• Toxicogenomics analyses may provide information about DNA-damaging properties of test compounds but are not routinely used for identification of a genotoxic potential. (nih.gov)
  • Our analyses underline that a common response related to DNA damages response, cell cycle alterations and cell death is initiated in HepaRG cells upon exposure to genotoxic compounds and allows for the identification of a common transcriptomic signature for genotoxic stress. (nih.gov)
  • When is it possible to avoid genotoxic compounds? (wazeesupperclub.com)
  • For genotoxic compounds without sufficient evidence for a threshold- reasonably practicable" (ALARP) principl e, where avoiding is not possible. (wazeesupperclub.com)
  • They can occur spontaneously but also result from DNA damage induced by the environment (e.g., sunlight) or genotoxic compounds (e.g, carcinogens). (fda.gov)
  • Therefore, this review intends to summarize the current knowledge on the genotoxic and carcinogenic potential of cobalt-, nickel - and copper-based nanoparticles indicated in in vitro and in vivo mammalian studies. (cdc.gov)
  • In the present review, we briefly state the sources, use and exposure routes of these nanoparticles and summarize the current literature findings on their in vivo and in vitro genotoxic and carcinogenic effects. (cdc.gov)
  • The conventional approach for testing the genotoxic potential of chemicals in vitro includes a battery of bacterial and mammalian mutagenicity tests. (nih.gov)
  • A novel, integrated in vitro carcinogenicity test to identify genotoxic and non-genotoxic carcinogens using human lymphoblastoid cells. (swansea.ac.uk)
  • We compared the cytotoxic and genotoxic effects of Cr(VI) in human cells with hawksbill sea turtle ( Eretmochelys imbricata ), American alligator ( Alligator mississippiensis ), and fin whale ( Balaenoptera physalus ) cells. (vin.com)
  • cytotoxic and genotoxic mechanisms are both proposed in the current literature. (nih.gov)
  • The NTP review was finalized after peer review by the "Report on Carcinogens Expert Panel for Styrene" The Panel made conclusions about the evidence for the carcinogenicity of styrene. (who.int)
  • However, the majority of European Commission's experts agreed to classify it as a Category 3 carcinogen as only benign tumors were produced following exposure to this substance in experimental animals. (gc.ca)
  • NDMA, a genotoxic substance and known carcinogen, is often found in contaminated water or cured and grilled foods. (medpagetoday.com)
  • A carcinogen is a substance that can cause cancer. (gov.hk)
  • It's a genotoxic substance, which means it can damage your DNA. (healthline.com)
  • In conclusion, we have established a characteristic transcript marker pattern to monitor genotoxicity in human HepaRG cells, and to distinguish genotoxic from non-genotoxic carcinogens. (nih.gov)
  • Although advances have been made and insights have been gained on the effect of transitional metals on susceptible biological systems, there still is much ground to be covered, particularly with respect to our knowledge on the genotoxic and carcinogenic effects. (cdc.gov)
  • There is usually a threshold dose for non-genotoxic carcinogens, below which no toxic or carcinogenic effects are seen. (gov.hk)
  • As well, a commentator indicated that development of tumours following exposure to 1,4-benzenediol is species-specific and that the weight of evidence shows that 1,4-benzenediol is not a genotoxic carcinogen. (gc.ca)
  • The terrorist attacks on the World Trade Center (WTC) created an unprecedented environmental exposure to aerosolized dust, gases and potential carcinogens. (nature.com)
  • Clonal hematopoiesis (CH) is defined as the acquisition of somatic mutations in blood cells and is associated with smoking and exposure to genotoxic stimuli. (nature.com)
  • For this type of carcinogens, it is assumed that no level of exposure is entirely safe and even at low levels, some damage to the genetic material may increase the chance of developing cancer. (gov.hk)
  • Non-genotoxic carcinogens also include substances which lead to epigenetic changes. (invitrojobs.com)
  • Epigenetic anomalies develop during carcinogenesis regardless of whether the molecular initiating event is associated with genotoxic (GTx. (diagenode.com)
  • Despite the health risks, the WHO noted there's "limited evidence" that aspartame can cause cancer and listed the sweetener as a Class 2B carcinogen. (medicalnewstoday.com)
  • However, agency officials said there was only "limited evidence" that aspartame can cause human cancer, so it was listing the sweetener as an IARC Group 2B carcinogen. (medicalnewstoday.com)
  • While it can be confusing and distressing to hear of this news around aspartame, it is essential to understand that the IARC does not consider the scale of risk of these carcinogens and a Class 2B carcinogen does not equate to a definite or even possible cause of cancer," Karimi said. (medicalnewstoday.com)
  • This is the second article in a series on the relation of food, carcinogens and cancer. (gov.hk)
  • The International Agency for Research on Cancer (IARC) and the United States Protection Agency (EPA) classify it as a known human carcinogen. (healthline.com)
  • Carcinogens are chemicals that can cause cancer. (healthline.com)
  • Why is ethylene oxide considered a cancer-causing agent (carcinogen)? (healthline.com)
  • NA is currently classified by the International Agency for Research on Cancer (IARC) as a Class 2B Carcinogen. (nih.gov)
  • According to in vivo te s t s, c h l o r oe t h a n e a n d a l ky l b r o mi d e s se e m t o be n o n - genotoxic carcinogens rather than genotoxic ca rcinogens. (wazeesupperclub.com)
  • Propylene oxide was tested for genotoxic effects in vivo in rats and mice. (europa.eu)
  • A commentator suggested that the European Commission's (EC's) classification of 1,4-benzenediol as a Group 3 carcinogen and mutagen was misinterpreted in the draft screening assessment report. (gc.ca)
  • Is the mutagen sodium azide a carcinogen? (roadlesstraveledstore.com)
  • See comments below regarding 1,4-benzenediol as a potential genotoxic carcinogen. (gc.ca)
  • World Health Organization (WHO) officials declared aspartame a potential carcinogen on July 14. (medicalnewstoday.com)
  • The chemical is considered to be a potential carcinogen in humans. (foodnavigator.com)
  • These materials may have some genotoxic potential. (bvsalud.org)
  • Non-genotoxic substances work through secondary mechanisms that do not involve any direct interaction with DNA. (invitrojobs.com)
  • Genotoxic carcinogens induce cancers via a mechanism involving direct damage to DNA. (gov.hk)
  • For non-genotoxic carcinogens, instead of acting on DNA, they induce cancers through other mechanisms such as disrupting structure of the cell, changing the rate of cell division and other processes that increase the risk of genetic error. (gov.hk)
  • Haloacetic acids are genotoxic, which means that they induce mutations and DNA damage. (ewg.org)
  • The application of toxicological risk assessment methods to cigarette smoke provides a plausible and objective framework for the prioritisation of carcinogens and other toxicant hazards in cigarette smoke. (bmj.com)
  • Carcinogen classification approaches and risk as- search institutions. (cdc.gov)
  • However, when these differences were adjusted for, alligator cells were the most sensitive to the genotoxic effects Cr(VI). (vin.com)
  • Due to their toxic effects, a distinction is made between genotoxic and non-genotoxic carcinogens. (invitrojobs.com)
  • Non-genotoxic carcinogens: early effects on gap junctions, cell proliferation and apoptosis in the rat. (urosario.edu.co)
  • Genotoxic effects were determined by a micronucleus assay (Bootman et al. (europa.eu)
  • Indeed, 14-d repeated oral administration of up to 250 mg/kg was also negative for genotoxic effects in a dominant lethal assay. (europa.eu)
  • However, with an adeq battery of necf expsre blmarkers, prospective studies of en- vironmental effects on pregnancy outcomes might be possible. (cdc.gov)
  • In this study, metabolically active human HepaRG hepatocarcinoma cells were exposed to five food-relevant genotoxic carcinogens. (nih.gov)
  • Hexavalent Cr(VI) is a human carcinogen and a global marine pollutant. (vin.com)
  • Of these, 45 were known or suspected human carcinogens. (bmj.com)
  • A commentator did not agree with the Health Canada's precautionary principle approach under which 1,4-benzenediol may be considered a genotoxic carcinogen. (gc.ca)
  • A joint Food and Agriculture Organisation and WHO scientific panel last year concluded that that ethyl carbamate is genotoxic and is a multisite carcinogen in all animal species tested. (foodnavigator.com)
  • The proliferation of scientific data on putative environmental carcinogens requires the setting of priorities for agents to be selected as topics for evaluation or re-evaluation in future monographs. (who.int)
  • In the next issue, we will go into more details about certain food carcinogens and the measures to reduce their levels in foods. (gov.hk)
  • First Venture Technologies' propriety yeast claims to be able to reduce levels of the carcinogen ethyl carbamate ​, a compound that can naturally occur in fermented foods and beverages, such as wine, beer and bread. (foodnavigator.com)
  • Epichlorohydrin should not be permitted in food packaging as it is a genotoxic carcinogen. (gc.ca)
  • Peroxisome proliferators are non-genotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family, termed peroxisome proliferator activated receptors (PPARs). (thermofisher.com)
  • According to the European Commission's summary report, 1,4-benzenediol was originally proposed as a Category 2 carcinogen based on the evidence of development of kidney adenomas and mononuclear cell leukemia in rats and liver adenomas in mice. (gc.ca)
  • Sulfonate impurities comprise the most investigated group of genotoxic impurities (GIs). (wazeesupperclub.com)
  • Carcinogens can be classified according to their mode of action into genotoxic and non-genotoxic. (gov.hk)
  • control of impurities processing genotoxic po tential in pharmaceutical products. (wazeesupperclub.com)
  • There was no difference found between controls and treated animals regarding any of the reproductive parameters to indicate a genotoxic effect of propylene oxide. (europa.eu)
  • Altogether the data suggest Cr(VI) is a concern for marine animals and that aquatic animals may be good sentinels for the genotoxic impacts of Cr contaminated ecosystems. (vin.com)
  • This review also concluded that 1,4-benzenediol is not a genotoxic carcinogen. (gc.ca)