Genotypic role disease susceptibility. Medical search. Frequent questions

Kaczorek E., Małaczewska J., Wójcik R., Rękawek W., Siwicki A. Phenotypic and genotypic antimicrobial susceptibility pattern of Streptococcus spp. (acarindex.com)
Biotyping and antimicrobial susceptibility profile was done for isolated strains. (who.int)
Clinical specimens such as urine, blood and cervical discharge specimens were collected from patients and antimicrobial susceptibility tests conducted following standard procedures. (bvsalud.org)

Allelic and genotypic frequencies of NOD2/CARD15 variations were calculated in patients and matched with those of 25 healthy controls. (biomedcentral.com)
CI = 1.2-13.5) but not for genotypic frequencies. (biomedcentral.com)
Genotypic frequencies of the DRD2TaqIA, COMT, and ALDH2 polymorphisms between the two BP-II groups were nonsignificant. (ncku.edu.tw)
When genotypic distribution was analyzed, E3/3 genotype and E3 allele frequencies were more prevalent. (biomedcentral.com)
The genotypic frequencies in the cases were not similar to that of the controls, differences being statistically significant ( P = 0.002). (biomedcentral.com)

We report a patient with pulmonary TB relapse with discordant genotypic and in vitro phenotypic drug susceptibility testing results associated with a mutation outside the RIF resistance determining region (RRDR) of the rpoB gene. (cdc.gov)
As MDR-TB strains are often resistant to one or more second-line anti-TB drugs, in-depth genotypic and phenotypic drug susceptibility testing is needed to construct personalised treatment regimens to improve treatment outcomes. (ingentaconnect.com)

This article sought to review the relationship between single nucleotide polymorphisms (SNPs) of CCL5/RANTES and HIV-1 disease susceptibility. (bvsalud.org)
Fcgamma receptor IIA and IIIB polymorphisms are associated with susceptibility to cerebral malaria. (ajtmh.org)
The genetic components most responsible for differences in individual disease risk are thought to be DNA variants (polymorphisms) that influence the expression or function of mediators involved in the pathological processes. (cdc.gov)
This study aimed to explore the associations between MTHFR or TS genetic polymorphisms and susceptibility to acute lymphocytic leukemia (ALL) in children. (medscimonit.com)
Methods: This case-control study conducted in Srinagar, Kashmir (North India) between 2013 and 2015 was designed to evaluate risk induced due to MTH-FR 677C>T gene polymorphisms to contribute in susceptibility for migraine in Kashmir population (North India). (scirp.org)
Studies on polymorphisms found in one cluster of closely-located genes coding for fatty acid desaturases (FADS), enzymes that play an important role in the biosynthesis of both omega-6 and omega-3 LCPUFA, are providing an interesting perspective on the interaction between traditional diets and the population genetic history of humans. (fatsoflife.com)
For CRC, polymorphisms in the genes involved in tumor progression, apoptosis, and angiogenesis have already been extensively studied for their association with cancer susceptibility and prognosis ( 1 - 7 ). (iiarjournals.org)

But exactly how a person's genes, the regulation of these genes and how the resulting proteins interact to cause disease is not widely understood. (uchicagomedicine.org)
Future therapies can target this pathway to tune the m6A level of disease susceptible genes without replacing the genetic code that alters the functioning of m6A. (uchicagomedicine.org)
Our paper provides some examples where genetic variations of immune traits change m6A levels in specific genes, suggesting possible paths from genotypic to phenotypic variations. (uchicagomedicine.org)
deCODE is a global leader in gene discovery - our population approach and resources have enabled us to isolate key genes contributing to major public health challenges from cardiovascular disease to cancer, genes that are providing us with drug targets rooted in the basic biology of disease. (decode.com)
This model was developed using data collected from molecular epidemiology studies of allergic asthma that examined variants in 16 susceptibility genes. (cdc.gov)
We examined whether interactions among these three genes are susceptibility factors in BP-II with AD (BP-II +AD ) and without AD (BP-II −AD ). (ncku.edu.tw)
Here we review the most recent advancements on C. concisus and other human hosted Campylobacter species including their clinical relevance, transmission, virulence factors, disease associated genes, interactions with the human immune system and pathogenic mechanisms. (frontiersin.org)
Background: As microRNAs play important roles in cancer development and progression by regulating the expressions of oncogenes and tumor suppressor genes though interacting with the 3' untranslated region (UTR) of target genes, we aimed to evaluate the association between genetic variants of miRNAs and their binding sites and prognosis in patients with colorectal cancer (CRC). (iiarjournals.org)

Centers for Disease Control and Prevention. (cdc.gov)
I'm Commander Ibad Kahn, and I'm representing the Clinician Outreach and Communication Activity, COCA, with the Emergency Risk Communication branch at the Centers for Disease Control and Prevention. (cdc.gov)
INTRODUCTION From 1989 though 1993, the percentage of nosocomial enterococcal infections reported to the Centers for Disease Control and Prevention (CDC) National Nosocomial Infections Surveillance (NNIS) System that were caused by vancomycin-resistant enterococci (VRE) increased from 0.3% to 7.9%[1]. (cdc.gov)

Study of antibiotic susceptibility. (biodonostia.org)
Role of antibiotic and antiviral treatment in the exacerbation. (biodonostia.org)
Comparison of phenotypic and genotypic techniques of antibiotic susceptibility in strains of Mycobacterium tuberculosis. (biodonostia.org)
Outbreaks have hospital in which the ICUs comprise Antibiotic susceptibility testing was been increasingly reported and most an internal medicine unit (10 beds), a determined using modified Kirby- of those outbreaks are caused by multi- coronary care unit (7 beds), a hepatol- Bauer method following the Clinical drug resistant (MDR) strains of this ogy unit (7 beds), a burns unit (10 beds) Laboratory Standards Institute guide- organism. (who.int)
To gain a handle on the factors that are propelling the problem of AMR, molecular and patient-level investigations are necessary to better elucidate the time-varying and heterogeneous role of antibiotic selection pressure on emergence and selection of AMR. (europa.eu)
was conducted to study the phenotypic and genotypic characterization of antibiotic resistance in the methicillin-resistant Staphylococcus aureus strains isolated from hospital cockroaches. (infectioncontroltoday.com)
The present investigation is the first report of the phenotypic and genotypic evaluation of antibiotic resistance in the MRSA strains isolated from P. americana and B. germanica hospital cockroaches. (infectioncontroltoday.com)
Phenotypic and genotypic characterization of antibiotic resistance in the methicillin-resistant Staphylococcus aureus strains isolated from hospital cockroaches. (infectioncontroltoday.com)

Once ApoE polymorphism may influence lipid metabolism, it is possible that it brings on individual susceptibility consequences for the development of MetS and cardiovascular risk. (biomedcentral.com)
The differentiated response to bacterial pathogenicity has been described as the basis for the individual susceptibility to periodontitis. (bvsalud.org)

Inherent in this technically accurate paradox is that while the former supports the well-established link between microbial pathogens and infectious diseases, the latter infers that disease susceptibility can be modified by extramicrobial factors [ 1 - 3 ]. (hindawi.com)
As C. jejuni and C. coli are the main Campylobacter pathogens which cause human acute intestinal disease and they originate from animal sources, Campylobacteriosis has historically been considered to be zoonotic. (frontiersin.org)
Modulating mechanisms of the host immune response to periodontal pathogens are seen as essential in disease development and progression, which varies among affected patients 2,3 . (bvsalud.org)

Genome analysis of C. concisus strains isolated from saliva samples has identified a bacterial marker that is associated with active Crohn's disease (one major form of IBD). (frontiersin.org)
Objective: To assess the bacterial profile, antibacterial susceptibility pattern and associated factors among mothers attending antenatal and postnatal care health services. (bvsalud.org)

Case-control investigation of invasive Salmonella disease in Malawi reveals no evidence of environmental or animal transmission of invasive strains, and supports human to human transmission. (liverpool.ac.uk)
Different T. cruzi strains and clones display extensive morphological, biological, immunological, biochemical and pharmacological differences, which directly interfere in the clinical state of individuals with Chagas disease. (biomedcentral.com)
Although these mutations result in phenotypic resistance to echinocandins in planktonic cells, there is little data on antifungal susceptibilities of CAS-R C. albicans strains within biofilms. (who.int)

Although novel rapid drug susceptibility testing tools are increasingly available, their clinical applicability is unsettled. (cdc.gov)
Another important anomaly is that exposure to pathogenic organisms does not necessarily result in development of clinical disease. (hindawi.com)
even so, exposure alone does not necessarily result in development of clinical disease. (hindawi.com)
The International Journal of Tuberculosis and Lung Disease (IJTLD) is for clinical research and epidemiological studies on lung health, including articles on TB, TB-HIV and respiratory diseases such as COVID-19, asthma, COPD, child lung health and the hazards of tobacco and air pollution. (ingentaconnect.com)
Maintaining Life-saving Testing for Patients With Infectious Diseases: Infectious Diseases Society of America, American Society for Microbiology, and Pan American Society for Clinical Virology Recommendations on the Regulation of Laboratory-developed Tests. (cdc.gov)
Many common human diseases are affected by thousands of genetic variants, each with individually small effects on the risk of developing these clinical conditions. (ukbiobank.ac.uk)
The results of this project should aid in early identification of individuals at higher risk of certain health conditions who will benefit from preventive interventions and personalized treatments, and will result in the generation of many PRS models for common diseases to optimize clinical care. (ukbiobank.ac.uk)
Aim of our study was to assess if NOD2/CARD15 variants have a role in the etiology or in the clinical course of patients with ACU, either idiopathic or associated with other inflammatory diseases. (biomedcentral.com)

No significant differences in the allelic or genotypic distribution between schizophrenics and controls were observed. (nature.com)
Genotypic differences in tolerance to manganese deficiency. (springer.com)

Infectious Disease Next Generation Sequencing Based Diagnostic Devices: Microbial Identification and Detection of Antimicrobial Resistance and Virulence Markers (draft guidance) FDA, May 13, 2016. (cdc.gov)

still plays a significant role in the etiology of subclinical mastitis. (acarindex.com)
In the past decade, there has been an increase in the number of lung cancer cases in young people, which suggests an important role for genetic background in the etiology of this disease. (scielo.br)
Granulomatosis with polyangiitis (GPA), formerly known as Wegener granulomatosis, is a rare multisystem autoimmune disease of unknown etiology. (medscape.com)

Evidence of in vivo or in vitro genotoxicity often plays an important role in IARC carcinogenicity classifications. (who.int)

They play important roles in the pain pathway where in concert with proinflammatory factors such as leukotrienes they mediate sensitization and hyperalgesia. (researchgate.net)
however, a minority of women exhibit persistent HPV infection, which might lead to cervical intraepithelial neoplasia (CIN) or cervical cancer (CC) [ 12 , 13 ], which means that the host immune system and genetic background play important roles in the progression of cervical cancer [ 14 ]. (biomedcentral.com)

While CFH protein function and its role within the immune response is widely known, the specific contribution of the significant genotypic variation observed in terms of disease progression has yet to be elucidated. (arvojournals.org)
Nothing is known about the protein function of LOC387715 , its role in AMD disease manifestation or its interaction, if any, with additional unidentified proteins or environmental risk factors that lead to the progression of age-related ophthalmic disease such as AMD or cataract. (arvojournals.org)
After STI, the 2 groups did not differ in HIV-1 RNA response or measures of disease progression. (patientcareonline.com)
Increased plasma levels of IL-18 have been shown in T1D patients, which were associated with disease progression. (geneticsmr.org)
C-C chemokine receptor 5 (CCR5) has attracted wide concern for its critical role in the progression of human immunodeficiency virus type 1 (HIV-1) infection. (biomedcentral.com)
CCR5 expression in tumor cells and various host cells plays a very important role in tumor progression [ 6 ]. (biomedcentral.com)

By studying immune cells, they found that abnormalities in m6A levels may correlate with autoimmune diseases and blood cell-related traits. (uchicagomedicine.org)
Anaerobic bacteria cultured from cystic fibrosis airways correlate to milder disease: a multisite study. (wolfganglab.com)

Common diseases of a chronic inflammatory nature such as asthma, Alzheimer disease, and cardiovascular disease are complex in nature, as they are variably influenced by genetic inheritance as well as environmental, physical, and lifestyle factors. (cdc.gov)
Several Campylobacter species utilize humans as their natural host and accumulated evidence supports their role in chronic inflammatory diseases of the human intestinal tract. (frontiersin.org)
Periodontitis is a chronic inflammatory disease associated with the destruction of tooth supporting tissues. (bvsalud.org)

The reduced influence of CFH reported in relation to AMD is most likely because the control cohort used in this investigation is derived from the general population and not selected specifically to be free from any AMD disease symptoms. (arvojournals.org)
Asymptomatic colonization as well as symptomatic disease can be caused by NTM, 2 including, among others, chronic pulmonary disease with symptoms similar to tuberculosis (TB) such as chronic cough (with or without sputum production), chest pain and weight loss. (who.int)

By understanding this relationship, there is an opportunity to change this process and treat inherited human diseases. (uchicagomedicine.org)
Many common human diseases such as asthma, cancer, and cardiovascular disease are complex in nature, as they are influenced variably by environmental, physiologic, and genetic factors. (cdc.gov)
They survive as commensal bacteria in their hosts, and some species, such as C. jejuni and C. coli , can cause human diseases. (frontiersin.org)

Two major AMD susceptibility loci have recently been identified as contributing significantly to the manifestation of AMD. (arvojournals.org)
Thus, for genetic variants to significantly affect disease severity or incidence, they must act cumulatively. (cdc.gov)
The effects on omega-3 LCPUFA homeostasis remain to be reported, but further exploration of indel frequency in populations may significantly augment our understanding of the link between diet and PUFA status in health and disease. (fatsoflife.com)

Hence, susceptibility to infection can be characterized by a construct that involves not only gene expression patterns of the host but also that of the microorganism, both of which continue to adapt in response to external stimuli. (hindawi.com)
Dr. Marimón has been Head of the Respiratory Infection and Antimicrobial Resistance Group of the Infection Diseases Area of the Biodonostia HRI since 2017. (biodonostia.org)
This systematic review explores the role of robots and smart environments in infection prevention and control (IPC) within health care settings. (infectioncontroltoday.com)
Role of miR-2392 in driving SARS-CoV-2 infection. (wolfganglab.com)
An increased risk of VRE infection and colonization has been associated with previous vancomycin and/or multi-antimicrobial therapy, severe underlying disease or immunosuppression, and intraabdominal surgery. (cdc.gov)
Immunocompromised cases (e.g. human immunodeficiency virus [HIV] positive cases) are susceptible to NTM infection, particularly disseminated M. avium disease. (who.int)

The identified variants are then aggregated to produce polygenic risk scores (PRS) to stratify individuals based on their susceptibility to developing a particular disease as a function of the genetic variants they carry. (ukbiobank.ac.uk)
We will utilize the rich individual-level genetic and phenotypic UKBB data to tackle the influence of lifestyle and environmental factors on human conditions across ethnicities and other socio-demographic groups in addition to the effects of aggregate polygenic risk scores, and evaluate the predictive performance of our novel absolute and relative disease risk models. (ukbiobank.ac.uk)
Regarded as a clinicopathological clustering of metabolic disorders determining increased cardiovascular disease (CVD) risk, MetS has a polygenic inherence in which abdominal fat accumulation plays pivotal role for such epidemic morbidity [ 2 ]. (biomedcentral.com)

Acute lymphocytic leukemia (ALL) in children is a clonal disease of bone marrow hematopoietic stem cells. (medscimonit.com)
the Campylobacter species that cause human acute intestinal disease such as Campylobacter jejuni and Campylobacter coli originate from animals. (frontiersin.org)

A total of three SNPs were identified and investigated under their dominant genotypic model and through a fixed-effects model. (bvsalud.org)
Several SNPs located in the FADS gene cluster are now known to be related to changes in risk for complex and chronic diseases. (fatsoflife.com)

Chronic obstructive pulmonary disease (COPD). (biodonostia.org)
Background The positive rate of sputum bacteria in patients with pneumoconiosis complicated with pulmonary tuberculosis is lower than that in patients with simple tuberculosis, which makes the disease assessment more difficult. (bvsalud.org)

This paper focuses on our increased, though by no means complete, understanding of the vitamin-D-dependent antimicrobial pathway and attempts to adjudicate published evidence regarding the vitamin's alleged role in altering host susceptibility to infections. (hindawi.com)
The role of pneumococcal biofilm in chronic respiratory infections (COPD). (biodonostia.org)
Diabetes Awareness Month in November highlights the heightened susceptibility of diabetes patients to infections. (infectioncontroltoday.com)

The latter conclusion infers that susceptibility to infectious disease can be modified by host-related factors. (hindawi.com)
A plausible extension of this concept relates to the involvement of vitamin D in immunomodulation and the role the vitamin appears to have in a number of infectious diseases. (hindawi.com)
Mastitis is a widespread and economically significant infectious disease that affects dairy cows globally. (acarindex.com)
Tuberculosis (TB) (see the image below), a multisystemic disease with myriad presentations and manifestations, is the most common cause of infectious disease-related mortality worldwide. (medscape.com)
See 11 Travel Diseases to Consider Before and After the Trip , a Critical Images slideshow, to help identify and manage infectious travel diseases. (medscape.com)
and Dr. Louise Francois Watkins, a Medical Officer, all with CDC's National Antimicrobial Resistance Monitoring System for Enteric Bacteria Team within the National Center for Emerging and Zoonotic Infectious Diseases. (cdc.gov)
BACKGROUND: Multi-drug Resistant (MDR) bacteria could lead to treatment failure of infectious diseases and could be transferred by non-potable water. (bvsalud.org)

Colonies which that able role in the colonization and infec- were morphologically consistent with tion of patients admitted to hospitals. (who.int)
Suez Canal Uni- Susceptibility testing patients confined to hospital intensive versity hospital is a tertiary-care teaching care units (ICUs) [1]. (who.int)
We also discuss the role of surgery, physiotherapy, rehabilitation, palliative care and smoking cessation in patients with MDR-TB. (ingentaconnect.com)
These are the best-replicated genetic variants ever linked to bladder cancer risk, and the study analysed genotypic data from more than 40,000 patients and controls from Iceland, the Netherlands and eight other European countries. (decode.com)
The present case-control study consisted of 753 HCC patients and 760 cancer-free controls from May 2010 to March 2013 at the Digestive Disease Department, Shandong Provincial Hospital Affliated to Shandong University. (biomedcentral.com)

Since the metalloprotein superoxide dismutase, SOD, is the key enzyme involved in the detoxification of superoxide radicals, it may play a vital role in interindividual variation in superoxide radical turnover. (nature.com)

Although both amyloid ß and tau proteins are known to be involved in AD pathology, their detailed functions in the pathogenesis of the disease are not fully understood. (bvsalud.org)
In short, the role of CCL5/CCR5 axis in the pathogenesis of AD is still intricate. (bvsalud.org)
Interleukin 18 (IL-18) is a potent proinflammatory cytokine, which is involved in the innate and adaptive immune responses, and in the pathogenesis of various diseases including T1D. (geneticsmr.org)
Tumor necrosis factor-alpha (TNF-α) encodes a pro-inflammatory cytokine that is secreted primarily by macrophages and plays critical roles in the pathogenesis of inflammatory autoimmune and malignant diseases. (biomedcentral.com)

One week later, drug susceptibility testing (BD BACTEC MGIT 960 System) results from the state mycobacteriology laboratory demonstrated that the M. tuberculosis isolate was resistant to INH and RIF. (cdc.gov)

The mammary tissue of dairy cattle is seriously harmed by the severe disease known as mastitis. (acarindex.com)

The purpose of this study was to estimate the combinatorial contribution of multiple genetic variants to disease risk. (cdc.gov)
We used a logistic regression model to help estimate the joint contribution that multiple genetic variants would have on disease risk. (cdc.gov)
In light of this, a multiplicative gene-gene interaction model was developed to allow for estimating the combinatorial contribution of multiple genetic variants to disease risk. (cdc.gov)

Even the recommended sufficient range of 25-80 ng/mL, which was extracted from previous data that did not account for sun exposure, race, age, and geographic latitude, may not necessarily apply to the noncalcemic effects for which the vitamin purportedly has a biological role. (hindawi.com)
Through the analysis of m6A data using a statistical methodology called QTL mapping, which links phenotypic traits to genotypic variations, researchers found that m6A was as impactful in modulating disease susceptibility as it was in RNA splicing and that m6A is about half as impactful as gene expression. (uchicagomedicine.org)
However, there are conflicting data concerning the effectiveness of STI, and its role has not been established. (patientcareonline.com)
To overcome GWAS challenges associated with non-coding variants, the need for repeated testing for different populations, and to address the massive increase in sample size required to determine if variants are disease-associated, we have developed new exploratory models which identify key disease variants, and novel PRS models which incorporate several levels and types of functional information, and phenotypic and genotypic data. (ukbiobank.ac.uk)
Estimating influenza disease burden from population-based surveillance data in the United States. (cdc.gov)
We analyse up-to-date epidemiological data of the Ebola virus disease outbreak in Nigeria as of 1 October 2014 in order to estimate the case fatality rate, the proportion of healthcare workers infected and the transmission tree. (who.int)

In a new paper published in Nature Genetics , University of Chicago researchers discovered that a form of RNA chemical modification, N6-Methyladenosine (m6A), plays an important role in human disease heritability. (uchicagomedicine.org)
We do not yet know the mechanisms of the genetic variants that are associated with common diseases," said Xin He, PhD, Assistant Professor of Human Genetics and co-senior author of the paper. (uchicagomedicine.org)
The paper, entitled 'Sequence variant on 8q24 confers susceptibility to urinary bladder cancer,' will appear today in the online edition of Nature Genetics at www.nature.com/ng. (decode.com)
About deCODE deCODE is a biopharmaceutical company applying its discoveries in human genetics to the development of diagnostics and drugs for common diseases. (decode.com)

Many heritable immune diseases such as rheumatoid arthritis and blood-cell related traits derive from critical proteins not being made or not functioning correctly. (uchicagomedicine.org)

Many studies focus on genetic variation's role in transcription (turning DNA into messenger RNA), whereas our study demonstrates that genetic variation is also involved in m6A mediated post-transcription regulation such as translation (turning messenger RNA into proteins). (uchicagomedicine.org)
We plan to evaluate and refine conceptually new statistical and computational methods that improve imputation performance of rarer variation, thus driving identification of additional disease-associated variants and improving disease risk estimation. (ukbiobank.ac.uk)

Although it has been known for some time that genetic factors also play a significant role, identifying validated genetic risk variants had been problematic. (decode.com)
Genome-wide association studies (GWAS) identify disease-associated variants by comparing hundreds of thousands of affected and unaffected individuals. (ukbiobank.ac.uk)
Our model predicts that multiple disease variants broaden the risk distribution, facilitating the identification of susceptible populations. (cdc.gov)

Sleep restriction increases the risk of developing cardiovascular diseases by augmenting proinflammatory responses through IL-17 and CRP. (who.int)

The morbidity and mortality associated with Alzheimer disease (AD), one of the most common neurodegenerative diseases, are increasing each year. (bvsalud.org)

Type 1 diabetes (T1D) is an autoimmune disease with a strong genetic component that has been associated with several genetic loci. (geneticsmr.org)
Glucose transporter 4 (GLUT4) is known to be an insulin-responsive glucose transporter and has been associated with various diseases, including diabetes mellitus. (geneticsmr.org)

This study confirms that in Northern Ireland, as has been reported in other populations, CFH and LOC387715 are major susceptibility loci associated with the manifestation of AMD. (arvojournals.org)
For example, according to Xin He, the same methodology could be used to study brain tissue to see if m6A plays a role in neuropsychiatric diseases. (uchicagomedicine.org)
However, no study examined the role of FOXP2 on cognitive impairment in schizophrenia. (aging-us.com)
Our study suggested that FOXP2 rs10447760 has no effect on the susceptibility to schizophrenia, while it may be associated with its cognitive impairment, especially immediate memory in chronic schizophrenia. (aging-us.com)
Because majority of the patient with M1 disease had no hematogenous metastasis in this study, there was a possibility that distant metastasis was not significant for prognosis in this study. (hsdpathway.com)
If omics-based assays were applied with appropriate study designs, thorough validation of the markers, and careful interpretation of study results then a bioinformatics database could be built of the human response to different chemical exposures and associated chronic diseases. (who.int)

Cystic Fibrosis Airway Mucus Hyperconcentration Produces a Vicious Cycle of Mucin, Pathogen, and Inflammatory Interactions that Promote Disease Persistence. (wolfganglab.com)

Collaborator with group 26 of the CIBERes (Network Centre for Biomedical Research in Respiratory Diseases) since June 2006 and its Head in 2017 and 2018. (biodonostia.org)

World Health Organization estimations of 390,000-510,000 new MDR TB cases and 150,000 related deaths in 2008 highlight the need for timely drug susceptibility testing and improved therapies ( 1 ). (cdc.gov)
if NTM are present in conjunction with Mtb , the former might remain undetected or cause failure of drug susceptibility testing (DST). (who.int)

Foodborne diseases are caused by food contaminated by pathogenic bacteria such as Escherichia coli, Salmonella, Staphylococcus aureus, Listeria monocytogenes, Campylobacter, and Clostridium, a critical threat to human health. (usda.gov)

This disease results from an inflammatory cascade generated by the interaction between periodontopathogenic bacteria and the host immune response, which includes a complex network of cytokines, reactive oxygen species, and proteolytic enzymes 1,2 . (bvsalud.org)

In conjunction with previous findings of increased free radicals and decreased SOD activities in TD subjects, these results suggest that the−9Ala (high activity) MnSOD allele may play a role in protecting against susceptibility to TD in schizophrenics. (nature.com)
found a biallelic polymorphism (Ala−9Val) in the mitochondrial targeting sequence (MTS) of human MnSOD in a Japanese population and reported a significant positive association between the MnSOD allele and Parkinson's disease. (nature.com)
In fact, epidemiological studies suggested that E4 allele carriers were particularly predisposed to develop higher cholesterol levels and higher coronary artery disease (CAD) mortality, meanwhile others studies concluded E3 and E4 alellles presences were associated with higher risk in men. (biomedcentral.com)

In addition, a growing body of evidence suggests vitamin D has an important contributory role in the antimicrobial pathway. (hindawi.com)

Among those individuals with MetS, dislipidemia and its consequences (coronary artery disease, stroke and others) are attributed to a conjunct and integrative action between genetic and environmental factors. (biomedcentral.com)

The genotypic susceptibility score (GSS) had no effect on the risk of VF in the overall population. (nih.gov)
Individuals who carry two copies of a common version of another SNP on chromosome 3 were found to be at a 40% higher risk of the disease than non-carriers. (decode.com)
Conclusions: We conclude that MTHFR gene C677T polymorphism has no role in predisposition to the migraine in our population and cannot serve as a predictive factor for the risk of migraine. (scirp.org)
Estimation of the level of genetic susceptibility showed that the individual calculated risk value (iCRV) ranged from 1 to 16, with a higher iCRV indicating a greater genetic susceptibility to lung cancer. (scielo.br)

5, 10-Methylenetetrahydrofolate reductase (MTHFR) involved in folate metabolism has an important role in a cell for folate availability which is critical for DNA integrity. (scirp.org)

Seeing m6A's association with the heritability of disease contributes to a larger understanding within the scientific community that posttranscriptional regulation plays an important role in common diseases. (uchicagomedicine.org)
Signaling involving chemokine (C-C motif) ligand 5 (CCL5) and its main receptor C-C chemokine receptor 5 (CCR5) plays an important role in normal physiologic processes as well as pathologic conditions such as neurodegeneration. (bvsalud.org)

Anatomy12

Organisms25

Diseases29

Chemicals and Drugs64

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Psychiatry and Psychology3

Phenomena and Processes77

Disciplines and Occupations5

Anthropology, Education, Sociology and Social Phenomena2

Information Science9

Named Groups4

Health Care22

Geographicals3

Antimicrobial susceptibility3

Frequencies5

Phenotypic drug susceptibility2

Polymorphisms7

Genes8

Centers for Diseas3

Antibiotic8

Individual susceptibility2

Pathogens3

Bacterial2

Strains3

Clinical8

Differences2

Virulence1

Etiology3

Vitro1

Play important roles2

Progression6

Correlate2

Chronic inflammatory3

Symptoms2

Human diseases3

Significantly3

Infection6

Polygenic3

Acute2

SNPs2

Pulmonary2

Infections3

Infectious7

Patients5

Interindividual1

Pathogenesis4

Tuberculosis1

Harmed by the severe1

Multiple genetic3

Data6

Genetics4

Rheumatoid arthritis1

Variation2

Variants3

Proinflammatory1

Neurodegenerative1

Diabetes2

Study6

Interactions1

Respiratory1

Drug2

Foodborne1

Immune response1

Allele3

Pathway1

Factors1

Risk4

MTHFR1

Important role2