• Comparative analyses of its 38.5-megabase genome, which encodes 13,210 predicted genes, reveal the species's unique wood-degrading machinery. (nature.com)
  • One-third of the 471 genes predicted to encode transcription factors are differentially expressed during sexual development of S. commune . (nature.com)
  • Based upon clustering the cDNAs and mapping them with their respective genomes, the estimated numbers of genes were 9,134 for the mouse neural retina and 12,050 for the rat retinal pigmented epithelium libraries. (bvsalud.org)
  • Within the Arabidopsis genome, 1,533 genes were found to encode members of known transcription factor families, 45% of which are from families specific for plants. (biomedcentral.com)
  • Tumor suppressor genes encode proteins that normally provide negative control of cell proliferation. (medscape.com)
  • As the authors point out, the function of approximately 40-50% of the proteins encoded by each genome cannot be determined on the basis of similarities to proteins of known function. (biomedcentral.com)
  • A comparative study based on four fully sequenced eukaryotic genomes has revealed profound differences in the sets of transcription factors used by plants, fungi and animals. (biomedcentral.com)
  • A variety of prominent transcription factor families are present in all four species, including Myb, basic helix-loop-helix, basic leucine zipper, C2H2 zinc finger and homeodomain transcription factors. (biomedcentral.com)
  • Exon shuffling has led to transcription factors unique to plants that contain both homeodomains and leucine zippers. (biomedcentral.com)
  • Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. (biomedcentral.com)
  • Np17 is located on chromosome 8, consists of 7 exons, and encodes a 16.8kDa nuclear protein with149 amino-acid residue. (aging-us.com)
  • Given that we previously defined the viral np9 gene, which is aberrantly activated in human leukemia, as a potent oncogene [ 1 ], we next attempted to search for cellular homologs of the viral oncogene np9 in NCBI database by performing alignment using Np9 protein sequence. (aging-us.com)
  • RB1 encodes the protein pRB and was the first tumor suppressor gene to be molecularly defined. (medscape.com)
  • TP53 encodes the protein p53, which is known as the "guardian of the genome. (medscape.com)
  • PTEN encodes a protein kinase of the same name and functions as a tumor suppressor through regulation of cell proliferation. (medscape.com)
  • Contrasting with high within-species nuclear genome divergence, mitochondrial genome divergence between the three ameiotic asexuals was very low, signifying that these putative hybrids share a recent common maternal ancestor. (bvsalud.org)
  • In this study, we have identified and characterized a novel cellular homolog of HERV-K np9 gene, which encodes a nuclear oncoprotein of 17kDa associated with human leukemia and is referred to as np17 gene. (aging-us.com)
  • To disentangle this surprising parasitic success despite the absence of sex and genetic exchanges, we have sequenced and assembled the genomes of three obligatory ameiotic and asexual Meloidogyne. (bvsalud.org)
  • Our understanding of the landscape of pediatric cancer genomics has improved markedly in the past 20 years with the advent of next generation sequencing and other high throughput genetic sequencing. (medscape.com)
  • With the completed genome sequences of Saccharomyces cerevisiae (budding yeast), Caenorhabditis elegans and Drosophila melanogaster , complete proteomes from representatives of three eukaryotic kingdoms (plants, fungi and animals) are now available for comprehensive comparative studies. (biomedcentral.com)
  • These results suggest a substantial functional impact of the genome structure. (bvsalud.org)
  • Considering the high ploidy levels of the Spartina genomes under study, and considering the absence of diploid reference genome and the need of an appropriate analytical strategy, we developed generic bioinformatics tools to (1) detect different haplotypes of each gene within each species and (2) assign a parental origin to haplotypes detected in the hexaploid hybrids and the neo-allopolyploid. (bvsalud.org)
  • Transposable elements (TE) cover a ~1.7 times higher proportion of the genomes of the ameiotic asexual Meloidogyne compared to the sexual relative and might also participate in their plasticity. (bvsalud.org)
  • See Fig. 2 for the nucleotide sequences of the primers. (nih.gov)
  • Samples of mtDNA were amplified using 24 pairs of overlapping primers to analyze the entire mitochondrial genome to screen for variations and analyzed for both coding and non-coding regions. (molvis.org)
  • Simple sequence repeat (SSR) markers were developed based on unpublished whole-genome sequencing data of Origanum vulgare, and 64 codominant SSR primers were screened on the parents of the six oregano combinations. (bvsalud.org)
  • One group of homeodomain proteins, called the TALE (for three amino acid loop extension) group, has an additional three amino acids separating the first and second alpha helices, resulting in a 63, instead of the more typical 60, amino acid homeodomain ( Burglin,1997 ). (biologists.com)
  • In addition, nucleotide sequence analysis of the homeobox regions of cloned Hox-4.3 and Hox-4.2 genomic DNA revealed some differences in nucleotide sequences and in the deduced homeodomain amino acid sequences compared with the sequences that have been reported. (nih.gov)
  • Two TALE subgroups, MEIS and PBC, function as cofactors for the Hox homeodomain proteins ( Mann and Affolter,1998 ). (biologists.com)
  • Conclusions We suggest that TBX20-I121M adopts a more fluid tertiary structure leading to enhanced interactions with cofactors and more stable transcriptional complexes on target DNA sequences. (bmj.com)
  • Many quantitative trait loci (QTLs) have been identified from genome-wide association studies (GWAS) for complex phenotypes over the last decade, but the understanding of their underlying functions is mostly vague [ 1 ]. (biomedcentral.com)