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  • PGCs
  • Contrary to previous assumptions, our results show that as they enter the genital ridge the PGCs still possess DNA methylation marks comparable to those found in somatic cells. (hu-berlin.de)
  • stem cell
  • Complete understanding of the germline reprogramming processes is important not only in the light of genomic imprinting but also for resolving other mechanisms connected with restoring cellular totipotency, such as cloning and stem cell derivation. (hu-berlin.de)
  • tumour
  • They are sometimes called mixed malignant germ cell tumours or secreting tumours because they can secrete substances (tumour markers) such as alpha-fetoprotein (AFP) and HCG. (cancer.ca)
  • Human chorionic gonadotropin (hCG) may be elevated in some cases, but this correlates more to the presence of trophoblast cells within the tumour than to the stage of the tumour. (wikipedia.org)
  • These areas of hemorrhage usually correspond to trophoblastic cell clusters within the tumour. (wikipedia.org)
  • The tumour cells themselves typically have abundant clear to pale pink cytoplasm containing abundant glycogen, which is demonstrable with a periodic acid-Schiff (PAS) stain. (wikipedia.org)
  • stem cells
  • A UMD researcher has uncovered new mechanisms that dictate the development of germline stem cells or germ cells, the only cell type capable of passing genetic information on to the next generation. (medicalxpress.com)
  • Little hints of immortality are lurking in fruit flies' stem cells. (medicalxpress.com)
  • To receive news and publication updates for Stem Cells International, enter your email address in the box below. (hindawi.com)
  • Generation of functional multipotent adult stem cells from GPR125 + germline progenitors," Nature , vol. 449, no. 7160, pp. 346-350, 2007. (hindawi.com)
  • Epigenetic control of mouse Oct-4 gene expression in embryonic stem cells and trophoblast stem cells," Journal of Biological Chemistry , vol. 279, no. 17, pp. 17063-17069, 2004. (hindawi.com)
  • Epigenetic regulation of Nanog gene in embryonic stem and trophoblast stem cells," Genes to Cells , vol. 12, no. 3, pp. 387-396, 2007. (hindawi.com)
  • Under special conditions in vitro germ cells can acquire properties similar to those of embryonic stem cells (ES). (wikipedia.org)
  • He is the founder of Department of Stem Cells in 2002 as well as Royan institute for Stem Cell Biology and Technology in 2010. (wikipedia.org)
  • For the first time, he generated the mouse and human embryonic stem cells (2003) and induced pluripotent stem cells (2008) in Iran. (wikipedia.org)
  • He has focused his research interests on improving the translational research and regenerative medicine mainly through the understanding of Stem Cells and Developmental Biology and Biologically inspired Engineering. (wikipedia.org)
  • In addition, he has been investigating the biologically inspiring engineering on stem cells and developmental biology. (wikipedia.org)
  • It is now known in some detail that this distinction between somatic and germ cells is partly artificial and depends on particular circumstances and internal cellular mechanisms such as telomeres and controls such as the selective application of telomerase in germ cells, stem cells and the like. (wikipedia.org)
  • Epigenetic manipulations may allow for restoration of totipotency in stem cells or cells more generally, thus generalizing regenerative medicine. (wikipedia.org)
  • these cells are reserve spermatogonial stem cells that do not usually undergo mitosis. (wikipedia.org)
  • Although spermatocytes that divide mitotically and meiotically are sensitive to radiation and cancer, spermatogonial stem cells are not. (wikipedia.org)
  • Males
  • Germ cells are the cells that develop in the embryo (fetus, or unborn baby) and become the cells that make up the reproductive system in males and females. (stlouischildrens.org)
  • Males with Klinefelter syndrome have a 50 times greater risk of germ cell tumors (GSTs). (wikipedia.org)
  • In the gonad of the invertebrate nematode C. elegans, a rachis is the central cell-free core or axis of the gonadal arm of both adult males and hermaphrodites where the germ cells have achieved pachytene and are attached to the walls of the gonadal tube. (wikipedia.org)
  • biology
  • In this Seminar, we provide an overview of advances in the understanding of the epidemiology, genetics, and biology of testicular germ cell tumours. (nih.gov)
  • Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells," Nature Cell Biology , vol. 8, no. 6, pp. 623-630, 2006. (hindawi.com)
  • Hossein Baharvand is an Iranian stem cell and developmental biologist and director of Royan Institute for Stem Cell Biology and Technology. (wikipedia.org)
  • He then obtained his Ph.D. in Cell and Developmental Biology from Khwarizmi University (former Tarbiat Moallem University) in 2004. (wikipedia.org)
  • and germ cell biology. (wikipedia.org)
  • In biology and genetics, the germline in a multicellular organism is the population of its bodily cells that are so differentiated or segregated that in the usual processes of reproduction they may pass on their genetic material to the progeny. (wikipedia.org)
  • Ruth Lehmann is a developmental and cell biologist at the New York University School of Medicine, where she is the Director of the Skirball Institute of Biomolecular Medicine, the Laura and Isaac Perlmutter Professor of Cell Biology, and the Chair of the Department of Cell Biology. (wikipedia.org)
  • Lehmann then moved to the Skirball Institute of Biomolecular Medicine at New York University in 1996 as the Laura and Isaac Perlmutter Professor of Cell Biology. (wikipedia.org)
  • She has since become the director of the Skirball Institute and the Helen L. and Martin S. Kimmel Center for Stem Cell Biology, and has recently been named chair of the Cell Biology Department. (wikipedia.org)
  • Lehmann has served as president of the Society of Developmental Biology, president of the Harvey Society, and council member of the American Society for Cell Biology. (wikipedia.org)
  • She is on the Council for the National Institute of Child Health and serves as editor for a number of scientific journals in Cell and Developmental Biology. (wikipedia.org)
  • clinical
  • Bosl GJ, Ilson DH, Rodriguez E, Motzer RJ, Reuter V, Chaganti RSK (1994) Clinical relevance of the i(12p) marker chro¬mosome in germ cell tumors. (springer.com)
  • 1995) Detection of recurrence in patients with clinical stage I nonseminomatous testicular germ cell tumors and consequences for further followup: a single center 10-year experience. (springer.com)
  • An overview of many of the preclinical and clinical developments in germ cell tumors over the past year is presented. (ovid.com)
  • Many children with germ cell tumours are treated in a clinical trial. (cancer.ca)
  • Information about pediatric CNS Germ Cell Tumors treatment, clinical trials, and research from Texas Children's Cancer Center. (texaschildrens.org)
  • On January 10, 2012 it was announced that China will halt new applications for clinical trials of stem-cell products until July 1 as part of a year-long campaign to regulate the development of the industry. (wikipedia.org)
  • determinant
  • Arumugam K, MacNicol MC, Wang Y, Cragle CE, Tackett AJ, Hardy LL, MacNicol AM (2012b) Ringo/cyclin-dependent kinase and mitogen-activated protein kinase signaling pathways regulate the activity of the cell fate determinant Musashi to promote cell cycle re-entry in Xenopus oocytes. (springer.com)
  • Blimp1 is a critical determinant of the germ cell lineage in mice," Nature , vol. 436, no. 7048, pp. 207-213, 2005. (hindawi.com)
  • mechanisms
  • Multiple mechanisms induce quiescence of translation in sea urchin primordial germ cells, including Nanos2-mediated downregulation of eIF1A and a switch to glycolytic metabolism. (biologists.org)
  • Complete understanding of the germline reprogramming processes is important not only in the light of genomic imprinting but also for resolving other mechanisms connected with restoring cellular totipotency, such as cloning and stem cell derivation. (hu-berlin.de)
  • There are two mechanisms to establish the germ cell lineage in the embryo. (wikipedia.org)
  • Weismann however worked long before such mechanisms were known, let alone epigenetic mechanisms or even the genetic role of chromosomes, and he believed that there was some clear qualitative difference between germ cells and somatic cells, though he did realise that the somatic cells differentiated from the germ cells. (wikipedia.org)
  • germline stem
  • Ariz M, Mainpal R, Subramaniam K (2009) C. elegans RNA-binding proteins PUF-8 and MEX-3 function redundantly to promote germline stem cell mitosis. (springer.com)
  • radiation
  • It may be the only type of therapy needed because these types of germ cell tumours are very sensitive to radiation and can often be cured with radiation therapy. (cancer.ca)
  • In children under 3 years old, radiation is delayed (if possible) to avoid long-term effects of radiation on developing brain cells. (cancer.ca)
  • zygotic genes
  • The second way is found in birds and mammals, where germ cells are not specified by such determinants but by signals controlled by zygotic genes. (wikipedia.org)
  • Under Nüsslein-Volhard, Lehmann began to study maternal genes like oskar, pumilio, and nanos, comparing the effects of maternal versus zygotic genes in germ cell formation, abdominal patterning, and cell signaling. (wikipedia.org)