Germ-Line MutationMutation, MissenseMutationLi-Fraumeni SyndromePoint MutationDNA Mutational AnalysisPedigreePolymerase Chain ReactionGenes, p53HeterozygoteBase SequenceGenetic Predisposition to DiseaseMolecular Sequence DataGerm CellsMicrosatellite RepeatsGenotypeFrameshift MutationBreast NeoplasmsCell LineExonsAllelesMutation RateAmino Acid SequenceAmino Acid SubstitutionNeoplasms, Germ Cell and EmbryonalPhenotypePolymorphism, Single-Stranded ConformationalCell Line, TumorSequence Analysis, DNACaenorhabditis elegansHomozygoteSpermatogenesisOogenesisMutagenesisMutagenesis, Site-DirectedCodon, NonsenseDNA PrimersTestisDNA-Binding ProteinsSequence DeletionCaenorhabditis elegans ProteinsDrosophila melanogasterGenetic TestingDrosophila ProteinsTranscription FactorsRNA, MessengerGonadsDNAGenes, RecessiveProtein Structure, TertiaryCloning, MolecularTranscription, GeneticChromosome MappingSequence Homology, Amino AcidNuclear ProteinsGene Expression Regulation, DevelopmentalDrosophilaGenes, DominantCodonSpermatozoaPromoter Regions, GeneticBinding SitesCrosses, GeneticSequence AlignmentModels, GeneticGenes, BRCA1Gene DeletionModels, MolecularSpermatogoniaRecombination, GeneticSuppression, GeneticDNA, NeoplasmProtein BindingSignal TransductionTransfectionEscherichia coliMembrane ProteinsDisorders of Sex DevelopmentMicronucleus, GermlineGenetic Complementation TestGenes, LethalSex Determination AnalysisAnimals, Genetically ModifiedMice, TransgenicSyndromeFounder EffectMeiosisMosaicismWheat Germ AgglutininsGene Expression RegulationPlasmidsCell Line, TransformedGenesGenetic LinkageMutagenesis, InsertionalCell DifferentiationCarrier ProteinsGerm LayersDNA Transposable ElementsGenetic Variation