ProgenitorMesenchymalStromal cellsPrimordial germPluripotent stemEmbryosEmbryoLineagesTissuesDifferentiation potentialUmbilical cordAbility to differentiateESCsHematopoietic stemMesodermRegenerationNeuronsBiologyTransplantationZygoteGenesProgenitorsVivoBoneUnipotentRegenerativeFetalSomatic stemOrganismMSCsTherapyGeneticTypes of stem cellsType of stem cellDental Pulp Stem CellsApoptosisPrecursorDevelopmentalNeural stemVitroFateTotipotent cellsProteinsSkeletalResearchMolecularTumorsSelf-renewSpermExpressionMyeloidDistinctEctodermBlastocystDevelopmentGenerateInactivation
Progenitor14
- Neurons that arise in the adult nervous system originate from neural stem cells and neural progenitor cells. (elifesciences.org)
- Neural stem cells can also give rise to neural progenitor cells, which proliferate rapidly during their short lives and then 'differentiate' into neurons or glia. (elifesciences.org)
- Consequently, neural stem and progenitor cells have usually been studied retrospectively, based on their ability to form colonies in laboratory cell cultures. (elifesciences.org)
- A region of the brain called the subventricular zone contains both neural stem cells and neural progenitor cells, and is one of only two regions of the brain where neural stem cells are found in adult mammals. (elifesciences.org)
- Only from the primordial germ cells of the gonadal ridge (progenitor cells of egg and sperm cells) can pluripotent stem cells be cultivated under laboratory conditions. (understanding-stemcells.info)
- Adult stem cells can be used to accelerate bone or tendon healing , and they can induce cartilage progenitor cells to produce a better matrix and repair cartilage damage . (thefutureofthings.com)
- Derivation and characterization of functional human neural stem cell derived oligodendrocyte progenitor cells (OPCs) that efficiently myelinate primary neurons in culture. (sigmaaldrich.com)
- Chemical compounds that modulate atrial and ventricular cell fate could be used to improve subtype-specific differentiation of endogenous or exogenously delivered progenitor cells in order to promote cardiac regeneration. (biomedcentral.com)
- Collectively, these results indicate the potential for therapeutic alteration of cell fate decisions and pathological gene regulatory networks by GATA4-targeted compounds modulating chamber-specific transcriptional programs in multipotent cardiac progenitor cells and cardiomyocytes. (biomedcentral.com)
- Thus, small molecules capable of influencing the fate decisions and differentiation programs of multipotent progenitor cells could facilitate therapeutic regeneration of lost myocardium. (biomedcentral.com)
- Committed myeloid progenitor cells and cells with long term reconstituting potential were lost from bone marrow within four days after poly injection. (biomedcentral.com)
- Clonal studies in the chronic myeloid disorders - Genetic and enzyme studies based upon X-chromosome inactivation patterns have revealed a multipotent progenitor cell origin for the neoplastic clone in both MDS [ 8 ] and MPN [ 9 ]. (medilib.ir)
- The clonal process may develop at different progenitor cell levels in individual patients, and the clonal progenitor cell may or may not involve T and B lymphocytes [ 10 ]. (medilib.ir)
- This process involves the release of a subset of maternal transcripts from the centrosome-attracting body (CAB) in the progenitor cells of the germ line. (biomedcentral.com)
Mesenchymal13
- CD140b is expressed by embryonic tissues and mesenchymal-derived cells of the adult mouse tissues. (thermofisher.com)
- These growth factors are mitogens for cells of mesenchymal origin. (thermofisher.com)
- Mesenchymal stem cells (MSC) are tissue stem cells originating in the mesoderm germ layer. (understanding-stemcells.info)
- We also summarize the important role of PRC2 in regulating biological behaviors such as epithelial mesenchymal transition, invasive metastasis, apoptosis, cell cycle regulation, autophagy, and PRC2-mediated resistance to LC chemotherapeutic agents in LC cells. (bvsalud.org)
- Information about mesenchyme, specifically mesenchymal stem cell procotols. (sigmaaldrich.com)
- Step-by-step cell culture protocols for mesenchymal stem cell (MSC) isolation, expansion and differentiation. (sigmaaldrich.com)
- Combining our CRISPR, ZFN gene editing , and stem cell expertise, we now offer novel stem cell lines, optimized media, and innovative kits for all areas of stem cell biology, including induced pluripotent stem cells (iPSCs), neural, mesenchymal and hematopoietic stem cell culture. (sigmaaldrich.com)
- Impact of Diabetes Mellitus on Human Mesenchymal Stromal Cell Biology and Functionality: Implications for Autologous Transplantation. (shengsci.com)
- Multipotent mesenchymal stem/stromal cells (MSCs) have regenerative and immunomodulatory properties to restore and repair injured tissues, making them attractive candidates for cell-based therapies. (shengsci.com)
- Both in animal models and humans, it has been shown that cell therapy can induce therapeutic angiogenesis, making mesenchymal stromal cell-based therapy one of the most promising therapeutic alternatives. (unav.edu)
- The aim of this study is to evaluate the feasibility, safety, and efficacy of cell therapy based on mesenchymal stromal cells derived from adipose tissue intramuscular administration to patients with type 2 diabetes mellitus with critical limb ischemia and without possibility of revascularization. (unav.edu)
- Mesenchymal stromal cells (MSCs) have shown benefit in other inflammatory diseases. (unav.edu)
- Mesenchymal stem cells (MSCs) are ASCs, and were first described in 1966 by Friedenstein et al. (bvsalud.org)
Stromal cells7
- They are also called stromal cells and are very similar to connective tissue cells, the fibroblasts. (understanding-stemcells.info)
- Furthermore, it is unknown whether endogenous progenitors/stromal cells in the adult human heart could be chemically induced to generate functional atrial or ventricular heart muscle to treat adult heart diseases. (biomedcentral.com)
- It is well-described that leptin receptor (LepR) + perivascular stromal cells provide a major source of bone-forming osteoblasts in adult and aged bone marrow. (nature.com)
- These Fgfr3-creER -marked endosteal stromal cells contribute to a stem cell fraction in young stages, which is later replaced by Lepr-cre -marked stromal cells in adult stages. (nature.com)
- Further, Fgfr3 + endosteal stromal cells give rise to aggressive osteosarcoma-like lesions upon loss of p53 tumor suppressor through unregulated self-renewal and aberrant osteogenic fates. (nature.com)
- These Fgfr3 + stem/stromal cells with OCT identities are abundant in the young bone marrow and depleted in the old bone marrow, denoting their transitional nature. (nature.com)
- Overall, our findings indicate that Fgfr3 + endosteal stem/stromal cells with OCT identities dictate active and aggressive osteogenesis, identifying these cells as an important regulator of long-term bone homeostasis. (nature.com)
Primordial germ3
- These cells are commonly termed embryonic germ (EG) cells because they are derived from primordial germ cells found at the genital ridges in developing fetuses. (biomedcentral.com)
- When germ-soma segregation is completed, CAB structures are missing from the newly formed primordial germ cells (PGCs). (biomedcentral.com)
- When the B7.6 blastomeres divide, they produce two distinct populations of daughter cells, two primordial germ cells (B8.12) and two endodermal strand cells (B8.11) [ 4 ]. (biomedcentral.com)
Pluripotent stem4
- Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells' (2007), by Junying Yu et al. (asu.edu)
- On 2 December 2007, Science published a report on creating human induced pluripotent stem (iPS) cells from human somatic cells: "Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells. (asu.edu)
- CLASSIFICATION OF HEMATOLOGIC MALIGNANCIES - The hematopoietic pluripotent stem cell is capable of both self-renewal and stepwise differentiation into either the lymphoid or myeloid lineage (which appears to be determined stochastically) [ 1 ]. (medilib.ir)
- A pluripotent stem cell has the potential to form all cells of the embryo, but cannot form a placenta. (papersowl.com)
Embryos12
- Fetal stem cells are isolated from older embryos or fetuses (five to nine weeks old) that have miscarried, or they are harvested after termination of pregnancy. (understanding-stemcells.info)
- For research purposes, embryonic stem cells from surplus, artificially inseminated embryos (in vitro fertilization) are currently being harvested in various countries, for example in Belgium and the United Kingdom. (understanding-stemcells.info)
- The issue of research involving stem cells derived from human embryos is increasingly the subject of a national debate and dinner table discussions," said President George W. Bush in a 2001 speech announcing his policy on embryonic stem cell research. (erlc.com)
- Where do the embryos for embryonic stem cells come from? (erlc.com)
- Currently, all human embryonic stem cell lines in use today were created from embryos generated by IVF. (erlc.com)
- Rossant, J. & Vijh, K. M. Ability of outside cells from preimplantation mouse embryos to form inner cell mass derivatives. (nature.com)
- Stem cells exist both in embryos and adult cells. (articlecity.com)
- Embryonic stem cells, which must be extracted from embryos three to five days old (known as blastocysts, which contain only about 150 cells at this point of development). (articlecity.com)
- This is seen in ascidian embryos, which develop in a typical mosaic manner, where maternally supplied factors control cell fate specification reviewed by [ 1 ]. (biomedcentral.com)
- This structure is called the centrosome-attracting body (CAB), which is first detectable in the B4.1 blastomeres of 8-cell stage embryos [ 2 ]. (biomedcentral.com)
- In ascidian embryos, vas transcripts are released from the CAB located in the germ line precursor B7.6 blastomeres. (biomedcentral.com)
- Transcripts found in unfertilized oocytes also encoded a large number of proteins implicated in cell adherence, tight junction and focal adhesion, suggesting high complexity in terms of structure and cellular interactions in embryos prior to midblastula transition (MBT). (biomedcentral.com)
Embryo15
- The removal of the hES cells leads to loss of the embryo. (understanding-stemcells.info)
- The production of hES cells in this manner is considered ethically unacceptable in Germany and is prohibited (Embryo Protection Act). (understanding-stemcells.info)
- Germ cells are cells that form the germ line and are already predetermined for development of the next cell generation in the early embryo. (understanding-stemcells.info)
- If this also becomes possible in the future with reprogrammed human stem cells, it may be possible to generate a human embryo without the need for natural germ cells. (understanding-stemcells.info)
- As stem cells within a developing human embryo differentiate within the cell, their capacity to diversify generally becomes more limited and their ability to generate many differentiated cell types also becomes more restricted. (erlc.com)
- Embryonic stem cells (ESCs) are stem cells that have been taken from the inner cell mass of a blastocyst, an embryo of about 150 cells that has not yet implanted into a woman's uterus. (erlc.com)
- The process of obtaining stem cells leads to the destruction of the embryo from which the cells are taken. (erlc.com)
- The early mammalian embryo consists of the extra-embryonic cell layers-the trophoblast and a body of cells called the inner cell mass (ICM), which eventually become the embryo proper. (thefutureofthings.com)
- The mechanisms underlying the appearance of asymmetry between cells in the early embryo and consequently the specification of distinct cell lineages during mammalian development remain elusive. (nature.com)
- Louvet-Vallee, S., Vinot, S. & Maro, B. Mitotic spindles and cleavage planes are oriented randomly in the two-cell mouse embryo. (nature.com)
- This process gets rid of unneeded cells and is particularly important for "sculpting" tissue and organ structure during development of the embryo (or larval metamorphosis in insects), but may occur at any time even in adult cells when a tissue needs to be remodeled. (agemed.org)
- A fertilized egg is totipotent, meaning that its potential is total, and as the fertilized egg divides all the cells in the embryo remain totipotent until the fertilized egg has reached the 8/16-cell stage. (biomedcentral.com)
- In theory, and to some extent in practice, an 8-cell embryo can be divided into eight single cells, and each cell has the potential of generating an individual if implanted in a woman's uterus. (biomedcentral.com)
- 3,4 The zygote and cells derived from the first two cellular divisions constitute the most primitive cells (totipotent cells) that are capable of forming the embryo and the embryonic annexes (e.g. placenta, amniotic membranes etc). (bvsalud.org)
- Today, it is generally thought that the combination of determinants deposited by the mother during oogenesis and the inductive signals between different cells trigger the specification of different cell lineages during development of the embryo [ 7 , 8 ]. (biomedcentral.com)
Lineages5
- Regarding vibrational spectroscopy analysis by FTIR, bands related with biomolecules were shown on mPSCs and DKCs spectra, observing distinct differences between cell lineages and maturation stages. (biomedcentral.com)
- Embryonic or adult SCs by definition are characterized by their self-renewal and potentiality, peculiarities that allow them to give rise to more SCs and differentiate into various cell lineages under appropriate conditions. (biomedcentral.com)
- Johnson, M. H. & Ziomek, C. A. The foundation of two distinct cell lineages within the mouse morula. (nature.com)
- These stem cells are considered committed to certain cell lineages. (biomedcentral.com)
- Microarray analyses detected a suite of master developmental regulators that control differentiation and maintenance of diverse cell lineages. (biomedcentral.com)
Tissues15
- Unlike some other tissues, it has not been possible to identify or purify neural stem cells directly from the tissue. (elifesciences.org)
- Body cells that can make copies of themselves and differentiate into different cell types or tissues are generally referred to as stem cells. (understanding-stemcells.info)
- Tissue stem cells (= adult stem cells) are specific dividable cells in already mature tissues. (understanding-stemcells.info)
- Second, stem cells may prove to be an indispensable source of transplantable cells and tissues for repair and regeneration. (erlc.com)
- They are found mainly in renewing tissues, such as the skin, the inner lining of the gastrointestinal tract and blood tissues. (thefutureofthings.com)
- In addition to their ability to supply cells at the turnover rate of their respective tissues, they can be stimulated to repair injured tissue caused by liver damage, skin abrasions and blood loss. (thefutureofthings.com)
- The ability of our body to regenerate some of its tissues is largely owed to the reserves of adult stem cells. (thefutureofthings.com)
- Similarly, the transplantation of other tissue-specific stem cells, such as stem cells isolated from epithelial and neural tissues, can treat mouse disease models and human patients in which epithelial and neural cells are damaged. (articlecity.com)
- A few of the cells in the inner cell mass will develop into the foetus, whereas the rest will form the placenta and other supporting tissues needed for foetal development in the uterus. (biomedcentral.com)
- Stem cells represent a small fraction of cells located in different tissues. (shengsci.com)
- Due to the ability to self-renew and to differentiate into cells that are found throughout the body, there is a great interest in using stem cells for the regeneration of injured tissues as well as to develop tissue-engineered implants and bio-hybrid organs, in order to restore tissue function. (bvsalud.org)
- In human postnatal dental tissues, five main sources of DSCs have been identified: dental pulp stem cells (DPSCs), 11 stem cells from human exfoliated deciduous teeth (SHEDs), 12 periodontal ligament stem cells (PDLSCs), 13 dental follicle stem cells (DFSCs) 14 and stem cells from apical papilla (SCAPs). (bvsalud.org)
- Tissues are made of cells that have joined together to perform those special functions. (utsouthwestern.edu)
- Totipotent stem cells contain all the constituents necessary to produce a living being, given that these cells can supply all embryonic and extraembryonic tissues required for proper growth (Can/Hematol 2008). (papersowl.com)
- The key functions of adult stem cells are to maintain and repair the specific tissues where they reside (e.g. skin or blood). (bvsalud.org)
Differentiation potential4
- This general definition includes a wide variety of cells with varying degrees of differentiation potential. (thefutureofthings.com)
- The established dogma has however been challenged by recent findings suggesting that multipotent stem cells have a broader differentiation potential than previously thought. (biomedcentral.com)
- Since suboptimal media may change the differentiation potential of stem cells, it is vital to select the correct stem cell-validated media and reagents at the start of your research process. (sigmaaldrich.com)
- Furthermore, MDLS could promote teratoma formation and enhanced differentiation potential of P19 cells in vivo. (biomedcentral.com)
Umbilical cord1
- Multipotent stem cells are present in the adult individual as well as the fetus and umbilical cord. (biomedcentral.com)
Ability to differentiate4
- These adult stem cells are considered multipotent, having the ability to differentiate into different cell types, albeit with a more limited repertoire than embryonic stem cells. (thefutureofthings.com)
- Embryonic stem cells have the ability to differentiate into more cell types than adult stem cells. (sigmaaldrich.com)
- To delve further into the specifics, embryonic and adult stem cells fall into potency categories reflecting their ability to differentiate: totipotent, pluripotent, multipotent, and unipotent. (papersowl.com)
- Oligopotent stem cells, though not often widely discussed, have the ability to differentiate into a few cells (Kara et al. (papersowl.com)
ESCs8
- According to their potentiality, embryonic stem cells (ESCs) are classified as totipotent and pluripotent, both of them can differentiate into the three germ lines. (biomedcentral.com)
- ESCs are obtained from inner cell mass, characterized by unlimited self-renewal and pluripotentiality, which allow them to differentiate into various specialized cells types in a morphologically and functionally way, characteristics that make them attractive for developing differentiated kidney cells (DKCs) [ 9 ]. (biomedcentral.com)
- Role of Otx2 in Embryonic Stem Cells (ESCs): Otx2 is an intrinsic determinant required to maintain the ESC metastable state by antagonizing ground state pluripotency and promoting commitment to differentiation. (cnr.it)
- It is expressed in ESCs, embryonic germ (EG) cells and embryonic carcinoma (EC) cells and essential for early embryonic development [ 14 , 15 ]. (biomedcentral.com)
- Metabolomic profiles of somatic cells, embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) reflect their metabolic phenotypes. (shengsci.com)
- 1,2 Regarding the origin, they can be classified as embryonic stem cells (ESCs) and adult stem cells (ASCs). (bvsalud.org)
- 3 Embrionic stem cells (ESCs) are derived from the inner cell mass of the blastocyst and form all cell types, derived from the three germ layers, and are therefore pluripotent. (bvsalud.org)
- The use of ASCs in regenerative medicine and tissue engineering research has important advantages in comparison with ESCs, since there are no ethical complications and the process of differentiation of these cells is better controlled. (bvsalud.org)
Hematopoietic stem3
- DNMT3A is a critical regulator of hematopoietic stem cell (HSC) differentiation and somatic DNMT3A mutations are frequent in hematologic malignancies and clonal hematopoiesis. (haematologica.org)
- There his work focused on transcriptional control of hematopoietic stem cell maturation and cell fate. (ubc.ca)
- In addition, he identified a number of novel hematopoietic stem cell surface proteins and began analyzing their function. (ubc.ca)
Mesoderm2
- The ICM continues to differentiate into three germ layers-ectoderm, mesoderm and endoderm, each of which follows a specific developmental destiny that takes them along an ever-specifying path at which end the daughter cells will make up the different organs of the human body. (thefutureofthings.com)
- Pluripotent stem cells, including embryonic stem cells (ES cells) and induced pluripotent stem cells (iPSCs), have the capacity to give rise to differentiated progeny representative of all three germ layers (ectoderm, endoderm, and mesoderm). (sigmaaldrich.com)
Regeneration6
- Skeletal muscle growth and regeneration involves the activity of resident adult stem cells, namely satellite cells (SC). (sdbonline.org)
- Collectively, this study provides the first evidence that transient levels of the evolutionarily conserved factor RACK1 are critical for adult SC activation and proper skeletal muscle regeneration, favoring the efficient progression of SC from a committed to a fully differentiated state. (sdbonline.org)
- With this raw material, biomedical firms can create stem cell lines that, among other things, aid recuperation via the regeneration of tissue that has been lost or damaged. (articlecity.com)
- These properties provide stem cells with powerful capabilities for tissue repair, replacement, and regeneration, so human stem cells are of special interest in medical research. (sigmaaldrich.com)
- These cells play a critical role in the regeneration and restoration of injured sites. (shengsci.com)
- These cells have been studied for the treatment of periodontitis, bone repair, regeneration of the pulp after necrosis as well as the development of new teeth. (bvsalud.org)
Neurons5
- Purpose: In this narrative review, we attempt to link research findings concerning the hormetic relationship between neurons and germ cells, and translate these findings into clinically relevant concepts. (mdpi.com)
- Since neurosphere-forming cells can self-renew and differentiate into neurons and glia, the ability of cells to form neurospheres has generally been taken as evidence that they are stem cells. (elifesciences.org)
- A particular field encouraged by the foundation is stem-cell research, with the great hope that it will result in the ability to get cells to differentiate into neurons and support cells to bridge the gap of a spinal cord injury. (thefutureofthings.com)
- ReNcell neural progenitors are immortalized human neural stem cell lines that can differentiate into neurons, astrocytes sand oligodendrocytes. (sigmaaldrich.com)
- Role of Otx2 in adult dopaminergic neurons: Otx2 specify post-mitotic neuron subtype identity in ventral tegmental area (VTA) and antagonizes dopaminergic vulnerability to the Parkinsonian neurotoxin MPTP. (cnr.it)
Biology4
- Results: The process of hormesis serves as a bridge between the biology of neuron-germ cell interactions on one hand, and the clinical relevance of these interactions on the other. (mdpi.com)
- Although these findings have been confirmed using cell lines, there is a growing evidence to suggest that cell lines do not fully recapitulate the biology of human disease. (biomedcentral.com)
- One of the challenges in developmental biology is to understand how cells adopt specific characteristics during embryogenesis. (biomedcentral.com)
- Before delving into the molecular biology and therapeutic potentials of induced pluripotent stem cells, it is crucial to provide foundational definitions and descriptions. (papersowl.com)
Transplantation2
- For example, because hematopoietic stem cells can reconstitute the entire blood system, bone marrow transplantation has long been used in the clinic to treat various diseases. (articlecity.com)
- in 1956 and Till and McCulloch in 1961, demonstrating that lethally irradiated mice could be rescued with cells from freshly isolated bone marrow [ 10 ] and that BM cells formed spleen clonies (CFU-S) following transplantation to irradiated recipients [ 30 ], respectively. (biomedcentral.com)
Zygote4
- At the top of the list comes the zygote-a fertilized egg, which of course has the ability to divide and differentiate into all cell types in the body and create a new organism. (thefutureofthings.com)
- The first three divisions of the zygote give birth to eight totipotent cells, each of which also has the ability to become an entire organism. (thefutureofthings.com)
- Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. (nature.com)
- The zygote and the cells within the initial zygotic divisions are considered totipotent (Kara et al. (papersowl.com)
Genes8
- In 2006, the Japanese scientist Shinya Yamanaka used viruses to introduce the genes Oct4, Sox2, cMyc and Klf4 into mouse body cells for the first time, activating quiescent developmental genes. (understanding-stemcells.info)
- Cells become cancerous by accumulating, stepwise, a series of several mutations that alter the function of genes important for cell growth. (agemed.org)
- Found within Wharton's jelly - which is easily harvested from what would otherwise be post-natal medical waste - are several distinct stem cell genes. (articlecity.com)
- The Polycomb repressive complex 2 (PRC2), composed of EZH1/2, SUZ12, and EED, is an epigenetic silencer that controls the expression of target genes and is crucial for cell identity in multicellular organisms. (bvsalud.org)
- Transcription factor GATA4-targeted compounds that have previously shown in vivo efficacy in cardiac injury models were tested for stage-specific activation of atrial and ventricular reporter genes in differentiating pluripotent stem cells using a dual reporter assay. (biomedcentral.com)
- Immunofluorescence, RT-PCR, and western blotting were used to measure expression changes of stem-related genes and activation of related signaling pathways. (biomedcentral.com)
- The methodology included inducing differentiated somatic cells with the primary genes responsible for embryonic stem cell potency. (papersowl.com)
- Numerous genes transcribed in oocytes are involved in multiple aspects of cell maintenance and protection, including metabolism, signal perception and transduction, RNA processing, cell cycle, defense against pathogens and DNA damage. (biomedcentral.com)
Progenitors2
- Otx2 cell-autonomous control of thalamic glutamatergic progenitors. (cnr.it)
- Thus, during normal hematopoiesis, there exists a cellular hierarchy headed by a stable population of pluripotent stem cells that generate lineage-specific progenitors, which differentiate into the various types of mature blood cells [ 2 ]. (medilib.ir)
Vivo5
- Pre-GEPCOT cells could not form neurospheres but expressed the stem cell markers Slc1a3-CreER T , GFAP-CreER T2 , Sox2 CreERT2 , and Gli1 CreERT2 and were long-lived in vivo. (elifesciences.org)
- Rossant, J. & Lis, W. T. Potential of isolated mouse inner cell masses to form trophectoderm derivatives in vivo . (nature.com)
- Differentiation is triggered by various factors in vivo , some of which can be replicated in in vitro stem cell cultures. (sigmaaldrich.com)
- The discovery of this new class of SSCs is based on the conjunction of evidence from unbiased single-cell molecular profiling and functional dissection of the BMSC lineage hierarchy using in vivo cell lineage analysis. (nature.com)
- Until recently, it was believed that they were tissue-specific…however, this concept has been challenged… (multipotent cells) can differentiate in vitro and in vivo into various cell types not only from the tissue of origin" (Can/Hematol 2008). (papersowl.com)
Bone6
- It has been demonstrated that MSC can differentiate into chondrocytes (cartilage-forming cells), osteoblasts (bone-forming cells) and adipocytes (adipose tissue cells). (understanding-stemcells.info)
- Investigation of bone marrow cells showed that these became apoptotic within seven days after poly injection. (biomedcentral.com)
- Furthermore, infusion of normal bone marrow cells rescued mice from death induced by loss of THOC5/Fms interacting protein. (biomedcentral.com)
- The bone marrow contains various populations of skeletal stem cells (SSCs) in the stromal compartment, which are important regulators of bone formation. (nature.com)
- The term "transitional" emphasizes the unique feature of these cells that are particularly abundant in the young bone marrow. (nature.com)
- The paradox of proliferative bone marrow together with peripheral blood cytopenias in MDS may be explained by increased intramedullary myeloid precursor cell apoptosis [ 6 ]. (medilib.ir)
Unipotent2
- Finally, unipotent stem cells, which can only produce differentiated daughter cells of one type, are another category of stem cells. (papersowl.com)
- Using these definitions, embryonic stem cells can be classified as totipotent or pluripotent at different developmental stages and locations, whereas adult stem cells can be categorized as pluripotent, multipotent, or unipotent (Figure 1). (papersowl.com)
Regenerative7
- therefore, new researches focused on regenerative medicine have been developed, including the use of stem cells. (biomedcentral.com)
- Consequently, because of the increased rate of RF in terminal stage and few alternative treatments, new investigations focused on regenerative medicine have been developed, including the use of stem cells (SCs) [ 7 ]. (biomedcentral.com)
- If stem cells can be used to produce new and differentiated cells that are damaged because of disease (such as Parkinson's disease) or injury (e.g., spinal cord damage), it would transform regenerative medicine. (erlc.com)
- Stem cells have been extensively explored for a variety of regenerative medical applications and they play an important role in clinical treatment of many diseases. (biomedcentral.com)
- The use of various types of stem cells for research purposes to make disease "models" in the lab for regenerative medicine and for "therapies" to cure sick patients for diseases is constantly in the news. (lifeissues.net)
- Conclusion: stem cells from dental origin are an interesting alternative for research and application in regenerative therapies in Dentistry. (bvsalud.org)
- 8,9 Because dental stem cells (DSCs) are easy to obtain and present a great potential of differentiation, there has been a growing interest in their use in regenerative medicine for treatment of various human diseases. (bvsalud.org)
Fetal2
- Células madre de un tejido específico (también denominadas células madre somáticas) que aparecen durante el desarrollo fetal y permanecen en el cuerpo durante toda la vida. (bvsalud.org)
- Tissue-specific stem cells (also known as Somatic Stem Cells) that appear during fetal development and remain in the body throughout life. (bvsalud.org)
Somatic stem1
- Adult stem cells are sometimes referred to as somatic stem cells to differentiate them from human germ cells, sperm cells and egg cells. (erlc.com)
Organism5
- Embryonic stem cells are isolated from the internal cell mass (embryoblast), from which the whole organism develops during natural embryonic development. (understanding-stemcells.info)
- Transferred to a cell culture dish, embryonic stem cells are considered to be pluripotent, so they can form many or almost all cell types of the adult, but not an entire organism. (understanding-stemcells.info)
- Internal signals producing apoptosis depend on interactions of several proteins and may serve to protect the organism from cancer by killing cells that have pre-cancerous changes. (agemed.org)
- They are able to differentiate into any cell of an organism and have the ability of self-renewal. (articlecity.com)
- The three germ layers and the body plan of the mature organism are established during gastrulation, and the period is characterized by extensive cell movements and intracellular communications [ 21 , 22 ]. (biomedcentral.com)
MSCs1
- Methods: A phase I multicentre clinical trial (ClinicalTrials.gov NCT01919827) with a single endobronchial administration of autologous adult BM-MSCs in patients diagnosed with mild-to-moderate IPF. (unav.edu)
Therapy12
- Avant-garde approaches to stem-cell therapy may be the first stepping-stones to a bright new future of stem-cell medicine and are emerging in leading laboratories worldwide. (thefutureofthings.com)
- Cell invasion is a crucial step of tumor metastasis , finding new regulators of which offers potential drug targets for cancer therapy. (sdbonline.org)
- Stem cell therapy in India is a safe, affordable, and legal treatment that relieves your ailments without any medicine. (medicaltourismco.com)
- Dr. Anand Srivastava: What is Stem Cell Therapy? (medicaltourismco.com)
- The Indian stem cell therapy ranges between $1,500 to $30,000 in India*, which further depends on the condition being treated. (medicaltourismco.com)
- Therefore, the cost of stem cell therapy in India lets you save nearly 50% of the price back in the USA. (medicaltourismco.com)
- All these diseases are readily treated by Stem Cell Therapy in India at a reasonable cost. (medicaltourismco.com)
- Medical Tourism Corporation has partnered with the Global Institute Of Stem Cell Therapy and Research (GIOSTAR). (medicaltourismco.com)
- However, one of the bottlenecks in the stem cell therapy is that stem cells tend to differentiate into other types of cells during culture in vitro. (biomedcentral.com)
- Also, the multidisciplinary coordination exercise needed to develop this clinical trial protocol will undoubtfully be useful to conduct academic clinical trials in the field of cell therapy in the near future. (unav.edu)
- Marking a vast leap in reproductive therapy, it became possible to isolate these human embryonic stem cells for reproductive purposes, such as in vitro fertilization. (papersowl.com)
- A successful therapy must therefore eliminate these cells known to be highly resistant to apoptosis. (hindawi.com)
Genetic10
- Olariu V, Manesso E, commitment and Peterson C. 2017 A deterministic method for estimating free energy genetic network reprogramming paths landscapes with applications to cell commitment and reprogramming paths. (lu.se)
- In this research, we generate differentiated kidney cells (DKCs) from mouse pluripotent stem cells (mPSCs) analyzing their morphological, genetic, phenotypic, and spectroscopic characteristics along differentiation, highlighting that there are no reports of the use of Fourier transform infrared (FTIR) spectroscopy to characterize the directed differentiation of mPSCs to DKCs. (biomedcentral.com)
- Induced pluripotent stem cells, which harness the power of genetic reprogramming - basically, the altering of a cell's DNA - to change the course of cellular development. (articlecity.com)
- [ 7 ] In addition, recent gene expression profiling studies support the concept that radial glial cells from different neuroanatomic sites may be predisposed to acquiring particular genetic aberrations that result in ependymomas with site-specific genetic signatures and biologic potential. (medscape.com)
- But what is not getting such wide reporting is the use of pluripotent stem cells (as well as many other types of cells and genetic engineering techniques) for reproductive purposes . (lifeissues.net)
- Trends Genetics , 2014), and investigating human diseases of telomere dysfunction (called telomeropathies) which are an emerging genetic spectrum disorder ( J. Cell Biol , 2014, Nucleic Acids Res , 2007, PNAS , 2007). (utsouthwestern.edu)
- During mitosis, cells make copies of their genetic material. (utsouthwestern.edu)
- Half of the genetic material goes to each new daughter cell. (utsouthwestern.edu)
- However, cancer cells overcome these controls, in particular by acquiring genetic mutations leading to the activation of oncogenes (pten, myc) or loss of tumor suppressors (p53) [ 1 ]. (hindawi.com)
- In contrast, cancer cells shift their metabolism toward lactate production even in the presence of oxygen [ 4 ], partly through genetic modifications that stabilize the transcription factor Hypoxia Inducible Factor (HIF) involved in the adaptation of the cells to hypoxia, under nonhypoxic conditions as well as generating an adaptive response to the hypoxic microenvironment (Figure 1 ). (hindawi.com)
Types of stem cells3
- There are different types of stem cells that best can be described in the context of normal human development [ 23 ]. (biomedcentral.com)
- It has been suggested that adults contain 20 different types of stem cells. (biomedcentral.com)
- Objective: the aim of this study was to conduct a literature review of the types of stem cells of dental origin and their applications in Dentistry. (bvsalud.org)
Type of stem cell3
- Depending on the type of stem cell and its influence, they have the potential to develop into any tissue (embryonic stem cells) or certain specified tissue types (adult stem cells). (understanding-stemcells.info)
- This type of stem cell is very versatile and has a wide range of uses, though procuring them entails medical and ethical challenges. (articlecity.com)
- That is to say, one type of stem cell may be capable of differentiating into all adult cell types, while another may only be capable of maturing into one specific somatic cell type. (papersowl.com)
Dental Pulp Stem Cells1
- In the present work, we have analyzed the influence of two Ti implant surfaces characterized by similar microtopography but different nanotopography and chemistry on the osteoblastic phenotype of Dental Pulp Stem Cells (DPSCs). (shengsci.com)
Apoptosis4
- Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)
- Apoptosis Programmed Cell Death (PCD). (agemed.org)
- Signals to trigger apoptosis may come from within the cell or from outside, by stimulating suicide receptors in the cell's external membrane. (agemed.org)
- In this paper, we describe the metabolic changes as well as the mechanisms of resistance to apoptosis occurring in cancer cells and cancer stem cells, underlying the connection between these two processes. (hindawi.com)
Precursor2
- We found no localization of vasa ( vas ) transcripts to any sub-region within the germ-line precursor cells. (biomedcentral.com)
- PEM-1 has a role in repressing gene expression in the germ line precursor cells during germ-soma segregation [ 6 , 7 ]. (biomedcentral.com)
Developmental2
- Specialized ependyma of the circumventricular organs and choroid plexus cells are additional highly specialized ependymal cells that ultimately derive from this developmental pathway. (medscape.com)
- Pharmacological modulation of cell fate decisions and developmental gene regulatory networks holds promise for the treatment of heart failure. (biomedcentral.com)
Neural stem1
- Neurosphere formation is commonly used as a surrogate for neural stem cell (NSC) function but the relationship between neurosphere-initiating cells (NICs) and NSCs remains unclear. (elifesciences.org)
Vitro5
- These protocols, such as organoid cell culture methods, have provided more predictive in vitro cellular "Disease-in-a-Dish" models. (sigmaaldrich.com)
- The ability to expand pluripotent cells in vitro and subject them to direct differentiation to produce specific cell types is crucial to the development of cell-based therapies to replace or restore tissue that has been damaged by disease or injury. (sigmaaldrich.com)
- However, the limited amount of stem cells and their tendency to undergo spontaneous differentiation upon extended propagation in vitro restrict their practical application. (biomedcentral.com)
- In addition, we found that in the presence of LIF, MDLS could replace feeder cells to maintain the undifferentiated state of OG2-mES cells (Oct4-GFP reporter gene mouse embryonic stem cell line), and the MDLS-expanded OG2-mES cells showed an elevated expression levels of pluripotency markers in vitro. (biomedcentral.com)
- Therefore, finding a way to effectively maintain the pluripotency of stem cells cultured in vitro is important for the application of stem cells. (biomedcentral.com)
Fate6
- The cells of the ICM are no longer omnipotent, because they no longer share the fate of the trophoblast, and they have committed themselves to an embryonic fate with the ability to become any cell in the body (but not the trophoblast). (thefutureofthings.com)
- We offer a large collection of cell culture media, supplements, bioactive small molecules, and growth factors used to control the cell fate of human iPSCs. (sigmaaldrich.com)
- Role of Otx2 in Epiblast Stem Cells (EpiSCs): Otx2 stabilizes the primed EpiSC state by suppressing mesendoderm into neural fate switch in cooperation with BMP4 and Fgf2. (cnr.it)
- His laboratory has followed two primary interests: 1) the transcription factor networks that regulate fate determination in various cells that make blood, and 2) the cell surface proteins expressed by hematopoietic stem cells that and allow them to communicate with their microenvironment. (ubc.ca)
- In normal cells, the fate of pyruvate depends on many factors, one of which is oxygen availability. (hindawi.com)
- The oocyte is loaded with maternal mRNAs and proteins that control the cell maintenance and fate and the formation of the body plan prior to the onset of zygotic genome expression [ 3 , 4 ]. (biomedcentral.com)
Totipotent cells1
- Approximately five days after fertilization the totipotent cells have differentiated and started to form a hollow sphere of cells called a blastocyst. (biomedcentral.com)
Proteins3
- Recent research has provided new insights into the function of Hox proteins in different germ layers and the mechanisms they employ to control tissue morphogenesis. (bvsalud.org)
- There he worked with Dr. Max D. Cooper (Howard Hughes Medical Institute, National Academy of Sciences) and his research focused on cell surface proteins expressed by preB cells that regulate B cell maturation and homing. (ubc.ca)
- In this regard, his lab has identified a novel family of hematopoietic cell surface proteins, called the CD34 family, and shown that these are essential for a number of developmentally important processes. (ubc.ca)
Skeletal2
- RACK1 was expressed transiently in the skeletal muscle of post-natal mice, being abundant in the early phase of muscle growth and almost disappearing in adult mature fibers. (sdbonline.org)
- In Drosophila with depleted RACK1 in all muscle cells or, specifically, in SC lineage resulted in a delayed recovery of skeletal muscle after physical damage as well as the low presence of active SC in the wound area. (sdbonline.org)
Research20
- desired for stem cell research. (freezingblue.com)
- Importing hES cells for research purposes is also generally prohibited but may be allowed under certain conditions. (understanding-stemcells.info)
- So when I was recently contacted by an earnest and amiable member of a local school board who was concerned about the questionable manner in which the issue of "stem cell" research - both human embryonic and adult - was presented to the high school students in his district in a currently-used science textbook, I agreed to evaluate that section in the text for him. (lifeissues.net)
- My edited analysis of the section on "stem cell research" in this science textbook is copied below. (lifeissues.net)
- In my opinion there is no question but that the scientific information on stem cell research included in this science text book being used in Illinois schools incorporates some inaccurate scientific facts, and seems to be very partial to the use of human embryonic "stem cell" research. (lifeissues.net)
- Though not intended to be an exhaustive explanation of this important topic, we believe this will help to clarify and explain the questions most frequently asked about embryonic stem cell research. (erlc.com)
- Why are stem cells so important to research? (erlc.com)
- There are two main reasons stem cells are of interest to both scientific and medical research. (erlc.com)
- Stem cells are at the forefront of medical research and incite some of the most controversial ethical and religious debates worldwide. (thefutureofthings.com)
- While regarded by many top scientists as the Holy Grail of medicine, others consider embryonic stem-cell research sacrilegious. (thefutureofthings.com)
- Recent advances in the field of stem-cell research are giving hope to millions. (thefutureofthings.com)
- It will quite effectively cater to the needs of molecular biologists, molecular geneticists, cell and molecular biologists, animal, plant, and crop geneticists, synthetic biologists, biotechnologists, and researchers involved with the fields of stem cell and molecular aspects of cancer research. (caister.com)
- I. Introduction The progress of stem cell research was a significant turning point in history and certainly caught the attention of scientific medicine. (proficientwriters.net)
- Stem cell research is being followed to achieve medical developments and breakthroughs in science. (proficientwriters.net)
- Current research is focused on growing a wide range of new tissue from stem cells, including muscle, blood, brain, and cartilage cells. (articlecity.com)
- This piece will focus on the medical technology being developed using Wharton's jelly as a source material for stem cells, but will also delve into broader aspects of stem cell research, one of the most fascinating current areas of scientific study. (articlecity.com)
- Recent advances in the realm of stem cell research are due to the advent of CRISPR genome editing technology and more advanced 3D cell culture techniques. (sigmaaldrich.com)
- Innovations in Training: Toward Mitigating "Eternal post-docdum" in Stem Cell Research. (shengsci.com)
- In particular, scientific developments in areas such as iPS cells open new possibilities of research and, at mid term, of therapeutic applications, but they also bring new ethical challenges and problems requiring further reflection and debate. (lifeissues.net)
- He is a member of the Stem Cell Network Centre of Excellence (past member of the Stem Cell Policy Committee and Research Management Committee and current Sub-chair of the Training and Education Committee), and a member of the AllerGen Network Centre of Excellence (Research Management Committee and Co-Chair of the Biomarkers Program). (ubc.ca)
Molecular3
- Molecular mechanism controlling the expression of the HOX Complex gene family in human teratocarcinoma cells (N-tera2/D1). (cnr.it)
- These data could help us to understand the possible viral infections in different stem cells and the activation of specific molecular mechanisms upon viral entrance. (shengsci.com)
- Through gene knockout studies he has shown that these molecules act as a type of molecular "Teflon" to make cells more mobile and invasive and also facilitate chemotaxis. (ubc.ca)
Tumors4
- Cancer cells often spread (or metastasize ) throughout the body by way of the bloodstream or lymphatic vessels to form tumors in new locations beyond the primary site of origin. (agemed.org)
- To theorize the "cell of origin" of ependymomas and related tumors, one needs only to look back through the stages of normal ependymal cell development. (medscape.com)
- Not only do choroid plexus tumors and ependymomas (including the various histologic subtypes) clearly recapitulate specific cell types found at various stages in this ontologic sequence, so too do a variety of other uncommon and/or recently recognized entities. (medscape.com)
- Human embryonal carcinoma (EC) cells are the stem cells of teratocarcinomas, and they are key components of germ cell tumors (GCTs). (sigmaaldrich.com)
Self-renew4
- The term stem cell can be defined by two very important qualities: the cell has the ability to self-renew and, in a more general sense, the cell has not completed differentiation into its final state. (thefutureofthings.com)
- There is no uniform definition of stem cells, but they are characterized by being i) undifferentiated, ii) having the potential to produce specialized differentiated cells for a long period of time, and iii) postulated to be capable of maintaining or expanding the number of stem cells (i.e. self-renew). (biomedcentral.com)
- Stem cells have the unique ability to self-renew or to differentiate into various cell types in response to appropriate signals. (sigmaaldrich.com)
- Specific stem cell types possess unique potencies, or abilities to self-renew. (papersowl.com)
Sperm1
- It is already possible today to artificially produce sperm and oocytes from induced pluripotent stem cells of the mouse and to use them for fertilization. (understanding-stemcells.info)
Expression5
- In this line, reporter gene assays with combinatorial treatment of 3i-1000 and the BET bromodomain inhibitor (+)-JQ1 demonstrated the cooperative role of GATA4 and BRD4 in the modulation of chamber-specific cardiac gene expression. (biomedcentral.com)
- Expression analysis of the human Hox Complex in teratocarcinoma cells (N-tera2/D1) upon treatment with retinoic acid and the definition of temporal colinearity concept. (cnr.it)
- We used real-time RT-PCR to compare PU.1 expression between de novo APL patient samples and normal blood specimens, and the results indicated that PU.1 expression was significantly lower in newly diagnosed APL patient samples as compared to normal hematopoietic cells. (biomedcentral.com)
- Furthermore, we measured PU.1 expression in APL-initiating cells isolated from de novo APL patients by side population cell analysis and found that suppression of PU.1 expression occurred concurrently with PML-RARα expression, indicating the pivotal role of PU.1 in APL initiation. (biomedcentral.com)
- In this investigation, comparative gene expression and electron microscopy studies were used to address germ cell formation in Oikopleura dioica ( O. dioica ). (biomedcentral.com)
Myeloid2
- Myeloproliferative neoplasms (MPN), unlike MDS, usually exhibit terminal myeloid cell expansion in the peripheral blood [ 7 ]. (medilib.ir)
- Lymphoid and myeloid stem cells are ideal examples of oligopotent stem cells. (papersowl.com)
Distinct2
- Today, it has become a distinct source of stem cells and, therefore, a critical element in advancing medical treatments for everything from hair loss, the treatment of wounds, and surgical procedures. (articlecity.com)
- More detailed structure-function analysis revealed a distinct subclass of GATA4/NKX2-5 inhibitory compounds with an acetyl lysine-like domain that contributed to ventricular cells (%Myl2-eGFP+). (biomedcentral.com)
Ectoderm1
- During the process of development, neural crest cells migrate out from their niche between the newly formed ectoderm and the neural tube. (shengsci.com)
Blastocyst2
- Embryonic Stem Cells (ES) are isolated from the blastocyst, an early embryonic stage in mammals. (understanding-stemcells.info)
- Fleming, T. P. A quantitative analysis of cell allocation to trophectoderm and inner cell mass in the mouse blastocyst. (nature.com)
Development6
- We explore the method on three circuits for haematopoiesis and embryonic stem cell development for commitment and reprogramming scenarios and illustrate how the method can be used to determine sequential steps for onsets of external factors, essential for efficient reprogramming. (lu.se)
- These adult stem cells serve self-renewal and the development of specialized tissue cell types. (understanding-stemcells.info)
- All specialized cells arise originally from stem cells, and ultimately form a small number of embryonic cells that appear during the first few days of development. (erlc.com)
- Graham, C. F. & Lehtonen, E. Formation and consequences of cell patterns in preimplantation mouse development. (nature.com)
- Differential dosage-dependent roles of OTX2 in specifying regional identities and neuronal cell types during brain development. (cnr.it)
- Overall, the presence of stem cells is essential for proper human development and function as they contribute to the growth, maintenance, and repair of numerous physiological systems (Kara et al. (papersowl.com)
Generate1
- Stem cells are able to generate daughter cells, which themselves possess stem cell properties. (understanding-stemcells.info)
Inactivation1
- The following chapters cover the epigenetic systems of plants, the epigenetic profile of embryonic stem cells, cell differentiation, imprinting marks, and random X chromosome inactivation. (caister.com)