Genotype polymorphism genetic. Medical search. Frequent questions

SNP genotyping is the measurement of genetic variations of single nucleotide polymorphisms (SNPs) between members of a species. (wikipedia.org)
SNPs are one of the most common types of genetic variation. (wikipedia.org)
The use of SNPs is being extended in the HapMap project, which aims to provide the minimal set of SNPs needed to genotype the human genome. (wikipedia.org)
SNPs can also provide a genetic fingerprint for use in identity testing. (wikipedia.org)
The increase of interest in SNPs has been reflected by the furious development of a diverse range of SNP genotyping methods. (wikipedia.org)
Because DASH genotyping is measuring a quantifiable change in Tm, it is capable of measuring all types of mutations, not just SNPs. (wikipedia.org)
We performed genotyping of 19 single nucleotide polymorphisms (SNPs) by Sequenom MassARRAY. (hindawi.com)
Previous study found that single nucleotide polymorphisms (SNPs) in nucleotide excision repair (NER) are associated with progression-free survival, including ERCC1, ERCC6, POLD2, POLE, and XPA [ 15 , 16 ]. (hindawi.com)
The SeqStudio instrument is easy to use across a broad range of applications, including de novo , targeted, and plasmid Sanger sequencing, CRISPR-Cas9 genome editing confirmation, cell line authentication, and detection of single nucleotide polymorphisms (SNPs). (thermofisher.com)
No clinical studies have explored the effect of single nucleotide polymorphisms (SNPs) resulting in reduced activity enzymes (e.g. (aspetjournals.org)
In this workshop, we will focus firstly on the website tools and criteria of selection of SNPs polymorphism that will be used on the study. (edu.sa)
A total of 13,589 single-nucleotide polymorphisms (SNPs) were selected andused for further association mapping. (cgiar.org)
ABSTRACT Single nucleotide polymorphisms (SNPs) in the Interleukin (IL)-28B gene, namely rs12979860, could predict response to pegylated interferon--ribavirin (PR) therapy in hepatitis C virus genotype 1 (HCV-1)-infected patients. (who.int)

The D allele of the ACE polymorphism is associated with a significantly increased SBP and risk of hypertension in smokers. (nih.gov)
The homozygotes and heterozygotes for the wild type allele named positive genotypes. (molvis.org)
Dynamic allele-specific hybridization (DASH) genotyping takes advantage of the differences in the melting temperature in DNA that results from the instability of mismatched base pairs. (wikipedia.org)
If a molecular beacon is designed to match a wild-type allele and another to match a mutant of the allele, the two can be used to identify the genotype of an individual. (wikipedia.org)
Apolipoprotein E gene allele 4 (APOE4) is a major genetic risk factor for late-onset Alzheimer's disease (AD). (j-alz.com)
The Q353 allele of the factor VII gene polymorphism is associated with decreased factor VII and could be protective against cardiovascular disease. (who.int)
From 189 healthy volunteers who were genotyped for CYP2C9 polymorphisms, 11 control subjects ( CYP2C9 * 1/ * 1 ), 9 heterozygous and 2 homozygous for the CYP2C9 * 3 allele participated in the pharmacokinetic drug interaction study. (aspetjournals.org)
Genotype frequency at codon 129 was Met/Met (84.7%) and Met/Val (15.3%), and allele frequency was Met (92.4%) and Val (7.6%).129 Met was a risk factor (OR: 3.728, 95% CI: 2.194 to 6.333, p=0.000) for FFI in the non-Asian population. (bmj.com)
1-3 It has an autosomal-dominant pattern linked to a point mutation (D178N) of the prion protein (PRNP) gene, which cosegregates with the methionine polymorphism at codon 129 of the mutated allele. (bmj.com)
Our study shows that carriers of the T allele have a higher risk of SHAI than carriers of the mutated C/C genotype. (frontiersin.org)
The homozygous C allele genotype (CC) was associated with sustained viral response (SVR) to therapy compared with the homozygous T allele genotype (TT) and the heterozygous genotype (CT). (who.int)
TLR2 2258G allele may provide protective effects against PTB susceptibility, particularly among Asians, whereas TLR2 T597C polymorphism might not be associated with PTB susceptibility. (cdc.gov)

In this review we define the field of occupational and environmental health (OEH) research as the study of interactions between the following domains: environment (the exposome), 4 individual (genetic) susceptibility (the (epi)genome), and biological outcomes (the responsome) 5 ( figure 1 ). (bmj.com)
Estimation of the level of genetic susceptibility showed that the individual calculated risk value (iCRV) ranged from 1 to 16, with a higher iCRV indicating a greater genetic susceptibility to lung cancer. (scielo.br)
This study aimed to explore the associations between MTHFR or TS genetic polymorphisms and susceptibility to acute lymphocytic leukemia (ALL) in children. (medscimonit.com)
CYP2C9 * 3 ) on drug clearance have been well characterized but much less is known about whether these polymorphisms alter susceptibility to drug-drug interactions. (aspetjournals.org)
Publications regarding the associations of toll-like receptor 2 (TLR2) G2258A and T597C polymorphisms with pulmonary tuberculosis (PTB) susceptibility are inconsistent. (cdc.gov)
A meta-analysis was conducted to investigate the relationship between TLR2 G2258A and T597C polymorphisms with PTB susceptibility. (cdc.gov)
A systematic search was performed for published studies on the relationship between TLR2 polymorphisms and PTB susceptibility. (cdc.gov)
The associations of T597C polymorphism with PTB susceptibility, in the ethnic-specific analyses, were still not significant. (cdc.gov)
0, 0001) in patients with TMDs, regardless the clinical type TMD, suggesting that Hp1-1 and likely genetic marker of susceptibility for the development of chronic pain in TMD. (bvsalud.org)

Statistical analysis showed a possible interaction between polymorphisms in the OPTN and the TNF-alpha genes that would increase the risk for glaucoma. (nih.gov)
The third objective was to determine the genetic diversity and presence of certain resistance genes in Pakistan wheat using resistance gene analog polymorphism, simple sequence repeat and sequence tagged site markers. (usda.gov)
We used detailed genomic methods to identify the genetic quantitative trait loci and the nearby putative candidate genes that have biological connections especially for immune-related activities. (usda.gov)
Patients were genotyped for a panel of 192 tagging polymorphisms in 34 immune-related genes. (frontiersin.org)
All of the genotypes analyzed were in Hardy-Weinberg equilibrium, but different degrees of linkage were observed for polymorphisms in the CYP1A1 and EPHX1 genes. (scielo.br)
in particular, genetic markers of risk, and integrating these genes with core brain and body measures including magnetic resonance imaging (MRI), electroencephalography (EEG), and electrocardiography (ECG). (edu.au)
Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios. (snpedia.com)
Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study. (snpedia.com)
Certain common changes (polymorphisms) in the CYP2C9 and VKORC1 genes account for most of the variation in warfarin metabolism due to genetic factors. (medlineplus.gov)
Polymorphisms in other genes, some of which have not been identified, have a smaller effect on warfarin metabolism. (medlineplus.gov)
Additionally, people who have more than one polymorphism in a gene or polymorphisms in multiple genes associated with warfarin sensitivity have a lower tolerance for the drug's effect or take even longer to clear the drug from their body. (medlineplus.gov)

Background: Different parameters have been determined for prediction of treatment outcome in hepatitis c virus genotype 1 infected patients undergoing pegylated interferon, ribavirin combination therapy. (uni-koeln.de)

It is a form of genotyping, which is the measurement of more general genetic variation. (wikipedia.org)
Three significant quantitative trait loci were identified for fetal_T3 on SSC1 and SSC4, which collectively explained 10% of the genetic variation. (usda.gov)
We will study statistical and algorithmic methods for the analysis of genetic variation in SNP (single nucleotide polymorphism) genotype data. (helsinki.fi)
Individual Genetic Variation Might Predict Acute Skin Reactions in Women Undergoing Adjuvant Breast Cancer Radiotherapy. (cancerindex.org)
The aim of this study was to explore whether genetic variation might be linked to acute radiation skin reactions (ARSR). (cancerindex.org)
Objective Elucidate the core clinical and genetic characteristics and identify the phenotypic variation between different regions and genotypes of fatal familial insomnia (FFI). (bmj.com)
Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. (snpedia.com)
COMT genetic variation confers risk for psychotic and affective disorders: a case control study. (snpedia.com)
PMID 16786032 ] Impact of complex genetic variation in COMT on human brain function. (snpedia.com)
Genetic variation in catechol-O-methyltransferase: effects on working memory in schizophrenic patients, their siblings, and healthy controls. (snpedia.com)
Since all tobacco products share the ability of stimulating the dopaminergic reward system, variation in the DRD2 genotype might be associated with waterpipe smoking addiction. (who.int)
A variation in the ACE gene, called the ACE I/D polymorphism, alters activity of the gene. (medlineplus.gov)

However, a specific FDA-approved CYP2C9 genotyping test for siponimod currently is not available. (drugs.com)
a reduced maintenance dosage is recommended in patients with CYP2C9*1/*3 or *2/*3 genotypes. (drugs.com)
Kostnadene for full genotyping av CYP2C9/-2C19/-2D6 tilsvarer én sykmeldingsdag. (tidsskriftet.no)
Genetic polymorphisms of the drug-metabolising cytochrome P-450 (CYP) enzymes CYP2C9, CYP2C19 and CYP2D6 have been characterized, and several of these variants lead to reduced or absent activity. (tidsskriftet.no)
At present, CYP genotyping (CYP2C9/2C19/2D6) is most frequently requested in psychiatry and anticoagulant therapy, but the field is expanding. (tidsskriftet.no)
The expenses of full genotyping (CYP2C9/2C19/2D6) are equivalent to one day of sick leave. (tidsskriftet.no)
Previous in vitro work has demonstrated that genotype-dependent inhibition of CYP2C9 mediated flurbiprofen metabolism, suggesting the possibility of genotype-dependent inhibition interactions in vivo. (aspetjournals.org)
In the current study, flurbiprofen was used as a probe substrate and fluconazole as a prototypical inhibitor to investigate whether genotype-dependent inhibition of CYP2C9 occurs in vivo. (aspetjournals.org)
Analysis of fractional clearances suggested that the fraction metabolized by CYP2C9, as influenced by genotype, determined the degree of drug interaction observed. (aspetjournals.org)
in individuals of the CYP2C9 * 1/ * 1, * 1/ * 3 , and * 3/ * 3 genotypes to characterize the magnitude of the drug interaction in subjects with different CYP2C9 polymorphisms. (aspetjournals.org)
Several CYP2C9 gene polymorphisms decrease the activity of the CYP2C9 enzyme and slow the body's metabolism of warfarin. (medlineplus.gov)

The null genotype of GSTM1 increased the risk of cataract (OR=1.51, 95%CI: 1.01-2.26, p=0.045). (molvis.org)
Conclusions Increased bronchial responsiveness was associated with gas cooking among subjects with the GSTM1 null genotype. (bmj.com)

Aims The aim of this observational study was to report the distribution of glycoprotein B (gB) genotypes in the eyes of cytomegalovirus (CMV) positive patients with Posner-Schlossman syndrome (PSS), and to investigate their clinical characteristics and outcomes. (bmj.com)
Clinical characteristics and responses to antiviral treatment were compared among patients with different gB genotypes. (bmj.com)
Besides clinical factors of age, sex, smoking stage, histology, and grade, many genetic polymorphisms also were considered correlation with prognosis in cancer patients. (hindawi.com)
Our aim was to integrate our previously reported clinical-genetic prognostic score with new immunogenetic markers of 5-year disease-free survival (DFS) to evaluate the recurrence risk stratification before fluoropyrimidine (FL)-based adjuvant therapy. (frontiersin.org)
The integration of IFNG -rs1861494 in our previous clinical genetic multiparametric score of DFS improved the patients' risk stratification (Log-rank P = 0.0026 in the pooled population). (frontiersin.org)
The relationships between the Arterial and venous thrombosis, which clinical presentation and FVII levels and the clinically manifest as stroke, myocardial in- associated molecular genetic defects lack farction or pulmonary embolism are a ma- apparent consistency [ 7,10 ]. (who.int)
However, genetic polymorphisms in drug-metabolizing enzymes are not routinely evaluated for their impact on drug interactions during clinical studies. (aspetjournals.org)
Therefore, it is biologically reasonable that CYP19A1 rs1008805 (A/G) polymorphism may be associated with the clinical outcome of hormone therapy. (spandidos-publications.com)
The prevalence of clinical symptoms and genetic profile were obtained, and then the phenotypic comparison between Asians versus non-Asians and 129Met/Met versus 129Met/Val were conducted. (bmj.com)
A recent clinical study has focused on: 1- the interaction between genetic variants of glutathione S-transferases M1 and T1 (GSTM1 and GSTT1) and smoking on the risk of cardiovascular diseases, 2- the potential capacity of GSTM1 and T1 genotypes in modifying the effect of smoking on inflammation and endothelial function. (tu-dortmund.de)
PMID 15962707 ] The differential clinical and neurocognitive profiles of COMT SNP rs165599 genotypes in schizophrenia. (snpedia.com)
PMID 17363961 ] Clinical involvement of catechol-O-methyltransferase polymorphisms in schizophrenia spectrum disorders: influence on the severity of psychotic symptoms and on the response to neuroleptic treatment. (snpedia.com)
Clinical and genetic factors can increase the risk for hypogonadism, and providers should screen testicular cancer survivors for hypogonadism and treat those with symptoms," he said. (medscape.com)

To investigate whether genetic polymorphisms of glutathione S-transferases ( GSTM1 , GSTT1 , and GSTO2 ) in relation to the work place contribute to the development of cataract. (molvis.org)
The GSTM1 , GSTT1 , and GSTO2 genotypes were determined using polymerase chain reaction (PCR) based methods. (molvis.org)
This finding suggests that the polymorphisms of GSTM1 and GSTO2 and also work place may act additively for developing cataract. (molvis.org)
Methods The study was performed in subjects with forced expiratory volume in one second at least 70% of predicted who took part in the multicentre European Community Respiratory Health Survey, had bronchial responsiveness assessed by methacholine challenge and had been genotyped for GSTM1 , GSTT1 and GSTP1 -rs1695. (bmj.com)
White blood cell count (WBC), albumin, C-reactive protein (CRP), interleukine-6 (IL-6), tumor necrosis factor-alpha (TNF-a), L-selectin, E-selectin, P-selectin and intracellular adhesion molecule-1 (ICAM-1) were measured in 189 non-smokers and 76 smokers (aged 20-55 years) genotyped for the GSTM1 and T1 polymorphisms. (tu-dortmund.de)
Our study confirms previous results showing that GSTM1 polymorphism could modulate the interrelationships between smoking and biological markers of inflammation and endothelial function. (tu-dortmund.de)

The prevalence of GSTT1 and GSTO2 genotypes was similar between cases and controls. (molvis.org)
No effect modification by GSTT1 or GSTP1 -rs1695 genotypes was observed. (bmj.com)
No significant interaction was found between smoking and GSTT1 genotypes, considering the 9 biological indices. (tu-dortmund.de)

Because patient selection and dosage of siponimod are based on cytochrome P-450 (CYP) 2C9 genotype, pharmacogenetic testing is recommended prior to initiation of siponimod therapy. (drugs.com)

The proportion of APOE genotypes and alleles differ between populations of different ethnic groups and gender [1]. (j-alz.com)
The use of a polygenic model to assess the additive effect of low penetrance risk alleles identified combinations of risk genotypes that could be useful in predicting a predisposition to lung cancer. (scielo.br)

Genetic typing methods to differentiate strains of M. tuber- were found to have isolates matching this cluster. (cdc.gov)
Methods: In a well characterized prospective cohort of 398 genotype 1 infected patients treated with pegylated interferon-alpha and ribavirin for 24-72 weeks (INDIV-2 study) 25-OH-vitamin D levels and different single nucleotide polymorphisms were analyzed together with known biochemical parameters for a correlation with virologic treatment outcome. (uni-koeln.de)
We will talk also about the methods for SNP genotyping and the advantage and disadvantage of each one. (edu.sa)
Methods A worldwide large sample of FFI patients from our case series and literature review diagnosed by genetic testing were collected. (bmj.com)

Investigators seeking to study TOMM40 poly-T and AD associations would benefit from a reliable and practical genotyping assay. (biospace.com)
Genotype data was generated using the Illumina iSelect beadchip assay platform for wheat germplasm lines. (cgiar.org)

One European study , for example, reported that the prevalence of metabolic syndrome was higher among survivors of testicular cancer who were homozygous for a single-nucleotide polymorphism (SNP), rs523349 (V89L), in 5-α-reductase gene ( SRD5A2 ). (medscape.com)

Subjects with R/R genotype had significantly higher FVIIc levels than Q353 heterozygote and homozygote subjects (96.36 versus 59.52). (who.int)

We therefore studied the association of two polymorphisms - R353Q polymorphism at codon 353 involving the catalytic region and the 10 base pair (bp) insertion polymorphism involving the promoter region - with FVIIc levels in 176 healthy Tunisians. (who.int)
Nous avons donc étudié l'association de deux polymorphismes - R353Q au niveau du codon 353 intervenant sur la région catalytique et le polymorphisme d'insertion de 10 paires de bases (pb) impliquant la région du promoteur - avec les taux de FVIIc chez 176 Tunisiens en bonne santé. (who.int)

To investigate sequence variations in the optineurin (OPTN) gene and their association with TNF-alpha polymorphisms in Japanese patients with glaucoma. (nih.gov)
Our TOMM 40 poly-T polymorphism kit provides researchers with the ability to investigate this marker's utility in risk assessment and prediction of disease progression in AD. (biospace.com)
Objective To investigate associations of APOE and Tau gene polymorphisms with sports-related acute concussions and baseline to post-concussion neuropsychological test score changes. (bmj.com)

City were part of this cluster, a fact that was later verified ters for Disease Control and Prevention (CDC) facilitated a through genotyping of the patients' isolates. (cdc.gov)
In the past decade, there has been an increase in the number of lung cancer cases in young people, which suggests an important role for genetic background in the etiology of this disease. (scielo.br)
Genotyping for the CYP19A1 rs1008805 polymorphism was performed for 287 females with hormone receptor (HR)‑positive early breast cancer, and potential associations were evaluated between CYP19A1 rs1008805 genotypes and disease‑free survival (DFS). (spandidos-publications.com)

ABSTRACT Factor VII gene polymorphisms may contribute to elevations in factor VII coagulant (FVIIc) levels that have been associated with cardiovascular risk. (who.int)

Significant differences are present between COMT genotypes for oxygen saturation and ventilatory responses to hypoxia at rest. (frontiersin.org)
PMID 15956988 ] COMT polymorphisms and anxiety-related personality traits. (snpedia.com)
The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression. (snpedia.com)
PMID 17006672 ] Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia. (snpedia.com)
PMID 17427186 ] Association analysis of COMT polymorphisms and schizophrenia in a Chinese Han population: a case-control study. (snpedia.com)

Animals were genotyped using 60 K Illumina or 650 K Affymetrix single nucleotide polymorphism (SNP) panels. (usda.gov)
Genotyping-by-sequencing was used to obtain ~3.5M single nucleotide polymorphisms from each 32 individual. (nih.gov)
Individual cartridges can be designated for different experimental designs or different researchers, enabling multiple users to share a single SeqStudio Genetic Analyzer. (thermofisher.com)
In the present study, a comprehensive analysis of vitamin D levels before and during therapy together with single nucleotide polymorphisms involved in vitamin D metabolism in the context of other known treatment predictors has been performed. (uni-koeln.de)
Is the Subject Area "Single nucleotide polymorphisms" applicable to this article? (plos.org)
Blood-based single nucleotide polymorphism (SNP) analysis was performed. (cancerindex.org)
It has been hypothesized that single nucleotide polymorphisms in CYP19A1 gene may alter aromatase activity and circulating steroid hormone levels in females. (spandidos-publications.com)

interaction term between smoking and genotype being significant (p=0.05). (tu-dortmund.de)

By t-test, the mean baseline to post-concussion neuropsychological changes were statistically significantly greater for CRT and SRT in those with the TauSer 'TT' genotype and for CRT in those with the APOEProm 'TT' genotype, and borderline significantly greater in those with the TauSer 'TT' genotype (p=0.09). (bmj.com)
Conclusions The statistically significantly worse mean baseline to post-concussion neuropsychological test scores in those with the APOEProm and TauSer polymorphisms suggests a possible genetic influence on post-concussion neurocognitive recovery. (bmj.com)
There was no correlation between SVR patients' genotypes and early response to therapy or HCV baseline viral load. (who.int)

There were no statistically significant differences in frequencies of acute concussions according to genotypes by χ 2 test. (bmj.com)
Based on the analysis of the whole cohort, no significant differences were observed between rs1008805 genotypes and DFS. (spandidos-publications.com)
Studies focused on similarities and differences in athletic performance within families, including between twins, suggest that genetic factors underlie 30 to 80 percent of the differences among individuals in traits related to athletic performance. (medlineplus.gov)

Maryland collection of either epidemiologic or molecular genotyping data. (cdc.gov)
The third objective was to determine the genetic diversity in Pakistan wheat germplasms using molecular markers. (usda.gov)

Future research would benefit from understanding the relationship between APOE genotype and how we could use micronutrients to accumulate in brain to help relive oxidative stress. (j-alz.com)
Assessment of Risk Factors APOE , APOE G-219T promoter (APOEProm), Tau exon 6 Ser53Pro (TauSer), and Tau exon 6 Hist47Tyr (TauHis) genetic polymorphisms. (bmj.com)
These preliminary findings provide no evidence for associations of the four APOE and Tau gene polymorphisms investigated with acute concussions, although the small sample size and lack of control for confounders are limitations. (bmj.com)

In conclusion, this study adds information on genetic factors involved in individual vulnerability to acute hypoxia and supports the critical role of the ≪ O 2 sensor ≫ - heme oxygenase-2 - in the chemosensitivity of carotid bodies in Humans. (frontiersin.org)

Conclusions: While 25-OH-vitamin D-levels levels show considerable variations during the long-lasting course of antiviral therapy they do not show any significant association to treatment outcome in genotype 1 infected patients. (uni-koeln.de)
Phenotypic variations in genotypes and geographic regions were documented. (bmj.com)
AIM: This study aims to explore genetic variations in DRD2 gene and waterpipe smoking, motives and addiction in Egyptian rural males. (who.int)
Research has also been limited, Dr Zaid noted, as far as taking into account genetic variations when evaluating the relationship between hypogonadism and adverse health outcomes. (medscape.com)

and having certain host genetic polymorphisms, most notably those near the IL28B gene ( 6 , 7 ). (cdc.gov)
Pharmacogenetic studies have been also performed in order to evaluate the role of host genetic variants in the prediction of recurrence risk and response to adjuvant treatment with FLs and OXA. (frontiersin.org)
The host genetic factors are assumed to play a critical role in tuberculosis pathogenesis, through impact on the gene expression of cytokines and chemokines, which are implicated in the host immune response. (cdc.gov)

We divide the field of genomics into genotyping (focused on the genome sequence), transcriptomics (focused on genomic expression) and epigenomics (focused on epigenetic regulation of genome expression). (bmj.com)
Post-PCR genomic DNA sequencing revealed MTHFR C677T and MTHFR A1298C genotypes and TS polymorphisms. (medscimonit.com)

Our objective was to estimate genetic parameters and identify quantitative trait loci (QTL) for absolute T3 and/or T4 levels of piglets and fetuses challenged with Porcine reproductive and respiratory syndrome virus. (usda.gov)
The purpose of this study was to identify 30 genetic loci underlying elevated IOP using HS rats. (nih.gov)
Is the Subject Area "Genetic loci" applicable to this article? (plos.org)
Finally, these loci will allow rapid genotyping for improved resolution of bull trout population structure, sex ratios, movement patterns, and introgressive hybridization with non-native brook trout for a wide range of management questions. (usgs.gov)

Individual drug metabolism rates are influenced by genetic factors, coexisting disorders (particularly chronic liver disorders and advanced heart failure), and drug interactions (especially those involving induction or inhibition of metabolism). (msdmanuals.com)

Studies of relevant literature (MedLine search) in addition to our own experiences, show that CYP genotyping can predict the phenotype and thereby explain some abnormal drug responses and may be used to individualise pharmacotherapy. (tidsskriftet.no)
Referenced article focusing on the relationship between phenotype and genotype. (cancerindex.org)
The enormous variants and mutations found mean that we are still far from being able to concretely clarify a genotype-phenotype relationship. (bvsalud.org)

To study the relationship between the ACE insertion/deletion (I/D) polymorphism, blood pressure and risk of hypertension in current, former and non-smokers in a population-based cohort. (nih.gov)
The resistant genotypes identified in this study should be useful in developing new wheat cultivars with stripe rust resistance. (usda.gov)
This study was based on DNA fingerprinting using resistance gene analog polymorphism (RGAP) marker analysis. (usda.gov)
In this study, we focus on evaluating association between DNA repair polymorphisms of EXO1, RPA1, and prognosis in lung cancer patients whom received platinum-based chemotherapy. (hindawi.com)
A total of 189 healthy subjects were enrolled in the genotype screening phase of the study. (aspetjournals.org)
If confirmed by further study, genotyping for CYP19A1 rs1008805 polymorphism may provide predictive information to improve the selection of endocrine treatment. (spandidos-publications.com)
In this study, we investigated whether carriage of these 2 polymorphisms altered the smoking impact on biological indices of inflammation and cellular adhesion. (tu-dortmund.de)
The aim of this study was to determine the possible genetic regulation of plasma pro-NT. (lu.se)
That study also found the prevalence of metabolic syndrome to be 67% in survivors with low testosterone levels who carried the variant genotype. (medscape.com)
SHBG polymorphisms appear important in survivors of testicular cancer, but the study was underpowered to confirm an association, Dr Zaid commented. (medscape.com)

Upon cal difficulty will facilitate TB control in this era of increased a review of the National Tuberculosis Genotyping and Surveil- mobility among difficult-to-reach populations. (cdc.gov)

0.3 in the univariate analysis were included in the analysis for investigating the additive effects of the genotypes and work place on risk of cataract. (molvis.org)
The percentage of polymorphism range for RAPD is from 89 to 45% while for ISSR is from 88 to 100%, the UPGMA dendogram obtained from the cluster analysis of RAPD and ISSR data gave similar clustering pattern, with Jaccards similarity coefficient ranging from 0.23 to 0.93. (academicjournals.org)
A col- laborative investigation among federal, state, and local TB controllers included TB record reviews, inter- views of patients, and restriction fragment length polymorphism (RFLP) analysis of selected M. tuberculosis isolates from diagnosed TB patients in several cities in 1996-2001. (cdc.gov)
Owing to the quantity requirement for CMV gB genotype analysis, results could be obtained from only 14 specimens. (bmj.com)
Cox regression analysis was used to assess overall survival (OS) and progression-free survival (PFS) among SNP genotypes. (hindawi.com)
The Applied Biosystems SeqStudio Genetic Analyzer is a low-throughput, easy-to-use, and convenient benchtop system that delivers gold-standard Sanger sequencing technology and fragment analysis by capillary electrophoresis with a simple click. (thermofisher.com)
Like the SeqStudio instrument, our SeqStudio Flex Genetic Analyzer is an easy-to-use, flexible system for Sanger sequencing and fragment analysis, but with higher throughput. (thermofisher.com)
The SeqStudio Genetic Analyzer is designed for both new and experienced users who need simple and affordable Sanger sequencing and fragment analysis, without compromising performance or quality. (thermofisher.com)
The SeqStudio Genetic Analyzer uses an innovative all-in-one cartridge that includes the capillary array, anode buffer, and a reservoir containing polymer for both sequencing and fragment analysis applications. (thermofisher.com)
The DHCR7-TT-polymorphism within the 7-dehydrocholesterol-reductase showed a significant association (P = 0.031) to sustained viral response in univariate analysis. (uni-koeln.de)
Hi R users, Does any one know a R package for genetic analysis of VNTR (variable number of tandem repeats) genotype data? (ethz.ch)
Workshop : Genetic Association Studies: From SNP design to analysis and interpretation. (edu.sa)
Effect modification by genotype on the association between the use of gas for cooking and bronchial responsiveness was assessed within each participating country, and estimates combined using meta-analysis. (bmj.com)
Genetic diversity of Leptospira isolates in Lao PDR and genome analysis of an outbreak strain. (cdc.gov)
6 eligible studies, totaling 1301 cases and 1217 controls on G2258A genotypes, and 8 studies, totaling 2175 cases and 2069 controls on T597C genotypes, were included in the analysis. (cdc.gov)

For example, performing Hardy Weinberg equilibrium test, calculating heterozygosity and polymorphism information content etc. (ethz.ch)

Phenotypic and genetic correlations of piglet_T3 levels with weight gain (0-42 DPI) were 0.26 ± 0.03 and 0.67 ± 0.14, respectively. (usda.gov)

To understand genetic relationships among these cultivars, Jaccard's similarity coefficient and UPGMA clustering algorithm were applied to the two marker data sets. (academicjournals.org)

but these polymorphisms resulted in expression of inactive proteins that should not be subject to inhibition. (aspetjournals.org)

the use of issr and rapd markers for detecting dna polymorphism, genotype identification and genetic diversity among trichosanthes dioica roxb. (academicjournals.org)
A number of markers are now available to detect nuclear DNA polymorphisms. (intechopen.com)
In genetic diversity studies, the most frequently used markers are microsatellites. (intechopen.com)
She took up a postdoctoral research position at the Brain Dynamics Centre based within the Westmead Millennium Institute, with a focus on the genetic and brain markers of risk for mental health. (edu.au)
We developed new bull trout genetic markers using Restriction-site Associated DNA sequencing (RAD-seq) to improve our ability to address questions important for their conservation and management. (usgs.gov)
GNP-5285 ] - Insert Walnut genetic resources, phenotyping, SSR markers data from BRC (ODS). (inra.fr)

The associations between the genotypes and age, intraocular pressure (IOP), and visual field defects at the time of diagnosis were examined. (nih.gov)
Elevated intraocular pressure (IOP) is influenced by environmental and genetic factors. (nih.gov)

Generally, genetic and epigenetic data might be used as endpoints in hazard identification, as indicators of exposure, as effect modifiers in exposure assessment and dose-response modeling, as descriptors ofmode of action, and to characterize toxicity pathways. (cdc.gov)

The impor- objectives of determining the frequencies tance of FVII in normal haemostasis is il- of these gene polymorphisms in the popula- lustrated by the severe bleeding diathesis tion and clarifying the genotype association associated with low plasma levels of the of the R353Q and 0/10 bp insertion poly- protein [ 3 ]. (who.int)
PMID 16525418 ] Association of the Val158Met catechol O-methyltransferase genetic polymorphism with panic disorder. (snpedia.com)

The SeqStudio Genetic Analyzer offers data quality, usability, service, and support at an affordable price. (thermofisher.com)
Although genetic and epigenetic data have not been widely used in risk assessment and ultimately, standard setting, it is possible to envision such uses. (cdc.gov)
The framework is a 4×4 matrix involving the risk assessment functions (hazard identification, dose-response modeling, exposure assessment, and risk characterization) on one axis and inherited and acquired genetic and epigenetic data on the other axis. (cdc.gov)
The cells in the matrix identify how genetic and epigenetic data can be used for each risk assessment function. (cdc.gov)
Vast amounts of genetic and epigenetic data may be generated by high-throughput technologies. (cdc.gov)
Results There were a total of 131 athletes with incident concussions and genetic data and neuropsychological test scores. (bmj.com)

Conclusion Genotype 1 was the most prevalent genotype in the aqueous humour of CMV-infected patients with PSS. (bmj.com)

Certain VKORC1 gene polymorphisms decrease the amount of functional VKORC1 enzyme available to help activate clotting proteins. (medlineplus.gov)

The identified variant differently distributed in the two pro-NT subgroups was genotyped in a cohort of nine hundred and thirty-two overweight/obese children and adolescents. (lu.se)

BayesR3 samples the polymorphisms affecting complex traits at reduced computational cost to predict the genetic value, breeding value, or individual risk of genotypes. (nature.com)

In each group, we assessed the relationship between the ACE I/D polymorphism, systolic (SBP) and diastolic (DBP) blood pressures and risk of hypertension. (nih.gov)
In non-smokers and former smokers, blood pressure and the risk of hypertension did not differ significantly between genotypes. (nih.gov)

However, the genetic control of T3 and T4 levels during infection is not completely understood. (usda.gov)

To this end, genetic and functional studies raise the possibility that a poly-T length polymorphism in the TOMM40 gene may influence AD risk. (biospace.com)
PMID 17482701 ] No associations exist between five functional polymorphisms in the catechol-O-methyltransferase gene and schizophrenia in a Japanese population. (snpedia.com)

Considerations for using genetic and epigenetic information in occupational health risk assessment and standard setting. (cdc.gov)
This presentation addresses the considerations for using genetic and epigenetic information in risk assessments, provides guidance on using this information within the classic risk assessment paradigm, and describes a framework to organize thinking about such uses. (cdc.gov)
Prion protein gene 129 Met was considered to be a risk factor for FFI in the non-Asian population, and 129 polymorphisms could modify survival duration. (bmj.com)
Aside from the genetic profile, the authors identified other risk factors for developing hypogonadism. (medscape.com)

Organisms2

Diseases8

Chemicals and Drugs37

Analytical, Diagnostic and Therapeutic Techniques and Equipment35

Psychiatry and Psychology1

Phenomena and Processes53

Disciplines and Occupations4

Anthropology, Education, Sociology and Social Phenomena1

Information Science6

Named Groups3

Health Care17

Geographicals12

SNPs13

Allele12

Susceptibility9

Genes11

Hepatitis c virus genoty1

Variation12

CYP2C911

Null genotype2

Clinical13

GSTM16

GSTT13

Cytochrome P-41

Alleles2

Methods4

Assay2

Homozygous1

Heterozygote1

Codon2

Investigate3

Disease3

Abstract1

COMT5

Single7

0.051

Baseline3

Differences3

Molecular2

APOE3

Acute1

Variations4

Host genetic3

Genomic2

Loci4

Metabolism1

Phenotype3

Study10

Populations1

Analysis15

Heterozygosity1

Phenotypic1

Cultivars1

Inhibition1

Markers6

Intraocular2

Characterize1

Association2

Data6

Prevalent1

Proteins1

Cohort1

Traits1

Hypertension2

Infection1

Functional2

Risk4