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  • Locus
  • Due to the similar organization of the mouse and human LNCAT/Ube3a-ATS and the fact that the mouse Ube3a locus is also imprinted, the mouse is an excellent model system to study imprinting and the interactions between Ube3a/Ube3a-ATs. (wikipedia.org)
  • mammals
  • Genetic imprinting prevents parthenogenesis in mammals, and hence forces sexual reproduction and its multiple consequences on genetics and phylogenesis. (wikipedia.org)
  • genetic
  • Researchers say that with a better understanding of genomic imprinting , a host of complex, inherited diseases may finally begin to make genetic sense. (thefreedictionary.com)
  • Imprinting is a type of genetic effect characterized by parent-to-offspring transmission whereby the expression of the phenotype in the offspring depends on whether the transmission originated from the mother or father. (biomedcentral.com)
  • DNMT3A is essential for genetic imprinting. (wikipedia.org)
  • Susceptibility
  • Welcome to the Genomic Imprinting and Environmental Disease Susceptibility Symposium webpage. (geneimprint.com)
  • Although imprinting has an important role in the regulation of growth and development through its role in regulating gene expression, its contribution to susceptibility to common complex disorders is not well understood. (biomedcentral.com)
  • In addition to the susceptibility genes identified through conventional association studies, a small number of diabetes-associated genes has been discovered whose effects are mediated through imprinting. (biomedcentral.com)
  • Imprinted genes are in fact only one mechanism through which transmission of disease risk from parent to offspring may be influenced by the sex of the parent transmitting the susceptibility factor. (biomedcentral.com)
  • disorders
  • Capsule Disturbances in imprinted genes cause several human diseases involving neurological disorders, obesity, diabetes and malignancies with expression patterns of imprinted genes potentially influenced by the environment including assisted reproductive technology. (springer.com)
  • A study on hybrid mice which investigated the possible causes for hybrid growth disorders reveals genomic imprinting to have a major effect. (wikipedia.org)
  • Overexpression of maternally imprinted genes is predicted to cause autism, which focuses attention to the maternally expressed genes on 15q11-13, although it is still possible that alterations in the expression of both imprinted and bilallelically expressed genes contribute to these disorders. (wikipedia.org)
  • Like other imprinting disorders (e.g. (wikipedia.org)
  • sequences
  • Genomic imprinting is when identical nucleotide sequences produce different phenotypes depending on whether they come from the male or female parent. (everything2.com)
  • A 2002 study revised the rules of CpG island prediction to exclude other GC-rich genomic sequences such as Alu repeats. (wikipedia.org)
  • parental
  • Genomic imprinting is the term that has been coined to describe this situation in which the phenotype expressed by a gene varies depending on its parental origin ( Sapienza, 1989 ). (jax.org)
  • molecular
  • Molecular biologists are particularly interested in understanding the nature of these imprints, and how it is possible to modify DNA in some way that is heritable but can then be reset. (edge.org)
  • abnormal
  • Just as normal imprints are maintained in long-term culture, this work suggests that abnormal imprints are also stable in culture. (biomedcentral.com)
  • Similarly, a study of hybrids between dwarf hamster species Phodopus campbelli and Phodopus sungorus suggests that gene imprinting causes abnormal interactions between growth-promoting and growth-repressing genes which regulate placental and embryonic growth. (wikipedia.org)
  • mouse
  • Publications] F.ISHINO et al: 'Screening of imprinting in the mouse. (nii.ac.jp)
  • Publications] F.Ishino et al: 'Screening of imprinting genes in the mouse' Abstracts in The Eighth International Conference of the International Society of Differentiation Hiroshima. (nii.ac.jp)
  • Studies of the mouse gene, however, which is also located in an imprinted gene domain, have shown that the product of this gene regulates placental growth. (wikipedia.org)
  • In addition, mouse neurons continue to retain their imprinting pattern in culture. (wikipedia.org)