doublings and stain positive for alpha smooth muscle actin and negative for von Willebrand (Factor VIII) antigen. (lonza.com)
  • It is a type of cancer that starts in the cells of the prostate gland. (simba.health)
  • The prostate gland is made up of several types of cells, including glandular cells, which produce prostate-specific antigen (PSA) and other substances that are important for prostate function, and stromal cells, which provide structural support to the gland. (simba.health)
  • Prostate cancer most commonly develops in the glandular cells, but it can also occur in the stromal cells. (simba.health)
  • In prostate, the functional role of this gene has never been reported and in this study, our aim was to investigate the effect of PMS2 on growth properties of prostate cancer (PCa) cells. (oncotarget.com)
  • Fig. 3) and recent studies have focused on prostate epithelial cells (Cai et al. (apexprep-dna-plasmid-miniprep.com)
  • By stimulating a variety of molecular pathways, fexapotide selectively causes loss of prostate glandular epithelial cell integrity, with subsequent decompression of the urethral lumen. (medscape.com)
  • Endometriosis, a chronic disease of heterogeneous etiopathology affects 10% of young women and is characterized by ectopic implantation of endometrial cells. (endometriosi.it)
  • During this phase, estrogen also induces the endometrial cells to express large numbers of progesterone receptors in preparation for the events of the next phase of the cycle. (byui.edu)
  • Progesterone also has an anti-estrogen effect and prevents further proliferation of the endometrial cells. (byui.edu)
  • In endometriosis, functioning endometrial cells are implanted in the pelvis outside the uterine cavity. (msdmanuals.com)
  • The most widely accepted hypothesis for the pathophysiology of endometriosis is that endometrial cells are transported from the uterine cavity during menstruation and subsequently become implanted at ectopic sites. (msdmanuals.com)
  • the lymphatic or circulatory system could transport endometrial cells to distant sites (eg, the pleural cavity). (msdmanuals.com)
  • The breast is composed of two main types of tissues: glandular tissues and stromal (supporting) tissues. (indiasurgerytour.com)
  • Glandular tissues house the milk-producing glands (lobules) and the ducts (the milk passages) while stromal tissues include fatty and fibrous connective tissues of the breast. (indiasurgerytour.com)
  • Because the cytological characteristics of hyperplasia, inflammation, and malignancy can differ in different tissues, it is important to first determine the most frequently occurring type of cell in the cytological preparation. (vin.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • RESULTS: Immunoreactivity for aFGF and FGFR4 was seen in epithelial cells, but it was lacking in myoepithelial cells of both normal tissues and fibroadenomas. (uninsubria.it)
  • The origins of the endometriosis-initiating stem cells were thought to be the bone marrow, uterine endometrium, and other tissues. (elsevierpure.com)
  • A complete understanding of the types of cells and tissues in which the virus replicates is critical for identifying potential diseases with which it may be associated. (cdc.gov)
  • In vitro tissue engineering of smooth muscle sheets with peristalsis using a murine induced pluripotent stem cell line. (otago.ac.nz)
  • De- cidual cells promote hemostasis through enhanced expression of tissue factor (TF), the primary initiator of hemostasis via thrombin generation, and plasminogen activator inhibitor-1, which inactivates tissue type plasminogen activator, the primary fibrinolytic agent. (scirp.org)
  • 2009) Progestin and thrombin regulate tissue factor expression in human term decidual cells. (scirp.org)
  • Cells of this type of tissue have the tendency to be connected to each other. (vin.com)
  • Within this type are included the cells arising from connective tissue, muscle, cartilage, and bone. (vin.com)
  • Smears of this type of tissue are thus also characterized by a low cellularity and the cells are mostly separate from each other, although groups of cells can also be found. (vin.com)
  • iii) Deep Infiltrating Endo (DIE) that is characterised by undifferentiated glandular and/or stromal cells surrounded by fibrotic tissue. (endometriosissouthcoast.com)
  • Additionally, spiral arteries arise to feed the new tissue and glandular structures develop. (byui.edu)
  • BACKGROUND/AIM: Fibroadenomas are benign tumours composed of both glandular and fibrous tissue. (uninsubria.it)
  • When uninflamed, they are characterized by a wall of relatively loose connective tissue, and an epithelial lining consisting of two to four layers of cuboidal cells. (bvsalud.org)
  • All MLAs exhibited architectural diversity, compactly aggregated small tubules, eosinophilic intraluminal secretions, overlapped and angulated nuclei, scant cytoplasm, and presence of spindle cells. (iiarjournals.org)
  • Various cell lineages such as the epithelial glandular cells and the stromal spindle cells are involved. (ijpmonline.org)
  • Twenty-nine of these genes were significantly regulated in UC-in-remission subjects compared with non-IBD controls, including a large number of epithelial cell-expressed genes such as REG4, S100P, SERPINB5, SLC16A1, DEFB1, AQP3 and AQP8, which modulate epithelial cell growth, sensitivity to apoptosis and immune function. (bmj.com)
  • Among the genes that remain deregulated during remission, we identify several that are expressed by epithelial cells and are involved in epithelial cell proliferation, resistance to apoptosis and response to stress. (bmj.com)
  • The model will be useful for understanding the mechanisms by which the prostatic stem cell niche controls the tumorigeneis of prostatic cancer stem cells. (jcancer.org)
  • Previous studies have shown PMS2 to be deficient in DU145 cells and this lack of expression was confirmed by Western blotting whereas normal prostatic PWR-1E and RWPE-1 cells expressed this gene. (oncotarget.com)
  • The stroma between the cystic/glandular spaces were fibromuscular without evidence of either endometrial stromal differentiation or recent/old haemorrhage. (bmj.com)
  • The initial hypothesis proposed that endometriosis arose from a single or a few specific cells with stem cell properties, including self-renewal and multilineage cell differentiation. (elsevierpure.com)
  • Subsequently, they give rise to endometriotic lesions followed by differentiation into various cell components of endometriosis, including glandular and stromal cells. (elsevierpure.com)
  • The tumor comprised tumor cells in a tubular pattern with intraluminal eosinophilic material, as well as mixed glandular and papillary, cord-like, and solid patterns. (bvsalud.org)
  • Other histologic subtypes include adenosquamous, clear cell, and papillary serous carcinomas. (medscape.com)
  • Some cysts were lined by serous (tubal) epithelium, whereas others exhibited attenuated serous epithelium or, rarely, endocervical-type mucinous epithelial cells (fig 2). (bmj.com)
  • Polymorphonuclear cells infiltrated the slightly edematous stroma but no morphological changes were observed in the epithelium. (healthweeks.com)
  • It is now proposed that stem/progenitor cells of at least two different origins-epithelium and stroma-sequentially, differentially, but coordinately contribute to the genesis of endometriosis. (elsevierpure.com)
  • Comparing HESC controls with HESCs deficient in SRC-3, gene enrichment analysis of the differentially expressed gene set revealed an overrepresentation of genes involved in chromatin remodeling, cell proliferation/motility, and programmed cell death. (frontiersin.org)
  • The inflammatory process causes persistent and repeated cell and genomic harm that leads to increased cell proliferation. (healthweeks.com)
  • Gene and protein expression signature of endometrial glandular and stromal compartments during the window of implantation. (otago.ac.nz)
  • We previously demonstrated the critical involvement of SRC-2 in murine embryo implantation as well as in human endometrial stromal cell (HESC) decidualization, a cellular transformation process required for trophoblast invasion and ultimately placentation. (frontiersin.org)
  • These molecular findings are supported at the cellular level by the inability of HESCs to morphologically transform from a stromal fibroblastoid cell to an epithelioid decidual cell when endogenous SRC-3 levels are markedly reduced. (frontiersin.org)
  • The pathological feature of adenosarcoma is called "cuffing structure", atypical hyperplasia of the cellular stromas that surround the glandular component, like dense periglandular cuffs. (scirp.org)
  • Of the nine samples of small cell carcinoma, categorized as atypical, suspicious for carcinoma, three (33%) were categorized as suspicious for small cell carcinoma, while the others were not further classified, due to limitations of cellular preservation. (cytojournal.com)
  • Good needle aspiration cytology Smear showed diffusely cellular stroma, bedding of epithelial cells and multiple bare nuclei with no atypia. (columbiagypsy.net)
  • It has a basal layer and a functional layer: the basal layer contains stem cells which regenerate the functional layer. (wikipedia.org)
  • Acidic fibroblast growth factor (aFGF) is a well known fibroblast activator, which acts through four specific cell surface receptors, among which, fibroblast growth factor receptor 4 (FGFR4) is highly specific. (uninsubria.it)
  • 2007). The AR is expressed in glandular epithelial and stromal/fibroblast CID 2745687 in the breast (Hickey et al. (apexprep-dna-plasmid-miniprep.com)
  • C: Tumor either Stage IA or Stage IB, but with tumor on the surface of one or both ovaries, or with capsule ruptured, or with ascites containing malignant cells or with positive peritoneal washings. (medscape.com)
  • or ascites present containing malignant cells or with positive peritoneal washings. (medscape.com)
  • The term breast cancer refers to a malignant tumor that has developed from cells in the breast. (indiasurgerytour.com)
  • Rapidly growing breast mass could hardly ever become metastasis GS-1101 kinase activity assay from rhabdomyosarcoma, leukaemia, lymphoma, primitive neuroectodermal tumours, Ewing sarcoma, malignant melanoma and renal cell carcinoma.3 However, the size of such masses is not usually as gigantic as in our individual. (columbiagypsy.net)
  • CONCLUSIONS: These results suggest a paracrine/autocrine modulation of epithelial and stromal cells of fibroadenomas through an aFGF-FGFR4 interaction. (uninsubria.it)
  • Staining was also observed in inflammatory cells localized in the stroma as well as inside of the glands. (openveterinaryjournal.com)
  • Under the influence of progesterone, the endometrial glands enlarge, coil, and begin to produce a glandular secretion high in nutritious organic molecules such as glycogen. (byui.edu)
  • We tested the hypothesis that the stromal cells from PZ and transitional zone (TZ) have differential effects on the ability of tumorigenesis. (jcancer.org)
  • During the past decade, a stem cell-based hypothesis has emerged (among many others) to explain the pathogenesis of endometriosis. (elsevierpure.com)
  • Extracellular vesicles released by mesenchymal stem/stromal cells (MSC-EV) are promising agents to positively influence joint homeostasis in the osteoarthritic surroundings. (bvsalud.org)
  • The candidate cells for endometriotic stroma-initiating cells may be endometrial mesenchymal stem cells positive for SUSD2. (elsevierpure.com)
  • Results: IP-10 dramatically attracted trophectoderm derived from hES cells and other lineages by interaction with CXCR3 chemokine receptors, as shown by both chemotaxis and transwell migration. (huji.ac.il)
  • Between the period of 1983 and 2009, there were a total of 25 cases of small cell carcinoma, 20 of squamous carcinoma, and 10 of adenocarcinoma, wherein prediagnosis urine cytology was available. (cytojournal.com)
  • There were eight cases (12 samples) of small cell carcinoma, four cases (6 samples) of squamous cell carcinoma and four cases (5 samples) of adenocarcinoma. (cytojournal.com)
  • Adenocarcinoma of the anal canal develops in glandular cells and tends to be more aggressive than squamous cell carcinoma. (healthline.com)
  • A mixed adenocarcinoma and squamous cell or epidermoid carcinoma. (bvsalud.org)
  • Abruptions (decidual hemorrhage) produce excess thrombin which acts as autocrine/paracrine inducer of decidual cell expressed matrix metalloproteinases and of neutrophil chemoattractant and activator, interleukin-8. (scirp.org)
  • During abruptions, decidual cell and neutrophil-derived proteases effectively degrade the decidual and fetal membrane extracellular matrix to promote preterm premature rupture of the membranes and preterm delivery (PTD). (scirp.org)
  • Decidual cell-derived thrombin weakens the amniotic membrane and lowers decidual cell-expressed progesterone receptor levels by increasing phospho-ERK1/2 signaling. (scirp.org)
  • Conclusion: Endometrial IP-10 may specifically attract human blastocyst trophectoderm cells early in implantation. (huji.ac.il)
  • This then disrupts the bi-directional communication between stem-cell signalling pathways that are affected by local inflammation which forms an inflammation-hormonal loop that is dysregulated (10). (endometriosissouthcoast.com)
  • We also found that SRC-3 depletion in cultured HESCs results in a significant attenuation in the induction of a wide-range of established biomarkers of decidualization, despite exposure of these cells to a deciduogenic stimulus and normal progesterone receptor expression. (frontiersin.org)
  • Other recent studies verified the presence of PAPP-A mRNA in granulosa cells of humans, monkeys, cattle, mice, and pigs. (bioone.org)
  • Increases in the amount of PAPP-A mRNA in granulosa cells during follicular development occurs in some but not all species, indicating that other proteases or protease inhibitors may be involved in IGFBP degradation. (bioone.org)
  • 2012). Down-regulation of receptor mRNA has been reported in response to DHT in a number of breast cancer cell-lines (T-47D, MFM-2333, MDA-453) (Hall et al. (apexprep-dna-plasmid-miniprep.com)
  • 1999). Interestingly, in the latter cell model the response was at the level of stability of the receptor mRNA (Yeap et al. (apexprep-dna-plasmid-miniprep.com)
  • 1999). In our studies we also observed down-regulation of the AR mRNA in MCF-7 cells, but not in BT-474 cells (Fig. 3). (apexprep-dna-plasmid-miniprep.com)
  • 1992). Auto-repression of the AR mRNA has also been observed in a number of human cell-lines (Shan et al. (apexprep-dna-plasmid-miniprep.com)
  • The corresponding specific proteins are expressed in the glandular and stromal cells of the endometrial mucosa. (wikipedia.org)
  • Other proteins such as the HOX11 protein that is required for female fertility, is expressed in endometrial stroma cells throughout the menstrual cycle. (wikipedia.org)
  • In the absence of progesterone, the arteries supplying blood to the functional layer constrict, so that cells in that layer become ischaemic and die, leading to menstruation. (wikipedia.org)
  • Endo is a hormone-dependent disease, where stem cells are dysfunctional due to progesterone resistance which causes disruption to endometrial homeostasis (9). (endometriosissouthcoast.com)
  • It contains stem cells that regenerate the functional layer, which develops on top of it. (wikipedia.org)
  • Stomach cancer develops when cells in the lining of the stomach change and grow out of control. (vic.gov.au)
  • Melanoma develops in skin cells that produce pigment. (healthline.com)
  • The mechanisms regulating the growth of these tumours and the relation between the stromal and epithelial cells are poorly understood. (uninsubria.it)
  • The study aimed to assess the diagnostic value of serial monitoring of biochemical inflammatory markers (C-reactive protein (CRP) and white blood cell (WBC) count) in the postoperative diagnosis of anastomotic leakage or ureteral injury after bowel resection for deep infiltrating endometriosis. (endometriosi.it)
  • this condition may be due to the existence of the cancer stem cells (CSCs) that are resistant to the hormone therapy. (jcancer.org)
  • The term 'microinvasive carcinoma' is no longer recommended, and the term 'superficially invasive squamous cell carcinoma' (SISCCA) should be used instead. (cancer.org.au)
  • Squamous cell carcinomas, adenocarcinomas, and small cell carcinomas of the urinary bladder are rare and account for less than 5, 2, and 0.5% of all bladder carcinomas, respectively. (cytojournal.com)
  • In the squamous cell carcinoma subgroup, the samples with 'atypical, suspicious for carcinoma' diagnoses did not show any keratinization and were interpreted as atypical urothelial cells. (cytojournal.com)
  • None of the samples of small cell carcinoma had a false negative diagnosis on cytology, while only one case of squamous cell carcinoma was diagnosed as negative. (cytojournal.com)
  • More than 90% of anal cancers are squamous cell carcinoma. (healthline.com)
  • Renal cell carcinoma (RCC) has an insidious onset and wide variations in pathology, clinical course and response to treatment. (mpconsulting.co.za)
  • LSIL is the morphologic expression of acute HPV infection and is characterised by cells with increased nuclear to cytoplasmic ratios and irregular nuclear membranes. (cancer.org.au)
  • In squamous epithelia, this is defined as continuous strong nuclear, or nuclear plus cytoplasmic, staining of the basal cell layer with extension upward involving at least one-third of the epithelial thickness. (cancer.org.au)
  • Cells of hematopoietic origin are individual cells, mostly round in shape, and have a distinct cytoplasmic membrane. (vin.com)
  • The cytoplasm is often abundant and the cell borders are distinct. (vin.com)
  • Stromal cells isolated from the PZ and TZ of normal human prostates mixed with DU145 cells subcutaneously injected into athymic nude mice. (jcancer.org)
  • The expression patterns of stem cell-specific genes of these DU145 cells were examined. (jcancer.org)
  • In contrast, the data was significantly lower with DU145 and stromal cells from TZ than DU145 alone. (jcancer.org)
  • These effects of the stromal cells in the PZ on DU145 cells could be blocked using imatinib mesylate. (jcancer.org)
  • All the adenocarcinomas categorized as negative by urine cytology had sparse cellularity and did not reveal any atypical cells on slide review. (cytojournal.com)
  • Conclusion : Une exploration chirurgicale doit être réalisée en cas d'hématocèle ou de rupture de l'albuginée testiculaire à l'échographie. (bvsalud.org)
  • Non-neoplastic smoke-related lung disease: chronic obstructive pulmonary disease, small airways disease/respiratory bronchiolitis, Langerhans cell histiocytosis of the lung. (unibo.it)
  • A subset of WUPyV-positive cells in the lung had morphologic features of macrophages. (cdc.gov)
  • That study determined that WUPyV was present in epithelial cells from a bronchoalveolar lavage from a lung transplant recipient with Job syndrome. (cdc.gov)
  • Since GISTs come from different types of cells than stomach and colon cancers, treatments are not the same. (bannerhealth.com)
  • The aim of this study was to evaluate the distribution of aFGF and FGFR4 in specific cell types of fibroadenomas to understand their possible role in the growth of these breast lesions. (uninsubria.it)
  • Flow cytometric detection of intracellular antigens has become a standard method in establishing proper leukemic cell lineage affiliation. (ijpmonline.org)
  • Materials and methods: Blastocyst trophectoderm cells and other trophoblast lineage cells were subjected to attraction assays by IP-10 and other chemokines using transwell migration and chemotaxis assays. (huji.ac.il)
  • Chemokine receptor expression by blastocyst trophectoderm following PGD biopsy, trophectoderm derived from hES, placental villi, and other trophoblast lineage cells were characterized by the same methods. (huji.ac.il)
  • DNA mismatch repair (MMR) enzymes act as proofreading complexes that maintains genomic integrity and MMR-deficient cells show an increased mutation rate. (oncotarget.com)
  • Clinical and cell-based studies as well as investigations on mice have demonstrated pivotal roles for each SRC in numerous physiological and pathophysiological contexts, underscoring their functional pleiotropy. (frontiersin.org)
  • Differences in growth properties of endometrial cancer in three dimensional (3D) culture and 2D cell monolayer. (otago.ac.nz)
  • Each cell type has an optimized growth media for best results in culture. (lonza.com)
  • TRP and its metabolites have key roles in diverse physiological processes including cell growth and maintenance, immunity, disease states and the coordination of adaptive responses to environmental and dietary cues. (mdpi.com)