Genome wide methylation analysis reveals. Medical search. Frequent questions

Gene ontology analysis revealed enrichment of genes associated with the immune system , inflammatory processes, and cancer pathways. (bvsalud.org)
Bioinformatics analysis determined seven gene clusters with a significant difference in overall survival (OS) and further revealed a distinct feature that the conservation of a large gene cluster (approximately 70 kb) metallothionein-1 (MT1) among 45 species is much lower than the average of all RefSeq genes. (biomedcentral.com)
One of the most widely studied DNA methylation dysregulation is the promoter hypermethylation where the CPGs islands in the promoter regions are methylated contributing or causing genes to be silenced. (wikipedia.org)
The changes include histone modifications, CpG island methylations and chromatin reorganizations which can cause the stable silencing or activation of particular genes. (wikipedia.org)
In colorectal cancers about 600 to 800 genes are transcriptionally silenced, compared to adjacent normal-appearing tissues, by CpG island methylation. (wikipedia.org)
Genes can be silenced by multiple methylation of CpG sites in the CpG islands of their promoters. (wikipedia.org)
compared transcriptional profiles using DNA microarrays to survey differentially expressed genes between parthenotes (2 maternal genomes) and control fetuses (1 maternal, 1 paternal genome). (wikipedia.org)
Epigenetic analysis revealed a specific N 6 -methyl adenine (m 6 A) methylating pattern including methylation of alginate, flagellar and quorum sensing associated genes. (frontiersin.org)
Genome imprinting is an epigenetic marking mechanism that causes genes to be expressed in a parental-origin-specific manner. (bmj.com)
Genome-wide location analysis revealed that Cbx3 predominantly binds active genes in both pre-iPSCs and pluripotent cells but with a strikingly different distribution: in pre-iPSCs, but not in embryonic stem cells, Cbx3 associates with active transcriptional start sites, suggesting a developmentally regulated role for Cbx3 in transcriptional activation. (ca.gov)
DNA methylation is a so-called epigenetic modification that is involved in regulating how the genes of each cell in the body are turned on or off, and is impacted by both hereditary as well as environmental factors, such as physical exercise. (neurosciencenews.com)
Our new findings indicate that sleep loss causes tissue-specific changes to the degree of DNA methylation in genes spread throughout the human genome. (neurosciencenews.com)
It is interesting that we saw changes in DNA methylation only in adipose tissue, and specifically for genes that have also been shown to be altered at the DNA methylation level in metabolic conditions such as obesity and type 2 diabetes. (neurosciencenews.com)
In a genome-wide screen for putative tumor suppressor genes, the EBF3 locus on the human chromosome 10q26.3 was found to be deleted or methylated in 73% of the examined cases of brain tumors. (aacrjournals.org)
Using Ingenuity pathway analysis, we found that differentially methylated genes were highly enriched in functional pathways such as cancer, cell death and survival, and hematological disease. (oncotarget.com)
A multidimensional bioinformatics analysis was performed to examine the relationship between NRP genes and prognostic and pathological features, tumour mutational burden (TMB), microsatellite instability (MSI), and immunological features based on public databases and find the potential prognostic value of NRPs in pancancer. (hindawi.com)
We found that p300/CBP-associated factor (PCAF)-dependent acetylation of histone 3 lysine 9 (H3K9ac), paralleled by a reduction in methylation of H3K9 (H3K9me2), occurred at the promoters of select genes only after PNS axonal injury. (nature.com)
Jumonji (JmjC) domain proteins (see Jarid2 ) influence gene expression and chromatin organization by way of histone demethylation, which provides a means to regulate the activity of genes across the genome. (sdbonline.org)
Generation of molecularly defined null mutants revealed that loss of 8 out of 13 JmjC genes modify position effect variegation (PEV) phenotypes, consistent with their ascribed role in regulating chromatin organization. (sdbonline.org)
Our analysis revealed that genes with conserved non-methylated promoters (e.g. (sruc.ac.uk)
Using DNAdemethylase genes sequence of Arabidopsis as reference, 25 DNA demethylase genes were identified in cotton byBLAST analysis. (zbook.org)
There are 4 genes in the genome D, 5 genes in the genome A, 10 genes in the genome AD1, and 6genes in the genome AD2. (zbook.org)
Forthe analysis of the conserved domain, it was known that the DNA demethylase family gene member has anendonuclease III (ENDO3c) domain.Conclusion: The genes of the DNA demethylase family are distributed differently in different cotton species, and thegene structure is very different. (zbook.org)
In this study, we performed quantitative methylation analyses of six differentially methylated imprinted genes (H19, MEG3, LIT1, NESP55, PEG3 and SNRPN), one hypermethylated pluripotency gene (OCT4) and one hypomethylated tumor suppressor gene (APC) in chorionic villus, fetal and adult cortex, and adult blood samples. (uni-wuerzburg.de)
Random set analysis was used to identify biological pathways enriched for genes differentially regulated in tumors (compared with 59 samples of normal mucosa). (biomedcentral.com)
2021). Genome-Wide DNA Methylation Profiling of Esophageal Squamous Cell Carcinoma from Global High-Incidence Regions Identifies Crucial Genes and Potential Cancer Markers. (who.int)
2020). Pan-cancer multi-omics analysis and orthogonal experimental assessment of epigenetic driver genes. (who.int)
The analysis revealed epigenetic changes in 800 genes in those with type 2 diabetes. (lu.se)

Unsupervised hierarchical clustering exhibited a significant association of methylation patterns with histological adenoma subtypes. (bvsalud.org)
Whole-exome sequencing and genome-wide methylation analyses identify novel disease associated mutations and methylation patterns in idiopathic. (oncotarget.com)
Differential methylation patterns in lean and obese non-alcoholicsteatohepatitis-associated hepatocellular carcinoma. (diagenode.com)
Using differential methylation hybridization as a genome-wide screening approach to determine DNA methylation patterns in gliomas, we recently identified two DNA fragments in 14q23.1 (CGI-clone musical sharp396) and 14q32.12 (CGI-clone musical sharp519) that were differentially methylated between astrocytic gliomas and mixed oligoastrocytomas. (nih.gov)
1986. "DNA methylation patterns of the calcitonin gene in human lung cancers and lymphomas. (esmed.org)
Now, researchers from the Hebrew University of Jerusalem have provided the first reconstruction of a Denisovan, based on patterns of methylation in their ancient DNA. (co.ke)
In the study, the researchers compared DNA methylation patterns between three early human groups to find regions in the genome that were very different. (co.ke)
The association of aberrant sperm DNA methylation patterns and compromised semen parameters suggests that disturbances in male germline epigenetic reprogramming contribute to this problem. (uni-wuerzburg.de)
However, little is known about the natural variation of genespecific methylation patterns. (uni-wuerzburg.de)
We found considerable variability of functionally important methylation patterns among unrelated healthy individuals and a trend toward more similar methylation levels in monozygotic twins than in dizygotic twins. (uni-wuerzburg.de)

In silico analysis revealed much lower gene expression of this cluster in The Cancer Genome Atlas (TCGA) cohort for ERα + tumors. (biomedcentral.com)
DNA methylation in cancer plays a variety of roles, helping to change the healthy cells by regulation of gene expression to a cancer cells or a diseased cells disease pattern. (wikipedia.org)
Differential gene expression analysis indicated that this isolate formed excessive biofilm by reducing flagellar formation (7.4 to 1,624.1 folds) and overproducing extracellular matrix components including CdrA (4.4 folds), alginate (5.2 to 29.1 folds) and Pel (4.8-5.5 folds). (frontiersin.org)
The cover for issue 52 of Oncotarget features Figure 1, "Volcano plots of DNA methylation in tumor tissues compared with nontumor tissue," published in "Reduction of T-Box 15 gene expression in tumor tissue is a prognostic biomarker for patients with hepatocellular carcinoma" by Morine, et al. (news-medical.net)
The tissue samples were used for multiple molecular analyses, which first of all revealed that the sleep loss condition resulted in a tissue-specific change in DNA methylation, one form of mechanism that regulates gene expression. (neurosciencenews.com)
For that purpose, hypotheses about the presence and responsiveness of different epigenetic mechanisms in corals, its interaction with the genome and microbial communities, as well as its role modulating gene expression and phenotypic responses to diverse stressors were explored. (fiu.edu)
Analysis of methylation quantitative-trait loci (metQTL) revealed that 28% of CpGs were associated with nearby SNPs, and when overlapping them with adipose expression quantitative-trait loci (eQTL) from the same individuals, we found that 6% of the loci played a role in regulating both gene expression and DNA methylation. (bcu.ac.uk)
Journal of Cotton Research(2019) RCHJournal of Cotton ResearchOpen AccessGenome-wide identification and expressionanalysis of DNA demethylase family incottonYANG Xiaomin, LU Xuke, CHEN Xiugui, WANG Delong, WANG Junjuan, WANG Shuai, GUO Lixue, CHEN Chao,WANG Xiaoge, WANG Xinlei and YE Wuwei*AbstractBackground: DNA methylation is an important epigenetic factor that maintains and regulates gene expression. (zbook.org)
Over the past 10 years we have been witness to an explosion of investigation into the epigenetic basis of cancer, and application of the powerful genome-wide DNA methylation profiling techniques to be reviewed have yielded critical insights into the organization of the cancer methylome with its broad regions of hypomethylation and foci of hypermethylation resulting in critical differences in gene expression and chromosomal stability compared to normal cells. (esmed.org)
DMRs show continuous gain or loss of methylation during differentiation, and the overall change in DNA methylation correlates inversely with gene expression at key loci. (lu.se)

Aberrant epigenetic changes, including DNA methylation and histone modifications, have been known to be the hallmark of cancer [ 1 ]. (biomedcentral.com)
Moreover, these long noncoding RNAs were transcriptionally regulated by epigenetic modification, including DNA methylation and histone methylation modification. (cancerindex.org)

Recent genome-wide analysis has shown that DNA methylation spans long stretches of chromosome regions consisting of clusters of contiguous CpG islands or gene families. (biomedcentral.com)
Previous research has shown that DNA methylation can drive speciation and modulate virulence in bacteria, but the impact of epigenetic modifications on the diversification and pathogenesis of R. solanacearum is unknown. (pacb.com)

Although gene methylation assays are used already for CRC screening , differential epigenetic alterations of recurring and nonrecurring colorectal adenomas have yet not been systematically investigated. (bvsalud.org)
2019). Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight. (who.int)
Our data reveal the differential expression landscape of 493 transcription factors and 682 lncRNAs and highlight specific expression clusters operating in HSCs. (lu.se)

Aberrant methylation of DNA is supposed to be a major and early driver of colonic adenoma development, which may result in colorectal cancer (CRC). (bvsalud.org)
Aberrant DNA methylation of GATA binding protein 3 (GATA3), interleukin-4 (IL-4), and transforming growth factor-β (TGF-β) promoters in. (oncotarget.com)
The purpose of this study was to investigate whether an aberrant DNA methylation of transcriptional and inflammatory factors, including TBX21, GATA3, RORγt, FOXP3, IFN-γ, IL-4, IL-17A and TGF-β , in CD4 + T confers risk to BD. (oncotarget.com)
Our results suggest that an aberrant DNA methylation of GATA3 and TGF-β is associated with their mRNA expression and participates in the pathogenesis of BD. (oncotarget.com)

Such quantitative approaches are thus able to provide more insights into the role of DNA methylation in the development of various diseases such as cancer. (biomedcentral.com)
Epigenetics and stroke: role of DNA methylation and effect of aging onblood-brain barrier recovery. (diagenode.com)

Here, the FDA's Epigenomics Quality Control (EpiQC) Group presents DNA methylation sequence data across all seven GIAB reference cell lines, as well as a comparative analysis of targeted and genome-wide methylation protocols, to serve as a comprehensive resource for epigenetics research. (biomedcentral.com)

We aimed to unveil differentially methylated CpG positions ( DMPs ) across the methylome comparing not only primary adenomas without recurrence vs primary adenomas with recurrence but also primary adenomas vs recurrent adenomas using the Illumina Human Methylation 450K BeadChip array. (bvsalud.org)
Differentially methylated CpG position (DMP) and region (DMR) analyses were performed alongside gradient boosting classification analyses to discern PSC-UC from UC patients. (figshare.com)

namely gain of methylation at paternally methylated loci and absence of methylation at maternally methylated regions. (nih.gov)
In addition, bioinformatic screening of the resulting methylation datasets identified over sixty loci with methylation profiles consistent with imprinting in the placenta, of which we confirm 22 as novel maternally methylated loci. (nih.gov)
An intriguing study surveying the transcriptome of murine brain tissues revealed over 1300 imprinted gene loci (approximately 10-fold more than previously reported) by RNA-sequencing from F1 hybrids resulting from reciprocal crosses. (wikipedia.org)

Surprisingly RHMs from two sisters with the same missense mutations, as well as consecutive RHMs from one affected female show subtle allelic methylation differences, suggesting inter-RHM variation. (nih.gov)
Our findings reveal that NRPs may be a potential prognostic marker associated with immune infiltration, tumour mutations, and tumour microenvironment, particularly in bladder urothelial carcinoma (BLCA). (hindawi.com)
RNA sequences, somatic mutations, and clinicopathological features of 33 cancers were downloaded from The Cancer Genome Atlas (TCGA) database. (hindawi.com)
Myelodysplastic Syndrome associated TET2 mutations affect NK cellfunction and genome methylation. (diagenode.com)
Our analyses of IDH1 mutations in for R132C mutations in astrocytes or glioblastomas from a population- precursor cel s that already carry a based study (407 cases) showed that germline TP53 mutation. (who.int)

It is an epigenetic process that involves DNA methylation and histone methylation without altering the genetic sequence. (wikipedia.org)

Our parallel analysis of both muscle and adipose tissue further enabled us to reveal that DNA methylation is not regulated similarly in these tissues in response to acute sleep loss," says Jonathan Cedernaes who led the study. (neurosciencenews.com)
Further analyses of e.g. gene and protein expression demonstrated that the response as a result of wakefulness differed between skeletal muscle and adipose tissue. (neurosciencenews.com)

The methylation defects observed in five RHM biopsies from NLRP7 defective patients are restricted to lack-of-methylation at maternal DMRs. (nih.gov)

Furthermore, we found that DNA methylation is an important epigenetic regulator contributing to gene repression of MT1 gene cluster in both ERα positive (ERα+) and ERα negative (ERα−) breast tumors. (biomedcentral.com)

Genomic and transcriptomic sequencing analyses were performed with phenotypic validation to investigate its adaptation in SARS-CoV-2 infected environment. (frontiersin.org)
Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1gamma in reprogramming to pluripotency. (ca.gov)
To do this, we will perform genome-wide siRNA screens on MITF-high and -low melanoma cells in combination with genomic analysis and suitable functional assays. (lu.se)

2018). DNA methylationis regulated by different pathways to establish methylation and reverse methylation (Ja and Se 2010). (zbook.org)
Our analysis revealed specific pathways whose dysregulation might play a role in each transition of the transformation process. (biomedcentral.com)

Comparative analysis of the relationship between translation efficiency and sequence features of endogenous proteins in multiple organisms. (go.jp)
The genome sequence of Barbarea vulgaris facilitates the study of ecological biochemistry. (pacb.com)
Here we report a draft genome sequence of the G-type, and re-sequencing of the P-type for comparison. (pacb.com)
Draft genome sequence of Micromonospora sp. (pacb.com)
Complete genome sequence of Kosakonia oryzae type strain Ola 51(T). (pacb.com)
Here we summarize the features of the strain Ola 51(T) and describe its complete genome sequence. (pacb.com)
Our results showed widespread population invariability yet sequence dependence on adipose DNA methylation but that incorporating maps of regulatory elements aid in linking CpG variation to gene regulation and disease risk in a tissue-dependent manner. (bcu.ac.uk)

Nevertheless, in 2018 genome editing allowed for bipaternal and viable bimaternal mouse and even (in 2022) parthenogenesis, still this is far from full reimprinting. (wikipedia.org)
2018. "Coral Epigenetic Responses to Nutrient Stress: Histone H2A.X Phosphorylation Dynamics and DNA Methylation in the Staghorn Coral Acropora Cervicornis. (fiu.edu)
2018). Genome-wide profiling of normal gastric mucosa identifies Helicobacter pylori- and cancer-associated DNA methylome changes. (who.int)

After rigorous quality assessment and comparison to Illumina EPIC methylation microarrays and testing on a range of algorithms (Bismark, BitmapperBS, bwa-meth, and BitMapperBS), we find overall high concordance between assays, but also differences in efficiency of read mapping, CpG capture, coverage, and platform performance, and variable performance across 26 microarray normalization algorithms. (biomedcentral.com)
Differences in gene-specific methylation between cancer cells and their normal counterparts were described more than 30 years ago. (esmed.org)
Genome wide methylation analysis did not reveal large differences between PSC-UC and UC patients nor HCs. (figshare.com)
Limiting dilution bisulfite sequencing of small pools of sperm from fertile donors did not reveal significant differences in the occurrence of abnormal methylation imprints between sperm with and without morphological abnormalities. (uni-wuerzburg.de)
The relative differences in methylation among neighboring CpGs in the generally hypomethylated APC promoter may not only reflect stochastic fluctuations but also depend on the tissue type. (uni-wuerzburg.de)

In this study, we present integrated quantitative proteome, transcriptome, and methylome analyses of hematopoietic stem cells (HSCs) and four multipotent progenitor (MPP) populations. (lu.se)

DNA methylation occurs mainly at CpG-rich 'CpG islands' and surrounding 'CpG-shore' regions, where more than 60% of them are located in 5′ promoters [ 2 ]. (biomedcentral.com)

Once differentiated tissues are formed, CpG island methylation is generally stably inherited from one cell division to the next through the DNA methylation maintenance machinery. (wikipedia.org)
Here, we present the genome-wide methylation profiles of both spontaneous androgenetic and biparental NLRP7 defective molar tissues. (nih.gov)

From early techniques that measured overall DNA methylation levels to enzyme-associated techniques that interrogated methylation at a single CpG dinucleotide to present day assays that catalogue the methylation of every cytosine in the genome, technical advancement progressively has brought increasing clarity to our understanding of the complex epigenomes of normal and neoplastic cells. (esmed.org)

However no systematic analyses for imprinting defects have been reported. (nih.gov)
Methylation defects have also been associated with male infertility. (wikipedia.org)
Epigenetic alterations, such as UPD including UPD(16)mat and other methylation defects, were excluded. (bmj.com)

Our results provide novel insight into the association between age-related DNA methylation changes and CLL relapse and may serve has biomarkers for treatment relapse, and potentially, treatment selection. (biomedcentral.com)

We examined both DNA methylation and various key histone modifications with regards to gene regulation following axonal injury. (nature.com)
However, the wide variety of approaches available to interrogate these modifications has created a need for harmonized materials, methods, and rigorous benchmarking to improve genome-wide methylome sequencing applications in clinical and basic research. (biomedcentral.com)
Epigenetic modifications such as DNA methylation play a key role in gene regulation and disease susceptibility. (bcu.ac.uk)
In addition, the restriction of 14q32.12 methylation to oligodendroglial tumours suggests a role for epigenetic DNA modifications in these particular gliomas. (nih.gov)

Methylation, expression, microsatellite marker, single nucleotide polymorphism array and trio whole-exome sequencing analyses were conducted. (bmj.com)
We analyzed purified eosinophils from patients with IHES by next-generation whole-exome sequencing and compared DNA methylation profiles from reactive eosinophilic conditions to known clonal and suspected clonal eosinophilia. (oncotarget.com)

We noted that DNA methylation variation was highly heritable (h(2)median = 0.34) and that shared environmental effects correlated with metabolic phenotype-associated CpGs. (bcu.ac.uk)

Single-cell genetic analysis of clonal dynamics in colorectal adenomas indicates CDX2 gain as a predictor of recurrence. (cancerindex.org)
Genome sequencing of multiple R. solanacearum strains has identified both unique and shared genetic traits influencing their evolution and ability to colonize plant hosts. (pacb.com)
However, little is known about the genome-wide frequency, localization, and function of methylation variation and how it is regulated by genetic and environmental factors. (bcu.ac.uk)

By comparing sperm DNA methylomes and large-scale genome-wide association study (GWAS) signals between human and cattle, we aimed to examine the DNA methylome evolution and its associations with complex phenotypes in mammals. (sruc.ac.uk)

Linear, quantile, and logistic regression and receiver operating characteristic curve analyses were conducted to assess the association between each epigenetic age metric and time to CLL relapse. (biomedcentral.com)
Development of DNA methylation-based epigenetic age predictors inloblolly pine (Pinus taeda). (diagenode.com)

Similarly, we find that inhibition of heterochromatin protein-1gamma (Cbx3), a protein known to recognize H3K9 methylation, enhances reprogramming. (ca.gov)
After 4 weeks of conversion, we performed global analyses of RNA and protein levels by RNA-sequencing and mass spectrometry. (lu.se)

The study revealed that persistent estrogen-mediated LRES leads to recruitment of H3K27me3 repressive chromatin marks, which are accompanied by accumulation of DNA methylation in a gene cluster located at 16p11.2. (biomedcentral.com)
Together, our findings demonstrate that Cbx3 and H3K9 methylation restrict late reprogramming events, and suggest that a marked change in global chromatin character constitutes an epigenetic roadblock for reprogramming. (ca.gov)
These results uncover a regulation loop where Jarid2 methylation fine-tunes PRC2 activity depending on the chromatin context. (sdbonline.org)

Dissecting the contribution of H3K9 methylation to reprogramming, we show that the H3K9 methyltransferases Ehmt1, Ehmt2 and Setdb1 regulate global H3K9me2/me3 levels and that their depletion increases iPSC formation from both fibroblasts and pre-iPSCs. (ca.gov)

TSS-DMR, of which only the paternal allele acquires methylation during postimplantation period. (bmj.com)

Each sample is processed in multiple replicates by three whole-genome bisulfite sequencing (WGBS) protocols (TruSeq DNA methylation, Accel-NGS MethylSeq, and SPLAT), oxidative bisulfite sequencing (TrueMethyl), enzymatic deamination method (EMSeq), targeted methylation sequencing (Illumina Methyl Capture EPIC), single-molecule long-read nanopore sequencing from Oxford Nanopore Technologies, and 850k Illumina methylation arrays. (biomedcentral.com)

2016). DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. (who.int)

Because MMP-13 and its regulatory networks are suitable targets for the development of effective early treatment strategies for OA, we discuss the specific targets of MMP-13, including upstream regulatory proteins, DNA methylation, non-coding RNAs, and autophagy-related proteins of MMP-13, and their therapeutic potential to inhibit the development of OA. (biomedcentral.com)

Finally to be discussed is the growing portfolio of epigenetic tools being provided by modern methylome profiling analyses. (esmed.org)
2012. "Single-CpG-resolution methylome analysis identifies clinicopathologically aggressive CpG island methylator phenotype clear cell renal cell carcinomas. (esmed.org)

2021). An epigenetic aging analysis of randomized metformin and weight loss interventions in overweight postmenopausal breast cancer survivors. (who.int)
2021). Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption. (who.int)

The vast majority of mouse embryos derived from parthenogenesis (called parthenogenones, with two maternal or egg genomes) and androgenesis (called androgenones, with two paternal or sperm genomes) die at or before the blastocyst/implantation stage. (wikipedia.org)
Sperm DNA methylation is predominantly stable in mice offspring bornafter transplantation of long-term cultured spermatogonial stem cells. (diagenode.com)
Sperm DNA methylation is crucial for fertility and viability of offspring but epigenome evolution in mammals is largely understudied. (sruc.ac.uk)

Genome-Wide DNA Methylation Analysis in Melanoma Reveals the Importance of CpG Methylation in MITF Regulation. (lu.se)
Analysis of the ~7.1-Mb genome provides insight into this strain's biosynthetic potential, means of regulation, and response to coculturing conditions. (pacb.com)
DNA methylation is an epigenetic modification that plays an important role in gene regulation. (uni-wuerzburg.de)
This study provides a comprehensive genome-wide resource for the functional exploration of molecular, cellular, and epigenetic regulation at the top of the hematopoietic hierarchy. (lu.se)

In a just published Nature Genetics paper, Wolfgang Busch and his research group at the Gregor Mendel Institute use genome-wide association studies on cellular traits to identify and characterize a new regulator of root development in Arabidopsis. (oeaw.ac.at)
We then characterize the reproducibility and challenges of methylation estimation across the genome. (biomedcentral.com)

2015) . Jarid2 methylation via the PRC2 complex regulates H3K27me3 deposition during cell differentiation . (sdbonline.org)

Nucleus transplantation experiments in mouse zygotes in the early 1980s confirmed that normal development requires the contribution of both the maternal and paternal genomes. (wikipedia.org)
However, in 2004, experimental manipulation by Japanese researchers of a paternal methylation imprint controlling the Igf2 gene led to the birth of a mouse (named Kaguya) with two maternal sets of chromosomes, though it is not a true parthenogenone since cells from two different female mice were used. (wikipedia.org)

Microsatellite analysis showed LOH in seven of 28 (25%) oligodendroglial tumours and three of 15 (20%) astrocytic tumours. (nih.gov)

Both average methylation level and range of methylation variation depended on the gene locus, tissue type and/or developmental stage. (uni-wuerzburg.de)
Our results are consistent with the view that most methylation variation may arise after fertilization, leading to epigenetic mosaicism. (uni-wuerzburg.de)
DNA methylation and copy number variation profiling of T-cell lymphoblastic leukemia and lymphoma. (cancercentrum.se)

While previous studies have identified epigenetic signatures associated with CLL, whether age-related DNA methylation changes modulate CLL relapse remains elusive. (biomedcentral.com)

In diploid organisms (like humans), the somatic cells possess two copies of the genome, one inherited from the father and one from the mother. (wikipedia.org)
Their analysis revealed 56 anatomical features that set Denisovans apart from modern humans or Neanderthals. (co.ke)
For example, the Denisovan's skull was likely wider than that of modern humans or Neanderthals, while they probably also had a longer dental arch. (co.ke)
However, several features were found to be similar to those in early modern humans and Neanderthals, including an elongated face and wide pelvis. (co.ke)
2019). Experimental and pan-cancer genome analyses reveal widespread contribution of acrylamide exposure to carcinogenesis in humans. (who.int)

See how the University of Washington used HiFi sequencing to uncover a key finding about ALS and the human genome. (pacb.com)
It's one of the most mysterious human ancestors in history, and now scientists have revealed what the Denisovans might have looked like. (co.ke)
2017). Genome-scale mutational signatures of aflatoxin in cells, mice, and human tumors. (who.int)
Recent work has demonstrated that clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems1-3 can serve as the basis of a simple and highly efficient method for performing genome editing in bacteria, yeast and human cells, as well as in vivo in whole organisms such as fruit flies, zebrafish and mice4-13. (cdc.gov)

Comparative analysis of Ralstonia solanacearum methylomes. (pacb.com)
Sequencing of R. solanacearum strains GMI1000 and UY031 using Single Molecule Real-Time technology allowed us to perform a comparative analysis of R. solanacearum methylomes. (pacb.com)

In this study, we conducted methyl-binding domain capture (MBDCap) sequencing (MBD-seq) analysis on a breast cancer cohort consisting of 77 patients and 10 normal controls, as well as a panel of 38 breast cancer cell lines. (biomedcentral.com)
Our data suggests that DNA methylation in large contiguous gene clusters can be potential prognostic markers of breast cancer. (biomedcentral.com)
Further investigation of these clusters revealed that estrogen mediates epigenetic repression of MT1 cluster in ERα + breast cancer cell lines. (biomedcentral.com)
International Cancer Genome Consortium. (cancerindex.org)
Data from whole transcriptome sequencing of 33 breast specimens in the Harbin Medical University Cancer Center cohort and The Cancer Genome Atlas was applied to identify and validate the landscape of tumor suppressor long noncoding RNAs, which was further validated by The Cancer Genome Atlas pancancer data including 33 cancer types and 12,839 patients. (cancerindex.org)
Aberrations in epigenetic signatures via DNA methylation is a major hallmark in the pathogenesis of cancer [ 13 ]. (biomedcentral.com)
A decade of DNA methylation profiling in cancer: What have we learned? (esmed.org)
Recent analyses of the whole genome sequencing data enable us to predict cancer incidence for healthy people at present. (intechopen.com)
2022). Cutaneous and acral melanoma cross-OMICs reveals prognostic cancer drivers associated with pathobiology and ultraviolet exposure. (who.int)

11] Even if silencing of a gene is initiated by another mechanism, this often is followed by methylation of CpG sites in the promoter CpG island to stabilize the silencing of the gene. (wikipedia.org)
We found that the promoter methylation level of GATA3, IL-4 and TGF-β was significantly up-regulated in active BD patients and negatively correlated with the corresponding mRNA expression. (oncotarget.com)

Our longitudinal integrated analysis of 30 patient-matched repeated relapses (3.67 ± 1.76 times) over 13 years (5.8 ± 3.8) reveals stable molecular sub. (diagenode.com)
These data have been combined with previously published LNET data to perform integrative analysis using multi-omics factor analysis (MOFA), resulting in a molecular map of lung neuroendocrine neoplasms for exploration. (who.int)
Multi-omics integration analysis of 319 carcinoids resulted in a molecular map forming a distinctive tetrahedron. (who.int)

Altered DNA methylation dynamics are a conserved aspect of biological ageing and ha. (diagenode.com)

2017). Unique DNA methylation signature in HPV-positive head and neck squamous cell carcinomas. (who.int)

In this review, we highlight the main MMP-13-related changes in OA chondrocytes, including alterations in the activity and expression level of MMP-13 by upstream regulatory factors, DNA methylation, various non-coding RNAs (ncRNAs), and autophagy. (biomedcentral.com)

Whole-genome bisulfite sequencing (WGBS) is increasingly used for fundamental and clinical research of CpG methylation. (biomedcentral.com)

The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. (nih.gov)
This study reveals an unexpected crosstalk between Jarid2 and PRC2, with Jarid2 being methylated by PRC2. (sdbonline.org)
The B. vulgaris genome will promote the study of mechanisms in ecological biochemistry to benefit crop resistance breeding. (pacb.com)
To address this aim we have designed the lungNENomics study, an international cohort of over 250 cases of pulmonary carcinoids, with clinical data and central pathology review, as well as whole-genome sequencing, RNA sequencing, DNA methylation array, and digital spatial profiling data. (who.int)

Genome-wide DNA methylation analysis of colorectal adenomas with and without recurrence reveals an association between cytosine-phosphate-guanine methylation and histological subtypes. (bvsalud.org)
Analysis of precancerous colorectal lesions of different sizes can thus furnish important information on the steps involved in their malignant transformation. (biomedcentral.com)

Anatomy13

Organisms8

Diseases9

Chemicals and Drugs83

Analytical, Diagnostic and Therapeutic Techniques and Equipment40

Phenomena and Processes105

Disciplines and Occupations6

Technology, Industry, Agriculture1

Information Science11

Health Care4

Genes28

Patterns10

GENE-EXPRESSION10

Including DNA methylation and histone2

Shown that DNA methylation2

Differential3

Aberrant4

Role of DNA methylation2

Epigenetics1

Differentially2

Loci3

Mutations5

Histone methylation1

Adipose tissue2

DMRs1

Important epigenetic1

Genomic3

Pathways2

Sequence7

20183

Differences5

Quantitative1

Promoters1

Tissues2

Assays1

Defects3

Biomarkers1

Modifications4

Whole-exome2

CPGs1

Genetic3

GWAS1

Epigenetic age2

Protein2

Chromatin3

H3K91

Allele1

Illumina1

20161

Proteins1

Methylome2

20212

Sperm3

Regulation4

Characterize2

Regulates1

Paternal2

Microsatellite1

Variation3

Modulate1

Humans5

Human4

Comparative2

Cancer9

Promoter2

Molecular3

Dynamics1

20171

RNAs1

Bisulfite1

Study4

Colorectal2