Porphyromonas gingivalisLipopolysaccharidePeriodontitis patientsAntibodiesAntibodyBacteriaOral pathogenAbstractInducesAggregatibacterBacterialInflammatoryBiofilmGingipainStrainsPrevalenceAssociated with periodontal diseasesDentistryNeutrophilAlzheimer'sAtherosclerosisColonizationMicrobiologyProteinEnzymeExtractsMicrobiomeStreptococcusInfection is associatedSignificantlyProteinsInfectionsArginineNeutrophilsDeficientCorrelateConcentrationsPatientsConcentrationSeverityInduceSystemicResultsSuggestsBiomarker
Porphyromonas gingivalis42
- The genome of Porphyromonas gingivalis , the bacterium that causes periodontitis or gum disease, has been fully sequenced by a team from The Institute for Genomic Research in Rockville, Maryland in collaboration with The Forsyth Institute in Boston, Massachusetts. (the-scientist.com)
- Strains of Porphyromonas gingivalis , Fusobacterium nucleatum , Streptococcus mutans and Streptococcus faecalis in suspension or grown on agar were exposed to visible light at wavelengths of 400-500 nm. (bioone.org)
- Periodontal diseases (PD) are complex oral inflammatory diseases initiated by keystone bacteria such as Porphyromonas gingivalis. (nih.gov)
- Transcriptional profiling of bone marrow stromal cells in response to Porphyromonas gingivalis secreted products. (alzforum.org)
- Porphyromonas gingivalis has been strongly associated to periodontal diseases severity, and elicits humoral and cellular host response. (pucrs.br)
- To correlate the IgA, IgG and IgG subclasses serum levels against a chromatographic fraction from Porphyromonas gingivalis ATCC33277 extract and the clinical periodontal parameter. (pucrs.br)
- Porphyromonas gingivalis extract was fractionated by ion exchange chromatography and the humoral response against the fraction IV was assayed by enzyme linked immunosorbent assay. (pucrs.br)
- The periodontal pathogen Porphyromonas gingivalis is genetically heterogeneous. (kcl.ac.uk)
- abstract = "The periodontal pathogen Porphyromonas gingivalis is genetically heterogeneous. (kcl.ac.uk)
- Porphyromonas gingivalis, previously classified as a strict anaerobe, can grow in the presence of low concentrations of oxygen. (microbiologyresearch.org)
- Role of the Porphyromonas gingivalis InlJ protein in homotypic and heterotypic biofilm development. (microbiologyresearch.org)
- Suppression of inflammatory gene expression in T cells by Porphyromonas gingivalis is mediated by targeting MAPK signaling. (bakerco.com)
- Porphyromonas gingivalis is a bacteria involved in gum infections and periodontal disease. (drellie.com)
- PD is mainly caused by infection with Porphyromonas gingivalis (P. gingivalis) and by the synergistic action of various microorganisms. (quintessence-publishing.com)
- An international team led by researchers from the University of Louisville (UofL) School of Dentistry in Kentucky says the finding suggests that Porphyromonas gingivalis may be classified as a risk factor for esophageal cancer. (decisionsindentistry.com)
- The study, "Presence of Porphyromonas gingivalis in Esophagus and its Association With the Clinicopathological Characteristics and Survival in Patients With Esophageal Cancer," was published in Infectious Agents and Cancer . (decisionsindentistry.com)
- Using a human monocytic cell line, we demonstrate that Porphyromonas gingivalis lipopolysaccharide (LPS), which is a major etiological factor in periodontal disease, induces only partial immune tolerance, with continued high production of interleukin-8 (IL-8) but diminished secretion of tumor necrosis factor alpha (TNF-a) after repeated challenge. (elsevierpure.com)
- Although the exact etiology is still unclear, Gram-negative bacteria, especially Porphyromonas gingivalis in subgingival pockets are thought to be one of the major etiologic agents of periodontitis. (elsevierpure.com)
- Periodontal disease is characterized by neutrophil accumulation in the gingival pocket, recruited by the subgingival biofilm consisting mainly of gram-negative, anaerobic and proteolytic species such as Porphyromonas gingivalis. (chalmers.se)
- Atopic responses following certain pathogens, such as Porphyromonas gingivalis (Pg), are currently an area of interest for further research. (unair.ac.id)
- The present cross-sectional study aimed to verify the prevalence of three periodontal pathogens, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, on different groups, with and without teeth. (bvsalud.org)
- The primary goal of our study was to assess Nigella sativa's (N. sativa) antibacterial effectiveness against Porphyromonas gingivalis (P. gingivalis) utilizing seed extract. (europeanreview.org)
- Periodontal pathogens, including Porphyromonas gingivalis , can form biofilms in dental pockets and cause inflammation, which is one of the underlying mechanisms involved in the development of periodontal disease, ultimately leading to tooth loss. (diva-portal.org)
- Porphyromonas gingivalis seems involved in RA initiation and progression, as supported by the high occurrence of periodontitis. (unipg.it)
- Role of superoxide dismutase in resistance of Porphyromonas gingivalis to killing by polymorphonuclear leukocytes. (docksci.com)
- Porphyromonas gingivalis, which seems to play a central role in the etiology of certain forms of periodontal disease, can colohize the periodontal pocket and invade gingival tissue (18, 22). (docksci.com)
- Porphyromonas gingivalis is one of the primary etiologic agents of adult periodontitis and is known to produce a unique class of cysteine proteinases, termed gingipains. (elsevierpure.com)
- SutroVax has developed a multivalent vaccine that has demonstrated protective immunity against Porphyromonas gingivalis. (dentistrytoday.com)
- Periodontal Pathogens: Serum Actinobacillus actinomycetemcomitans antibody and Porphyromonas gingivalis antibodies, NHANES III, phase 2, ages 12 +years. (cdc.gov)
- The aim of the present study was to investigate whether non-obese Japanese type 2 diabetic patients with porphyromonas gingivalis infection have atherosclerotic vascular diseases. (elsevierpure.com)
- Immunoglobulin G (IgG) titer against porphyromonas gingivalis was 245 ± 65 (mean ± 2 SD) in nondiabetic healthy subjects. (elsevierpure.com)
- In contrast, there was a wide variation in IgG titer against porphyromonas gingivalis in type 2 diabetic patients studied (range, 16 to 26,800). (elsevierpure.com)
- From these results, it can be concluded that porphyromonas gingivalis infection, although still a subclinical infection, is associated with atherosclerotic vascular disease in non-obese Japanese type 2 diabetic patients. (elsevierpure.com)
- In the present study, the effects of growth in hemin- replete (H+) and hemin-depleted (H-) media on the lipopolysaccharide (LPS) of the oral pathogen Porphyromonas gingivalis were investigated. (elsevierpure.com)
- Anti-Porphyromonas gingivalis antibody testing was performed to assess prior exposure to the bacterial pathogen P gingivalis. (nih.gov)
- Porphyromonas gingivalis (Pg) and Treponema denticola (Td) are the main etiology of alveolar bone loss. (ui.ac.id)
- Porphyromonas gingivalis induces entero-hepatic metabolic derangements with alteration of gut microbiota in a type 2 diabetes mouse model. (bvsalud.org)
- We orally treated obese db/db diabetes mice using Porphyromonas gingivalis (Pg). (bvsalud.org)
- Growth and proteolytic activity of three Porphyromonas gingivalis strains in nutrient broth or a serum environment were assessed using A 600 and a fluorescent protease substrate, respectively. (biomedcentral.com)
- The periodontal pathogen Porphyromonas gingivalis is hypothesized to be important in rheumatoid arthritis (RA) aetiology by inducing production of anti-citrullinated protein antibodies (ACPA). (biomedcentral.com)
- Periodontitis is a chronic inflammatory disease of periodontal tissues that results in alveolar bone loss, and Porphyromonas gingivalis, which has a high hemagglutinating activity, has been implicated as an important pathogen in the development of periodontitis. (tmu.edu.tw)
- Colonizing organisms include Aggregatibacter actinomycetemcomitans , Porphyromonas gingivalis , Eikenella corrodens , and many gram-negative bacilli. (msdmanuals.com)
Lipopolysaccharide2
- Certain studies show that P. gingivalis lipopolysaccharide (LPS) could induce the expression of intercellular adhesion molecule 1 and vascular cell adhesion molecule 1 in human umbilical vein endothelial cells (HUVECs) ( 13 , 14 ), which significantly enhances trans-endothelial migration of inflammatory cells. (spandidos-publications.com)
- Stimulation of HGECs with P. gingivalis or P. gingivalis lipopolysaccharide increased the expression of ET-1 and ETA suggesting the activation of the endothelin signaling pathway. (elsevierpure.com)
Periodontitis patients1
- The prevalence of P. gingivalis resulted similarly in RA and periodontitis patients (48·9 versus 52·7%, P = not significant). (unipg.it)
Antibodies5
- This non-immunological binding interferes with enzyme linked immunosorbent assay (ELISA) of salivary antibodies against B.gingivalis.B.melaninogenicus and B.intermedius showed only weak IgG binding while nine other species of oral bacteria did not bind IgG. (ukhsa.gov.uk)
- The serum contained antibodies to P. gingivalis as measured by enzyme-linked immunosorbent assay in this laboratory. (docksci.com)
- The aim of this study was to investigate whether anti- P. gingivalis antibodies pre-date symptom onset and ACPA production. (biomedcentral.com)
- Antibodies against P. gingivalis virulence factor arginine gingipainB (RgpB), and a citrullinated peptide (CPP3) derived from the P. gingivalis peptidylarginine deiminase enzyme, were analysed by ELISA. (biomedcentral.com)
- In the present study, in order to clarify the pathological role of 40-kDa OMP and develop passive immunotherapy, we examined the inhibitory effect of monoclonal antibodies (MAbs) against r40-kDa OMP on the hemagglutinating activity of P. gingivalis vesicles. (tmu.edu.tw)
Antibody4
- The presence of P gingivalis was not correlated with anti-citrullinated protein antibody (ACPA) titers. (nih.gov)
- We have shown that ACPA precede RA onset by years, and that anti- P. gingivalis antibody levels are elevated in RA patients. (biomedcentral.com)
- Anti- P. gingivalis antibody concentrations were significantly increased in RA patients compared with controls, and were detectable years before onset of symptoms of RA, supporting an aetiological role for P. gingivalis in the development of RA. (biomedcentral.com)
- Furthermore, an affinity-purified antibody against r40-kDa OMP inhibited the hemagglutinating activity of P. gingivalis vesicles. (tmu.edu.tw)
Bacteria5
- In the presented work wildtype (wt-) mice and DDR1-Knockout mice were inoculated with the human periodontopathogenic bacteria Porphyromonas (P.) gingivalis over a period of several weeks. (uni-goettingen.de)
- Although SCFAs, produced by bacterial fermentation of dietary fiber in the gut, has previously been shown to utilize FFAR2, our data demonstrate that the pronounced proteolytic metabolism employed by P. gingivalis (and likely also other subgingival biofilm bacteria associated with periodontal diseases) may result in the generation of SCFAs that attract neutrophils to the gingival pocket. (chalmers.se)
- This finding highlights the interaction between SCFAs and FFAR2 in the context of P. gingivalis colonization during periodontal disease, but may also have implications for other inflammatory pathologies involving proteolytic bacteria. (chalmers.se)
- All subjects underwent a standard cytological swab to identify the rate of P. gingivalis/total bacteria by using quantitative real-time polymerase chain reaction. (unipg.it)
- We found a significant correlation between P. gingivalis rate in total bacteria genomes and disease activity score in 28 joints (DAS28) (erythrocyte sedimentation rate) (r = 0·4, P = 0·01). (unipg.it)
Oral pathogen1
- The results led researchers to conclude that either esophageal cancer cells provide an ideal host for P. gingivalis, or the presence of this oral pathogen facilitates development of esophageal cancer. (decisionsindentistry.com)
Abstract1
- abstract = "Bacteroides gingivalis bound IgG labelled with three different enzymes even in well-buffered isotonic systems. (ukhsa.gov.uk)
Induces1
- Additionally, P. gingivalis induces macrophage foam cell formation ( 11 ) and stimulates oxidation of low-density lipoprotein ( 12 ). (spandidos-publications.com)
Aggregatibacter2
- Meanwhile, E. gingivalis carriers and non-carriers were more likely to have Aggregatibacter and Rothia, respectively, among the top-ten most common genera. (lu.se)
- Conclusion: About one third of the cohort carried E. gingivalis ST1, and carriers had higher oral microbiome diversity and were more predominantly colonized by Aggregatibacter. (lu.se)
Bacterial5
- P. gingivalis HSP60 is reported to accelerate the development of experimental atherosclerosis by cross-reactivity of the immune response to bacterial HSPs ( 19 ). (spandidos-publications.com)
- Measuring the expression of an enzyme unique to P. gingivalis , as well as the presence of the bacterial cell DNA within the esophageal tissues, researchers found both to be significantly higher in the cancerous tissue than in surrounding tissue or normal control sites. (decisionsindentistry.com)
- These results suggest that secreted products from P. gingivalis , including proteinases, are able to cause damage and significantly modulate the levels of inflammatory mediators, independent of a physical host-bacterial interaction. (diva-portal.org)
- In the current review, we summarize recent knowledge on the pathophysiological role of gingipains in the virulence of P. gingivalis including host cell responses to bacterial infection and its evasion from host defense mechanisms. (elsevierpure.com)
- Adherence of P. gingivalis strains to serum-coated surfaces was studied with confocal microscopy and 2D-gel electrophoresis of bacterial supernatants used to investigate extracellular proteins. (biomedcentral.com)
Inflammatory6
- Porphyromonus gingivalis (P. gingivalis), a major periodontal pathogen, has already been shown to have a significant role in the inflammatory response of CAD in vivo. (spandidos-publications.com)
- Periodontitis is a chronic tissue-destruction inflammatory state that is predominantly induced by Porphyromonus gingivalis ( P. gingivalis ) in the gingival pockets of certain individuals with advanced and severe periodontal disease. (spandidos-publications.com)
- Overall, these findings suggest that induction of an imbalanced immune tolerance in monocytes by P. gingivalis LPS, which favors continued secretion of IL-8 but decreased TNF-a production, may be associated with enhanced migration of neutrophils to the site of infection but also with decreased apoptosis and may play a role in the chronic inflammatory state seen in periodontal disease. (elsevierpure.com)
- Moreover, P. gingivalis infection has been shown to induce the production of ET-1 along with other inflammatory cytokines. (elsevierpure.com)
- Although P. gingivalis is protected in the biofilm, it can still cause damage and modulate inflammatory responses from the host, through secretion of microvesicles containing proteinases. (diva-portal.org)
- P. gingivalis with Kgp affected the viability of gingival fibroblasts and modulated host inflammatory responses, including induction of TGF-β1 and suppression of CXCL8 and IL-6 accumulation. (diva-portal.org)
Biofilm1
- We demonstrated a significant association between the percentage of P. gingivalis on the total tongue biofilm and RA disease activity (DAS28), suggesting that the oral cavity microbiological status could play a role in the pathogenic mechanisms of inflammation, leading to more active disease. (unipg.it)
Gingipain3
- Recombinantly generated P. gingivalis minor fimbriae protein (Mfa1), RgpA gingipain hemagglutinin domain 1 (HA1), and RgpA gingipain hemagglutinin domain 2 (HA2) were combined in equivalent doses in adjuvants and injected intramuscularly to immunize mice. (nih.gov)
- By comparing the wild type W50 with its gingipain deficient strains we show that cysteine proteinases are required by P. gingivalis to form morphologically normal colonies. (diva-portal.org)
- Whereas they are constitutively expressed by P. gingivalis in nutrient broth, gingipain expression in the model periodontal pocket environment (serum) appeared to be orchestrated through signaling to P. gingivalis from other members of the community, a phenomenon which then promoted growth of the whole community. (biomedcentral.com)
Strains3
- Polyclonal antiserum raised to whole-cell antigens of P. gingivalis A7436, W83, and HG405 grown in H+ media, but not in H- media, recognized the 26 LPSC in the purified H+ LPS from any of the three strains. (elsevierpure.com)
- The P. gingivalis strains showed different growth rates in nutrient broth related to the level of proteolytic activity (largely gingipains) in the cultures. (biomedcentral.com)
- In the multi-species consortium, growth was facilitated by the wild-type and Rgp-expressing strains of P. gingivalis, suggesting that Rgp is involved in delivery of nutrients to the whole community through degradation of complex protein substrates in serum. (biomedcentral.com)
Prevalence1
- RA patients in remission showed a significantly lower prevalence of P. gingivalis in comparison with non-remission (P = 0·02). (unipg.it)
Associated with periodontal diseases1
- Background: Entamoeba gingivalis has been associated with periodontal diseases. (lu.se)
Dentistry1
- Huizhi Wang, MD, PhD, an assistant professor of oral immunology and infectious diseases in the UofL School of Dentistry, characterizes the discovery as "the first direct evidence that P. gingivalis infection could be a novel risk factor for esophageal squamous cell carcinoma. (decisionsindentistry.com)
Neutrophil1
- In agreement with the selective neutrophil recruitment, the chemotactic activity found in P. gingivalis supernatants was mediated in part by a mixture of short chain fatty acids (SCFAs) that are recognized by FFAR2, and other leukocytes (including monocytes) did not respond to SCFA stimulation. (chalmers.se)
Alzheimer's3
- This work aims to do a systematic, integrative review on published literature to evaluate if there is a link between Porphyromonas gumivalis (P. gingivalis), and Alzheimer's. (medsciencejournals.com)
- P. gingivalis could serve as a therapeutic target for patients suffering from Alzheimer's disease. (medsciencejournals.com)
- Patients with Alzheimer's disease could benefit from preventive dental care and the inhibition of neurotoxicity by P. gingivalis. (medsciencejournals.com)
Atherosclerosis2
- Furthermore, atherosclerosis can be triggered and aggravated by the pathogen-driven antigenic peptide from P. gingivalis heat-shock protein 60 (HSP60) ( 15 - 17 ). (spandidos-publications.com)
- peptide 14 or 19 from P. gingivalis HSP60 may have either an anti- or pro-atherogenic role, respectively, in the ApoE(−/-) mouse model of infection-triggered atherosclerosis through distinct mechanisms operating in the polarization of T cells. (spandidos-publications.com)
Colonization1
- Although colonization with P gingivalis correlated with the severity of PD, overall exposure to P gingivalis was similar among the groups. (nih.gov)
Microbiology1
- Then, anaerobic procedures were conducted in the microbiology lab to find P. gingivalis development. (europeanreview.org)
Protein7
- The P. gingivalis genome contains 2.3 million DNA base pairs forming 2226 genes, many of which are involved in protein synthesis and energy metabolism. (the-scientist.com)
- To investigate cell-free protein synthesis (CFPS) as a platform to produce vaccinable targets suitable for efficacy testing in a P. gingivalis-induced murine oral bone loss model. (nih.gov)
- Recombinantly generated P. gingivalis proteins possessed high fidelity to predicted size and elicited protein-specific IgG following immunization. (nih.gov)
- The aim of the present study was to identify whether P. gingivalis heat‑shock protein 60 (HSP60) induced the dysfunction of human umbilical vein endothelial cells (HUVECs) in vitro. (spandidos-publications.com)
- P. gingivalis HSP60 at a concentration of 10 ng/l significantly decreased the expression levels of VE‑cadherin and eNOS protein at 24 h stimulation, whereas no difference in these proteins was identified following a low dose of P. gingivalis HSP60 (1 ng/l). (spandidos-publications.com)
- P. gingivalis HSP60 at 100 ng/l significantly downregulated the expression levels of VE‑cadherin and eNOS protein at 12 h in HUVECs. (spandidos-publications.com)
- We previously succeeded in gene cloning the 40-kDa outer membrane protein (OMP) from P. gingivalis 381. (tmu.edu.tw)
Enzyme3
- Our results suggest firstly either an inactive or deactivated form of a trypsin- or papain-like enzyme, or a molecule such as the haemagglutinin, binds immunoglobulins and other proteins to the surface of B.gingivalis. (ukhsa.gov.uk)
- Secondly, binding to arginine in proteins is an important ecological factor for B.gingivalis since it is a property shared by its IgG binding receptor, its haemagglutinin and its trypsin- or papain-like enzyme. (ukhsa.gov.uk)
- Studies with various P. gingivalis mutants deficient in Rgp-and/or Kgp-encoding genes and proteinase inhibitors specific for each enzyme have demonstrated that both enzymes play a substantial role in disruption of host defense mechanisms by the bacterium and its survival in vivo. (elsevierpure.com)
Extracts2
- Both SODs (anaero-SOD and aero-SOD) were purified from extracts of either anaerobically maintained or aerated P. gingivalis 381 cells by the method of Amano et al. (docksci.com)
- The MAbs reacted with r40-kDa OMP, the outer membrane fraction, vesicles, and P. gingivalis cell extracts, and significantly inhibited the hemagglutinating activities of the polymeric r40-kDa OMP as well as of P. gingivalis vesicles. (tmu.edu.tw)
Microbiome1
- Objective: To describe epidemiological features, genetic diversity, and associations with oral microbiome signatures of E. gingivalis colonisation in Tanzanians with non-oral/non-dental diseases. (lu.se)
Streptococcus2
- A model multi-species sub-gingival community containing Fusobacterium nucleatum, Streptococcus constellatus , Parvimonas micra with wild type or isogenic mutants of P. gingivalis was then created and growth and proteolytic activity in serum assessed as above. (biomedcentral.com)
- We also observed colonized livestock workers to be more likely to carry P. gingivalis which may act as a bridge allowing S. aureus to adhere to Streptococcus in the oral cavity. (cdc.gov)
Infection is associated1
- The aim of this review was to explore whether P. gingivalis periodontal infection is associated with AD and to provide possible mechanisms of association. (quintessence-publishing.com)
Significantly2
- The minimal inhibitory dose for P. gingivalis and F. nucleatum was 16-62 J/cm 2 , a value significantly lower than that for S. mutans and S. faecalis (159-212 J/cm 2 ). (bioone.org)
- In contrast, neutrophils treated with P. gingivalis LPS-tolerized monocyte supernatant showed a high migration index but significantly decreased apoptosis. (elsevierpure.com)
Proteins1
- The broad specificity of the receptor binding IgG to B.gingivalis includes not only IgG and IgA, but also proteins unrelated to immunoglobulins. (ukhsa.gov.uk)
Infections1
- Many articles have shown that P. gingivalis infections directly increase the risk of PD and may indirectly lead to the development of AD. (quintessence-publishing.com)
Arginine1
- Like the haemagglutinin of B.gingivalis, the receptor that binds IgG has a specificity for arginine residues with an adjacent or neighbouring aromatic amino acid residue. (ukhsa.gov.uk)
Neutrophils2
- Primary human neutrophils incubated with P. gingivalis LPS-treated naïve monocyte supernatant displayed a high migration index and increased apoptosis. (elsevierpure.com)
- 3 kDa) soluble chemoattractants released by growing P. gingivalis, and show that these are selective for neutrophils. (chalmers.se)
Deficient1
- In contrast to the strong IgG binding of its parent, an avirulent variant B.gingivalis W50/BE1 that is deficient in trypsin-like activity, has a low level of IgG binding. (ukhsa.gov.uk)
Correlate1
- In addition, the presence of P. gingivalis was found to correlate with cancer cell differentiation, metastasis and overall survival rates. (decisionsindentistry.com)
Concentrations1
- HUVECs were stimulated with a range of P. gingivalis HSP60 concentrations (1, 10 and 100 ng/l) at different time‑points. (spandidos-publications.com)
Patients1
- Overall exposure to P gingivalis was similar between patients with new-onset RA and controls, observed in 78% of patients and 83% of controls. (nih.gov)
Concentration3
- Consistently, P. gingivalis HSP60 induced apoptosis of HUVECs in a concentration‑dependent manner. (spandidos-publications.com)
- At 12.5 mg/ml concentration, P. gingivalis did not show any zone of inhibition (ZOI). (europeanreview.org)
- However, N. sativa, at a concentration of 25 mg/ml, demonstrated a ZOI of 6.2 mm against P. gingivalis. (europeanreview.org)
Severity1
- The presence and abundance of P gingivalis were also directly associated with the severity of PD and were not unique to RA. (nih.gov)
Induce1
- These results indicated that P. gingivalis HSP60 may induce dysfunction and apoptosis in HUVECs via downregulating the expression levels of VE‑cadherin and eNOS, and promoting the cleavage of caspase‑3. (spandidos-publications.com)
Systemic1
- Certain studies have identified that P. gingivalis was detected frequently in atheromatous plaques of the aorta and coronary artery, and it was reported to perpetuate systemic inflammation ( 8 - 10 ). (spandidos-publications.com)
Results4
- Results: Sixteen (31%) of the 52 study participants were E. gingivalis-positive, with no difference in positivity rate according. (lu.se)
- These results suggest that endothelin plays an important role in P. gingivalis-mediated periodontitis. (elsevierpure.com)
- These results suggest that SOD may form part of a defense mechanism that helps protect P. gingivalis against killing by polymorphonuclear leukocytes. (docksci.com)
- Taken together, these results suggest that the antigenicity and hemin-binding properties of P. gingivalis LPS can be modified by growth in H+ media. (elsevierpure.com)
Suggests2
- If the latter proves to be the case, Wang suggests that "improving oral hygiene may reduce risk, screening for P. gingivalis in dental plaque may identify susceptible subjects, and using antibiotics or other antibacterial strategies may prevent the progression of esophageal cancer. (decisionsindentistry.com)
- This study provides new insight of the pathogenesis of P. gingivalis and suggests gingipains as targets for diagnosis and treatment of periodontitis. (diva-portal.org)
Biomarker1
- The team notes this may lead to P. gingivalis being used as a prognostic biomarker for esophageal cancer. (decisionsindentistry.com)