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  • mouse germ cells
  • Barrios F, Filipponi D, Pellegrini M, Paronetto MP, Di Siena S, Geremia R, Rossi P, De Felici M, Jannini EA, Dolci S (2010) Opposing effects of retinoic acid and FGF9 on Nanos2 expression and meiotic entry of mouse germ cells. (springer.com)
  • Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells," Nature Cell Biology , vol. 8, no. 6, pp. 623-630, 2006. (hindawi.com)
  • Neoplasms
  • They are much less common than germinal tumors arising in the testes, and account for only 1 to 5% of all germ cell neoplasms. (health.am)
  • While the general surgical objectives in patients with these neoplasms are similar to those with other types of CNS tumors, to obtain an accurate histopathologic diagnosis and to contribute towards improving patient survival the unique features of germ cell tumors have necessitated novel treatment strategies. (springer.com)
  • The clinical and pathologic characteristics of benign and malignant germ cell tumors and of "poorly differentiated carcinoma" of the mediastinum are presented, with special attention focused on the treatment of these neoplasms. (health.am)
  • mediastinum
  • The most common sites for germ cell tumors outside of the reproductive tract are the mediastinum (part of the chest between the breastplate and spine), tailbone, abdomen, and pelvis. (rchsd.org)
  • The most common sites for extragonadal germ cell tumors are the midline mediastinum, retroperitoneum and, much less frequently, the stomach. (cancerindex.org)
  • Malignant germ cell tumors of the mediastinum are uncommon, representing only 3 to 10% of tumors originating in the mediastinum. (health.am)
  • Other patients with "poorly differentiated carcinoma" of the mediastinum have clinical characteristics and treatment responses typical of patients with extragonadal germ cell tumors. (health.am)
  • The Lung Center at Brigham and Women's Hospital (BWH) uses the most current diagnostic methods and offers proven treatments for patients with germ cell tumors of the mediastinum, including minimally invasive surgical techniques aided by video and robotic technology. (brighamandwomens.org)
  • midline
  • These cells normally develop along what's called the "midline" of a fetus (usually where the stomach and other internal organs will lie) before finally settling into place in the reproductive organs. (rchsd.org)
  • mammalian germ
  • Epigenetic reprogramming in mammalian germ cells, zygote and early embryos, plays a crucial role in regulating genome functions at critical stages of development. (hu-berlin.de)
  • Many of the Drosophila germ plasm components are conserved and play an essential role in mammalian germ cell formation as well, but it is interesting to note that the key factor in Drosophila, Oskar, has no known orthologs in any other species. (stembook.org)
  • 2002 ). Mammalian germ cell specification is a plastic process and occurs after the embryo has implanted into the uterus. (stembook.org)
  • Stem
  • There are also methods for PCR-based cloning, differentiating embryonic stem cells into embryonic bodies, live imaging of mammalian embryos using multiphoton microscopy, and the cloning of pig, cattle, rabbit, and mouse oocytes. (springer.com)
  • Ariz M, Mainpal R, Subramaniam K (2009) C. elegans RNA-binding proteins PUF-8 and MEX-3 function redundantly to promote germline stem cell mitosis. (springer.com)
  • Complete understanding of the germline reprogramming processes is important not only in the light of genomic imprinting but also for resolving other mechanisms connected with restoring cellular totipotency, such as cloning and stem cell derivation. (hu-berlin.de)
  • Following the first cleavage divisions, cells that receive the germ plasm are destined to become the germline stem cells. (stembook.org)
  • A UMD researcher has uncovered new mechanisms that dictate the development of germline stem cells or germ cells, the only cell type capable of passing genetic information on to the next generation. (medicalxpress.com)
  • Little hints of immortality are lurking in fruit flies' stem cells. (medicalxpress.com)
  • To receive news and publication updates for Stem Cells International, enter your email address in the box below. (hindawi.com)
  • Generation of functional multipotent adult stem cells from GPR125 + germline progenitors," Nature , vol. 449, no. 7160, pp. 346-350, 2007. (hindawi.com)
  • Epigenetic control of mouse Oct-4 gene expression in embryonic stem cells and trophoblast stem cells," Journal of Biological Chemistry , vol. 279, no. 17, pp. 17063-17069, 2004. (hindawi.com)
  • Epigenetic regulation of Nanog gene in embryonic stem and trophoblast stem cells," Genes to Cells , vol. 12, no. 3, pp. 387-396, 2007. (hindawi.com)
  • germline
  • In egg-laying species, which have limited control over the embryo's extra-embryonic milieu, the specification of germ cells through pre-localized germ-plasm may protect the germline against environmental influences. (stembook.org)
  • Patients
  • 1995) Detection of recurrence in patients with clinical stage I nonseminomatous testicular germ cell tumors and consequences for further followup: a single center 10-year experience. (springer.com)
  • Optimal management of patients with germ cell tumors requires effective multidisciplinary management with medical oncology, urology, and in some instances, radiation oncology, working as a team. (oncologynurseadvisor.com)
  • The prognostic classification, shown below, was agreed on in early 1997 by all major clinical trial groups worldwide and should be used for the reporting of clinical trials' results of patients with extragonadal germ cell tumors. (oncolink.org)
  • mechanisms
  • The inheritance of germ plasm in lower organisms is sufficient to install a germ cell identity, but the specific mechanisms by which this occurs remain unknown. (stembook.org)
  • These findings suggest that chemical approaches to therapeutic cell reprogramming may be feasible and provide a powerful platform for analyzing molecular mechanisms of in vivo cell reprogramming. (biomedsearch.com)
  • In a new study published this month in the Proceedings of the National Academy of Sciences, Newmark and his colleagues at the U. of I. report that planarians share some important characteristics with mammals that may help scientists tease out the mechanisms by which germ cells are formed and maintained. (huliq.com)
  • So we're hoping that we can use the molecular biological tools available for studying planarians to get at the mechanisms that tell a cell: 'You're going to be a germ cell. (huliq.com)
  • Having a simple organism that also uses inductive signaling is going to help us tease apart the more conserved mechanisms (of germ cell development and maintenance),"Â Newmark said. (huliq.com)
  • plasm
  • The term "germ plasm" was first coined by August Weismann in a 1893 book of the same title, although in Weismann's view germ plasm was the carrier of hereditary information, reminiscent of our current understanding of genetic information (Weismann, 1893 ). (stembook.org)
  • Currently the term "germ plasm" refers to a large complex of proteins and RNA that visually polarizes the oocyte. (stembook.org)
  • The keystone component of Drosophila germ-plasm assembly is Oskar (Ephrussi et al. (stembook.org)
  • 1991 ). Oskar RNA becomes localized to the posterior pole of the egg where it's translation leads to the assimilation of additional germ plasm components. (stembook.org)
  • However, no higher order germ plasm complexes have been identified in the mammalian oocyte. (stembook.org)
  • Abnormal
  • Some investigators suggest that this distribution arises as a consequence of abnormal migration of germ cells during embryogenesis. (health.am)
  • earliest
  • It offers an awareness and understanding of germ cell tumors: from the earliest stages to their va- rious differentiations. (springer.com)
  • Unlike fruit flies and nematodes, which show signs of germ cell initiation in the earliest stages of their embryonic development, planarians do not generally express nanos or produce germ cells until several days after hatching. (huliq.com)