Genotypes apolipoprotein e4. Medical search. Frequent questions

Moreover, apolipoprotein genotype analysis revealed that AD subjects with the E3/E4 alleles had the highest content of mitochondrial APP. (jneurosci.org)
Participants with one or two alleles of APOE E4 were assigned to the positive group and those without the allele to the negative group. (nutraingredients.com)
Every person has an APOE genotype determined by pairs of these alleles: APOE3/E3 (the most common), APOE3/E4, APOE3/E2, APOE2/E4, APOE4/E4, or APOE2/E2. (alzforum.org)
Methods: Apolipoprotein E alleles and genotypes were determined, and their distributions were compared on the basis of glaucoma status. (edu.au)
The major alleles are called e2, e3, and e4. (medlineplus.gov)
The proportion of APOE genotypes and alleles differ between populations of different ethnic groups and gender [1]. (j-alz.com)
Apo E has three different alleles (E2, E3 and E4) determining different and complex associations with clinical phenotype expressions. (biomedcentral.com)
Results: The mean total CAA scores summed across all 4 brain regions, and the mean scores within each region, did not differ either according to Apo E genotype, or between patients with 1, 2 or no 4 alleles. (confex.com)
The risk of allele E4 which is a reliable marker for lipid profiles, but did not correlate with ApoE alleles. (edu.pl)
95% of ApoE alleles worldwide1;2 and in most populations ApoE3 is the most common followed by E4 and then E24;9 (Number 1). (careersfromscience.org)
Of the common HhAntag ApoE alleles in the overall Qatari populace E3 dominated with E4 becoming more common than E2 (Table 1). (careersfromscience.org)
Desk 2 ApoE Genotypes and Alleles in Topics in the 1000Genomes Data source1 2 In keeping with our hypothesis Mouse monoclonal to RTN3 53 of 1226 (4%) African-Americans had been R145C heterozygotes (Desk 3). (careersfromscience.org)
From the 1012 Caucasians nothing had the R145C polymorphism on the normal E2 E4 or E3 alleles. (careersfromscience.org)

Reduced telomere length in subjects with dementia and diabetes mellitus type 2 is independent of apolipoprotein E4 genotype. (telomerescience.com)
Apolipoprotein E4 gene is associated with increased risk of dementia with comorbid diabetes mellitus. (telomerescience.com)
We assessed relative telomere length and apolipoprotein E genotype in subjects with dementia (n=70) and cognitively normal control groups (n=55) with and without comorbid diabetes mellitus type 2. (telomerescience.com)
Apolipoprotein E4 allele frequency was highest in dementia with comorbid diabetes mellitus type 2 (0.26). (telomerescience.com)
Apolipoprotein E4 allele was not significantly associated with telomere attrition in both dementia and cognitively normal group irrespective of comorbid diabetes mellitus type 2 (P>0.05). (telomerescience.com)
The findings suggest that relative telomere length is unrelated to apolipoprotein E4 genotype in dementia and cognitive normal subjects with or without comorbid diabetes mellitus type 2. (telomerescience.com)
Apolipoprotein E e4 genotype and the temporal relationship between depression and dementia. (usc.edu)
Apolipoprotein (APOE) genotypes (a risk factor for dementia) were determined using TaqMan PCR Assays. (nutraingredients.com)
Similar analyses were performed using positive control outcomes associated with the APOE E4 allele (death, dementia, age-related macular degeneration) and negative control outcomes not associated with the APOE E4 allele (cataract, diabetic eye disease). (edu.au)
Outcome phenotypes were also correlated with Alzheimer's dementia (AD), a clinical outcome highly associated with the APOE E4 allele. (edu.au)
It is unclear why some people with the APOE e4 allele develop Alzheimer's disease while others develop dementia with Lewy bodies. (medlineplus.gov)
The ApoE ε4 genotype is associated with earlier age of onset for the disease, with heterozygous patients having a 50% chance of dementia in their mid to late 70s and homozygous patients having a 50% chance of dementia in their mid to late 60s. (biomedcentral.com)

Objective: To investigate the association between the extent of cerebral amyloid angiopathy (CAA) and Apolipoprotein E (Apo E) e4 allele in Alzheimer's disease (AD). (confex.com)
OBJECTIVE: To gain insight into different cerebral amyloid angiopathy (CAA) phenotypes and mechanisms, we investigated cortical superficial siderosis (CSS), a new imaging marker of the disease, and its relation with APOE genotype in patients with pathologically proven CAA, who presented with and without intracerebral hemorrhage (ICH). (mcmaster.ca)

To characterize the lipidation states of Aβ peptides and apolipoprotein E in the cerebrospinal fluid in adults with respect to cognitive diagnosis and APOE ε4 allele carrier status and after a dietary intervention. (nih.gov)
Lipid-depleted Aβ42 and Aβ40 and apolipoprotein E in cerebrospinal fluid. (nih.gov)

The apolipoprotein E (ApoE) polymorphism has been well studied in the adult human population, in part because the e4 allele is a known risk factor for Alzheimer's disease. (bmj.com)
Groups were compared on clinical and laboratory characteristics as well as allele and genotype distribution towards ApoE polymorphism. (biomedcentral.com)

In parallel to the adaptive process, amyloid-β deposition was more pronounced in peri- and postmenopausal women carrying the apolipoprotein E-4 (APOE-4) genotype, the major genetic risk factor for late-onset Alzheimer's disease (AD), relative to genotype-matched males. (imsociety.org)
The e4 version of the APOE gene increases an individual's risk for developing late-onset Alzheimer's disease. (medlineplus.gov)
The APOE e4 allele may also be associated with an earlier onset of memory loss and other symptoms compared to individuals with Alzheimer's disease who do not have this allele. (medlineplus.gov)
It is not known how the APOE e4 allele is related to the risk of Alzheimer's disease. (medlineplus.gov)
It is important to note that people with the APOE e4 allele inherit an increased risk of developing Alzheimer's disease, not the disease itself. (medlineplus.gov)
Not all people with Alzheimer's disease have the APOE e4 allele, and not all people who have this allele will develop the disease. (medlineplus.gov)
Apolipoprotein E4 ( APOE4 ) is the strongest genetic risk factor for Alzheimer's disease (AD). (eneuro.org)
Classically, the apoE4 genotype has been associated with cardiovascular disease and Alzheimer's disease5Mahley R.W. Weisgraber K.H. Huang Y. Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS.J Lipid Res. (researcher.life)
The apolipoprotein E4 (APOE4) genotype is predictive of Alzheimer's disease (AD). (bvsalud.org)
Apolipoprotein E gene allele 4 (APOE4) is a major genetic risk factor for late-onset Alzheimer's disease (AD). (j-alz.com)
Maioli, Silvia (2011) Interaction between APOE4 genotype and environmental risk factors in Alzheimer's disease , [Dissertation thesis], Alma Mater Studiorum Università di Bologna. (unibo.it)
Association of apolipoprotein E genetic variation in Alzheimer's disease in Indian population: a meta-analysis. (edu.pl)

Through this study, we examine how HFD affects the APOE3 and APOE4 genotype and how these effects differ across sexes. (eneuro.org)
Here, using a humanised APOE3 and APOE4 targeted replacement transgenic mouse model, the interactive influence of cocoa flavanols (FLAV) and APOE genotype on the blood and subcortical brain PUFA status following the supplementation of a high fat (HF) enriched with DHA from fish oil (FO) was investigated. (bvsalud.org)

In certain subsets of MCI where the disease will progress to Alzheimer disease, one must consider apolipoprotein (APO) E4 genotype: Various pathways exist leading to amyloid accumulation and deposition thought to be associated with Alzheimer disease. (unboundmedicine.com)
Should the ApoE genotype be a covariate for clinical trials in Alzheimer disease? (biomedcentral.com)
With regard to therapeutic drug trials in Alzheimer disease (AD), a frequent and appropriate concern is whether the apolipoprotein E (ApoE) genotype should be taken as a covariate in statistical analyses regarding efficacy or adverse effects. (biomedcentral.com)
Evidence for major gene inheritance of Alzheimer disease in families of patients with and without apolipoprotein E epsilon 4. (ox.ac.uk)
Apolipoprotein E (APOE) genotype is the single most important determinant to the common form of Alzheimer disease (AD) yet identified. (ox.ac.uk)

The ApoE ε4 genotype is the major genetic risk factor identified for AD. (biomedcentral.com)
The major genetic risk factor is the E4 variant of apolipoprotein E gene called apoE4. (unibo.it)

Thus, the genetic risk factor apoE4 genotype associated with a high carbohydrate diet seems to affect cognitive functions in young mice, corroborating the theory that the combination of genetic and environmental risk factors greatly increases the risk of developing AD and leads to an earlier onset of cognitive deficits. (unibo.it)
We carried out a complex segregation analysis in 636 nuclear families of consecutively ascertained and rigorously diagnosed probands in the Multi-Institutional Research in Alzheimer Genetic Epidemiology study in order to derive models of disease transmission which account for the influences of APOE genotype of the proband and gender. (ox.ac.uk)

Six possible apoE genotypes exist: e2/e2, e2/e3, e2/e4, e3/e3, e3/e4 and e4/e4. (news-medical.net)

In MCI subjects, although there was no significant difference between the H2- and control groups in ADAS-cog score after 1 year, carriers of the apolipoprotein E4 (APOE4) genotype in the H2-group were improved significantly on total ADAS-cog score and word recall task score (one of the sub-scores in the ADAS-cog score). (eurekaselect.com)
At the same time, emerging evidence suggests the hypothesis that the apolipoprotein E4 (apoE4) genotype can predict coronavirus disease 2019 (COVID-19) severity in adults.3Goldstein M.R. Poland G.A. Graeber C.W. Does apolipoprotein E genotype predict COVID-19 severity? (researcher.life)
20: 1-2Google Scholar Accordingly, we propose the hypothesis that the apoE4 genotype may identify children at increased risk of developing MIS-C from SARS-CoV-2 infection. (researcher.life)

Since there is evidence that the ApoE genotype may differentially affect disease mechanisms, efficacy, and adverse effects in both AD and mild cognitive impairment trials, the ApoE genotype should be included as a covariate in future studies. (biomedcentral.com)
In mild cognitive impairment (MCI) or very-early-stage AD, the E4 genotype is associated with greater deficits on the New York Paragraph Recall test, Auditory-Verbal Learning Test, and Buschke test at baseline. (biomedcentral.com)

APOE encodes a secreted apolipoprotein involved in lipid metabolism. (alzforum.org)
Like other apolipoproteins, APOE is involved in lipid binding, and it is the predominant cholesterol transporter in the brain. (j-alz.com)

While APOE genotype and obesity independently affect metabolism and cognition, they may also have synergistic effects. (eneuro.org)
Apolipoprotein E (ApoE) is involved on cholesterol and triglycerides metabolism regulation. (biomedcentral.com)

We performed a 4.5-year longitudinal study in 75 older community dwellers (48 women, mean age: 79.3 years) including magnetic resonance imaging at baseline and follow-up, positron emission tomography amyloid during follow-up, neuropsychological assessment at 18 and 55 months, and APOE genotyping. (unige.ch)

Main Outcome Measures: Results of APOE E4 genotype-phenotype comparisons were reported as odds ratios (ORs) with 95% confidence intervals (CIs). (edu.au)
The raised prevalence of ApoE e2 associated with perinatal death suggests that this allele is detrimental to pregnancy outcome, whereas ApoE e4 may be less so. (bmj.com)
542 (of 707) trial participants had both genotype and colonoscopy outcome data. (bvsalud.org)

The ApoE2, E3, and E4 protein phenotypes have differential affinities for lipids and Aβ and consequent variable efficiencies in these transport roles. (biomedcentral.com)
In summary, the different ApoE2, E3, and E4 genotypes code for different ApoE protein phenotypes, which result in functional variation in the actions of this protein as it plays roles that virtually span known and theorized disease mechanisms involved in the pathogenesis or progression (or both) in AD. (biomedcentral.com)

Purpose: To elucidate a potential association between the apolipoprotein E (APOE) E4 allele and glaucoma prevalence in large cohorts. (edu.au)
In contrast, the prevalence of ApoE e4 was raised in healthy liveborn infants (19%) compared with stillbirths (13%, OR = 1.59, 95% CI 1.11 to 2.26) and with adults (15%, OR = 1.35, 95% CI 1.04 to 1.76). (bmj.com)
Mets CVD prevalence was analysed according to E4 allele prevalence. (biomedcentral.com)
On the opposite way, E4 allele carriers without visceral obesity had lesser prevalence of CVD. (biomedcentral.com)

Variants of apolipoprotein E have been studied extensively as risk factors for many different conditions. (medlineplus.gov)

With regard to the influence of the ApoE genotype on clinical factors of potential importance in AD clinical trials, there may be differential effects related to disease stage, trial length, and the specific effects of the drug regarding symptomatic actions versus effects on longer-term biological progression of the disease. (biomedcentral.com)
In fact, epidemiological studies suggested that E4 allele carriers were particularly predisposed to develop higher cholesterol levels and higher coronary artery disease (CAD) mortality, meanwhile others studies concluded E3 and E4 alellles presences were associated with higher risk in men. (biomedcentral.com)

The lipidation states of apolipoproteins and Aβ peptides in the brain differ depending on APOE genotype and cognitive diagnosis. (nih.gov)
ApoE genotyping was undertaken in a Scottish cohort of perinatal deaths (n = 261), some of whom had prenatal brain damage. (bmj.com)
However, no correlation was found between ApoE genotype and the presence or absence of perinatal brain damage. (bmj.com)
However, ApoE genotype did not appear to influence the vulnerability for perinatal hypoxic/ischaemic brain damage, in agreement with findings in adult brains and in animal models. (bmj.com)
However, the impact of flavanol co-supplementation with fish oil on brain DHA uptake, status and partitioning, and according to APOE genotype is currently unknown. (bvsalud.org)
Future research would benefit from understanding the relationship between APOE genotype and how we could use micronutrients to accumulate in brain to help relive oxidative stress. (j-alz.com)
However, once again there were significant differences in mean CAA score between the 4 brain areas according to Apo E genotype. (confex.com)
Conclusion: The likelihood of patients with AD suffering from CAA is not influenced by Apo E genotype, nor is the overall burden of the pathological change in the brain so influenced. (confex.com)
However, the distribution of CAA within the brain with AD is at least partly influenced by genotype and dosage of Apo E 4 allele, with the occipital cortex being more severely affected in those patients where Apo E 4 allele is present. (confex.com)

The APOE gene provides instructions for making a protein called apolipoprotein E. This protein combines with fats (lipids) in the body to form molecules called lipoproteins. (medlineplus.gov)
It is thought that the apolipoprotein E produced from the e4 allele of the APOE gene may disrupt the transport of a protein called alpha-synuclein into and out of cells. (medlineplus.gov)
Apolipoprotein E (APOE) is a lipid-transport protein abundantly expressed in most neurons in the central nervous system. (dovepress.com)
Apolipoprotein E (ApoE) a protein component of bloodstream lipid particles has an important function in lipid transportation. (careersfromscience.org)

Conclusions: A small negative association observed between APOE E4 and glaucoma within the UKBB was not evident in either replication cohort and may represent an artifact of glaucoma underdiagnosis in APOE E4 carriers. (edu.au)
113: 537-538Crossref Scopus (13) Google Scholar,4Kuo C.L. Pilling L.C. Atkins J.L. Masoli J.A.H. Delgado J. Kuchel G.A. et al.ApoE E4 genotype predicts severe COVID-19 in the UK Biobank Community Cohort.J Gerontol A Biol Sci Med Sci. (researcher.life)

The results presented demonstrate that the association between ApoE gene and CVD may be modulated by the presence of MetS, with an increased CV burden observed among E4 allele carriers with the syndrome. (biomedcentral.com)
OR = 0.50 [95% CI, 0.27-0.96], β = -0.68, p = 0.04) in cognitively normal participants, 60-80 years old, who are APOE e4-carriers. (lu.se)

Apolipoprotein E4 ( APOE4 ) and obesity are independently associated with increased risk of metabolic syndrome and cognitive impairment. (eneuro.org)

Replication analyses investigated APOE E4 associations in 2 replication cohorts (CLSA and ANZRAG/BMES). (edu.au)
Treatment effects were reported as the incidence rate ratio (IRR) and 95% confidence interval (CI) by stratifying negative binomial and Poisson regression analyses of colorectal polyp risk on SNP genotype. (bvsalud.org)

2. Premio para la comunicación ¿Record of preanalytical errors in the laboratory information system¿ en el XXII National Congress of the Spanish Society of Clinical Biochemistry and Molecular Pathology, celebrado en Barcelona del 1 al 5 de Junio de 2003. (unav.edu)
Notably, 14/20 patients who exhibited worsening of clinical manifestations at one -year follow-up possessed this combination of NK receptors and HLA genotype, and the combination was also associated with significantly lower Mini-Mental State Examination scores at diagnosis of AD. (hhv-6foundation.org)

The apolipoprotein E4 allele (APOE epsilon 4) and atherosclerosis are risk factors for cognitive decline. (ox.ac.uk)

Thus, given to the importance of the involvement of leptin in AD, we wanted to clarify the function of leptin in the pathogenesis of AD and to investigate if apoE genotype affect leptin levels through studies in vitro, in mice and in human. (unibo.it)

In this study we wanted to characterize the effects of the interaction between environmental risk factors and apoE genotype on neurodegeneration processes, with particular focus on behavioural studies and neurodegenerative processes at molecular level. (unibo.it)
Our work supports previous findings, suggesting that the KL-VSHET+ on an APOE ε4 genotype background may modulate Aβ and tau pathology, thereby lowering the intensity of neurodegeneration and incidence of cognitive decline in older controls susceptible to AD. (lu.se)

executive function: β = -0.04 [SE = 0.02], P = .008) participants were greater than those with adequate status after controlling for age, sex, education, ethnicity, body mass index, season of blood draw, vascular risk, and apolipoprotein E4 genotype. (fabresearch.org)

People who carry at least one copy of the APOE e4 allele have an increased chance of developing atherosclerosis, which is an accumulation of fatty deposits and scar-like tissue in the lining of the arteries. (medlineplus.gov)
Apolipoprotein E genotype, atherosclerosis, and cognitive decline: the Rotterdam Study. (ox.ac.uk)

In other words, knowing a patient's apoE genotype helps a doctor predict whether or not the patient would be better off on statins versus a low-fat diet, for example. (news-medical.net)

It is unclear how the APOE e4 allele contributes to the development of this condition. (medlineplus.gov)

Some patients might respond well to a low fat diet, some patients might respond better to statin medications, depending on their apoE genotype,' states Dr. Jonathan Stein, PhD and Director of Science and Research at SpectraCell Laboratories. (news-medical.net)
There is evidence in neuropathological studies of AD patients of greater microglial activation around Aβ plaques in patients with the ApoE 4 genotype [ 7 ]. (biomedcentral.com)
After isolating genomic DNA from the whole blood of 98 AD patients, the genotype of NK killer Ig-like receptors (KIR) was examined. (hhv-6foundation.org)
APOE genotype was available in 53 patients. (mcmaster.ca)

The characteristic components of the syndrome are mostly determined by apolipoprotein E (ApoE) modulation of atherogenic plasma Apo-B containing lipoproteins. (biomedcentral.com)

These findings may provide insight into the mechanisms through which apolipoprotein E4 and unhealthy diets impart risk for developing AD. (nih.gov)

The response of plasma lipids to dietary fat manipulation is highly heterogeneous, with some indications that APOE genotype may be important. (uea.ac.uk)

When genotypic distribution was analyzed, E3/3 genotype and E3 allele frequencies were more prevalent. (biomedcentral.com)

The ApoE genotype has not affected efficacy in short symptomatic AD trials. (biomedcentral.com)

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