Ginsenoside. Medical search. Frequent questions

although Asian ginseng, Panax ginseng, has been most widely studied due to its use in traditional Chinese medicine, there are ginsenosides unique to American ginseng (Panax quinquefolius) and Japanese ginseng (Panax japonicus). (wikipedia.org)
Ginsenosides extracted from ginseng, which is derived from the roots and rhizomes of Panax ginseng C. A. Meyer, have been used in China as an adjuvant in the treatment of diabetes mellitus. (frontiersin.org)
The content and yield of ginsenosides vary drastically not only between different species such as the Asian ginseng ( Panax ginseng ), the Japanese ginseng ( Panax japonicus ) and the American ginseng ( Panax quinquefolius ), but also between individual plants. (acib.at)
20GPPD is the primary bioactive metabolite of Rb1, a major ginsenoside found in ginseng (Panax ginseng). (oregonstate.edu)
CLEAN PANAX GINSENG EXTRACT - 455.4mg of Clean Panax Ginseng extract (227.7mg Ginsenosides) + 50.6mg Uptake Blend (details below) in Vegetarian Capsules. (british-supplements.net)
Compound K (CK) is a ginsenoside, which is a metabolite of Panax ginseng. (ginsengnation.com)
Due to the fact the company established, we've been committed to 80 ginsenosides panax ginseng extract in puerto rico in China sales and service, we've consistently adhering for the "quality initially, service first" business philosophy to serve our clients and generally place this philosophy all through our 80 ginsenosides panax ginseng extract in puerto rico sales and after-sales service. (comextbiotech.com)
We're among the most highly effective and comprehensive market network of contemporary integrated 80 ginsenosides panax ginseng extract in puerto rico item sales company. (comextbiotech.com)
Panax ginseng contains chemicals (ginsenosides) that can act like estrogen . (webmd.com)
Ginsenoside Rg1 is one effective anticancer and antioxidant constituent of total saponins of Panax ginseng(TSPG), which has been shown to have various pharmacological effects. (waocp.org)
Derived from the root of the Panax ginseng plant, this supplement contains a potent dose of ginsenosides, which are believed to increase blood flow to the genital area and enhance sexual performance. (discovermagazine.com)

Ginsenosides or panaxosides are a class of natural product steroid glycosides and triterpene saponins. (wikipedia.org)
Ginsenosides (also called panaxosides) are the well-known natural products from Ginseng ( Panax ) plants, which have longstanding use in traditional medicine exhibiting a variety of pharmacological effects. (acib.at)
The most important are called ginsenosides or panaxosides. (webmd.com)

Many studies suggest that ginsenosides have antioxidant properties. (wikipedia.org)
Usage These studies suggest that ginsenosides protect vascular endothelial cells through the signaling pathways. (nacchemical.com)

However, monoclonal antibodies (MAbs) against ginsenosides such as ginsenoside Rb1, Rg1, and Re and notoginsenoside R1 have been applied in recently developed techniques like Eastern blotting, one-step separation methods, and knockout extract preparations from ginseng. (novapublishers.com)
This product is ginseng dry root extract,Ginsenosides can be extracted from the stem, leaf, root and fruit of ginseng. (newleafherb.com)

In some cases the metabolites of ginsenosides may be the biologically active compounds. (wikipedia.org)
The pharmacological active substances include ginsenosides, flavonoids and polysaccharides, etc., among which ginsenosides are the main bioactive compounds in ginseng [ 2 ]. (biomedcentral.com)
But did you know that ginseng has a very high cost of production, leading to the price of ginsenosides i.e. the active compounds being almost 1,000x higher than gold with approx. (acib.at)
While you may not be familiar with their name, ginsenosides are potent plant compounds that have been isolated from a plant called Panax, which is widely known for its healthy roots-ginseng. (elquanah.com)
Unlike white ginseng, which is dried without steaming, Red Ginseng is considered to be more potent due to its richer concentration of bioactive compounds, like ginsenosides. (historyfashions.com)
Consistent with the old version, the newly upgraded Redsenol-1 remains sixteen rare ginsenosides, the main active compounds in ginseng known for an array of antioxidant and anti-inflammatory properties. (nationwidenewsbulletin.com)
A detailed phytochemical investigation on the roots of P. ginseng led to the isolation of 6 new natural protopanaxatriol (PPT)-type ginsenosides, ginsenosides Re 1 -Re 6 (compounds 1-6), along with 10 known PPT-type ginsenosides. (edu.hk)

Ginsenoside Rh2 (GRh2) is a monomer isolated from red ginseng that has extensive pharmacological effects. (spandidos-publications.com)
Responsible for the pharmacological effects of ginseng, ginsenosides play a critical role in the body's inflammatory and disease responses and are featured in a deepening catalog of research that may help prevent and treat inflammatory diseases, including those affecting the brain. (elquanah.com)

In today's study, we induced ER stress-associated irritation by revealing adipose adipocytes or tissues to high blood sugar insult, and observed the consequences of ginsenoside Rb1 and its own order MK-8776 metabolite CK on insulin PI3K signaling, with focus on the Rabbit polyclonal to TIMP3 inhibition of NLRP3 inflammasome activation in the placing of ER tension. (bioinf.org)
20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol, a metabolite of ginsenoside Rb1, enhances the production of hyaluronic acid through the activation of ERK and Akt mediated by Src tyrosin kinase in human keratinocytes. (oregonstate.edu)

The biosynthetic pathway of ginsenosides is not entirely characterized, though as steroids they derive from pathways that lead to the synthesis of isoprene units. (wikipedia.org)
Based on previous studies, the biosynthetic pathways of ginsenosides are as follows. (biomedcentral.com)
Yeast strains with modifications in precursor supply and integrated pathways for ginsenoside-aglycon synthesis are available. (acib.at)

The anticancer activity of red ginseng is higher than that of white ginseng due to the production of active anticancer ginsenosides during the steaming process, resulting in apoptosis/paraptosisinduction and angiogenesis inhibition. (novapublishers.com)
2014). 'Ginsenoside Rg1 Induces Apoptosis through Inhibition of the EpoR-Mediated JAK2/STAT5 Signalling Pathway in the TF-1/Epo Human Leukemia Cell Line', Asian Pacific Journal of Cancer Prevention , 15(6), pp. 2453-2459. (waocp.org)

Ginsenoside Rh4 (Rh4) is a rare triol ginsenoside that is characterized by being more soluble in water than other polysaccharide ginsenosides [ 25 ]. (hindawi.com)

Ginsenoside is a triterpenoid saponin predominantly extracted from P. ginseng C. A. Meyer. (frontiersin.org)

They can be broadly divided into two groups based on the carbon skeletons of their aglycones: the four-ring dammarane family, which contains the majority of known ginsenosides, and the oleanane family. (wikipedia.org)
Most known ginsenosides are classified as members of the dammarane family. (wikipedia.org)
The structure of these dammarane ginsenosides consists of a 4-ring, steroid-like structure. (wikipedia.org)
There are two main classes of ginsenosides based on the skeletons of their aglycones, namely, the dammarane type and the oleanane type. (biomedcentral.com)

Ultra-performance liquid chromatography and time-of-flight mass spectrometry analysis of ginsenoside metabolites in human plasma. (uchicago.edu)

Ginsenosides, triterpenoid saponins with a four-ring skeleton structure, are unique to ginseng genus. (biomedcentral.com)

Accumulating evidence has shown that ginsenosides exert antidiabetic effects. (frontiersin.org)

One of its most potent components is Ginsenoside Rg3, a compound that amplifies its therapeutic effects. (historyfashions.com)
Among the various ginsenosides found in Red Ginseng, Ginsenoside Rg3 stands out for its potent health benefits. (historyfashions.com)
In the holistic journey through the world of traditional and modern medicine, the unique properties of Red Ginseng and Ginsenoside Rg3 stand out as potent ingredients that have been reverentially celebrated for thousands of years. (historyfashions.com)

Ginsenosides likely serve as mechanisms for plant defense. (wikipedia.org)
Two broad mechanisms of action have been suggested for ginsenoside activity, based on their similarity to steroid hormones. (wikipedia.org)
It is not known how these mechanisms yield the reported biological effects of ginsenosides. (wikipedia.org)
This paper highlights the underlying pharmacological mechanisms of the anti-diabetic effects of ginsenosides. (frontiersin.org)
Additionally, the cognitive benefits of major ginsenosides and their mechanisms have been widely confirmed. (novapublishers.com)
This study complemented the gaps in the genetic information of wild ginseng in different growth periods and helped to clarify the potential mechanisms of the effect of growth years on the physiological state in wild ginseng and cultivated ginseng, which also provided a new insight into the mechanism of ginsenoside regulation. (biomedcentral.com)
Nitric oxide production has been induced by ginsenosides through various mechanisms. (nacchemical.com)
A recent study published in Frontiers in Pharmacology explored the effects of ginsenosides and their probable neuroprotective mechanisms in ischemic strokes, the most common type of stroke. (elquanah.com)
After an exhaustive meta-analysis evaluating the effects of ginsenoside-Rb1, researchers concluded that ginsenosides have a potential neuroprotective effect that works through an array of mechanisms, including attenuating brain water content, promoting neurogenesis, reducing cell death, and providing antioxidative, anti-inflammatory effects. (elquanah.com)

In vitro release showed that ginsenoside Rg3-loaded PEGylated liposomes showed a more obvious sustained release effect, which suggests that ginsenoside Rg3-loaded PEGylated liposomes might enhance the therapeutic effect of ginsenoside Rg3. (ijpsonline.com)

Ginsenosides Rg3 and Rh2 have been observed in cell models as having an inhibitory effect on the cell growth of various cancer cells while studies in animal models have suggested that ginsenosides have neuroprotective properties and could be useful in treating neurodegenerative disease such as Alzheimer's and Parkinson's diseases. (wikipedia.org)
Ginsenoside Rg1 (Rg1), one of the major active components of ginseng, has been reported possessing notable neuroprotective activities. (ijbs.com)

Background This study was made to investigate whether ginsenoside Rb1 (Rb1) and compound K (CK) ameliorated insulin resistance by suppressing endoplasmic reticulum (ER) stress-induced inflammation in adipose tissue. (bioinf.org)
root is the most abundant ginsenoside, and ginsenoside compound K (CK) is definitely generated from Rb1 via ginsenoside F2 (Fig.?1) by intestinal bacteria after dental administration [14]. (bioinf.org)

Previous studies indicated that 20(S)-ginsenoside Rh2 [20(S)-Rh2] could synergistically enhance the anticancer effects of conventional chemotherapeutic agents at a nontoxic dose. (indexindex.com)

As a class, ginsenosides exhibit a large variety of subtle and difficult-to-characterize biological effects when studied in isolation. (wikipedia.org)
Ginsenoside content also varies significantly due to environmental effects. (wikipedia.org)
Most studies of the biological effects of ginsenosides have been in cell culture or animal models and thus their relevance to human biology is unknown. (wikipedia.org)
Among the remedies, ginsenoside Rg1, a major active component of ginseng, is often recommended for its antiaging effects. (nih.gov)
Online ahead of print.ABSTRACTAlthough the anticonvulsant effects of ginsenosides are recognized, little is known about their effects on the convulsive behaviors induced by the activation of L-type Ca2+ channels. (medworm.com)
Similarly, ginsenoside CK also exerts beneficial effects on glucose and lipid rate of metabolism, as well as insulin level of sensitivity in diabetic rats [17]. (bioinf.org)
Furthermore, the growth years had significant effects on the genes related to ginsenoside synthesis in cultivated ginseng, and the effects were different in the roots, stems and leaves. (biomedcentral.com)
Emerging studies have shown the promising effects of Ginsenoside Rg3 in inhibiting the growth of certain types of cancer cells. (historyfashions.com)
Anti-Inflammatory Effects of Ginsenoside-Rh2 Inhibits LPS-Induced Activation of Microglia and Overproduction of Inflammatory Mediators Via Modulation of TGF-ß1/Smad Pathway. (bvsalud.org)

Ginseng is generally consumed orally as a dietary supplement, and thus its component ginsenosides may be metabolized by gut flora. (wikipedia.org)

These liposomes were characterized, the cumulative release profiles were investigated and compared with ginsenoside Rg3-loaded liposomes in vitro . (ijpsonline.com)

Ginsenoside, as the main active substance in ginseng, has the function of treating various diseases. (biomedcentral.com)

In addition, there are significant differences in morphology and physiology between wild ginseng and cultivated ginseng, and the effect of growth years on ginsenoside synthesis not yet understood in wild ginseng. (biomedcentral.com)
However, it had little influence on the expression of genes related to ginsenoside synthesis in wild ginseng. (biomedcentral.com)
Growth years might affect the expression of genes for ginsenoside synthesis by influencing the expression of these transcription factors (TFs), like my elob lastosis (MYB), NAM, ATAF1 and 2, and CUC2 (NAC), APETALA2/ethylene-responsive factor (AP2/ERF), basic helix-loop-helix (bHLH) and WRKY, etc., thereby affecting the content of ginsenosides. (biomedcentral.com)

Ginsenosides that are a member of the oleanane family are pentacyclic, composed of a five ring carbon skeleton. (wikipedia.org)

While Red Ginseng serves as a powerful adaptogen that fights against physical and emotional stress, Ginsenoside Rg3 elevates these qualities, marking its strong presence in anti-cancer, anti-inflammatory, and cognitive function enhancement. (historyfashions.com)

With properties that help improve focus and cognitive function, Red Ginseng, fortified with Ginsenoside Rg3, can be an excellent addition to your daily routine for mental clarity. (historyfashions.com)

Suitable analytical methods for detection of ginsenoside aglycons have been established. (acib.at)

However, the ginsenosides content of cultivated ginseng is obviously affected by the growth years, but the molecular mechanism is not clear. (biomedcentral.com)

Open up in another window Fig.?1 Buildings of ginsenoside chemical order MK-8776 substance and Rb1 K. Ginsenoside CK is normally produced from ginsenoside Rb1 through the elimination of the C-20 and two C-3 glucose chains pursuing hydrolysis by intestinal bacterias after dental administration. (bioinf.org)

This paper reports the characteristics and hemostatic ability of the collagen/ginsenoside Rb1 composites with different ginsenoside Rb1 content, in which, collagen was extracted from fresh water fish scales and ginsenoside Rb1 was extracted from Panax notoginseng . (ac.vn)

Ginsenoside molecules are naturally bitter-tasting and discourage insects and other animals from consuming the plant. (wikipedia.org)

Superior to other products with only one or two rare ginsenosides on the market, Redsenol-1 features sixteen rare ginsenosides in high concentrations and enables people to obtain the maximal medicinal benefits of ginseng. (nationwidenewsbulletin.com)

Ginsenosides such as ginsenoside Rh4 have been widely studied in the antitumor field. (hindawi.com)

Ginsenoside Rb3 reduces smoke-induced lungs injury through H19/miR-29b-3p/HGMB1/TLR4 signalling path. (gsk-3signaling.com)

Our tests showed a very wide range in the amount of ginsenosides in ginseng supplements. (consumerlab.com)

Glutaraldehyde exhibits a positive effect on improvement the dispersion of ginsenoside Rb1 in collagen matrix as well as on the interactions between ginsenoside Rb1 and collagen. (ac.vn)

Ginsenosides have been found to have both antimicrobial and antifungal properties. (wikipedia.org)
Key "Ginsenosides" Found to Range 10-Fold Across Products. (consumerlab.com)

Owing to the technical complexity of ginsenoside production, the total ginsenosides are generally extracted. (frontiersin.org)
acib is going to change that by developing an industrial yeast for ginsenoside production and is looking for interested companies! (acib.at)
acib has initiated metabolic engineering of the industrial yeast Komagataella phaffii (aka Pichia pastoris ) for the production of highly-valued ginsenosides, providing an inexpensive and environmentally benign way superior to extraction from ginseng roots. (acib.at)
acib has all the expertise in glycosylation technology required and applicable for the production of natural and new-to-nature ginsenosides. (acib.at)
acib offers to develop Ginsenoside-producing yeast strains, including upscaling of (lab-scale) bioreactor-production for you. (acib.at)

Ginsenosides have been observed to increase internal antioxidant enzymes and act as a free-radical scavenger. (wikipedia.org)

Ginsenoside Rg3, in particular, has shown potential in enhancing skin elasticity and reducing wrinkles. (historyfashions.com)

Anatomy3

Organisms10

Chemicals and Drugs23

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes6

Panax Ginseng11

Panaxosides3

Studies suggest that ginsenosides2

Extract2

Compounds7

Pharmacological effects2

Metabolite2

Pathways3

Apoptosis2

Polysaccharide1

Saponin1

Dammarane4

Metabolites1

Triterpenoid1

Antidiabetic1

Potent3

Mechanisms9

Therapeutic1

Neuroprotective2

Compound2

Anticancer1

Effects9

Supplement1

Vitro1

Active1

Synthesis3

Oleanane1

Adaptogen1

Cognitive function1

Analytical1

Mechanism1

Intestinal1

Content1

Insects1

Concentrations1

Widely1

Reduces1

Supplements1

Effect1

Found2

Production5

Antioxidant1

Potential1