Germ cell tumors containing embryonal. Medical search. Frequent questions

Embryonal carcinoma. (kidshealth.org)
To explain the origin of occult carcinoma in situ cells, 2 models have been proposed. (medscape.com)
Germ cell tumors of the brain include germinoma, teratoma, embryonal carcinoma and yolk-sac tumors. (cincinnatichildrens.org)
76 patients were confirmed germinoma, 29 mixed germ cell tumor, 4 teratoma, 9 malignant teratoma, 6 endodermal sinus tumor, 20 choriocarcinoma and 1 embryonal carcinoma. (researchsquare.com)
Classification of central nervous system germ cell tumors according to the World Health Organization divides them into germinoma and non-germinoma germ cell tumors(NGGCTs), with 6 different types of the latter, which includes teratoma, embryonal carcinoma, endodermal sinus tumor (yolk sac tumor), chorionic epithelioma (also called choriocarcinoma) and mixed germ cell tumors(GCTs) 7 (including above components sometimes teratoma and germinoma as well). (researchsquare.com)
1] Among mixed GCTs, seminoma is also commonly present in combination with teratoma, yolk sac tumor, and/or embryonal carcinoma. (medscape.com)
Malignant germ cell tumors include several types of cancer, such as immature teratoma, yolk sac tumor, embryonal carcinoma, and choriocarcinoma. (curesearch.org)
Patients with lymphovascular invasion and embryonal carcinoma are at genuinely high risk and should have intervention," he stated. (ascopost.com)
Human embryonal carcinoma (EC) cells are the stem cells of teratocarcinomas, and they are key components of germ cell tumors (GCTs). (sigmaaldrich.com)
A malignant mixed germ cell tumor that arises from the testis and is characterized by the presence of choriocarcinoma and embryonal carcinoma morphologic components. (nih.gov)
Of these, 14 (82%) had primary testicular carcinoma and 3 (18%) had extragonadal tumors. (tau.ac.il)
About 85 per cent of the ovarian tumours are carcinomas, which include mucinous cystadenocarcinoma, serous cystadenocarcinoma, clear cell cystadenocarcinoma, endometrioid adenocarcinoma and undifferentiated carcinoma. (cancertame.com)
In stage I of the ovarian carcinoma, the tumour is localised in one or both of the ovaries. (cancertame.com)
The germ cell tumours include dysgerminoma, endodermal sinus tumour, embryonal carcinoma, malignant teratoma and choriocarcinoma. (cancertame.com)
Embryonal carcinoma has most cancers cells that normally blend with every other kind of germ cell tumor. (satyughealthcare.com)
For example, embryonal carcinoma cells could to blend with a teratoma and make it most cancers. (satyughealthcare.com)
AIMS: Papillary renal cell carcinoma (PRCC) with micropapillary carcinoma (MC) has been rarely described. (bvsalud.org)
Seminomatous tumors are seminomas, and non-seminomatous tumors comprise mainly teratoma (mature and immature), yolk sac tumor (YST), embryonal carcinoma (EC), and choriocarcinoma. (autopsyandcasereports.org)
3 Teilum G. Classification of endodermal sinus tumour (mesoblatoma vitellinum) and so-called "embryonal carcinoma" of the ovary. (autopsyandcasereports.org)
Similarly, under Carcinoma, specific renamed or deleted in later revisions of tumour classifications. (who.int)

6 , 8 ] Prognosis was poor for patients with large tumors when more than one-third of the tumor was composed of endodermal sinus elements, choriocarcinoma, or grade 3 immature teratoma. (kaiserpermanente.org)
GTN)-a disease spectrum that includes hydatidiform mole, nonmetastatic GTN, and metastatic GTN-and in about two thirds of men with testicular embryonal cancer or choriocarcinoma. (msdmanuals.com)

Teratoma are most common germ cell tumor of ovary. (wikipedia.org)
Germ cell component was pure teratoma in 27 cases, teratoma mixed with other components in 17, pure seminoma in 2, intratubular GCT in 1 and hepatoid yolk sac tumor in 1. (biomedcentral.com)
I. To evaluate whether a strategy of complete surgical resection followed by surveillance can maintain an overall survival rate of at least 95.7% at two years for pediatric, adolescent and adult patients (ages 0- 50 years) with stage I (low risk) malignant germ cell tumors, and at least 98% for patients with ovarian pure immature teratoma. (yalemedicine.org)
When the clinical and imaging suspicion of either Sacrococcygeal teratoma or other germ cell tumor is high, serum biomarkers as alfa-fetoprotein should be requested. (autopsyandcasereports.org)
Malignant sacrococcygeal teratoma-endodermal sinus, yolk sac tumor-in infants and children: a 32-year review. (autopsyandcasereports.org)

Teratomas are the most common type of germ cell tumor to develop in extragonadal (not in the ovary or testes) areas. (kidshealth.org)
Doctors usually treat teratomas with surgery because chemotherapy doesn't work in a benign tumor. (kidshealth.org)
OGCTs can be classified into dysgerminoma, teratomas, yolk sac tumors, and choriocarcinomas, listed in the order of prevalence. (wikipedia.org)
Most ovarian germ cell tumors are benign mature teratomas (dermoid cysts). (cigna.com)
Most of these tumors are benign teratomas in the sacrum or coccyx. (cigna.com)
Patients with mature teratomas usually experience long-term survival, but survival for patients with immature teratomas after surgery only is related to the grade of the tumor, especially its neural elements. (kaiserpermanente.org)
There are several sub-types of non-germinomatous germ cell tumors, including teratomas, choriocarcinomas, endodermal sinus tumors (yolk sac tumors), embryonal carcinomas, and mixed tumors. (dana-farber.org)
Benign germ cell tumors include certain kinds of teratomas, a type of tumor that may contain several different types of tissue. (curesearch.org)
Teratomas are embryonal tumors that normally arise from germ cells and are typically benign. (asu.edu)
Mature teratomas (aka dermoid cysts) are germ cell tumors of the ovary that are both common and benign. (proprofs.com)
Ovarian teratomas are the most common group of ovarian germ cell tumors . (radiopaedia.org)
Teratomas (from Greek teras, meaning "monster," and - oma, a suffix denoting a tumor or neoplasm) and other germ cell tumors are relatively common solid neoplasms in children. (medscape.com)
Teratomas may be classified as mature or immature on the basis of the presence of immature neuroectodermal elements within the tumor. (medscape.com)
Mutter suggested that these genes or the cells have only the maternal imprint because many teratomas arise from a parthenogenetically activated egg. (medscape.com)

Extragonadal germinal cell tumors (EGGCTs) are rare tumors that predominantly affect young males. (medscape.com)
The only known risk factor for extragonadal germ cell tumors is Klinefelter syndrome (47XXY), which is associated with mediastinal nonseminomatous germ cell tumors, which are characterized by their location on the midline from the pineal gland to the coccyx. (medscape.com)
[ 1 , 2 ] In extragonadal germ cell tumors, no evidence of a primary malignancy is present in either the testes or ovaries by radiologic imaging or physical examination. (medscape.com)
Controversy remains regarding the origin of extragonadal germ cell tumors. (medscape.com)
Some retroperitoneal extragonadal germ cell tumors may represent metastases from a testicular cancer , with subsequent spontaneous necrosis of the primary tumor. (medscape.com)
Childhood extracranial germ cell tumors are grouped as gonadal or extragonadal extracranial tumors. (cigna.com)
Extragonadal extracranial germ cell tumors form in areas of the body other than the brain or gonads (testicles and ovaries). (cigna.com)
Most extragonadal extracranial germ cell tumors form along the midline of the body. (cigna.com)
In children younger than 11 years, extragonadal extracranial germ cell tumors usually occur at birth or in early childhood. (cigna.com)
In older children, adolescents, and young adults (11 years and older), extragonadal extracranial germ cell tumors are often in the mediastinum. (cigna.com)
However, GCTs, including seminomas, can occur in extragonadal sites along the midline of the body, following the embryologic migration route of its precursor cells -- the primordial germ cells. (medscape.com)
Normal migration of these germ cells may cause gonadal tumors, whereas abnormal migration produces extragonadal tumors. (medscape.com)
The presence of sarcomatous components (SC) in gonadal or extragonadal germ cell tumors (GCT) is an infrequent phenomenon whose clinical outcome and biological significance remains unsettled. (biomedcentral.com)
Germ cell tumors that arise in locations apart from the testicles and ovaries (extragonadal germ cell tumors) are very rare. (satyughealthcare.com)
Tumor sites out of doors the gonad are referred to as extragonadal sites. (satyughealthcare.com)
The sacrococcygeal region is the most common site for the extragonadal germ cell tumors comprising seminomatous and non-seminomatous tumors. (autopsyandcasereports.org)
Other common sites for extragonadal germ cell tumors are the brain and mediastinum, although they may occur anywhere in the body. (autopsyandcasereports.org)
6 Teilum G. Special tumors of ovary and testis and related extragonadal lesions: comparative pathology and histological indentification. (autopsyandcasereports.org)
Extracranial and extragonadal germ cell tumors and melanoma were both significantly decreasing. (cdc.gov)

Overall, 60% of germ cell neoplasms have seminoma in their composition, but pure seminomas are genetically different from those that present as a component of a mixed tumor. (medscape.com)
Neoplasms originating from the blood or bone marrow (leukemias and myeloproliferative disorders) are not considered solid tumors. (mycancergenome.org)

The ovarian yolk sac tumors, also known as endodermal sinus tumors, are accountable for approximately 15.5% of all OGCTs. (wikipedia.org)
These malignant elements are typically yolk sac tumors but may also represent primitive neuroectodermal tumor (PNET). (medscape.com)
Yolk sac tumors , (additionally known as endodermal sinus tumors) are normally most cancers. (satyughealthcare.com)

What Are the Signs & Symptoms of Germ Cell Tumors? (kidshealth.org)
The following are the maximum not unusualplace signs and symptoms of germ cell tumors. (satyughealthcare.com)

Often, these tumors form in the ovaries or testes. (kidshealth.org)
These malignant tumors most often develop in the ovaries, testes, or tailbone. (kidshealth.org)
These cells later become sperm in the testicles or eggs in the ovaries. (cigna.com)
Gonadal germ cell tumors form in the gonads (testicles and ovaries). (cigna.com)
Most germ cell tumors appear in the ovaries ( ovarian tumors ) or testes ( testicular tumors ), but they can also get "trapped" in the brain during the fetal period. (dana-farber.org)
Germ cell tumors most commonly appear in the testes for boys and the ovaries for girls. (curesearch.org)
Germ cell tumors in children are growths that typically develop from reproductive cells in the ovaries in girls and in the testes in boys. (shebaonline.org)
Because the surfaces of the ovaries, the lining of the fallopian tubes, and the covering cells of the peritoneum are made up of the same types of cells, most of these diseases look alike under a microscope. (cancer.net)
Germ cell ovarian tumour arises from the germ cells (the cells that give rise to ovaries during the foetal development). (cancertame.com)
In stage I, a germ cell ovarian tumour is localised to one or both ovaries. (cancertame.com)
Most germ cell tumors arise with inside the testicles or the ovaries. (satyughealthcare.com)
They're the maximum not unusualplace germ cell tumors determined withinside the ovaries. (satyughealthcare.com)

Sodium/iodide symporter is expressed in the majority of seminomas and embryonal testicular carcinomas. (nih.gov)

Other GCTs include the dysgerminoma and yolk sac tumor. (proprofs.com)

These malignant tumors are also called dysgerminomas when they're in the ovary, or seminomas when they're in the testes. (kidshealth.org)
Dygerminomas are Malignant germ cell tumor of ovary and particularly prominent in patients diagnosed with gonadal dysgenesis. (wikipedia.org)
OGCT is caused mainly due to the formation of malignant cancer cells in the primordial germ cells of the ovary. (wikipedia.org)
Germ cell tumors of the ovary are uncommon but aggressive tumors, seen most often in young women and adolescent girls. (kaiserpermanente.org)
Endodermal sinus tumors of the ovary are particularly aggressive. (kaiserpermanente.org)
Some studies have found that size and histology were the major factors determining prognosis for patients with malignant mixed germ cell tumors of the ovary. (kaiserpermanente.org)
Therapy of endodermal sinus tumor of the ovary. (kaiserpermanente.org)
Kurman RJ, Norris HJ: Malignant germ cell tumors of the ovary. (kaiserpermanente.org)
GCTs account for about 1 in 5 tumors in the ovary. (proprofs.com)
The term "ovarian cancer" is often used to describe cancers that begin in the cells in the ovary, fallopian tube, or peritoneum. (cancer.net)
5 Talerman A, Haije WG, Baggerman L. Serum alphafetoprotein (AFP) in diagnosis and management of endodermal sinus (yolk sac) tumor and mixed germ cell tumor of the ovary. (autopsyandcasereports.org)
7 Talerman A, Vang R. Germ cell tumors of the ovary. (autopsyandcasereports.org)

What Are the Types of Germ Cell Tumors? (kidshealth.org)
A mixed germ cell tumor has two types of germ cells in it. (texaschildrens.org)
The two main types of germ cell tumors of the brain are germinomas and non-germinomatous tumors. (dana-farber.org)
There are two types of germ cell tumors: malignant (life-threatening) or benign (not life-threatening). (curesearch.org)

The classic theory suggests that germ cell tumors (GCTs) in these areas are derived from local transformation of primordial germ cells misplaced during embryogenesis. (medscape.com)

Background: Malignant gonadal (GGCT) and extragonal germ cell tumors [GCT (EGCT)] are thought to originate from primordial germ cells. (uni-luebeck.de)

A retrospective review was done on ail high volume choriocarcinomas and other germ cell tumors of men with serum beta‐human chorionic gonadotropin (beta‐HCG) levels greater than 50,000 mIU/ml to determine the incidence and characteristics of hyperthyroidism in this setting. (tau.ac.il)

Early on, a child with a benign or malignant germ cell tumor might have few symptoms or none at all. (kidshealth.org)
Germ cell tumors can be either benign or malignant. (texaschildrens.org)
Childhood extracranial germ cell tumors may be benign or malignant. (cigna.com)

Seminoma is the most common pure germ cell tumor (GCT) of the testis, accounting for up to 50% of cases. (medscape.com)
The testis is usually enlarged, and the tumor nodule may distort the external appearance of the organ (see the image below). (medscape.com)
Why not give this regimen to all patients with stage I nonseminomatous or combined germ cell tumors of the testis? (ascopost.com)
Looking at surveillance-taking the opposite view-the overall expected relapse rate is 30.6% for stage I nonseminomatous or combined germ cell tumors of the testis. (ascopost.com)
The approach to treatment of high-risk, clinical stage I, nonseminomatous or combined germ cell tumors of the testis is not written in stone. (ascopost.com)
Histopathological evaluation revealed seminoma of the right testis, nonseminomatous germ cell tumor of the left testis, and metastatic seminoma in the right groin postoperatively. (cancernetwork.com)
As an immune-privileged organ, the normal testis immune environment consists of macrophages, mast cells and few T cells, all having anti-inflammatory effects to protect developing germ cells from autoimmune attack. (uni-giessen.de)
In summary, despite high inter-individual variation and sample heterogeneity, all study approaches showed a similar composition of immune cells in the human testis, with an overall increase of immune cells in TGCT compared to other pathological conditions and normal controls. (uni-giessen.de)
Furthermore, the number of Treg and Tfh was significantly increased in TGCT compared to other pathological conditions and normal testis, possibly providing a tumor growth advantage. (uni-giessen.de)
Intratubular germ cell neoplasia of the testis: a brief review. (nih.gov)

Nonseminomatous germ cell tumors are most cancers and are determined withinside the brain. (satyughealthcare.com)

Boys with undescended testicles (testes that stay up inside the pelvis) also seem to be at a higher risk for a germ cell tumor. (kidshealth.org)
In contrast, tumors arising in the retroperitoneum are virtually always associated with premalignant lesions in one of the testes and behave clinically similar to metastatic testicular seminomas. (medscape.com)
mixed TGCT n=6) were analyzed by flow cytometry from different areas of tumor-bearing and contralateral (control) testes. (uni-giessen.de)
In addition, it became clear that the predominance of resident macrophages in normal testes is shifted in favor of T cells as the main component of TIL in TGCT. (uni-giessen.de)
Conclusions: Patients with stage I germ cell tumors of the testes have excellent survival rates when treated with surgery alone. (johnshopkins.edu)

Genetic changes have also been studied in the past few decades, with documentation of aneuploid DNA content in seminomas and intratubular germ cell neoplasia of the unclassified type (IGCNU), the precursor lesion. (medscape.com)
Elevated serum human chorionic gonadotropin (hCG) levels can occur in seminomas and correlate with syncytiotrophoblastic giant cells seen histologically. (medscape.com)
Using immunohistochemistry (IHC), T cells were confirmed as most abundant TIL, with Treg and Tfh cells most frequently observed in seminomas. (uni-giessen.de)
Consistent with IHC, T cells were most abundant in seminomas. (uni-giessen.de)

According to this theory, the differences in phenotypes expressed by mediastinal germ cell tumors (MGCTs) and gonadal germ cell tumors may be explained by differences in the cellular environment between the gonad and the anterior mediastinum. (medscape.com)
Mediastinal tumors form in the part of the chest between the breastbone and spinal column and can grow without symptoms until they become quite large. (curesearch.org)
Mediastinal tumors/lesions are frequently encountered in daily cytopathology practice. (allenpress.com)
Tumors metastatic to mediastinal lymph nodes represent the most common mediastinal lesions and must be differentiated from primary lesions. (allenpress.com)
To provide an updated review on the fine-needle aspiration cytology of mediastinal tumors/lesions, with an emphasis on diagnostic challenges. (allenpress.com)
Data were gathered from a PubMed search of peer-reviewed literature on mediastinal tumors. (allenpress.com)
1 The most frequent primary tumor types of anterior mediastinal masses are thymic tumors and lymphoma, with approximate proportions of 35% and 25% among mediastinal lesions, respectively. (allenpress.com)
Forty-eight cases of GCT with SC were retrieved from the files of the Instituto Nacional de Cancerologia, Armed Forces Institute of Pathology and Mount Sinai Medical Center (23 gonadal, 23 mediastinal and 2 retroperitoneal tumors). (biomedcentral.com)

Most ovarian tumors and testicular tumors are of germ cell origin. (satyughealthcare.com)

These tests also can show how the cancer treatment is working and, after treatment, whether the tumor has come back. (kidshealth.org)
Information about pediatric CNS Germ Cell Tumors treatment, clinical trials, and research from Texas Children's Cancer Center. (texaschildrens.org)
Texas Children's Cancer Center's Brain Tumor Program and the Neuro-oncology Team treat patients with Intracranial Germ Cell Tumors. (texaschildrens.org)
Atypical teratoid rhabdoid tumor (ATRT) is a rare and aggressive type of cancer that can appear in the brain or spinal cord. (cincinnatichildrens.org)
At Dana-Farber/Boston Children's Cancer and Blood Disorders Center, your child will receive care at one of the largest and most experienced pediatric brain tumor treatment programs in the world. (dana-farber.org)
Germ cell cancer is a rare tumor that affects children, teens, and adults. (curesearch.org)
Brain and spinal cord tumors are a common type of childhood cancer. (vicc.org)
Although cancer is rare in children, brain and spinal cord tumors are the second most common type of childhood cancer , after leukemia . (vicc.org)
Metastatic tumors are formed by cancer cells that begin in other parts of the body and spread to the brain or spinal cord. (vicc.org)
The Identification of CELSR3 and Other Potential Cell Surface Targets in Neuroendocrine Prostate Cancer. (harvard.edu)
The American Joint Committee on Cancer (AJCC) TNM classification and the International Federation of Gynecology and Obstetrics (FIGO) staging system for germ cell tumors are listed below (see Tables 1 and 2). (medscape.com)
Germ cell tumors are considered rare, accounting for approximately 4% of all cases of pediatric cancer. (shebaonline.org)
Potential roles of rarer subtypes, such as regulatory (Treg) and follicular helper T (Tfh) cells, being associated with tumor biology in other cancer entities, have not been investigated in TGCT. (uni-giessen.de)
Some are benign tumors, which aren't cancer. (medlineplus.gov)
These types of cancer begin when healthy cells in these areas change and grow out of control, forming a mass called a tumor. (cancer.net)
Although most tumors release detectable antigenic macromolecules into the circulation, no tumor marker has all the requisite characteristics to provide enough specificity or sensitivity to be used in early diagnosis or mass cancer screening programs. (msdmanuals.com)
Monitoring CEA levels may be useful for detecting cancer recurrence after tumor excision if the patient initially had an elevated CEA and for refining estimates of prognosis by stage. (msdmanuals.com)
More than any other cancer, brain tumors can have lasting and life-altering physical, cognitive, and psychological impacts on a patient's life. (braintumor.org)
Other specified malignant neoplasm (Other specified cancer tumour Other codes are obsolete, ie the entities have been in the previous edition). (who.int)

Neuroendocrine Tumors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition. (harvard.edu)
This graph shows the total number of publications written about "Neuroendocrine Tumors" by people in Harvard Catalyst Profiles by year, and whether "Neuroendocrine Tumors" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Neuroendocrine Tumors" by people in Profiles. (harvard.edu)
Systemic Therapy for Tumor Control in Metastatic Well-Differentiated Gastroenteropancreatic Neuroendocrine Tumors: ASCO Guideline. (harvard.edu)
Intertumoral lineage diversity and immunosuppressive transcriptional programs in well-differentiated gastroenteropancreatic neuroendocrine tumors. (harvard.edu)
Genome-Wide Association Study Identifies 4 Novel Risk Loci for Small Intestinal Neuroendocrine Tumors Including a Missense Mutation in LGR5. (harvard.edu)

These are pure germ cell tumors. (dana-farber.org)
So, sectioning from different areas should be done before labeling them as pure germ cell tumors. (autopsyandcasereports.org)

Stage III: Visible traces of tumor are evident in the lymph nodes. (shebaonline.org)
In stage III, the tumour metastasises to the abdominal lymph nodes and abdominal organs such as the intestines and surface of the liver. (cancertame.com)

Before they settle into the reproductive organs, germ cells develop along the baby's "midline. (kidshealth.org)
Because the germ cells travel along the midline to reach the reproductive organs as a fetus grows, they can sometimes settle in other places. (kidshealth.org)
These tumors can be found anywhere on the midline, particularly the retroperitoneum, the anterior mediastinum, the sacrococcyx, and the pineal gland. (medscape.com)
These germ cells observe a midline course via the frame after improvement and descend into the pelvis as ovarian cells or into the scrotal sac as testicular cells. (satyughealthcare.com)
The tumors additionally arise alongside the midline course and may be located with inside the head, chest, abdomen, pelvis, and sacrococcygeal (lower back) area. (satyughealthcare.com)

They are unlikely to have metastasized and therefore the standard tumor management is surgical resection, coupled with chemotherapy. (wikipedia.org)
The use of combination chemotherapy after initial surgery has dramatically improved the prognosis for many women with these tumors. (kaiserpermanente.org)
A review of the literature in 1979 prior to the widespread use of combination chemotherapy found only 27% of 96 patients with stage I endodermal sinus tumor alive at 2 years after diagnosis. (kaiserpermanente.org)
Cisplatin-based chemotherapy for ovarian germ cell malignancies: the Australian experience. (kaiserpermanente.org)
Failure of tumor marker normalization or subsequent elevation suggested advanced disease requiring further surgery and chemotherapy. (johnshopkins.edu)
Achievement of complete remision (CR) in disseminated germ cell tumors with cisplatin-based combination chemotherapy translates to long-term disease-free survival and cure for the majority of patients, with preservation of functional status. (wustl.edu)
Treatment alternatives for germ cell tumors might also additionally consist of surgical procedure to cast off the tumor, chemotherapy with tablets that kill most cancers cells and radiation remedy with effective strength beams. (satyughealthcare.com)
Drugs used in chemotherapy, such as bleomycin, carboplatin, etoposide, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (yalemedicine.org)
I. To compare the incidence of ototoxicity and nephrotoxicity in children, adolescents and young adults with standard risk germ cell tumors treated with carboplatin-based chemotherapy as compared to cisplatin-based chemotherapy. (yalemedicine.org)
To compare self-reported peripheral neuropathy and other patient-reported outcomes between children, adolescents and young adults with standard risk germ cell tumors treated with carboplatin-based chemotherapy as compared to cisplatin based chemotherapy. (yalemedicine.org)

During this stage of germ cell development, aberrant chromatid exchange events associated with crossing over can occur. (medscape.com)
Testicular germ cell tumors usually occur before the age of 4 years or in adolescents and young adults. (cigna.com)
Subependymal giant cell tumors may occur in children and adults who have a condition called tuberous sclerosis . (cincinnatichildrens.org)
It's important to understand that these and other brain tumors most often occur with no known cause. (dana-farber.org)
Leiomyosarcoma is a malignant non-epithelial smooth muscle tumor that can occur anywhere in the body. (nepjol.info)
Brain tumors can occur in both children and adults. (vicc.org)
In addition to gonadal germ cell tumors, the growths can occur in several other parts of the body, including the lower back, abdomen, chest, and inside the brain. (shebaonline.org)
These tumors occur in newborns, infants, and adolescents. (autopsyandcasereports.org)
These tumors may occur in mixed as well as pure form. (autopsyandcasereports.org)

More than 900 children and adolescents are diagnosed with germ cell tumors in the U.S. each year, comprising about 5% of all childhood cancers . (curesearch.org)
Germ cell cancers are not common, which is why it is critical to choose a medical center with top tier technologies and specialists who are experienced in diagnosing and treating the disease. (shebaonline.org)
Germ cell tumors account for approximately 2 to four percentage of all cancers in kids and youngsters less youthful than age 20. (satyughealthcare.com)

Less frequently, a tubular morphology can be seen (see the images below), posing a differential diagnosis with Sertoli cell tumor. (medscape.com)
We initially use surgery to biopsy the tumor and form a complete diagnosis. (dana-farber.org)
In girls, diagnosis of germ cell tumors is rare until about age 6, and then it rises until about age 15. (shebaonline.org)
Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues. (nih.gov)
Procedures used in the diagnosis and evaluation of a germ cell ovarian tumour include pelvic examination, ultrasound, CT scan and biopsy. (cancertame.com)
Accurate diagnosis, aided by characteristic histological and immunohistochemical features, is essential for appropriate management of this rare vascular tumor. (bvsalud.org)
Diagnosis of MC was made using routine histology, based on the presence of small clusters of cells without a vascular core. (bvsalud.org)

This study retrospectively analyzed serum lymphocyte subsets and survival outcomes in intracranial germ cell tumors (iGCTs) patients. (researchsquare.com)
Intracranial Germ Cell Tumors (iGCTs) are rare brain tumors that originate from embryonic germ cells. (researchsquare.com)

Germ cell tumors can spread to other parts of the brain and spinal cord. (texaschildrens.org)
Meningeal tumors , such as meningioma, which arise from the membranes (meninges) surrounding the brain and spinal cord. (cincinnatichildrens.org)
There are many types of childhood brain and spinal cord tumors . (vicc.org)
This summary is about primary benign and malignant brain and spinal cord tumors. (vicc.org)
Treatment of metastatic brain and spinal cord tumors is not covered in this summary. (vicc.org)
The cause of most childhood brain and spinal cord tumors is unknown. (vicc.org)
The signs and symptoms of childhood brain and spinal cord tumors are not the same in every child. (vicc.org)
Signs and symptoms may be caused by childhood brain and spinal cord tumors or by other conditions . (vicc.org)
In addition to these signs and symptoms of brain and spinal cord tumors, some children are unable to reach certain growth and development milestones such as sitting up, walking, and talking in sentences. (vicc.org)
Childhood brain and spinal cord tumors can cause headaches and other symptoms. (medlineplus.gov)

WHO has published a new classification of soft tissue tumors and a group of undifferentiated round cell sarcomas, including CIC-rearranged sarcoma has been added. (nepjol.info)

these cancerous growths have played a pivotal role in the discovery of stem cells. (asu.edu)
They can be benign or cancerous, and while both types can grow, only malignant tumors can spread to other organs. (shebaonline.org)
Turner syndrome: This genetic condition, which occurs in girls, is linked to a higher chance of developing a benign germ cell tumor that can eventually become cancerous. (shebaonline.org)
Malignant tumors are cancerous. (medlineplus.gov)
A tumor can be cancerous or benign. (cancer.net)
A cancerous tumor is malignant, meaning it can grow, invade, and spread to other parts of the body. (cancer.net)
The tumors can be cancerous or now no longer cancerous. (satyughealthcare.com)
Germ cell tumors are malignant (cancerous) or nonmalignant (benign, noncancerous) tumors which are comprised ordinarily of germ cells. (satyughealthcare.com)

Childhood extracranial germ cell tumors form from germ cells in parts of the body other than the brain. (cigna.com)
This summary is about germ cell tumors that form in parts of the body that are extracranial (outside the brain). (cigna.com)
Extracranial germ cell tumors are most common in adolescents, with rates in this age group lower for females than males. (cigna.com)
Malignant extracranial germ cell tumors are tumors that form outside the brain. (cigna.com)
Influence of tumor site and histology on long-term survival in 193 children with extracranial germ cell tumors. (autopsyandcasereports.org)

Testicular germ cell tumor (TGCT) incidence has increased over the last 40 years in the United States. (nih.gov)
In boys, the incidence of germ cell tumors peaks at around two years old, then declines and only increases again in adolescence. (shebaonline.org)

The treatment of cranial germ cell tumours. (nih.gov)
The remaining 15 per cent of the ovarian tumours are germ cell tumours, stromal tumours and the borderline tumours. (cancertame.com)
Ovarian germ cell tumours and stromal tumours constitute about 10 per cent of the ovarian tumours. (cancertame.com)
The stromal tumours include granulosa cell tumour and Sertoli-Leydig tumour. (cancertame.com)
Ovarian germ cell tumours and stromal tumours affect young women usually below 20 years of age. (cancertame.com)
Ovarian germ cell tumours and stromal tumours remain asymptomatic during initial stages of the disease. (cancertame.com)
Common presenting symptoms of the ovarian germ cell tumours and stromal tumours include mass in the abdomen and vaginal bleeding. (cancertame.com)

Ovarian germ cell tumors are more common in adolescent girls and young women. (cigna.com)
To compare the event-free survival of a carboplatin versus (vs.) cisplatin-based regimen in the treatment of pediatric, adolescent and young adult patients with standard risk germ cell tumors. (yalemedicine.org)
check the tag ADOLESCENCE HN - 2008 BX - Nutrition in Adolescence FX - Adolescent Nutrition Physiology MH - Peritoneal Stomata UI - D054048 MN - A01.047.025.600.700 MN - A10.810 MS - Natural openings in the subdiaphragmatic lymphatic plexus in the PERITONEUM, delimited by adjacent mesothelial cells. (bvsalud.org)

Ovarian germ cell tumors (OGCTs) are heterogeneous tumors that are derived from the primitive germ cells of the embryonic gonad, which accounts for about 2.6% of all ovarian malignancies. (wikipedia.org)
This antibody reacts with TRA-1-60 antigen that is expressed upon the surface of human tetracarcinoma stem cells (EC), human embryonic germ cells (EG) and human embryonic stem cells (ES). (sigmaaldrich.com)

Usually, germ cells migrate to the gonads during fetal development. (dana-farber.org)

Adjuvant therapy of ovarian germ cell tumors with cisplatin, etoposide, and bleomycin: a trial of the Gynecologic Oncology Group. (kaiserpermanente.org)
A retrospective analysis of the initial 229 cases of disseminated germ cell tumors treated at Indiana University with cisplatin, vinblastine, and bleomycin (PVB), with or without doxorubicin revealed 146 pateints who are alive and disease-free with a minimum follow-up of 6 years and a median follow-up of 8.5 years. (wustl.edu)
This partially randomized phase III trial studies how well active surveillance, bleomycin, carboplatin, etoposide, or cisplatin work in treating pediatric and adult patients with germ cell tumors. (yalemedicine.org)

Most childhood brain tumors are diagnosed and removed in surgery. (medlineplus.gov)

These lesions are accessible through endoscopic/endobronchial ultrasound-guided or computed tomography-guided fine-needle aspiration cytology and represent a wide range of primary and metastatic tumors. (allenpress.com)
Metastatic tumor showed only GCT elements in 3 cases. (biomedcentral.com)

However, these tumors can also arise in the abdomen and pelvis, the mediastinum (the part of the chest between the breastplate and the spinal column), and the brain. (curesearch.org)

Serum levels of microRNAs miR-371-3: a novel class of serum biomarkers for testicular germ cell tumors? (nih.gov)
Alpha fetoprotein (AFP) is not produced by seminoma cells, and its serum detection usually indicates a nonseminomatous component. (medscape.com)
none of the patients had thyroid gland enlargement, We conclude that subclinical hyperthyroidism is a relatively common phenomenon in germ cell tumors of men with high levels of beta‐HCG and that control of the primary disease results in serum T 4 level normalization. (tau.ac.il)

These tests help doctors see the size of the tumor and where it is. (kidshealth.org)

Cbl0137, cudc-907, and allogeneic hematopoietic stem cell transplantation are the most common interventions in solid neoplasm clinical trials. (mycancergenome.org)

Anatomy31

Organisms8

Diseases95

Chemicals and Drugs37

Analytical, Diagnostic and Therapeutic Techniques and Equipment48

Phenomena and Processes40

Disciplines and Occupations1

Information Science6

Named Groups1

Health Care11

Geographicals1

Carcinoma20

Choriocarcinoma2

Teratoma5

Teratomas14

Extragonadal19

Neoplasms2

Yolk sac tumors3

Symptoms of Germ Cell T2

Ovaries12

Carcinomas1

Dysgerminoma1

Ovary12

Types of germ4

GCTs1

Primordial germ1

Choriocarcinomas1

Benign or malignant3

Testis10

Nonseminomatous germ cell t1

Testes5

Seminomas4

Mediastinal8

Ovarian tumors1

Cancer19

Neuroendocrine tumors7

Pure germ2

Lymph nodes2

Midline5

Chemotherapy10

Occur9

Cancers3

Diagnosis7

Intracranial germ2

Brain and spinal10

Soft tissue tumors1

Cancerous8

Extracranial5

Incidence2

Tumours7

Adolescent3

Embryonic2

Gonads1

Cisplatin3

Childhood Brain Tumors1

Metastatic2

Mediastinum1

Serum3

Size of the tumor1

Clinical trials1