Germ-Line MutationMutation, MissensePoint MutationMutationPedigreeDNA Mutational AnalysisNeoplastic Syndromes, HereditaryFrameshift MutationColorectal Neoplasms, Hereditary NonpolyposisGenes, BRCA1MutS Homolog 2 ProteinParagangliomaExonsGenetic TestingBRCA2 ProteinHeterozygoteHamartoma Syndrome, MultipleGenetic Predisposition to DiseaseAdenomatous Polyposis ColiGenes, BRCA2Germ CellsPolymorphism, Single-Stranded ConformationalBase SequenceLi-Fraumeni SyndromeMutation RateAllelesPolymerase Chain ReactionDNA Mismatch RepairMolecular Sequence DataPhenotypeLoss of HeterozygosityPeutz-Jeghers SyndromeGenes, APCAge of OnsetProto-Oncogene Proteins c-retFamily HealthMicrosatellite RepeatsBRCA1 ProteinSuccinate DehydrogenaseSequence Analysis, DNAPenetranceMultiple Endocrine Neoplasia Type 2aGenotypeDNA, NeoplasmNuclear ProteinsIntestinal Polyposisvon Hippel-Lindau DiseaseAdaptor Proteins, Signal TransducingPheochromocytomaFumarate HydrataseParaganglioma, Extra-AdrenalCodon, NonsenseAmino Acid SubstitutionDNA-Binding ProteinsSequence DeletionNoonan SyndromeFounder EffectCostello SyndromeSyndromeAmino Acid SequenceNeoplasm ProteinsMicrosatellite InstabilityLeiomyomatosisBreast NeoplasmsProto-Oncogene ProteinsCarcinoma, MedullaryBase Pair MismatchGenes, p53Ovarian NeoplasmsAdrenal Gland NeoplasmsCodonTumor Suppressor ProteinsHomozygoteJewsMultiple Endocrine Neoplasia Type 1Heterozygote DetectionColorectal NeoplasmsDrosophila ProteinsTranscription FactorsDNA PrimersMosaicismMutagenesisCarrier ProteinsPTEN PhosphohydrolaseGene DeletionNeoplasms, Multiple PrimaryGene FrequencyGenes, p16Polymorphism, GeneticVon Hippel-Lindau Tumor Suppressor ProteinGenes, RecessiveGenes, DominantExomeCaenorhabditis elegansDNA RepairMutagenesis, Site-DirectedDNAAdenomaFamilyGenes, Tumor Suppressor