Genotype or hla. Medical search. Frequent questions

Detect donor-specific HLA antibodies against Class I and/or Class II antigens. (immucor.com)
The impact of different HLA genotypes, AB0 blood group antigens, and the CCR5 mutant CD195 were investigated for their role in the clinical course of COVID-19. (biomedcentral.com)
Variant genotypes associated with reduced expression of RhCE antigens among Brazilian blood donors. (nih.gov)

This region is the most polymorphic region within the human genome, and as such, genotyping alleles in this region is problematic. (wits.ac.za)
HLA alleles were imputed from genome-wide genotype data for 1326 patients for whom 90% reduction in Psoriasis Area and Severity Index score (PASI90) response status was observed after 3, 6, or 12 months of treatment. (manchester.ac.uk)
We genotyped KIRs and HLA class I alleles using DNA from uninfected controls, EVD survivors, and persons who died of EVD. (cdc.gov)
Univariate HLA analyses identified putatively protective HLA alleles (HLA class II DRB1*01:01 and HLA class I B*35:01, with a trend for DRB1*03:01). (biomedcentral.com)
Conversely, analyses also identified HLA alleles (HLA class II DQB1*03:02 und HLA class I B*15:01) not associated with such benefit in the patient cohort of this study. (biomedcentral.com)
Hierarchical testing by Cox regression analyses confirmed the significance of the protective effect of the HLA alleles identified (when assessed in composite) in terms of disease duration, whereas AB0 blood group antigen heterozygosity was found to be significantly associated with disease severity (rather than duration) in our cohort. (biomedcentral.com)
Genetic susceptibility to CBD is associated with alleles of the major histocompatibility gene, human leukocyte antigen DP (HLA-DP) containing glutamic acid at the 69th position of the beta chain (HLA-DPbeta-E69). (cdc.gov)
How someone's immune system functions is largely determined by three genes HLA-A, HLA-B and HLA-C. Of these three genes there are thousands of different variations known as alleles, and with there being two alleles of each gene in each person genomes the 'HLA type' of any two non-related people is likely to be different. (ukbiobank.ac.uk)
The results support an association of certain HLA class Ib alleles with allo-immunization during pregnancy. (frontiersin.org)
Researchers have identified hundreds of different versions (alleles) of the HLA-DPB1 gene, each of which is given a particular number (such as HLA-DPB1*03:01 ). (medlineplus.gov)
Genotyping of HLA-I and HLA-II alleles in Chinese patients with paraneoplastic pemphigus. (medscape.com)

Fully phased allele-level sequencing of highly polymorphic HLA genes is greatly facilitated by SMRT Sequencing technology. (pacb.com)
Specifically MHC class I genes HLA-A, -B, and -C were indexed via DNA Barcodes by either tailed primers or barcoded SMRTbell adapters. (pacb.com)
Eight symmetric barcoded primers were generated for HLA class I genes. (pacb.com)
These genes are called HLA (human leukocyte antigen) class II genotypes. (cdc.gov)
Genotyping was performed using an ABI PRISM 7900HT instrument and HLA-SE genes were identified using PCR sequence-specific primers. (nih.gov)
We hypothesise that there may be some combinations of these HLA genes that are more able to recognise and kill cancer types leading to a lower incidence of cancer in this population. (ukbiobank.ac.uk)
Asthma studies have found a relationship between developing the disease and the following genes: cytokine genes, cytokine receptor genes, HLA genes and CD14 gene. (news-medical.net)
Also, the range of candidate genes linked to a certain phenotype, that is the observable characteristics resulting from the interaction of its genotype with the environment, is rather small if you compare it to the total number of genomes. (news-medical.net)
The HLA-DPB1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. (medlineplus.gov)
The HLA-DPB1 gene belongs to a group of MHC genes called MHC class II. (medlineplus.gov)

The accuracy of the tools were compared to Sanger sequenced HLA data, where exons 2 and 3 were sequenced for HLA class I. As exons 2 and 3 were available as a reference from the Sanger sequencing, an accurate allele call was determined on its similarity to the reference data. (wits.ac.za)

Identify KIR genotypes with an easy-to-use assay. (immucor.com)
Genotyping Assay (Innogenetics) testing on negative or inadequate specimens. (cdc.gov)
Detection of Circulating HPV16 DNA as a Biomarker for Cervical Cancer by a Bead-Based HPV Genotyping Assay. (who.int)

Classical human leucocyte antigen (HLA) variants at 2-digit and 4-digit resolution were obtained via imputation from single marker genotypes. (edu.au)
Serious skin reactions such as Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) due to carbamazepine therapy are more common in people with a particular human leukocyte antigen gene-variant (allele), HLA-B*1502. (wikipedia.org)
It is suggested that carbamazepine acts as a potent antigen that binds to the antigen-presenting area of HLA-B*1502 alike, triggering an everlasting activation signal on immature CD8-T cells, thus resulting in widespread cytotoxic reactions like SJS/TEN. (wikipedia.org)
Interaction of killer immunoglobulin-like receptors (KIRs) and human leukocyte antigen class-I (HLA-I) regulates NK cytotoxicity and function. (atcmeetingabstracts.com)
We studied the relationship between KIR-human leukocyte antigen (HLA) combinations and the clinical outcomes of patients with Ebola virus disease (EVD). (cdc.gov)
A recent focused literature review from College of Pharmacy Assistance Professor Jason Karnes, PharmD, PhD, BCPS, FAHA , has provided updates to the 2014 Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for cytochrome P450 2C9 (CYP2C9) and/or human leukocyte antigen B (HLA-B) Genotypes and Phenytoin Dosing. (arizona.edu)
The goal of the current study was to assess the association of COVID-19 clinical courses controlled by patients' adaptive immune responses without progression to severe disease with patients' Human Leukocyte Antigen (HLA) genetics, AB0 blood group antigens, and the presence or absence of near-loss-of-function delta 32 deletion mutant of the C-C chemokine receptor type 5 (CCR5). (biomedcentral.com)
The analysis of genetic factors other than CFTR may help our understanding of genotype-phenotype relationships in CF. As human leukocyte antigen (HLA) class II polymorphism has been associated with a number of diseases including autoimmune and inflammatory diseases, asthma, and allergy, we investigated the possibility that HLA polymorphism contributes to CF-associated pulmonary inflammation. (nih.gov)
During pregnancy the formation of alloreactive anti-human leukocyte antigen (HLA) antibodies are a major cause of acute rejection in organ transplantation and of adverse effects in blood transfusion. (frontiersin.org)
Alloreactive anti-human leukocyte antigen (HLA) antibodies formed during pregnancy are a major cause of acute rejection in organ transplantation and of adverse effects in blood transfusion, such as febrile non-hemolytic transfusion reactions, immunological platelet refractoriness or transfusion-related acute lung injury (TRALI) ( 1 , 2 ). (frontiersin.org)
Surprisingly, we find that shared antigen exposure to CMV leads to fewer shared TCRβ clones, even after controlling for HLA, indicative of a largely private response to major viral antigenic exposure. (biorxiv.org)
As the MHC is encoded by highly polymorphic human leukocyte antigen (HLA) loci in humans, this process of thymic selection occurs within the context of an individual's HLA type. (biorxiv.org)
As a result, VDJ recombination, HLA restriction, and antigen exposure collectively contribute to a largely private TCRβ repertoire. (biorxiv.org)

Prospective studies in larger patient populations also including novel SARS-CoV-2 variants will be required to assess the impact of HLA genetics on the capacity of mounting protective vaccination responses in the future. (biomedcentral.com)

OBJECTIVE: We sought to test whether HLA-C*06:02, the primary genetic susceptibility allele for psoriasis, predisposes patients to respond differently to the 2 most commonly prescribed biologics for psoriasis: adalimumab (anti-TNF-α) and ustekinumab (anti-IL-12/23). (manchester.ac.uk)
In 99 living donor liver transplant patients including 8 patients with biopsy-proven EAR, KIR genotypes in recipients and HLA-C genotypes in recipients and donors were tested by sequence-specific oligonucleotide probes (SSOP) methods. (atcmeetingabstracts.com)
This study shows a KIR/HLA-C genotype status in Korean LT patients. (atcmeetingabstracts.com)
Detect C3d-binding donor specific anti-HLA antibodies (DSAs) for better risk stratification of patients. (immucor.com)
The risk for abacavir HSR to occur is high for patients who test positive for the HLA-B*5701 allele. (who.int)
HA371 trade name] should never be initiated in patients with a positive HLA-B*5701 status, nor in patients with a negative HLA-B*5701 status who had a suspected abacavir HSR on a previous abacavir containing regimen. (who.int)
The patient population enrolled in the FOCUS Study included patients with hepatic and extra-hepatic lesions subject to a treatment plan, as well as both treatment naïve (56.0%) and previously treated (44.0%) patients, irrespective of HLA genotype. (biospace.com)
More than 90% of patients with AS have the HLA-B27 genotype. (eisai.com)
[ 3 ] There is an association between paraneoplastic pemphigus and HLA class II DRB I*03 and HLA-Cw*14 (in Chinese patients). (medscape.com)
RÉSUMÉ L'objectif de cette étude menée en Tunisie était de classifier le diabète débutant par une cétose chez des patients adultes. (who.int)

Therefore, in conclusion, future improvements include varying the parameters when genotyping diﬀerent loci. (wits.ac.za)

We analysed relationships between the PTPN22 1858 polymorphism and antibodies to cyclic citrullinated peptide (CCP), rheumatoid factors (RFs) and the shared epitope (SE) gene (HLA-DRB1*0404 or 0401) and determined their combined predictive value for rheumatoid arthritis (RA) in individuals who subsequently developed RA. (nih.gov)
LIFECODES offers the complete antibody product portfolio for the transplant laboratory, including kits designed to detect and identify non-HLA antibodies in serum. (immucor.com)
Maternal blood serum was screened for HLA class I and II antibodies, identification of Donor Specific Antibody (DSA), activation of complement measured by C1q and IgG4 concentrations. (frontiersin.org)
Mothers were genotyped for HLA class Ib ( HLA-E, -F and -G ). Anti-HLA class I and II antibodies were identified in 24% of the women. (frontiersin.org)
The discrepancy between studies may be due to screening differences, both in method sensitivity and the sampling time after delivery, as HLA antibodies may persist or become gradually undetectable over time ( 1 - 5 ). (frontiersin.org)
The level of anti-HLA antibodies increases with the number of pregnancies and the number of children delivered ( 1 - 5 ). (frontiersin.org)
Expand your knowledge of HLA antibodies and molecular typing. (thermofisher.com)

Protective effect of HLA-B57 on HCV genotype 2 infection in a West African population. (ox.ac.uk)
20%) in western populations but reaches 50% in West Africa where genotype 2 infection is predominant. (ox.ac.uk)
Eighty-one percentage of subjects with chronic infection (RNA positive) carried genotype 2 HCV. (ox.ac.uk)
HLA-B*57 was significantly more frequent in the group which had recovered from HCV infection compared with chronically infected subjects (P = 0.0053, OR = 8.02). (ox.ac.uk)
In untreated HIV infection, associations between HLA genetic polymorphism and disease progression were identified in several studies, using both candidate gene (reviewed in Carrington and O'Brien, 2003 ), and genome-wide strategies ( The International HIV Controllers Study, 2010 ). (frontiersin.org)

The maternal HLA-E*01:06 allele was significantly associated with a higher fraction of anti-HLA I immunization (20.0% vs. 4.8%, p = 0.048). (frontiersin.org)

RESULTS: Forty-two markers gave rise to genome-wide significant association signals, all contained within the HLA region on chromosome 6 (best p=4.2×10(-10) for SNP rs4143332). (edu.au)

To examine sex differences in children with newly diagnosed type 1 diabetes (T1D) with respect to age at diagnosis, presence of autoantibodies (GADA, IA-2A, IAA, and ZnT8A), and HLA risk. (figshare.com)

132.03) for developing RA than the combination of the T variant and HLA-SE (OR = 7.85). (nih.gov)
Furthermore, the variant allele HLA-B*15:02 is associated with an increased risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in response to phenytoin treatment. (arizona.edu)
This technique examines the association between the genotype of a common variant and the disease susceptibility across the entire genome. (news-medical.net)
At least one variant of the HLA-DPB1 gene has been associated with granulomatosis with polyangiitis (GPA). (medlineplus.gov)
However, it is unclear what specific role the HLA-DPB1 gene variant plays in development of this condition. (medlineplus.gov)

Knowing a patient's HLA type is important for many new types of cancer treatment including immunotherapy. (ukbiobank.ac.uk)
When a health care provider is considering prescribing a drug, knowledge of a patient's genotype may be used to aid in determining a therapeutic strategy, determining an appropriate dosage, or assessing the likelihood of benefit or toxicity. (fda.gov)

Immunochip and targeted single nucleotide polymorphism (SNP) genotype data were produced, respectively, for discovery and replication purposes. (edu.au)
HLA class II polymorphism in cystic fibrosis. (nih.gov)

In addition, clinical studies, if available, may only have linked genetic variation to a drug's pharmacokinetics (such as the way in which the drug is metabolized), and differences in drug efficacy or safety across different genotype subgroups may not be known. (fda.gov)

Both HLA‑G and HLA - F*01:03:01 showed significantly higher levels of IgG4 compared with the other haplotypes. (frontiersin.org)

Consensus sequences generated were typed using GenDx NGS engine HLA-typing software. (pacb.com)
Report high-quality Next Generation Sequencing (NGS) HLA Typing results, with an optimized workflow, in less time than ever before using the MIA FORA NGS MFlex HLA Typing Kit. (immucor.com)
Perform HLA SSO typing with a ready-to-use kit and rapid protocol. (immucor.com)
HLA Typing h. (aarkstore.com)

By using a large dataset such as the UK biobank and grouping similar HLA types together we hope to overcome this and if a person's HLA type can be shown to be predictive of cancer risk it will provide a very useful tool enabling increased monitoring of high risk populations. (ukbiobank.ac.uk)

We used logistic regression analysis and Bayesian modeling to identify 2DL2 , 2DL5 , 2DS4-003 , HLA-B-Bw4-Thr , and HLA-B-Bw4-Ile as probably having a significant relationship with disease outcome. (cdc.gov)

HLA class I homozgosity and loss of heterozygosity are associated with poor response to checkpoint blockade therapy. (nature.com)
The current study shows that the presence of HLA class II DRB1*01:01 and HLA class I B*35:01 is of even stronger association with reduced disease duration in mild and moderate COVID-19 than age or any other potential risk factor assessed. (biomedcentral.com)
The purpose of the study was to identify maternal HLA class Ib genetic factors associated with anti-HLA allo-immunization in pregnancy and the degree of tolerance estimated by IgG4 expression. (frontiersin.org)
The current study is in line with this important scientific theme by investigating a role of maternal HLA class Ib polymorphisms in pregnancy allo-immunization. (frontiersin.org)
Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy. (standuptocancer.org)
The protein produced from the HLA-DPB1 gene attaches (binds) to the protein produced from another MHC class II gene, HLA-DPA1 . (medlineplus.gov)

HCV antibody was confirmed by Western blot using genotype 2 recombinant core, E2 and NS3 proteins. (ox.ac.uk)
The new, enhanced LSA Assays deliver increased coverage, optimized performance, and improve the overall workflow of the LIFECODES® HLA Antibody Analysis portfolio. (immucor.com)

The HLA complex is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. (medlineplus.gov)

SNPs and HLA variants passing quality control filters were tested for association with CC with logistic regression adjusting for age, sex and country of origin. (edu.au)
Variants of the HLA-DPB1 gene are associated with immune reactions to beryllium, a metallic element that can be toxic. (medlineplus.gov)
Having variants of the HLA-DPB1 gene that contain the protein building block (amino acid) glutamic acid at position 69 (written as E69) increases the risk of developing beryllium sensitization or chronic beryllium disease. (medlineplus.gov)

CONCLUSIONS: HLA genotype associates with CC, thus implicating HLA-related immune mechanisms in its pathogenesis. (edu.au)

Results Age, Bath ankylosing spondylitis functional index (BASFI) score, enthesitis, therapy, C-reactive protein (CRP) and HLA-B27 genotype were identified as predictors. (bmj.com)
The HLA-DPB1 gene provides instructions for making a protein that plays a critical role in the immune system. (medlineplus.gov)

For immunization/vaccination trials or to aid the clinical diagnosis of diseases strongly associated with the HLA-DR locus. (aruplab.com)
May be useful in immunization/vaccination trials or may aid in the clinical diagnosis of diseases strongly associated with the HLA-DP locus. (aruplab.com)
We developed regression models of PASI90 response, examining the interaction between HLA-C*06:02 and drug type (adalimumab or ustekinumab) while accounting for potentially confounding clinical variables. (manchester.ac.uk)
CONCLUSION: This large observational study suggests that reference to HLA-C*06:02 status could offer substantial clinical benefit when selecting treatments for severe psoriasis. (manchester.ac.uk)
But, the clinical impact of KIR/HLA-C ligand combination between recipient and donor on early acute rejection (EAR) is unclear and a controversial topic in liver transplantation (LT). (atcmeetingabstracts.com)
Learn the latest HLA technical and clinical advancements in transplant diagnostics. (thermofisher.com)

Polymyositis (PM) and dermatomyositis (DM) can be genetically discriminated by HLA-DRB1 genotyping. (ox.ac.uk)

The KIR genotypes, HLA-C mismatch (MM) and KIR/HLA-C combination were analyzed in association with EAR and MELDscore (Model for End-Stage Liver Disease). (atcmeetingabstracts.com)
It is not well known however how exactly a person's HLA type determines the general course and evolution of cancer as a disease. (ukbiobank.ac.uk)

This series of six virtual workshops trains users on how to use LABType assays, TypeStream Visual software, LABScreen assays, AllType NGS assays, AllType FASTplex assays, and HLA Matchmaker software. (thermofisher.com)

Evaluation of multiplexing strategies for HLA genotyping using PacBio Sequencing technology. (pacb.com)
Eight DNA barcoded adapters in symmetric pairing were independently ligated to a pool of HLA-A, -B and -C for eight different individuals, one at a time and pooled for sequencing on a single SMRT Cell. (pacb.com)

HLA-A, -B and -DR types were determined by DNA methodology. (ox.ac.uk)

Results from HLA-wide analyses were consistent with HLA-C*06:02 itself being the primary effect allele. (manchester.ac.uk)

NK regulation influences on NK/T cell alloreactivity in transplantation, and HLA mismatch allows the prediction of transplant rejection. (atcmeetingabstracts.com)
Park K, Ryu J, Park H, Kim Y, Oh E-J. HLA-C, KIR Genotypes and KIR Genotype/HLA C Ligand Combination in Prediction of Early Acute Rejection After Liver Transplantation [abstract]. (atcmeetingabstracts.com)

HLA-B*5701 status must always be documented prior to initiating therapy. (who.int)

It was also noted that, with the exception of HISAT-Genotype, each tool was most accurate at HLA-B, and least accurate at HLA-C. From evaluating HLA population-speciﬁc variability, it was found that the four super-populations tested African, Asian, European and South American, did not signiﬁcantly vary, in regards to HLA variability. (wits.ac.za)
HLA-B*1502 occurs almost exclusively in people with ancestry across broad areas of Asia, but has a very low or absent frequency in European, Japanese, Korean and African populations. (wikipedia.org)

In conclusion, it is hypothesized that the dominance of genotype 2 HCV strains may be an important factor explaining the high rate of recovery from HCV infections in Ghana via an efficient contribution of HLA-B*57 which is relatively frequent in the population. (ox.ac.uk)

We found no evidence for genetic interaction between HLA-C*06:02 and ERAP1. (manchester.ac.uk)

However, we detect a significant correlation between increased HLA allele sharing and increased number of shared TCRβ clones, with each additional shared HLA allele contributing to an increase in ∼0.01% of the total TCRβ clones being shared, supporting a key role for HLA type in shaping the immune repertoire. (biorxiv.org)

As specialized HLA genotyping tools have been developed which utilize NGS data, the aim of this study was to compare four HLA genotyping tools, namely - BWAkit, xHLA, Kourami and HISAT-Genotype, and to evaluate whether population-speciﬁc HLA variability would aﬀect their accuracy. (wits.ac.za)

Small sex differences in HLA risk were found in children under 9 years of age. (figshare.com)
No significant difference of these allelic distributions was found according to the CFTR genotype. (nih.gov)

We have hands-on workshops geared to beginner and advanced HLA technicians who want to learn how to troubleshoot and analyze data results. (thermofisher.com)

Further studies with long term follow-up will be needed to demonstrate the role of KIR/HLA status in LT. (atcmeetingabstracts.com)
Studies of this kind have illustrated the role of HLA gene in allergies. (news-medical.net)

Anatomy7

Organisms12

Diseases16

Chemicals and Drugs79

Analytical, Diagnostic and Therapeutic Techniques and Equipment50

Psychiatry and Psychology3

Phenomena and Processes65

Disciplines and Occupations5

Anthropology, Education, Sociology and Social Phenomena3

Technology, Industry, Agriculture1

Information Science7

Named Groups8

Health Care29

Geographicals15

Antigens3

Alleles11

Genes10

Sequenced for HLA class1

Assay3

Antigen13

Genetics1

Patients10

Loci1

Antibodies7

Infection5

Allele was significantly associated1

Genome-wide1

Autoantibodies1

Variant5

Patient's2

Polymorphism2

Genetic Variation1

Haplotypes1

Typing4

Predictive1

2DL21

Class6

Antibody2

Human1

Variants3

CONCLUSIONS1

Protein2

Clinical6

DRB11

Disease2

Assays1

Sequencing2

Methodology1

Analyses1

Transplantation2

Therapy1

Populations2

Conclusion1

Interaction1

TYPE1

Study1

Found2

Results1

Role2