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  • vivo
  • Consistent with the strong positive correlation in vivo, we also observed a dose response in genetic instability and PTTG expression (GI-Index low dose (0.5μg DNA/ 6-well plate) PTTG = 15.3% +/-1.7 vs. high dose (2 μg DNA) PTTG = 50.8% +/-3.3, p = 0.006). (aacrjournals.org)
  • Defects
  • The mitotic and cytokinesis defects caused by SETD2 loss were independent of SETD2-dependent histone methylation, confirming that α-tubulin methylation is responsible for the observed genomic instability. (aacrjournals.org)
  • Here, we show that besides the premature mitotic entry phenotype, Wee1 mutant murine cells fail to complete mitosis properly and exhibit several additional defects that contribute to the deregulation of mitosis, allowing mutant cells to progress through mitosis at the expense of genomic integrity. (sigmaaldrich.com)
  • scientists
  • Scientists have currently identified twenty-five of these regions to be directly associated with some form of a genomic disorder. (wikipedia.org)
  • results
  • The report will contain data from literature and results of own research directed to the analyzing the impact of the degree of emotional stress expression on the children's and adults' genomic instability. (scirp.org)
  • Our results suggest that paternal exposure to a wide variety of mutagens can result in transgenerational instability manifesting in their offspring. (nih.gov)
  • repair
  • Recent data from our groups and others support two main notions, that these damaged clusters are: (1) repair resistant, increasing genomic instability (GI) and malignant transformation and (2) can be considered as persistent "danger" signals promoting chronic inflammation and immune response, causing detrimental effects to the organism (like radiation toxicity). (mdpi.com)
  • higher
  • Moreover, BubR1 +/− Apc Min/+ MEFs slipped through mitosis in the presence of nocodazole and exhibited a higher rate of genomic instability than that of wild-type or BubR1 +/− or Apc Min/+ MEFs, which was accompanied by premature separation of sister chromatids. (aacrjournals.org)