Genomic studies. Medical search. Frequent questions

During the past fifteen years, high-throughput genomic experiments, which involve the usage of micro-arrays or next generation sequencing technologies, have significantly changed biomedical research and clinical practice. (biomedcentral.com)
Applicants are particularly encouraged to propose integrative analysis of existing large-scale, high-throughput data sets generated by utilizing advanced genomic technologies and combined analysis of multiple data sets obtained with other high dimensional technologies such as imaging, if feasible. (nih.gov)
This year, the Nordic conference will take place in Odense and, as always, it will focus on high throughput genomic technologies with a special focus on Next Generation Sequencing in the research and clinical analysis of human disease. (wikicfp.com)
Therefore it is not surpris- pansion of biological understanding from the analysis of in- ing that the advent of high-throughput genomic and pro- dividual genes to the analysis of systems of genes (and pro- teomic technologies is drawing a growing interest from the teins). (lu.se)

NEW YORK - The SARS-CoV-2 virus that is causing the COVID-19 pandemic appears to have entered New York City mainly from Europe, according to independent viral genome sequencing studies from researchers at the Icahn School of Medicine at Mount Sinai, New York University Grossman School of Medicine, and Weill Cornell Medicine. (genomeweb.com)
Genomic sequencing allowed a number of unique imported SARS-CoV-2 genomes to be identified that could be monitored to see how widely they had spread. (sanger.ac.uk)
The Tapestry DNA Sequencing Research Study is designed to understand the short-term and long-term impact of genetic testing on people's health care when their DNA results are part of the electronic health record. (mayo.edu)
With increasing utility and decreasing cost of genomic sequencing, augmentation of standard newborn screening (NBS) programs with newborn genomic sequencing (nGS) has been proposed. (frontiersin.org)
Although enhanced viral genomic sequencing capacity can improve outbreak detection and response, acquiring this tool remains challenging for many public health laboratories because of the high startup costs of traditional bench-top sequencing ( 8 ). (cdc.gov)
An intriguing study surveying the transcriptome of murine brain tissues revealed over 1300 imprinted gene loci (approximately 10-fold more than previously reported) by RNA-sequencing from F1 hybrids resulting from reciprocal crosses. (wikipedia.org)
This report describes SARS-CoV-2 genomic surveillance conducted by the Department of Defense (DoD) Global Emerging Infections Surveillance Branch and the Next-Generation Sequencing and Bioinformatics Consortium (NGSBC) in response to the COVID-19 pandemic. (health.mil)
Future research will focus on exploiting these known genomic alterations through the generation of new therapies and/or with the identification of the optimal sequencing of agents. (medpagetoday.com)
Genomic sequencing of tumors, when appropriate, is encouraged as this will help to further the field's understanding of the evolving genomic landscape of metastatic breast cancer. (medpagetoday.com)
Also, this study adds significantly to the number of commensal E. coli genomes, a group that has been traditionally underrepresented in the sequencing of this species. (peerj.com)
This research study is evaluating the use of specialized testing of solid tumors including sequencing. (ucsf.edu)

Methods Among 323 wheat accessions, we investigated phenotypic differences in root traits at booting and mid-grain fill stages in PVC tubes, shoot traits including plant height (PH), canopy temperature (CT) and grain yield per plant (YPP) in a field experiment, and performed a genome-wide association study with a Wheat 660K SNP Array. (cgiar.org)
We thus investigated genomic and phenotypic diversity in 109 pearl millet landrace accessions, i.e., 66 early-flowering and 43 late-flowering, grown in the groundnut basin, the first area of rainfed agriculture in Senegal dominated by dry cereals (millet, maize, and sorghum) and legumes (groundnuts, cowpeas). (frontiersin.org)
These existing genetic, genomic, and phenotypic data sets relevant to the NEI mission provide a resource to investigate new and insightful research questions or to develop novel computational and bioinformatics approaches and tools for the analysis and interpretation of these data sets. (nih.gov)
Workshop recommendations highlighted the need for utilizing and developing improved approaches to methodically evaluate the function and phenotypic outcomes of genomic variation. (nih.gov)

The U.S. and British organizations are working together on the H3Africa project, which aims to improve the health of Africans through the study of genomics and environmental determinants of common diseases. (nih.gov)
The H3Africa initiative will help develop expertise among African scientists, foster increased collaboration among African investigators, enhance the infrastructure for genomics research in Africa, and contribute to the training of the next generation of African researchers in the use of contemporary genomic approaches in the study of important health problems. (nih.gov)
The MSc Genomic Medicine Programme aims to equip students with a multi-disciplinary perspective on genomics and its applications to clinical practice and medical research. (birmingham.ac.uk)
University of Birmingham is accredited by Health Education England (HEE) to provide genomic medicine training as part of the Genomics Education Programme. (birmingham.ac.uk)
Representation in genomics studies has been dominated by populations descending from Europe. (nature.com)
Genomics studies all of a person's genes-also known as the genome-and looks at how someone's genes work together. (medlineplus.gov)
More- ing with the global understanding of functional genomics, over, signal processing is based on a holistic view of regu- with special emphasis on genomic regulation. (lu.se)

The expanded use of testing both within medical specialties highly familiar with genetic and genomic testing (pediatrics and obstetrics/gynecology) and other less experienced medical specialties has also created a need to develop new approaches to counseling. (karger.com)
This Funding Opportunity Announcement (FOA) issued by the National Eye Institute (NEI), National Institutes of Health (NIH), encourages the submission of applications proposing integrative and in-depth analyses of existing large-scale genetic and genomic data sets relevant to the NEI mission, as well as the development of novel bioinformatics approaches and innovative computational tools to interpret these data sets. (nih.gov)
The NEI has supported an extensive portfolio of genetic and genomic research projects with numerous data collection activities undertaken to meet each project's specific aims. (nih.gov)
Applicants are encouraged to utilize multiple genetic and genomic resources such as those available from the NCBI database of Genotype and Phenotype (dbGaP) or other sources of genotype and phenotype data. (nih.gov)
Genetic research capitalizing on the remarkable progress made by the Human Genome Project and the application of GWAS has not only led to the discoveries of susceptibility genes for many eye diseases but has also provided extremely valuable resources for future genetic and genomic studies to elucidate biochemical and cellular pathways. (nih.gov)

You will also meet patient group representatives to learn about the impact of genomic medicine from the patient's viewpoint. (birmingham.ac.uk)
NHGRI recently issued multiple funding opportunities to establish the Impact of Genomic Variation on Function (IGVF) Consortium , the overarching aim of which is to apply experimental and computational approaches for systematically examining the relationships among genomic variation, genome function, and phenotypes. (genome.gov)
Systematic Characterization of Genomic Variation on Genomic Function and Phenotype , Defining Genomic Influence on Gene Network Regulation , Single-cell Profiling of Regulatory Element and Gene Activity in Relationship to Genome Function , Genomic Variation and Function Data and Administrative Coordinating Center , and Developing Predictive Models of the Impact of Genomic Variation on Function . (genome.gov)
August 19, 2020 - Notice of Pre-Application Webinars for the Impact of Genomic Variation on Function (IGVF) Consortium FOAs. (nih.gov)
The DACC will serve as the coordinating center for the Impact of Genomic Variation on Function (IGVF) Consortium and will be responsible for establishing a resource of consortium generated data, metadata, analyses, methods, and tools, and coordination of consortium activities. (nih.gov)

I]n the era of precision medicine, there is an urgent need to include quality-of-life evaluations and psychological outcomes as secondary end points in clinical trials exploring the utility of genomic profiling in women with early-stage breast cancer," the pair said. (genomeweb.com)
To date, however, the utility of genomic testing in a clinically ascertained, prospectively recruited kidney disease cohort remains unknown. (bmj.com)

Inadequate pre-treatment tissue sample for tumor genomic analyses. (mayo.edu)
The reassuring findings are the result of genomic analyses conducted by an international research team, partly supported by NIH. (nih.gov)
In this study, we performed serial comprehensive genome profiling analyses to evaluate time-dependent changes in genomic profiles of patients receiving the FLT3 inhibitors gilteritinib, and quizartinib in AML. (confex.com)
There is a dearth of genomic analyses of section Flavi that are mitochondrial in focus, with most focusing exclusively on nuclear genomes. (vanderbilt.edu)
As a member of the IGVF Consortium, the DACC will work closely with all consortium components to accelerate understanding of how genomic variation impacts human health and disease through the coordination of data collection strategies and analyses. (nih.gov)

For instance, they noted that 90 percent of the tumors from patients at high clinical risk, but low genomic risk of recurrence were luminal and HER2 negative, and that 71 percent were grade 1 or grade 2 tumors. (genomeweb.com)
However, only half the tumors from patients at both high clinical and genomic risk were luminal and HER2-negative, and three-quarters were grade 3 tumors. (genomeweb.com)
From this, the Leiden trio calculated that 82 percent of luminal grade 1 or grade 2 tumors from patients at high clinical risk would be classified as being at low genomic risk. (genomeweb.com)
Patients with extra-cranial (not in the brain) solid tumors that are either difficult to diagnose or more difficult to treat are eligible to participate in this study. (ucsf.edu)
In this prospective multi-center cohort study, the primary objective is to describe the outcomes of pediatric patients with advanced solid tumors according to whether or not they received of targeted therapy matched to an iCat recommendation. (ucsf.edu)

For their study, the Mount Sinai researchers sequenced 90 SARS-CoV-2 genomes from 84 patients, which came from 21 neighborhoods in Manhattan, the Bronx, Queens, and Brooklyn, as well as from two towns in Westchester County. (genomeweb.com)
In August, researchers from the Microarray in Node-negative and 1 to 3 positive lymph node Disease may Avoid ChemoTherapy (MINDACT) study reported in NEJM that women with early-stage breast cancer who have a high clinical risk of disease recurrence might be able to forgo adjuvant chemotherapy if they have a low genomic risk of recurrence, as gauged using Agendia's MammaPrint assay. (genomeweb.com)
In a letter appearing this week in NEJM , though, a trio of researchers from Leiden University Medical Center pointed out some potential hitches with the study. (genomeweb.com)
The MINDACT researchers responded that they, too, consider quality of life to be an important measure, but didn't include such an analysis in their study as it would have entailed some participants to sign four different informed consent documents. (genomeweb.com)
This program will enable African researchers to study African populations, to solve African problems and to train the next generation of African scientists. (nih.gov)
The researchers went on to analyze genomic data related to the overall molecular structure, or backbone, of the new coronavirus. (nih.gov)
Accordingly, Michael S. Leapman, MD, MHS, and fellow researchers conducted a qualitative descriptive study comprised of in-depth, semi-structured interviews of patients with low- or favorable-intermediate-risk prostate cancer undergoing active surveillance. (urologytimes.com)
Researchers looked at drugs approved by the US Food and Drug Administration (FDA) for genomic indications from 2006 to 2020. (cancertherapyadvisor.com)
The researchers acknowledged that this study is limited by the fact that they used only PubMed to search for randomized studies associated with each drug and indication. (cancertherapyadvisor.com)
Despite that limitation, the researchers concluded that these results suggest "further trials or post-marketing studies are needed to ascertain the impact on survival and quality of life, the magnitude of these gains, and the cost-effectiveness of these agents. (cancertherapyadvisor.com)
Over the past two decades, researchers have cataloged numerous genomic variants that may play a role in human disease. (genome.gov)
What happened when genomic researchers targeted more diverse groups of people in their studies? (medlineplus.gov)
By increasing diversity in genomic studies, researchers can better tailor new treatments that benefit all populations. (medlineplus.gov)
Researchers at the Keck School of Medicine (KSOM) of USC are among the contributors to a large-scale ethnically diverse genetic study that has expanded what we know about potential causes of type 2 diabetes. (usc.edu)

This approach can greatly increase the number of potential annotated genes that can be studied beyond that which is currently available, particularly for species that do not have comprehensively characterised genomes. (cambridge.org)
Besides demonstrating that the probe selection method can be used to study the ovine transcriptome, the benefits of this approach are that it can greatly increase the number of annotated and novel genes that can be studied beyond those currently possible using ovine- or bovine-specific microarrays. (cambridge.org)
Introduction Recent advances in genomic technology have allowed better delineation of renal conditions, the identification of new kidney disease genes and subsequent targets for therapy. (bmj.com)
The aim of this study was thus to detect genes linked to flowering but also linked to relevant traits within each flowering group. (frontiersin.org)
Genomic imprinting is an epigenetic phenomenon that causes genes to be expressed or not, depending on whether they are inherited from the mother or the father. (wikipedia.org)
In a secondary analysis, the team also used health records from the Queen Mary University of London Genes & Health Study, which contains health information on individuals of South Asian ancestry. (medscape.com)
Yet the range of possibilities is wider: "With this genomic information on their cows, farmers will be able to select the bulls that give the most favourable combination of genes. (europa.eu)
Gene amplification and gene expression of several proto-oncogenes (K-ras, c-jun, c-fos, c-myc, c-sis and erb-B2) and tumor suppressor genes (p53 and p16) were studied using differential PCR. (cdc.gov)
None of the genes studied were amplified in these transformed cells. (cdc.gov)

A 2021 study by the JRC concluded that the current legal framework is not fit for purpose. (technopolis-group.com)

The lack of genomic characterization restricts our understanding of DENV diversity within Angola and the frequency and directionality with which DENVs are exchanged with other countries. (cdc.gov)
In addition, we discuss progress and achievements on related technological challenges and diversity among scientists conducting genomic research. (nature.com)
The call for increased diversity in genomic research has been accompanied by the need for overcoming related technological challenges and for greater diversity among those conducting research. (nature.com)
Little is known about the genomic diversity of Escherichia coli in healthy children from sub-Saharan Africa, even though this is pertinent to understanding bacterial evolution and ecology and their role in infection. (peerj.com)
These were spread over 37 seven-allele sequence types and the E. coli phylogroups A, B1, B2, C, D, E, F and Escherichia cryptic clade I. Immigration events accounted for three-quarters of the diversity within our study population, while one-quarter of variants appeared to have arisen from within-host evolution. (peerj.com)
Our results suggest that within-host evolution plays a minor role in the generation of diversity compared to independent immigration and the establishment of strains among our study population. (peerj.com)
According to the GWAS Diversity Monitor , launched in Nature Genetics in 2020 as a way to track participants included across all published genome-wide association studies in real time, more than 88 percent of research has been conducted in Europeans. (usc.edu)

Host genomic studies play an important part in understanding disease susceptibility, severity, and outcomes. (cdc.gov)
Observational study - observes people and measures outcomes without affecting results. (mayo.edu)
Secondary outcomes will include change in clinical diagnosis following genomic testing, change in clinical management following genomic testing and the cost-effectiveness of genomic testing compared with usual care. (bmj.com)

G band cytogenetic analysis often leads to the discovery of unbalanced karyotypes that require further characterisation by molecular cytogenetic studies. (bmj.com)
Comparative genomic hybridisation (CGH) is one of several molecular approaches that can be applied to ascertain the origin of extra chromosomal material. (bmj.com)
Conclusions These results uncovered promising genomic regions for functional gene discovery of root traits in the late growth period, enhanced understanding of correlation between root and shoot traits, and will facilitate intensive study on root morphology and breeding through molecular design. (cgiar.org)
The primary outcome will be the proportion of patients who receive a molecular diagnosis via genomic testing (diagnostic rate) compared with usual care. (bmj.com)
Zyagen offers a pure and intact high molecular size control genomic DNA of 32 different plant species. (delos.info)
Lacks definitive diagnosis or classical genomic findings after histologic review and standard molecular testing (rare tumor group). (ucsf.edu)
To cap- lular phenotypes (e.g. disease) on a mechanistic level, and ture the complex network of nonlinear information process- to use genomic signals to classify disease on a molecular ing based upon multivariate inputs from inside and outside level. (lu.se)

adequately represent genomic regulation for diagnosis and Historically, it has been within the domain of signal therapy. (lu.se)

One of the central challenges in biology is understanding how genomic variation affects genome function to influence phenotypes. (genome.gov)
The IGVF Consortium will build on the input received as part of NHGRI's 'Genomics2020' strategic planning process, including the January 2019 workshop " From Genome to Phenotype: Genomic Variation Identification, Association, and Function in Human Health and Disease . (genome.gov)
In addition, the study identified the human genetic variation associated with the L1 insertion polymorphisms in major geographic groups. (ojp.gov)
The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications for the Genomic Variation and Function Data and Administrative Coordinating Center (DACC). (nih.gov)
NHGRI considered this problem in part through a workshop entitled "From Genome to Phenotype: Genomic Variation Identification, Association, and Function in Human Health and Disease" as part of its strategic planning efforts . (nih.gov)

We have used comparative genomic hybridisation to analyse 19 constitutional chromosome abnormalities detected by G band analysis, including seven deletions, five supernumerary marker chromosomes, two interstitial duplications, and five chromosomes presenting with abnormal terminal banding patterns. (bmj.com)
Comparative genomic hybridisation (CGH) is a dual fluorescence in situ hybridisation protocol capable of detecting global gains and losses of genomic regions by competitive DNA hybridisation. (bmj.com)
Screening for chromosome imbalances was carried out using comparative genomic hybridisation (CGH) in 14 frozen samples of tumour from a series of 13 breast cancer patients with multiploid (n = 11) and hypertetraploid (n = 2) tumours. (bmj.com)
COSMO: Comparative Studies in Modernism. (wikipedia.org)
Comparative genomic hybridization (CGH) is now often recommended to identify a greater number of subtle cytogenetic abnormalities in pervasive developmental disorder (PDD). (medscape.com)

The study also suggests that the virus was likely circulating as early as late January 2020 in the New York City area," Simon, a professor of microbiology and infectious diseases at Mount Sinai, said in a statement. (genomeweb.com)
This study was initiated in January 2019, and 91 patients were recruited by March 2020. (confex.com)
Establishment of SARS-CoV-2 Genomic Surveillance Within the Military Health System During 1 March-31 December 2020. (health.mil)
The authors of a chapter in the 2020 ASCO Educational Book present the basics of the known genomic alterations in metastatic breast cancer, describe various methods of clinical detection, and then provide basic guidance on the interpretation and clinical applicability of these mutations. (medpagetoday.com)

Amelogenesis imperfecta: genotype-phenotype studies in 71 families. (medlineplus.gov)

The NYU findings "broadly coincide with our study in that the main route by which the virus arrived in NYC was through Europe," said Harm van Bakel, assistant professor of genetics and genomic sciences at Mount Sinai, in an email. (genomeweb.com)
In this interview, Leapman, an associate professor of urology and clinical program leader, Prostate & Urologic Cancers Program, Yale Cancer Center, describes the background and findings of this study, which he presented at the 2023 Genitourinary Cancers Symposium. (urologytimes.com)
The study findings reveal that mutations in the viral spike protein and RNA polymerase complex can increase the risk of COVID-19 mortality. (news-medical.net)
These findings have the potential to allow for a faster and more accurate release of varieties with a substantial reduction of resources for the application of genomic prediction in blueberry. (nature.com)
As these initiatives are beginning to yield results and more findings from studies including diverse populations are accumulating, it is worthwhile to revisit the promises of this inclusion to evaluate whether the anticipated advances are, indeed, emerging. (nature.com)

Thus, continuous monitoring of the viral genomic alterations would be vital to identify potential targets for drug or vaccine development. (news-medical.net)
Another important aspect of this manuscript is Table 1 , where the authors clearly show the presence of mutations not only in the primary and metastatic setting but also highlight that some of these genomic pathway alterations are preserved across breast cancer subtypes. (medpagetoday.com)
The chapter is a comprehensive review of what is known about genomic alterations in breast cancer to date. (medpagetoday.com)
Genomic pathways can be preserved across breast cancer subtypes, but not all genomic alterations behave the same in different tumor subtypes. (medpagetoday.com)

This same method also has the potential to allow the study of other species where species-specific microarrays are not available or whose genomes have not been comprehensively characterised. (cambridge.org)
The study focused on the mitochondrial genomes of 20 different Aspergillus species, a type of fungi, to examine the relationships within section Flavi , a group of closely related species within the genus Aspergillus . (vanderbilt.edu)
The team found that while the genomic content of Flavi nuclei is approximately 1000 times larger than that of the mitochondria, phylogenies (the relationships between organisms and their common ancestor) produced by mitochondrial genomes are consistent with those produces by nuclear genomes. (vanderbilt.edu)
This is significant because it shows that mitochondrial genomes may be underutilized in constructing phylogenies, as most previous studies have focused only on nuclear genomes. (vanderbilt.edu)
Fungal mitochondria have been linked to diverse processes including energy metabolism, cell differentiation, drug resistance, biofilm and hyphal growth regulation, and virulence, among others, so an understanding of these organellar genomes is important to grasping the complete genomic profile of section Flavi ," explained Hugaboom. (vanderbilt.edu)
VU alumni Miya Hugaboom studied the nuclear and mitochondrial genomes of 20 different Aspergillus species within section Flavi . (vanderbilt.edu)
The study suggests that the majority of Alu insertions in primate genomes are the products of unique evolutionary events. (ojp.gov)

Improved viral genomic surveillance can assist in better understanding viral transmission dynamics in Africa. (cdc.gov)
Since the emergence of the COVID-19 pandemic, many genomic studies have shown that the SARS-CoV-2 genome undergoes recurrent mutations, indicating a continuous viral adaptation process inside host cells. (news-medical.net)

Advances in genomic technologies and understanding are transforming personalised medicine. (birmingham.ac.uk)
As genomic medicine has provided important advances in the clinical realm, genomic approaches can also have major implications for public health. (cdc.gov)

We performed a comprehensive genome profiling assay in patients with relapsed and refractory (R/R) AML, using the Foundation One Heme (F1H) panel, as a part of hematologic malignancies (HM)-SCREEN-Japan 01 (UMIN000035233), an actionable mutation profiling multicenter study. (confex.com)

The genomic and clinical resources generated by H3Africa investigators will facilitate studies of the environmental, cultural and genetic determinants of diseases that are important to Africans and other human populations. (nih.gov)
The genomic research landscape has transformed dramatically since the completion of the human genome project in 2003, but focus in the field has been constrained, in terms of worldwide populations included in this research. (nature.com)
Using this process to interrogate an individual's entire genome, the proportion of an individual's genomic inheritance from specific ancestral populations can be estimated. (nature.com)
The aim is to develop a genomic tool to monitor inbreeding in wild populations. (wur.nl)
Survival, migration patterns and population genetics will be studied and compared with patterns of large populations. (wur.nl)
Genetic studies to date have primarily been in populations of northern European ancestry," Watanabe added. (usc.edu)

Previously, a probe-selection method based on hybridisation of genomic DNA (gDNA) was developed, which enables GeneChips to be used for species that they were not designed for. (cambridge.org)

Genomic approaches to cardiovascular disease (CVD) have greatly improved our understanding of CVD and its risk factors and our ability to prevent and treat CVD. (cdc.gov)

Affymetrix GeneChip microarrays are a powerful tool to study global gene expression profiles and have been used on many species. (cambridge.org)
In this study, we demonstrate that gDNA-based probe selection on the Affymetrix Human U133+2 GeneChip array can be used to study gene expression profiles in sheep tissues. (cambridge.org)
The primary purpose of this study is to assess novel tumor genomic biomarkers (TRAF3 and CYLD gene defects and HPV integration) of recurrence risk in patients with Human papillomavirus+oropharyngeal squamous cell carcinoma (HPV+OPSCC) undergoing curative-intent therapy. (mayo.edu)
In this study, we analyzed the high frequency of FLT3 mutations in patients with R/R AML and found several patients who were positive for FLT3-N676K, a subclonal gene without concurrent ITD. (confex.com)
According to the study analysis, the mutation at 12053bp occurred within the open reading frame1ab (ORF1ab) gene. (news-medical.net)
Sequence analysis showed that these "young" Alu insertions represented gene conversion events of pre-existing ancient Alu elements or independent parallel insertions of older Alu elements in the same genomic region. (ojp.gov)
For example, a gene difference known for its role in sickle cell disease in African Americans was newly confirmed in Hispanics and Latinos during the study. (medlineplus.gov)

2022). Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission. (sanger.ac.uk)

A Johns Hopkins Kimmel Cancer Center team recently developed a model that uses such histopathological factors to predict whether Genomic Health's Oncotype DX would place a patient at high or low risk of tumor recurrence. (genomeweb.com)
Michael S. Leapman, MD, MHS, highlights a study of patient experiences with tissue-based genomic testing during active surveillance for prostate cancer. (urologytimes.com)
The main message is that patients have a wide variety and broad range of informational needs when it comes to tissue-based genomic testing in localized prostate cancer," says Michael S. Leapman, MD, MHS. (urologytimes.com)
The interviews were designed to gain an understanding of the patients' experiences with biopsy-based genomic testing as they made decisions regarding management of their prostate cancer. (urologytimes.com)
We'll begin by discussing your presentation on patient experiences with tissue-based genomic testing during active surveillance for prostate cancer. (urologytimes.com)
The purpose behind this study was to understand and elevate the experience of patients with prostate cancer who undergo active surveillance. (urologytimes.com)
And so there had been a proliferation of new tools that help us risk stratify and diagnose prostate cancer in general, and for the subset of patients who are diagnosed with a low grade, non-aggressive prostate cancer who monitor their disease, genomic testing has been one of the tools that has been useful to identify patients who may be at higher or lower risk for reclassification or progression over time. (urologytimes.com)
We took purposeful efforts to make sure that we included racial and ethnic minorities that are historically underrepresented in prostate cancer studies. (urologytimes.com)
You will learn how to interrogate genomic data to identify and investigate the pathogenicity of genetic variants, and relate these to real-life case-studies, providing meaningful information that can be useful for families affected by inherited conditions, or for patients with acquired diseases including cancer and infections. (birmingham.ac.uk)
Funding for this study was provided by the Olayan Fund for Precision Pediatric Cancer Medicine. (ascopost.com)
There is a lack of survival data for many oncology drugs approved for genomic indications in recent years, according to research published in the European Journal of Cancer . (cancertherapyadvisor.com)

Human diseases involving genomic imprinting include Angelman, Prader-Willi, and Beckwith-Wiedemann syndromes. (wikipedia.org)

As new variants emerge, DoD medical and public health practitioners should maximize the use of genomic surveillance resources within DoD to inform force health protection measures. (health.mil)
Genomic surveillance supports the development of diagnostics, therapeutics, and vaccines and can help monitor their effectiveness over time. (health.mil)

7 Genomic data have also become critical components of epidemiology and outbreak response. (health.mil)

A team of scientists from South Korea and the United States has conducted an interesting study to investigate whether mutations in the genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can affect the severity of coronavirus disease 2019 (COVID-19). (news-medical.net)

Apart from its genetic complexity, the feasibility of genomic prediction has been proven for blueberry, enabling a reduction in the breeding cycle time and increasing genetic gain. (nature.com)
We anticipate that the benefits and pipeline described in our study can be applied to optimize genomic prediction for other diploid and polyploid species. (nature.com)
Genomic prediction, originally proposed for animal breeding (Meuwissen et al. (nature.com)
The increase in accuracy of prediction by using genomic information has been well-documented. (springer.com)
In this study, we explored (1) G × E interactions for broiler body weight (BW) at weeks 5 and 6, and (2) the benefits of using genomic information for prediction of BW traits when selection candidates were raised and tested in a B environment and close relatives were tested in a C environment. (springer.com)
The use of combined pedigree and genomic information increased population accuracy of EBV, and reduced bias of EBV prediction for genotyped birds compared to the use of pedigree information only. (springer.com)

Alissa Interpret is your universal genomic data interpretation software for clinical decision support. (agilent.com)
Develop the skills and knowledge to apply genomic technologies and data interpretation to clinical practice or scientific research. (manchester.ac.uk)

African scientists will conduct genomic research on kidney disease, diabetes, heart disease, obesity, tuberculosis and African sleeping sickness through inaugural grants of the Human Heredity and Health in Africa Consortium (H3Africa). (nih.gov)
Genetic data from participants will also be used to create a genomic registry meant to support research for many years. (mayo.edu)
Medical records research - uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best. (mayo.edu)
The Center for Genomic Gastronomy is an independent research group that examines the biotechnology and biodiversity of human food systems. (wikipedia.org)
Their Research is split into five primary research streams: Cultures of Biotechnology Eating in the Anthropocene Databases of Taste Protein Futures Food Phreaking WHABBH poster designed by the Center for Genomic Gastronomy (2010) The Center for Genomic Gastronomy's research has been featured and reviewed in The Lancet, Nature, and Chemical & Engineering News. (wikipedia.org)
Hugaboom joined the Rokas Lab after completing an independent study course taught by Hatmaker and started this research as an undergraduate honors thesis project. (vanderbilt.edu)
This study was funded by Vanderbilt Data Science Institute Summer Research Program, the National Institutes of Health/National Eye Institute (F31 EY033235), the National Science Foundation (DEB-2110404), the National Institutes of Health/National Institute of Allergy and Infectious Diseases (R56 AI146096 and R01 AI153356), and the Burroughs Wellcome Fund. (vanderbilt.edu)
The lack of representation of diverse ancestral backgrounds in genomic research is well-known, and the resultant scientific and ethical limitations are becoming increasingly appreciated. (nature.com)
It is expected that greater representation of those with African ancestry in genomic research will bring novel insights into human biology, and lead to improvements in clinical care and improved understanding of health disparities. (nature.com)
Here, we evaluate the promise of including diverse individuals in genomic research in the context of recent literature on individuals of African ancestry. (nature.com)
With a focus on the African continent, consistent with the authors' expertise, we evaluate the evidence to support the expected progress from including diverse individuals in genomic research relative to: novel insights into human biology, improvements in clinical care, and enhanced understanding of health disparities (Table 1 ). (nature.com)
For clarity, and to be consistent with recently published guidelines for characterizing ancestry in genomic research, 10 we here use "individuals of African ancestry" to describe sub-Saharan Africans and those who identify as African American or Afro-Caribbean. (nature.com)
This is important because the majority of genomic research has been based on people of white European ancestry. (medlineplus.gov)
By including multi-ethnic participants, a large-scale genetic study has identified more regions of the genome linked to type 2 diabetes-related traits than if the research had been conducted in Europeans alone. (usc.edu)

The study concluded that multiplex analysis of these loci was not reproducible as a result of the large PCR (polymerase chain reaction) amplicons that contained a significant proportion (greater than 98 percent) of nearly identical genetic material (L1 element). (ojp.gov)

2001 ), involves the use of genomic information to predict the genetic merit of untested genotypes. (nature.com)
After validation, the model is used to predict the genomic breeding value of candidates in a selection set. (nature.com)
A single-step genomic BLUP (ssGBLUP) model that combined pedigree and genomic information was used to predict EBV. (springer.com)

The IGVF Consortium is being designed to advance the state-of-the-art for finding and characterizing genomic variants, the genomic elements in which they reside or affect, and the influences that they have on human health and disease. (genome.gov)

Methods and analysis This is a prospective observational cohort study performed at 16 centres throughout Australia. (bmj.com)
These include the AMD-MMAP Cohort Study, Whole Genome Association Twin Study of Myopia and Glaucoma Risk Factors, and NEI Age-related Eye Disease Study. (nih.gov)

Genomic imprinting is an inheritance process independent of the classical Mendelian inheritance. (wikipedia.org)

It's no exaggeration to say that we're at the dawn of a new genomic era in which the systematic study of repeats and their functions is possible," says Christopher Douse. (lu.se)

Finally, they created new methods to improve the genomic evaluation of cross-bred animals. (europa.eu)

Constitutional chromosome studies involving conventional GTG band cytogenetic analysis, however, often show unbalanced karyotypes which cannot be fully defined because the extra material is too small to have a recognisable banding pattern. (bmj.com)
We provided the support study for the impact assessment by doing a thorough literature analysis, conducting around 60 interviews, launching a survey addressing 400 targeted stakeholders, and organising focus groups and case studies. (technopolis-group.com)
They conducted whole-genome sequence analysis to study the presence or absence of mutations on each genetic locus of SARS-CoV-2, as well as to evaluate the correlation between genetic mutations and patient mortality rates. (news-medical.net)
The analysis encompassed 53 drugs approved by the FDA for 92 genomic indications. (cancertherapyadvisor.com)
The study, a genome-wide meta-analysis, has identified more regions of the genome that are linked to blood glucose and insulin levels, features that contribute to the risk of type 2 diabetes. (usc.edu)
Random Amplified Polymorphic DNA (RAPD) analysis was carried out to study genomic changes using 10 different random primers. (cdc.gov)
No significant genomic changes were observed by RAPD analysis. (cdc.gov)

The aim of the present study was to dissect the genetic basis of root traits at late growth stages and its implications on shoot traits in wheat. (cgiar.org)
Recently developed genomic technologies measure hundreds of thousands of single nucleotide polymorphisms (SNPs) across the genome and relate them to complex disorders and common genetic traits. (nih.gov)
The G × E interaction was strong for BW traits of broilers measured in environments B and C. The use of combined pedigree and genomic information increased population accuracy of EBV substantially for genotyped birds in the B environment compared to the use of pedigree information only. (springer.com)

Despite their abundance, scientists have yet to fully understand their role in human biology - in large part due to technological limitations in studying these genetic repeats. (lu.se)

Literature and Food Studies (2017), Amy L. Tigner, Allison Carruth. (wikipedia.org)

The goal of this study was to develop a Fast Healthcare Interoperability Resources (FHIR)-based web app, NGS Quality Reporting (NGS-QR), to report and manage the quality of the information obtained from clinical NGS genomic tests. (jmir.org)

CGH has been widely applied to detect gains and losses of DNA sequences on specific chromosomes in the study of solid tumours, 1 but has not been extensively used to study unbalanced constitutional karyotypes. (bmj.com)

Forms of genomic imprinting have been demonstrated in fungi, plants and animals. (wikipedia.org)

The genomic data of the new coronavirus responsible for COVID-19 show that its spike protein contains some unique adaptations. (nih.gov)

This is precisely what the EU-funded GenTORE (Genomic management Tools to Optimise Resilience and Efficiency) project has set out to achieve. (europa.eu)

The study, published in Nature Communications , examined the effectiveness of this policy by analysing contact-tracing data from NHS Test and Trace and genome sequences made available through COG-UK. (sanger.ac.uk)

The aim of this study is to explore the clinical utility and cost-effectiveness of genomic testing within a national cohort of patients with suspected genetic kidney disease who attend multidisciplinary renal genetics clinics. (bmj.com)

You can also contact the Center for Individualized Medicine for information on clinical studies and trials. (mayo.edu)
Learn from clinical and academic experts from The University of Manchester, Manchester Centre for Genomic Medicine. (manchester.ac.uk)
Study at a university ranked 8th in the UK and among the top 35 in the world for medicine (QS World University Rankings 2023). (manchester.ac.uk)
Please visit the Genomic Medicine CPD units page. (manchester.ac.uk)
Genomic Medicine Nordic Conference is an annual event organized by Biotexcel in partnership with Odense University Hospital and the Kennedy Centre at Rigshospitalet. (wikicfp.com)

It's great that our Mount Sinai colleagues reached the same conclusions from their patient samples," said Adriana Heguy, director of the Genome Technology Center at NYU Langone Health, in an email, calling the study a "nice independent replication. (genomeweb.com)
If you do not want the results of this genetic testing to be part of your electronic health record, you should not take part in this study. (mayo.edu)
The delivery of personal genomic risk through a trained health professional resulted in significantly higher comprehension. (karger.com)
However, the concepts presented may extend directly to all individuals with any degree of a particular ancestry, as ancestry at a genomic locus of interest may have important health effects, regardless of self-identification. (nature.com)
To implement clinical NGS applications, health care providers operate their own NGS laboratories or request genomic tests to external laboratories. (jmir.org)
This information, along with data on ZDV efficacy in preventing perinatal transmission (3) and evidence that PEP prevented or ameliorated retroviral infection in some studies in animals (4), prompted a Public Health Service (PHS) interagency working group *, with expert consultation (5), in June 1996 to issue provisional recommendations for PEP for HCWs after occupational HIV exposure (6). (cdc.gov)
1998. In January 2002, the Ministry of dence of pneumococcal sepsis provided a Health decided to launch a pilot study for powerful incentive for the widespread im- neonatal screening of sickle cell disease be- plementation of neonatal screening for fore expanding it at the national level. (who.int)

Results from this study suggest that] the two datasets, nuclear and mitochondrial, had overall similar evolutionary histories," said Hatmaker. (vanderbilt.edu)

This app could also motivate laboratories to perform diagnostic tests to provide high-quality genomic data. (jmir.org)

These studies require a minimum number of participants to ensure statistical power. (cdc.gov)
Participants were asked to indicate their genomic risk and overall lifetime risk as reported on their test report as well as to interpret their genomic risk (increased, decreased, or same as population). (karger.com)
Participants who received their results in-person were more likely than those who reviewed their results on-line to correctly interpret their genomic risk (72 vs. 47%, p = 0.0002) and report their actual genomic risk (69 vs. 49%, p = 0.002). (karger.com)

Anatomy20

Organisms10

Diseases11

Chemicals and Drugs34

Analytical, Diagnostic and Therapeutic Techniques and Equipment48

Phenomena and Processes155

Disciplines and Occupations6

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Information Science12

Health Care5

High-throughput4

Sequencing11

Phenotypic4

Genomics7

Genetic and genomic5

Impact of genomic5

Utility of genomic2

Analyses5

Tumors5

Researchers14

Genes9

20211

Diversity7

Outcomes3

Molecular7

Diagnosis1

Variation5

Comparative5

20204

Phenotype1

Findings5

Alterations4

Genomes7

Viral2

Advances2

Profiling1

Populations6

Hybridisation1

Approaches1

Gene7

20221

Cancer11

Prader-Willi1

Surveillance2

Epidemiology1

20191

Prediction6

Data interpretation2

Research14

Loci1

Predict3

Consortium1

Cohort study2

Inheritance1

Systematic1

Methods1

Analysis7

Traits3

Scientists1

20171

Develop1

Tumours1

Fungi1

Coronavirus1

Resilience1

Sequences1

Kidney disease1

Medicine5

Health7

Suggest1

Diagnostic1

Participants3