Choriocarcinoma of the ovary is a highly malignant ovarian tumor which is characterized pathologically by the presence of trophoblastic malignant cells, and biochemically by the production of the pregnancy hormone human chorionic gonadotrophin (hCG) in the absence of an ongoing pregnancy. (atlasgeneticsoncology.org)
This disease is classified two types in origin, gestational choriocarcinoma and nongestational germ cell tumor. (atlasgeneticsoncology.org)
Microscopically, hemorrheage and necrosis are found, and tumor cells resemble placental trophoblastic cells: cytotrophoblast (CT), intermediate trophoblast (IT), and syncytiotrophoblast (ST). The CT and IT tend to grow in clusters and sheets separated by ST. The typical pattern of choriocarcinoma has been called two cell pattern, biphasic-terms that reflect the relatively regular, alternating arrangement of CT and ST in the tumor interspread with intermediate trophoblast. (atlasgeneticsoncology.org)
Metastasis3
The gestational type includes an ovarian metastasis from primary uterine choriocarcinoma which occurs in association with a normal pregnancy or spontaneous abortion, complete hydatidiform mole, or partial mole, and primary gestational ovarian choriocarcinoma which arises from ectopic pregnancy in the ovary. (atlasgeneticsoncology.org)
Clinical symptoms are variety in gestational type, because choriocarcinoma is likely to metastasis to multiple organs, such as lung, liver, and brain. (atlasgeneticsoncology.org)
More than 90% of patients with extrauterine gestational choriocarcinoma will have lung metastasis. (atlasgeneticsoncology.org)
CHORIOCARCINOMA8
Nongestational pure choriocarcinoma is so rare that the prognosis, chemo-sensitivity, and genetics analysis of nongestational type have not been decided compared with that of gestational type. (atlasgeneticsoncology.org)
It is necessary, but difficult to distinguish nongestational choriocarcinoma from gestational choriocarcinoma except by DNA analysis. (atlasgeneticsoncology.org)
Classification of choriocarcinoma of the ovary is based on gestational or not. (atlasgeneticsoncology.org)
By far the most important risk factor for gestational choriocarcinoma is the nature of the preceding pregnancy. (atlasgeneticsoncology.org)
Women over the age of 40 are at increased risk for gestational choriocarcinoma. (atlasgeneticsoncology.org)
Gestational choriocarcinoma follows normal pregnancy (25%), spontaneous abortion (25%), and hydatidiform mole (50%), but only about 3-5% of all molar pregnancies eventuate in choriocarcinoma. (atlasgeneticsoncology.org)
Gestational primary ovarian choriocarcinoma is extremely rare, with an estimated incidence of 1 in 3.7 x 10 8 pregnancies. (atlasgeneticsoncology.org)
There is no difference in pathological appearances between gestational type and nongestational pure choriocarcinoma. (atlasgeneticsoncology.org)
Malignant1
It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract. (curehunter.com)
Ovarian1
It is very difficult to differentiate a pure ovarian carcinoma with a non-gestational origin from a gestational one using histopathological investigation. (atlasgeneticsoncology.org)
Year1
This graph shows the total number of publications written about "Gestational Trophoblastic Neoplasms" by people in Harvard Catalyst Profiles by year, and whether "Gestational Trophoblastic Neoplasms" was a major or minor topic of these publication. (harvard.edu)
Choriocarcinoma2
We present a complicated case of recurrence of gestational trophoblastic neoplasms (GTN), mixed ETT and choriocarcinoma at an abdominal cesarean scar. (hindawi.com)
Gestational trophoblastic neoplasms (GTN) are a group of neoplasms from fetal trophoblastic cells including choriocarcinoma (CC), epithelioid trophoblastic tumors (ETT), and placental site trophoblastic tumors (PSTT) [ 1 ]. (hindawi.com)
MeSH1
This strategy uses terms from the Neoplasms (and related) branches of MeSH , cancer-related text words, and MEDLINE journal titles. (nih.gov)
Thyroid1
The whitish neoplasm showed an aggressive invasion pattern to the thyroid and adjacent deep soft tissues and occluded the trachea. (bvsalud.org)
Present1
The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS. (nih.gov)