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  • induce
  • Previously, through analysis of the E6 proteins of HR-HPVs, we identified the Notch1 gene as a novel p53 target and showed that genotoxic stress activates the p53-Notch1 pathway to induce differentiation of normal human keratinocytes ( 38 ). (aacrjournals.org)
  • Thus
  • Thus, in addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, IL-1α could directly sense DNA damage and act as signal for genotoxic stress without loss of cell integrity. (uni-konstanz.de)
  • show
  • Conclusions: Here we show that MYSM1 deficiency is associated with developmental aberrations, progressive BMF with myelodysplastic features, and increased susceptibility to genotoxic stress. (uni-muenchen.de)