• Whipworms are common soil-transmitted helminths that cause debilitating chronic infections in man. (nature.com)
  • They are one of three major groups of soil-transmitted helminths (STHs), the others being Ascaris and hookworms, that impede the socioeconomic development of entire populations. (nature.com)
  • The most common human diseases are caused by soil-transmitted helminths (STHs) causing ascariasis, trichuriasis and hookworm infection (necatoriasis, ancylostomiasis), followed by schistosomiasis and lymphatic filariasis [ 1 ]. (biomedcentral.com)
  • Here we present high-quality genome sequences for T. trichiura and T. muris , the first duo of a major human STH and its mouse counterpart. (nature.com)
  • In parallel, multiple technologies and manual finishing were used to produce an 85-Mb reference genome assembly from the more readily available mouse parasite species T. muris (Online Methods and Supplementary Note ). (nature.com)
  • Further analyses of the genomes of 72 arthropods species show that the loss of arginine synthesis is common in arthropods. (biomedcentral.com)
  • Awarded to Dr. Ken Cadwell at the Skirball Institute of Biomolecular Medicine for his project "Whole genome sequencing of helminth-associated Clostridia species" and Dr. Ralf Duerr at the Department of Pathology for his project "Unraveling functional HIV-1 sequence marks that are associated with beneficial disease parameters using SMRT Sequencing. (pacb.com)
  • It will be vitally important for UK species and UK genome science, and will lay the pathway for future biodiversity genome projects around the world. (sanger.ac.uk)
  • However, the application of new techniques, such as CRISPR, to the study of trematodes and nematodes has opened new avenues for genome editing-powered functional genomics for these pathogens. (biomedcentral.com)
  • This review summarises the historical advances in functional genomics in parasitic helminths and highlights pending limitations that will need to be overcome to deploy transgenesis tools. (biomedcentral.com)
  • At the time of its official opening by the Princess Royal in 1994, the Wellcome Genome Campus was already home to the Wellcome Sanger Institute (then called the Sanger Centre), the Medical Research Council's Human Genome Mapping Project Resource Centre, the European Molecular Biology Laboratory's European Bioinformatics Institute (EMBL-EBI). (wikipedia.org)
  • The Wellcome Trust established the Sanger Centre in 1992 to undertake the most ambitious project ever attempted in biology, sequencing the human genome. (wikipedia.org)
  • Understanding the biology of helminths using genomic and proteomic approaches could contribute to advances in understanding host-helminth interactions and lead to new vaccines, drugs and diagnostics. (biomedcentral.com)
  • This step relies on the availability of well-curated genomic, transcriptomic and proteomic databases, as well as on a detailed knowledge of helminth biology. (biomedcentral.com)
  • Progress in helminth biology research has gone hand in hand with the advances in techniques for genome sequencing and proteome characterisation. (biomedcentral.com)
  • Awarded to Dr. Hindra Hindra of Dr. Marie Elliot's lab at the Department of Biology and the Michael G. DeGroote Institute for Infectious Disease Research at McMaster University for his project "Unlocking the treasure chest: New antibiotic discovery and characterization using PacBio-enabled genome sequences. (pacb.com)
  • The Parasite Genomics group uses comparative and functional genomics approaches to investigate the biology of helminths and protozoan parasites. (sanger.ac.uk)
  • Genome biology and evolution. (nyu.edu)
  • Awarded to Dr. Aya Nonaka at the Genome Science Laboratory for her project "Involvement of isoform genes in heterogeneous alpha-fetoprotein producing gastric cancer (AFPGC)", which will include single-cell Iso-Seq analysis of AFPGC organoids using a PacBio Sequel II System to identify the contribution of isoforms to the differentiation of AFPGC. (pacb.com)
  • The draft genomes encode multiple antibiotic-resistance genes, competition factors, Flavobacterium johnsoniae-like gliding motility genes and a homologue of the Pasteurella multocida mitogenic toxin. (ox.ac.uk)
  • The availability of these two important whipworm genomes and the integration of parasite and host data presented here will underpin future efforts to control these parasites and exploit their immunological interplay for human benefit. (nature.com)
  • We report here the whole-genome sequences of the human-infective Trichuris trichiura and the mouse laboratory model Trichuris muris . (nature.com)
  • PacBio Genome Sequences of Escherichia coli Serotype O157:H7, Diffusely Adherent E. coli , and Salmonella enterica Strains, All Carrying Plasmids with an mcr-1 Resistance Gene. (cdc.gov)
  • Genome-based prediction of bacterial antibiotic resistance. (cdc.gov)
  • Since the announcement of the completion of the draft human genome in 2000, and final completion in 2003, rapid progress in sequencing technology has enabled new and exciting areas of Science to be opened up for exploration. (wikipedia.org)
  • The rapid development of new sequencing platforms, such as Roche 454 sequencing system (Roche Diagnostics) and Illumina sequencing platforms (Illumina, Inc.) offered 1000-fold increase in throughput over the Sanger sequencing technology and supported the progressive publication of more helminth genomes [ 11 ]. (biomedcentral.com)
  • Whole-Genome Sequencing and Bioinformatic Analysis of Isolates from Foodborne Illness Outbreaks of Campylobacter jejuni and Salmonella enterica. (cdc.gov)
  • Evaluation of Whole-Genome Sequencing for Identification and Typing of Vibrio cholerae. (cdc.gov)
  • See how the University of Washington used HiFi sequencing to uncover a key finding about ALS and the human genome. (pacb.com)
  • Our revolutionary sequencing technologies combine the completeness of long reads with the accuracy of short reads to provide the most comprehensive view of genomes, transcriptomes, and epigenomes. (pacb.com)
  • We produced a 75.2-Mb high-quality draft genome assembly from a clinically isolated adult male T. trichiura using Illumina technology. (nature.com)
  • Candidatus Ornithobacterium hominis': insights gained from draft genomes obtained from nasopharyngeal swabs. (ox.ac.uk)
  • Here, we report seven genomes assembled from metagenomic data, two to improved draft standard. (ox.ac.uk)
  • The Wellcome Genome Campus is a scientific research campus built in the grounds of Hinxton Hall, Hinxton in Cambridgeshire, England. (wikipedia.org)
  • Wellcome funded the establishment of the Sanger Centre in 1993 and chose Hinxton as the home for its new genome research institute. (wikipedia.org)
  • Intra- and inter-host genome comparison suggests that colonization with this bacterium is both persistent and strain exclusive. (ox.ac.uk)
  • This was the largest single contribution of any centre to the Human Genome Project, making the Campus and its collaborations uniquely important in the history of genomics. (wikipedia.org)
  • To address this question, here, we present a chromosome-level genome assembly of the parasitoid wasp Cotesia chilonis and reconstruct its amino acid biosynthetic pathway. (biomedcentral.com)
  • Helminth infections impact the health of hundreds of millions of persons globally and also cause important economic losses in livestock farming. (biomedcentral.com)
  • Globally, helminth infections have been estimated to have resulted in approximately 14 million disability-adjusted life years (DALYs) lost yearly during the last decade [ 1 ]. (biomedcentral.com)
  • Despite all attempts, most vaccines against helminth infections remain trapped in early-stage development or are undergoing pre-clinical evaluation, and no human anti-helminth vaccine has yet been approved for widespread use [ 7 , 10 ]. (biomedcentral.com)
  • Notwithstanding, the marked complexity as well as the limitations in availability and access to samples still represent a great handicap for basic research on helminth infections [ 11 ]. (biomedcentral.com)
  • The genome assembly was produced by the Mitreva laboratory of the Division of Infectious Diseases at theWashington University School of Medicine in St. Louis . (wormbase.org)
  • Shortly after, EMBL-EBI located on the same site, and the two institutes formed a natural fit, consolidating expertise, facilities and knowledge in one place and enabling both to contribute a major role in the Human Genome Project - a global collaboration to sequence the first 'reference' human genome. (wikipedia.org)
  • The first version of this assembly submitted in late 2013 as part of the 50 Helminth Genomes project. (wormbase.org)
  • The Darwin Tree of Life's ambition, to map the genome of every Eukaryotic organism in the UK and Ireland, is at the leading edge of the Earth BioGenome Project - a global effort to map the DNA of all complex life. (sanger.ac.uk)
  • We sequenced the genome of a parasitoid wasp, C. chilonis , and revealed the features of trait loss in amino acid biosynthesis. (biomedcentral.com)
  • The genomes are approximately 1.9 Mb, sharing 62 % average amino acid identity with the only other member of the genus, the bird pathogen Ornithobacterium rhinotracheale. (ox.ac.uk)
  • One third of the human genome was sequenced for the first time at the Wellcome Trust Sanger Institute, and the precious data was stored and shared through EMBL-EBI. (wikipedia.org)
  • The site remained under their ownership until it was sold to Genome Research Limited in 1992. (wikipedia.org)
  • As viral genomic imprints in host genomes, endogenous viral elements (EVEs) shed light on the deep evolutionary history of viruses, ancestral host ranges, and ancient viral-host interactions. (worktribe.com)