In this study, metabolically active human HepaRG hepatocarcinoma cells were exposed to five food-relevant genotoxic carcinogens. (nih.gov)
Specificity of the transcript signature was confirmed by using non-genotoxic carcinogens as comparators. (nih.gov)
In conclusion, we have established a characteristic transcript marker pattern to monitor genotoxicity in human HepaRG cells, and to distinguish genotoxic from non-genotoxic carcinogens. (nih.gov)
A novel, integrated in vitro carcinogenicity test to identify genotoxic and non-genotoxic carcinogens using human lymphoblastoid cells. (swansea.ac.uk)
Carcinogens can be classified according to their mode of action into genotoxic and non-genotoxic. (gov.hk)
Genotoxic carcinogens induce cancers via a mechanism involving direct damage to DNA. (gov.hk)
For non-genotoxic carcinogens, instead of acting on DNA, they induce cancers through other mechanisms such as disrupting structure of the cell, changing the rate of cell division and other processes that increase the risk of genetic error. (gov.hk)
There is usually a threshold dose for non-genotoxic carcinogens, below which no toxic or carcinogenic effects are seen. (gov.hk)
Due to their toxic effects, a distinction is made between genotoxic and non-genotoxic carcinogens. (invitrojobs.com)
Current chemical testing strategies are limited in their ability to detect non-genotoxic carcinogens (NGTxC). (diagenode.com)
Peroxisome proliferators are non-genotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family, termed peroxisome proliferator activated receptors (PPARs). (thermofisher.com)
This newly formed group is exploring the use of error corrected sequencing to detect clonal expansion of non-genotoxic carcinogens. (hesiglobal.org)
Carcinogenicity4
The mechanism by which ochratoxin A causes carcinogenicity is unknown, although both genotoxic and nongenotoxic modes of action have been proposed. (who.int)
These effects have thresholds, with indirect genotoxic and epigenetic events underlying the threshold mode of action for nickel carcinogenicity. (mdpi.com)
Speakers included Koji Urano from the Central Institute of Experimental Animals in Japan (CIEA) and Marie McKeon of BioReliance Inc . Both speakers highlighted the increased utility of this model and how faster, more accurate nongenotoxic and genotoxic carcinogenicity testing helps pharmaceutical companies with strategic decision making in their drug development pipeline. (taconic.com)
This study addresses effects on EDCs on adjacent prepubertal Sertoli TM4 cells, specifically on 1) testicular gap junctional intercellular communication (GJIC), one of the hallmarks of non-genotoxic carcinogenicity, 2) GJIC building blocks connexins (Cx), and 3) mitogen-activated protein kinases MAPKs. (muni.cz)
Epigenetic1
Epigenetic anomalies develop during carcinogenesis regardless of whether the molecular initiating event is associated with genotoxic (GTx. (diagenode.com)
Vitro3
Aristolochic acid IVa forms DNA adducts in vitro but is non-genotoxic in vivo. (bvsalud.org)
In brief, although it could form DNA adducts in vitro , AA IVa was non-genotoxic in vivo, which was attributed to its low reactivity and biotransformation into an easily excreted metabolite rather than bioactivation. (bvsalud.org)
The conventional approach for testing the genotoxic potential of chemicals in vitro includes a battery of bacterial and mammalian mutagenicity tests. (nih.gov)
Effects3
Thus, individuals who metabolise a larger proportion of oestrogen to 16α-OHE 1 may be at increased risk of diseases that result from both the mitogenic and genotoxic effects of oestrogens, such as breast and prostate cancers 18 . (ersjournals.com)
The weight of evidence from the available literature indicates that adverse toxicologic (non-genotoxic) effects in humans are unlikely to occur at ambient air or water levels found or expected in the general environment. (epa.gov)
The assessment concluded that FutureGrown™ CBG caused no adverse effects and was non-mutagenic, non-clastogenic and non-genotoxic, completing the first step toward GRAS designation in the United States. (canadianmanufacturing.com)
Mechanisms1
Non-genotoxic substances work through secondary mechanisms that do not involve any direct interaction with DNA. (invitrojobs.com)
Conventional1
These two therapeutic compounds both indirectly activate p53, thereby presenting a combinational non-genotoxic p53 activation strategy, in contrast to conventional chemotherapy and bone marrow transplantation. (uib.no)
Identification2
Toxicogenomics analyses may provide information about DNA-damaging properties of test compounds but are not routinely used for identification of a genotoxic potential. (nih.gov)
Our analyses underline that a common response related to DNA damages response, cell cycle alterations and cell death is initiated in HepaRG cells upon exposure to genotoxic compounds and allows for the identification of a common transcriptomic signature for genotoxic stress. (nih.gov)
Cell1
The goal of this grant was to develop a non-genotoxic antibody-based conditioning regimen that can be used to treat people with FA who are undergoing a hematopoietic cell transplant (HCT). (fanconi.org)
Test1
The positive control material (cyclophosphamide) produced a marked increase in the frequency of micronucleated PCE when compared to the concurrent vehicle control group The test material was considered to be non-genotoxic and non-clastogenic under the conditions of the test. (europa.eu)
Groups1
Besides the statistically insignificant changes (p>0.05) of MN rates of erythrocytes between the control and experimental groups revealed the non-genotoxic feature of COL on zebrafish. (trjfas.org)
Studies1
Non-genotoxic hepatocarcinogens (NGHCs) can only be confirmed by 2-year rodent studies. (tmu.edu.tw)
Carcinogenesis6
Consumption of Red No. 3, which has estrogenlike growth stimulatory properties and may be genotoxic, could be a significant risk factor in human breast carcinogenesis. (researchgate.net)
1. Evidence for and possible mechanisms of non-genotoxic carcinogenesis in the rodent thyroid. (nih.gov)
8. Mechanisms of non-genotoxic carcinogenesis. (nih.gov)
15. Interaction and distinction of genotoxic and non-genotoxic events in carcinogenesis. (nih.gov)
Bibliography: Risk Assessment, Mechanisms of Action of Non- genotoxic Agents with Carcinogenesis and Activation of Protooncogenes. (cdc.gov)
modes of action of non-genotoxic carcinogenesis and the extrapolation of animal data to human hazard assessment. (thebts.org)
Substance is non-genotoxic2
All available data indicate the study substance is non-genotoxic. (europa.eu)
The test substance is non-genotoxic in bacterial. (europa.eu)
Vivo genotoxic1
14. Absence of in vivo genotoxic potential and tumor initiation activity of kojic acid in the rat thyroid. (nih.gov)
Cytotoxic5
Cytotoxic and genotoxic effect of methanolic flower extract from Gentiana asclepiadea on COS 1 cells. (nel.edu)
The purpose of this study was to assess whether a methanol extract isolated from the flower of Gentiana asclepiadea had potential cytotoxic or genotoxic effect on COS 1 (monkey kidney) cell line. (nel.edu)
Five various concentrations of the extract were investigated for cytotoxicity and genotoxicity and to determine non-cytotoxic and non-genotoxic concentrations suitable for utilization in pharmacology and medicine. (nel.edu)
We found that only the highest (5 and 25 mg/ml) concentrations of the extract revealed cytotoxic and genotoxic effect. (nel.edu)
We found out that extract of G. asclepiadea was neither cytotoxic nor genotoxic in a wide range of concentrations (0.25-2.5 mg/ml) and thus can be used to further investigate potential beneficial usage in pharmacology and medicine. (nel.edu)
Ochratoxin1
To elucidate this question, TSC2-/- Eker rats were gavaged with genotoxic aristolochic acid or nongenotoxic ochratoxin A for 3 and 6 months, respectively. (uni-konstanz.de)
Exposure1
Genotoxic exposure assessment by simplified DNA analysis. (cdc.gov)
Pathway1
To potentiate the response of acute myeloid leukemia (AML) to TRAIL cytotoxicity, we have adopted a strategy of combining nutlin-3, a potent non-genotoxic activator of the p53 pathway, with recombinant TRAIL. (unife.it)
Modes of action1
With a strong drive to reduce animal testing and costs in mind, it is essential that proper and robust alternatives for animal testing (3Rs) methods for addressing non-genotoxic modes of action are developed and used. (norecopa.no)
Genetic2
The genotoxic action of contaminating agents affects human health directly, damaging the genetic material, which is considered to play an important role in oncogenesis [6,7]. (researchgate.net)
A study is ongoing to identify possible genetic and non-genotoxic effects of these high doses. (medscape.com)
Concentrations2
All tested concentrations of FNS were found to be nongenotoxic. (tubitak.gov.tr)
We have also determined concentrations that stimulated cell growth (0.25 mg/ml) and colony forming ability (0.25-2.5 mg/ml) and did not exhibit genotoxic effect (0.25-2.5 mg/ml). (nel.edu)
Agents1
Additionally, many pesticide agents are non-genotoxic, making it harder to demonstrate harm or a risk of developing cancer. (nih.gov)