Genotoxic and mutagenic. Medical search. Frequent questions

A genotoxic substance is mutagenic, carcinogenic and teratogenic. (whale.to)
Despite these recognised benefits, long-standing concerns regarding the risks of mutagenic and potentially carcinogenic drug exposure have hampered efforts for broad hydroxyurea use in SCA, although these are based largely on outdated experimental models and treatment experiences with myeloproliferative neoplasms. (cdc.gov)
This absence of mutagenic activity is consistent with the observed lack of any compelling carcinogenic potential. (cdc.gov)
Sodium azide for example may be mutagenic (and highly toxic), but it has not been shown to be carcinogenic. (roadlesstraveledstore.com)
Directive 2009/48/EC establishes general requirements for substances which are classified as carcinogenic, mutagenic or toxic for reproduction (CMR) under Regulation (EC) No 1272/2008. (europa.eu)
They are highly toxic, mutagenic, carcinogenic and genotoxic and also exhibit toxicity to algae, fish and can bio accumulate along the food chain [ 2 ]. (omicsonline.org)
Disinfection of surface drinking water, particularly water chlorination, produces by-products with potential genotoxic and/or carcinogenic activity. (scirp.org)

Although several techniques for identifying individual exposures have been developed and tested, and although more and more xenobiotics have been recognized to have teratogenic and mutagenic potential, "essentially no specific biomarkers are cur- rently available to indicate that exposure to a given xenobiotic is directly associated with a cellular, subcellular, or phar- macodynamic event" (6). (cdc.gov)

Acrylamide (AA) has been identified as neurotoxic, mutagenic, and a probable genotoxic to animals and humans (Clin Chem, 2016). (cdc.gov)

Certain benzene metabolites, including benzoquinone (BQ), are genotoxic and mutagenic. (rti.org)
Many mutagens are not mutagenic by themselves, but can form mutagenic metabolites through cellular processes. (roadlesstraveledstore.com)

Like other high molecular weight phthalates, DTDP was not mutagenic in vitro in bacterial mutation assays (with and without metabolic activation). (europa.eu)
Quinoline is considered as genotoxic and mutagenic in vitro and in vivo only after metabolisation by the liver. (europa.eu)

This study aimed to assess the genotoxic and cytotoxic effects of dental radiographic modalities on buccal mucosal cells in children. (thieme-connect.com)
X-ray exposure in panoramic, periapical, bitewing, and bitewing plus panoramic radiographies can be cytotoxic, while bitewing plus panoramic radiography can be genotoxic in children as well. (thieme-connect.com)

It was non-mutagenic in the assay. (europa.eu)
Noni leaf extract was not mutagenic in the Ames assay, demonstrating that the leaf poses no significant genotoxic risk to humans. (noniresearch.org)
possibility is that the damage is not induces mutations in a mutation integrated viral genome ( Todaro and repaired at al , and when the cell rep- assay permits it to be classified as Huebner, 1972) , and alteration of im- licates, the DNA polymerase correct- mutagenic. (who.int)

Data demonstrate that DFB exerts genotoxic and mutagenic effects in a dose-dependent manner. (unesp.br)
I am referring to taking fluoride internally, where it has been found to cause unscheduled DNA synthesis, sister chromatid exchanges and yes, mutagenic effects on the cells. (drkaslow.com)
Rather, its genotoxic effects are limited to indirect clastogenicity occurring in select cell types, and only when high dose and time thresholds are exceeded. (cdc.gov)
The objective of the project is to analyze the relationship between the exposure to genotoxic chemicals and the induction of genetic effects in several genotoxicity assays as they are used under laboratory conditions. (europa.eu)
The results to date include that measurements of DNA adduct frequencies can give information concerning the mutagenic potency of a genotoxic agent, but these determinations should be accompanied by measurements of the effects of DNA repair mechanisms on the persistence of the DNA lesions. (europa.eu)
The results of this toxicological safety assessment indicate that GanedenBC30 B. coagulans does not demonstrate mutagenic, clastogenic, or genotoxic effects. (newhope.com)
In this study, we tried to understand if (and to what extent) the temperature parameter could actually play an independent role in the registered seasonal variation of mutagenic effects, neglecting the variation of other parameters, e.g. physical conditions and chemical composition of the lake water. (scirp.org)
Long-term expo- sure at the temperatures of 20℃ (both Vicia faba and Allium cepa ) and 30℃ ( Vicia faba only) to disinfected waters induced clear mutagenic effects. (scirp.org)
However, with an adeq battery of necf expsre blmarkers, prospective studies of en- vironmental effects on pregnancy outcomes might be possible. (cdc.gov)

The genotoxicity results clearly demonstrate that hydroxyurea does not directly bind DNA and is not mutagenic. (cdc.gov)

This study assessed the genotoxic and mutagenic potential of diflubenzuron (DFB) insecticide in mice. (unesp.br)
Several Fatty Acid Glycerides Category members were tested for their genotoxic potential in bacteria (Ames Test). (europa.eu)
A weight of evidence approach is also required to assess mutagenic potential of chemicals. (cdc.gov)
In the context of the process of a necessary role in the potential mu- agents were found to be mutagens, mutagenesis described above, the tagenic activity of such compounds, leading to the conclusion that carcin- term "mutagen" refers to an agent or even that DNA, as opposed to ogens were general y not mutagenic. (who.int)
These materials may have some genotoxic potential. (bvsalud.org)

Genotoxic and mutagenic substances may interact with DNA and lead to aberrant cell growth. (dguv.de)

This is the only test showing a mutagenic activity of quinoline in absence of metabolic activation. (europa.eu)

Any substance that damages DNA or chromosomes, or changes genetic activity, is genotoxic because it is acting on the same material, i.e. the DNA molecule. (whale.to)
It carries no alerts for possible genotoxic activity based on established Structure Activity Relationship (SAR) principles ( Tennant RW and Ashby J (1991). (europa.eu)
A study carried out at a pilot plant for drinking water disinfection of lake water revealed mutagenic activity of three different disinfectants (sodium hypochlorite, chlorine dioxide and peracetic acid) in different seasons using in situ mutagenicity assays, both in animal (micronucleus test) and in plant organisms (anaphase chromosomal aberration and micronucleus tests). (scirp.org)

Its role providing information on important general principles or new scientific discoveries in connection with mutagenic and genotoxic hazards and risk is set to become even more important in future as the committee's guidance will be replacing advice previously given by equivalent European organisations. (swansea.ac.uk)

The mutagenic properties of each of these type of adducts can vary significantly. (europa.eu)

Based on these data, DTDP is not mutagenic or genotoxic. (europa.eu)

Methane was not mutagenic in this test system. (europa.eu)

These results show that human CD34(+) cells are sensitive targets for 1,4-BQ toxicity that use the p53 DNA damage response pathway in response to genotoxic stress. (rti.org)

Half of the articles said fluoride promotes cancer (mutagenic). (drkaslow.com)

In all testings Fatty Acid Glycerides were shown to be non-mutagenic in bacteria. (europa.eu)

The three concentrations utilized reduced the genotoxic effects of dietary-aflatoxin on MN and abnormal sperm morphology assay in a concentration-dependent manner. (scialert.net)

Genotoxic chemotherapy exerts toxicity towards proliferating cells, including tumor cells and stem cells in tissues (left). (nature.com)
One study that directly focused on the mutagenic potential of psilocybin did not found this type of toxicity. (who.int)

In addition, micronucleus and chromosomal aberration tests were used for mutagenic and genotoxic studies. (tubitak.gov.tr)
Whereas, treatment of CHO cell lines with different concentrations of ZER along with 2.5 µM Cisplatin was found to reduce chromosomal aberrations, suggesting an antagonistic genotoxic effect. (waocp.com)

With this in mind, it has been hypothesized that the inhibition of mutagenic TLS might (i) increase the responses of cancer to genotoxic chemotherapeutics and (ii) reduce the mutagenicity and tumorigenicity of chemotherapy (see Fig. 1 ). (nature.com)

DINP and 4-NP were mutagenic in the Ames assay and also induced significant levels of unscheduled DNA synthesis and DNA strand breakage. (scirp.org)

This hides the REV7-binding domain of REV1 and therefore abolishes REV1/REV3/REV7-mediated highly mutagenic TLS while leaving TLS by less mutagenic polymerases intact. (nature.com)

These compounds have also not been shown to have any direct mutagenic or genotoxic activity. (alchetron.com)

DMCHDC was mutagenic in bacteria without metabolic activation. (nih.gov)
It was not mutagenic to bacteria. (inchem.org)

Indeed, experiments using Rev1 -knockout mouse embryonic fibroblasts (MEFs) or REV1-depleted human cells, provided genetic evidence that JH-RE-06 specifically inhibits a REV1-mediated highly mutagenic TLS pathway at severely helix-distorting nucleotide lesions such as those induced by chemotherapeutic drugs. (nature.com)

A detailed method development and validation study was conducted to identify and evaluate the level of genotoxic impurities present in the synthetic Piperonal produced by Catàsynth Speciality Chemicals. (antheagroup.com)

A combination of selected test systems has been undertaken to aid in the screening and assessment of the oestrogenic and genotoxic activity of EDCs found in Irish waterways. (scirp.org)

S-cdA was found mutagenic and highly genotoxic. (nih.gov)

Classical genotoxic chemotherapy of cancer is aimed at killing proliferating tumor cells by the introduction of DNA lesions that arrest the replication machinery. (nature.com)
Notably, some lesions are rapidly repaired, some slowly, and some are resistant and thus particularly genotoxic, a phenomenon that is poorly understood. (nih.gov)

In this study, we demonstrate that the specific SIRT2 inhibitor, the compound 33i, does not exhibit genotoxic or mutagenic properties. (unav.edu)

provides a proof of principle that cancer cells can be sensitized to DNA-damaging chemotherapy by the drug-induced inhibition of mutagenic DNA translesion synthesis, a process that endows tolerance of DNA damage. (nature.com)

However, the possible genotoxic effect of ultrashort laser pulses was not investigated. (nih.gov)

OMEs can be produced from sustainably sourced methanol, and tests indicate that they are neither genotoxic nor mutagenic. (york.ac.uk)

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