• For genome-wide association studies (GWAS) and other studies involving human subjects, the use of standard measures can facilitate cross-study analyses. (wikipedia.org)
  • It is striking that the "old-fashioned" linkage analysis can resolve the missing heritability problem arisen in the high-throughput genome-wide association study (GWAS) era. (frontiersin.org)
  • Genome-wide association studies (GWAS) and large-scale replication studies have identified common variants in 79 loci associated with breast cancer, explaining ∼14% of the familial risk of the disease. (ox.ac.uk)
  • To identify new susceptibility loci, we performed a meta-analysis of 11 GWAS, comprising 15,748 breast cancer cases and 18,084 controls together with 46,785 cases and 42,892 controls from 41 studies genotyped on a 211,155-marker custom array (iCOGS). (ox.ac.uk)
  • Individual hypothesis testing for SNP-SNP pairs as in common genome-wide association study (GWAS) however involves difficulty in setting overall p-value due to complicated correlation structure, namely, the multiple testing problem that causes unacceptable false negative results. (biomedcentral.com)
  • GWAS using whole genome SNPs is thus an attractive solution to this issue. (biomedcentral.com)
  • Many procedures proposed for GWAS so far are based on marginal association between each SNP and phenotype. (biomedcentral.com)
  • In this study, to identify new ER-negative susceptibility loci, we performed a meta-analysis of 11 genome-wide association studies (GWAS) consisting of 4,939 ER-negative cases and 14,352 controls, combined with 7,333 ER-negative cases and 42,468 controls and 15,252 BRCA1 mutation carriers genotyped on the iCOGS array. (kb.se)
  • This study uses data from the Framingham Heart Study to examine the relevance of the gene-environment interaction paradigm for genome-wide association studies (GWAS). (dukeupress.edu)
  • Our results highlight the sensitivity of parameter estimates obtained from GWAS models and the difficulty of framing genome-wide results using the existing gene-environment interaction typology. (dukeupress.edu)
  • We highlight the fact that GWAS is just one use of genome-wide data, and we encourage demographers to develop methods that incorporate this vast amount of information from respondents into their analyses. (dukeupress.edu)
  • Genetic overlap between endometriosis and endometrial cancer: evidence from cross-disease genetic correlation and GWAS meta-analyses. (ox.ac.uk)
  • Genetic correlation analysis of summary level statistics from genomewide association studies (GWAS) using LD Score regression revealed moderate but significant genetic correlation (rg = 0.23, P = 9.3 × 10-3 ), and SNP effect concordance analysis provided evidence for significant SNP pleiotropy (P = 6.0 × 10-3 ) and concordance in effect direction (P = 2.0 × 10-3 ) between the two diseases. (ox.ac.uk)
  • Cross-disease GWAS meta-analysis highlighted 13 distinct loci associated at P ≤ 10-5 with both endometriosis and endometrial cancer, with one locus (SNP rs2475335) located within PTPRD associated at a genomewide significant level (P = 4.9 × 10-8 , OR = 1.11, 95% CI = 1.07-1.15). (ox.ac.uk)
  • We performed a GWAS of VMS derived from linked primary-care records and cross-sectional self-reported HRT use in up to 153,152 women from UK Biobank, a population-based cohort. (biomedcentral.com)
  • Additionally, population-based genome-wide association studies (GWAS) have identified several more common genetic variants in or near the TACR3 gene associated with normal variation in age at menarche [ 16 ]. (biomedcentral.com)
  • AD susceptibility has an established genetic basis which has been the focus of a large number of genome-wide association studies (GWAS) published over the last decade. (uni-luebeck.de)
  • An alternative and potentially more powerful study design is afforded by using quantitative AD-related phenotypes as GWAS outcome traits, an analysis paradigm that we followed in this work. (uni-luebeck.de)
  • Specifically, we utilized genotype and phenotype data from n = 931 individuals collected under the auspices of the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery (EMIF-AD MBD) study to perform a total of 19 separate GWAS analyses. (uni-luebeck.de)
  • Our GWAS analyses revealed several genome-wide significant associations for the neuropsychological performance measures, in particular those assayed longitudinally. (uni-luebeck.de)
  • While polygenic score (PGS) analyses showed the expected strong associations with SNPs highlighted in relevant previous GWAS on hippocampal volume and cognitive function, they did not show noteworthy associations with recent AD risk GWAS findings. (uni-luebeck.de)
  • In summary, our study highlights the power of using quantitative endophenotypes as outcome traits in AD-related GWAS analyses and nominates several new loci not previously implicated in cognitive decline. (uni-luebeck.de)
  • Replication of associations between GWAS SNPs and melanoma risk in the Population Architecture Using Genomics and Epidemiology (PAGE) Study. (icompbio.net)
  • The genome-wide association study (GWAS) is a popular research method to search for genotype-phenotype relationships. (psychedelicreview.com)
  • 8 Completed GWAS have identified novel variant-trait associations with tested clinical applications, however, they do not inherently reveal causal mechanisms. (psychedelicreview.com)
  • QC, imputation, GWAS and pathway-analysis of genetic data. (lu.se)
  • Cross-ancestry genome-wide association meta-analyses identify new risk loci for peptic ulcer diseases and provide evidence that gastrointestinal cell differentiation and hormone regulation contribute to their etiology. (nature.com)
  • conducted a linkage analysis in a large yeast Saccharomyces cerevisiae cross with high statistical power to map functional quantitative trait loci (QTL) and found that nearly all the additive genetic contribution can be explained by the detected QTL. (frontiersin.org)
  • To identify new susceptibility loci to lung cancer among diverse populations, we performed cross-ancestry genome-wide association studies in European, East Asian and African populations and discovered five loci that have not been previously reported. (uky.edu)
  • We replicated 26 signals and identified 10 new lead associations from previously reported loci. (uky.edu)
  • Association analysis identifies 65 new breast cancer risk loci. (kb.se)
  • We identify four previously unidentified loci including two loci at 13q22 near KLF5, a 2p23.2 locus near WDR43 and a 2q33 locus near PPIL3 that display genome-wide significant associations with ER-negative breast cancer. (kb.se)
  • Trans-ancestry analysis strengthened evidence of association for SNV-loop diuretic interaction at two loci (KIAA1217 and BAALC). (escholarship.org)
  • The application of such technologies will require to reliably estimate the effect of loci in plant genomes by avoiding the situation where the number of loci assayed ( p ) surpasses the number of plant genotypes ( n ). (springer.com)
  • Our aim was to identify additional loci for stroke by doing a meta-analysis of genome-wide association studies. (uai.cl)
  • Novel loci for Alzheimer's disease identified by a genome-wide association study in Ashkenazi Jews. (icompbio.net)
  • These studies typically focus on associations between single-nucleotide polymorphisms (SNPs) and major diseases. (nature.com)
  • Four hundred and twenty-five EASZ and four reference populations (Holstein-Friesian, Jersey, N'Dama and Nellore) were analysed using 46,171 SNPs covering all autosomes and the X chromosome. (nature.com)
  • Genome-wide gene-gene interaction analysis using single nucleotide polymorphisms (SNPs) is an attractive way for identification of genetic components that confers susceptibility of human complex diseases. (biomedcentral.com)
  • In this paper, we tackle a development of powerful method for the genome-wide gene-gene interaction analysis using SNPs. (biomedcentral.com)
  • Single nucleotide polymorphisms (SNPs) are ubiquitous in genomes and have emerged as a marker of choice, especially in sequenced plants [ 15 , 16 ]. (genominfo.org)
  • Now comes the prospect, first seriously proposed a decade ago by Risch and Merikangas ( 2 ), of testing virtually all ∼10 million common single nucleotide polymorphisms (SNP) in the human genome for associations with a given disease, either directly or by linkage disequilibrium with other SNPs. (aacrjournals.org)
  • Coupled with the extensive haplotype tagging SNP information being catalogued by the HapMap project ( 3 ), it now seems that that this density may be sufficient to permit indirect tests of association with the majority of all common SNPs ( 4 ), although this fundamental assumption has recently been questioned ( 5 ). (aacrjournals.org)
  • Whole-genome sequencing data of individuals from the UK Biobank and Iceland and a somatic mutation barcoding strategy enabled detection of clonal hematopoiesis at scale. (nature.com)
  • Whole genome sequencing was carried out, and the DNA variations in the whole genome were compared between the normal and dwarf samples. (genominfo.org)
  • We found a large number of DNA variations in both the dwarf and semi-dwarf lines, with one single nucleotide polymorphism (SNP) per at least 3.68 kb in the dwarf lines and 1 SNP per 11.13 kb of the whole genome. (genominfo.org)
  • Although a great deal of information is available from whole genome sequencing, resequencing strategies have become an important tool to study allelic variations. (genominfo.org)
  • Evaluation of Oxford Nanopore's MinION Sequencing Device for Microbial Whole Genome Sequencing Applications. (cdc.gov)
  • Dietary omega-3 fatty acids and endometrial cancer risk in the Epidemiology of Endometrial Cancer Consortium: An individual-participant meta-analysis Gynecol Oncol. (usc.edu)
  • Radiogenomics Consortium Genome-Wide Association Study Meta-Analysis of Late Toxicity After Prostate Cancer Radiotherapy. (bvsalud.org)
  • Drug-gene interactions were estimated using covariable-adjusted linear regression and results were combined with fixed-effects meta-analysis. (escholarship.org)
  • Both longitudinal and cross sectional data were used to compute cohort-specific interaction results, which were then combined through meta-analysis in each ancestry. (escholarship.org)
  • These ancestry-specific results were further combined through trans-ancestry meta-analysis. (escholarship.org)
  • Summary-level results of discovery and follow-up stages were combined using inverse-variance weighted fixed-effects meta-analysis, and in-silico lookups were done in stroke subtypes. (uai.cl)
  • A systemic literature reference search inclusive to August 12, 2016 yielded 35 articles, from which 11 studies met the inclusion criteria for the final meta-analysis, including 3889 patients with GDM and 6708 controls. (viamedica.pl)
  • Our meta-analysis indicated that the rs10830963 polymorphism might serve as a risk factor of GDM in the Chinese population. (viamedica.pl)
  • This comprehensive study provides insights into the epidemiology, somatic and germline genetics, and disease associations of clonal hematopoiesis. (nature.com)
  • 2018). Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights. (harvard.edu)
  • note = "Funding Information: Our study was supported by the National Institutes of Health (NIH) for Integrative Analysis of Lung Cancer Etiology and Risk (U19CA203654) and Sequencing Familial Lung Cancer (R01CA243483). (uky.edu)
  • Interethnic Differences in Bladder Cancer Incidence and the Association between Type 2 Diabetes and Bladder Cancer in the Multiethnic Cohort Study Cancer Res Commun. (usc.edu)
  • Smoking and pancreatic cancer: a sex-specific analysis in the Multiethnic Cohort study Cancer Causes Control. (usc.edu)
  • Single SNP association study is a popular method to detect genes that are susceptible to human diseases. (biomedcentral.com)
  • Here we report the results of a genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry. (kb.se)
  • A previously reported study, where the wild soybean Glycine soja was sequenced and compared to the Glycine max reference, found 2.5 megabases (Mb) of substituted sequences, 4.6 kilobases (kb) of indels, 32.4 Mb of deletions and 8.3 Mb of new sequences in a total of 915.5 Mb of genome sequence [ 14 ]. (genominfo.org)
  • The cost of the genotyping technology is bound to keep falling over the next few years, and many study design and analysis issues remain to be resolved. (aacrjournals.org)
  • In a recent cross-sectional study aimed at characterizing the prevalence of malaria in people living with HIV, the prevalence of malaria was 7.3% [ 12 ]. (biomedcentral.com)
  • In 11 ethnically diverse cohorts that included 71 857 European, African-American and Hispanic/Latino ancestry individuals with repeated measures of medication use and electrocardiogram (ECG) measurements, we conducted a pharmacogenomic genome-wide association study of sulfonylurea use and three ECG phenotypes: QT, JT and QRS intervals. (escholarship.org)
  • This study demonstrates the value of cross-disease genetic analysis to support epidemiological observations and to identify biological pathways of relevance to multiple diseases. (ox.ac.uk)
  • A recent review of 168 studies with objectively recorded (polysomnography or actigraphy) sleep duration over the last 50+ years showed no significant association of duration with study year [17]. (researchsquare.com)
  • Hepatocellular Carcinomas from Iran: Evidence study of lung cancer among European asphalt carcinoma among postmenopausal women in the for Lack of Association between HBV Genotype workers. (who.int)
  • Oral Oncol, Retinoblastoma-independent antiproliferative activity socioeconomic status: a cross-sectional study. (who.int)
  • Mycotoxin Exposure and Renal Cell Carcinoma Risk: An Association Study in the EPIC European Cohort. (who.int)
  • Genetic predictors of risk and resilience in psychiatric disorders: a cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia. (nih.gov)
  • Using genome-wide association studies and DNA sequencing technologies the study identified over 56,000 genomes, utilized including patients of nonHispanic white, African American, Hispanic, and East Asian ancestry. (neurologylive.com)
  • This study will characterize the diversity and evolution of SARS-CoV-2 strains circulating in Georgia, for the purpose of understanding if possible population-level changes in the rates of viral spread and whether there are associations between viral genotype, the viral phenotype in vitro, and clinical phenotype/outcome. (cdc.gov)
  • The cross-sectional study was carried out among students selected from seventeen universities across Lebanon. (who.int)
  • Mediators of the association between childhood trauma and pain sensitivity in adulthood: a Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network analysis. (medscape.com)
  • Relationship, differences, and agreement between objective and subjective sleep measures in chronic spinal pain patients with comorbid insomnia: a cross-sectional study. (medscape.com)
  • This journal is the official publication of the International Association for the Study of Pain and publishes original research on the nature, mechanisms and treatment of pain. (medscape.com)
  • Genome-wide association studies (GWASs) are unbiased genome screens of unrelated individuals and appropriately matched controls or parent-affected child trios to establish whether any genetic variant is associated with a trait. (nature.com)
  • Genome-wide analyses yield insights into the polygenic effects contributing to clinical heterogeneity in attention deficit hyperactivity disorder, advancing understanding of its genetic etiology and serving as a model for future studies in other complex disorders. (nature.com)
  • Such analyses compare independent findings to validate results or combine studies to increase sample size and statistical power. (wikipedia.org)
  • Clinicians are well versed in the strengths and limitations of such trials and have an increasingly sophisticated understanding of traditional analyses of observational studies. (bmj.com)
  • One source of evidence is the association between alcohol and blood pressure in observational studies. (bmj.com)
  • This includes exploratory analysis (clustering, biclustering, correlation mining), variable selection in genome wide association studies, and multi-tissue eQTL analysis. (unclineberger.org)
  • Are We Ready for Genome-wide Association Studies? (aacrjournals.org)
  • The tension between hypothesis-driven and exploratory research crosses scientific disciplines ( 1 ) but is particularly well illustrated in the current excitement about genome-wide association (GWA) studies. (aacrjournals.org)
  • Thus, molecular epidemiologists are turning to candidate-gene association studies or studies of entire candidate pathways, driven by specific biological hypotheses, as an alternative approach. (aacrjournals.org)
  • Time will tell whether these early reports represent true positives, but the simultaneous publication in Science of two confirmatory studies ( 11, 12 ) for the Complement Factor H association with age-related macular degeneration along with the GWA scan has sparked great enthusiasm, and several reports have seemed subsequently confirming the association. (aacrjournals.org)
  • Is the Gene-Environment Interaction Paradigm Relevant to Genome-Wide Studies? (dukeupress.edu)
  • Recent declines in the costs of genome-wide genotyping in conjunction with an increasing number of population-based studies with genome-wide data make a genome-wide gene-by-environment interaction (GWGEI) approach possible (Cornelis et al. (dukeupress.edu)
  • Variability in response to drug use is common and heritable, suggesting that genome-wide pharmacogenomics studies may help explain the 'missing heritability' of complex traits. (escholarship.org)
  • Because these approaches will rely on novel data types such as DNA sequences and high-throughput phenotyping images, Breeding 4 will call for analyses that are complementary to traditional quantitative genetic studies, being based on machine learning techniques which make efficient use of sequence and image data. (springer.com)
  • Epidemiological, biological, and molecular data suggest links between endometriosis and endometrial cancer, with recent epidemiological studies providing evidence for an association between a previous diagnosis of endometriosis and risk of endometrial cancer. (ox.ac.uk)
  • 5 Ã- 10 âˆ'6 ) with all-stroke, ischaemic stroke, cardioembolic ischaemic stroke, or non-cardioembolic ischaemic stroke in the largest available cross-sectional studies (70 804 participants, of whom 19 816 had stroke). (uai.cl)
  • Large-scale genomic analyses offer the possibility of biological insights but few such studies have collected data on VMS, while proxy phenotypes such as hormone replacement therapy (HRT) use are likely to be affected by changes in clinical practice. (biomedcentral.com)
  • Dietary fats and their sources in association with the risk of bladder cancer: A pooled analysis of 11 prospective cohort studies. (who.int)
  • Studies have been conducted to investigate the association between rs10830963 of MTNR1B and the risk of gestational diabetes mellitus (GDM), but with inconclusive results. (viamedica.pl)
  • Association between gestational diabetes mellitus and subsequent risk of cancer: a systematic review of epidemiological studies. (viamedica.pl)
  • Further genome-wide association studies in obese and diabetic Arab populations could add to our understanding of the pathophysiology, prevention and reversal of this disease. (who.int)
  • A systematic review of genome-wide association studies for pain, nociception, neuropathy, and pain treatment responses. (medscape.com)
  • We also find that heritability of breast cancer due to all single-nucleotide polymorphisms in regulatory features was 2-5-fold enriched relative to the genome-wide average, with strong enrichment for particular transcription factor binding sites. (kb.se)
  • At the 2023 Alzheimer's Association International Conference , July 16-20, in Amsterdam, the Netherlands, Adam Naj, PhD , genetic epidemiologist and assistant professor of epidemiology at the University of Pennsylvania Perelman School of Medicine, presented findings from a genetic diverse ancestry cohort in a featured research session. (neurologylive.com)
  • Combining association analysis with ChIP-seq chromatin binding data in mammary cell lines and ChIA-PET chromatin interaction data from ENCODE, we identified likely target genes in two regions: SETBP1 at 18q12.3 and RNF115 and PDZK1 at 1q21.1. (ox.ac.uk)
  • Standard linkage analysis has the potential to localize major susceptibility genes to within a few million base pairs using as few as 300 microsatellite markers for a genome-wide scan. (aacrjournals.org)
  • However, it has increasingly been recognized that linkage analysis may not be powerful enough to detect genes involved in "complex diseases" like cancer, which are caused by multiple genes and multiple environmental factors, interacting in complicated ways. (aacrjournals.org)
  • Breast Cancer Risk Genes - Association Analysis in More than 113,000 Women. (nih.gov)
  • Multi-Ancestry Genome-wide Association Analysis of Late-Onset Alzheimer's Disease (LOAD) in 60,941 Individuals Identifies Multiple Novel Cross-Ancestry Associations and Implicates Amyloid and Complement Pathways. (neurologylive.com)
  • Ben-Haroush A, Yogev Y, Hod M. Epidemiology of gestational diabetes mellitus and its association with Type 2 diabetes. (viamedica.pl)
  • We are proud to work together with the leading biotech company in Sweden for biomarker panel analyses in epidemiology, OLINK Proteomics AB, Uppsala, and its representatives! (lu.se)
  • Here, we describe four independent analyses in 33 781 participants of European ancestry from 10 cohorts that were designed to identify genetic variants modifying the effects of drugs on QT interval duration (QT). (escholarship.org)
  • Genome-wide meta-analyses with 39,710 European-ancestry (EA) individuals and 9925 African-ancestry (AA) individuals were performed to identify genetic variants that modify the effect of loop or thiazide diuretic use on blood lipid concentrations. (escholarship.org)
  • Methods For the discovery sample, we did a genome-wide analysis of common genetic variants associated with incident stroke risk in 18 population-based cohorts comprising 84 961 participants, of whom 4348 had stroke. (uai.cl)
  • In a subset of this cohort ( n = 39,356), we analysed exome-sequencing data to test the association with VMS of rare deleterious genetic variants. (biomedcentral.com)
  • 2018). Mixed-model association for biobank-scale datasets. (harvard.edu)
  • 2018) Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk. (harvard.edu)
  • Cross-cancer pleiotropic analysis of endometrial cancer: PAGE and E2C2 consortia. (icompbio.net)
  • G = ZZ T / n, R = XX T / m , where n is the number of markers across the genome (11,623), m is the number of randomly selected markers (32), Z is an N (number of individuals)-by- n matrix of genotype data and X is an N -by- m matrix for the selected markers. (frontiersin.org)
  • Here, we assess the presence of candidate signatures of positive selection in their genome, with the aim to provide qualitative insights about the corresponding selective pressures. (nature.com)
  • Rare-variant associations tended to be specific to populations, but even common-variant associations influencing smoking behavior, such as those with CHRNA5 and CYP2A6, showed population specificity. (uky.edu)
  • Using genomics we demonstrate changes in genetic associations with HRT use over time, arising from a change in clinical practice since the early 2000s, which is likely to reflect a switch from preventing post-menopausal complications in women with earlier menopause to primarily treating VMS. (biomedcentral.com)
  • 4 ] suggest that the use of arbitrary single locus-disease association model under which some interaction effect is present might prevent from finding susceptible interaction effect. (biomedcentral.com)
  • Analysis of AA data identified one genome-wide significant locus adjacent to BMP2 with SNV-loop diuretic interaction on TG concentrations. (escholarship.org)
  • Conditional analyses demonstrated independence of genetic signals for puberty timing and VMS at the TACR3 locus, including a rare variant predicted to reduce functional NK3R levels that was associated with later menarche ( P = 5 × 10 -9 ) but showed no association with VMS ( P = 0.6). (biomedcentral.com)
  • But they may be less aware of the strengths and limitations of a more recently developed approach to analysing observational data known as Mendelian randomisation. (bmj.com)
  • Our methodological research is focused on the statistical analysis of high dimensional data. (unclineberger.org)
  • Although they are motivated by biomedical data, our methods have application to other high dimensional problems, including the analysis of social and political networks. (unclineberger.org)
  • Nevertheless, genome-wide data contain rich information about individual respondents, and we demonstrate the utility of this type of data. (dukeupress.edu)
  • Epidemiological and experimental data suggest that FOXF2 mediates this association, potentially via differentiation defects of cerebral vascular mural cells. (uai.cl)
  • For the latter, longitudinal data from at least two timepoints were available in addition to cross-sectional assessments at baseline. (uni-luebeck.de)
  • To develop a data management system to support joint analysis of distributed data. (lu.se)
  • Data from long concluded experiments with moderate and high doses of radiation delivered by internal emitters were significantly re-interpreted because the length of the cell cycle was used as one of the variables in the analysis. (cdc.gov)
  • It will support the broader public health genomics community by developing bioinformatics tools for open data analysis, easy data sharing, and privacy controls. (cdc.gov)
  • Linkage analysis or QTL interval mapping in an experimental design is a classic method in quantitative genetics to detect QTL, which allows inferring QTL effects in an un-typed chromosomal interval harbored by flanking genetic markers ( Lynch and Walsh, 1998 ). (frontiersin.org)
  • This increased power makes it possible to identify more subtle and complex associations such as gene-gene and gene-environment interactions. (wikipedia.org)
  • We argue that SNP-environment interactions across the human genome are not likely to provide consistent evidence regarding genetic influences on health that differ by environment. (dukeupress.edu)
  • As a human geneticist and bioinformatician, Dr. Bush's research interests include understanding the functional impact of genetic variation, developing statistical and bioinformatics approaches for integrating functional genomics knowledge into genetic analysis, and the use of electronic medical records for translational research. (icompbio.net)
  • Even a small number of randomly selected markers can resemble the genomic kinship and give similar heritability estimates (Figure 1B ), because the number of LD blocks in the entire genome is limited. (frontiersin.org)
  • 5 Ã- 10 âˆ'8 ), we explored associations with additional cerebrovascular phenotypes and did functional experiments using conditional (inducible) deletion of the probable causal gene in mice. (uai.cl)
  • Modifying effects of race and ethnicity and APOE on the association of physical activity with risk of Alzheimer's disease and related dementias Alzheimers Dement. (usc.edu)
  • Highlighting Clinical Metagenomics for Enhanced Diagnostic Decision-making: A Step Towards Wider Implementation. (cdc.gov)
  • The draft genomes of Elizabethkingia anophelis of equine origin are genetically similar to three isolates from human clinical specimens. (cdc.gov)
  • Specifically, there is a difficulty in setting genome-wide significance level using, e.g. (biomedcentral.com)
  • The Toolkit is funded by the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH) with co-funding by the Office of the Director (OD), the National Institute of Neurological Disorders and Stroke (NINDS), and the National Heart, Lung, and Blood Institute (NHLBI). (wikipedia.org)
  • Design and methodological considerations for biomarker discovery and validation in the Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Program. (who.int)
  • A recent genome wide SNP analysis revealed an ancient stable African taurine x Asian zebu admixture. (nature.com)
  • Our results support that different selection pressures (e.g. environmental constraints, human selection, genome admixture constrains) have shaped the genome of EASZ. (nature.com)
  • Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network. (nih.gov)
  • We propose ranking strategy using promising dummy coding methods and following variable selection procedure in the SIS method suitably modified for gene-gene interaction analysis. (biomedcentral.com)
  • In our patient based registries there is additional information e.g. phenotypic association, population association, expression analysis, cross-references to other databases, and usually a long list of disease parameters and measurements. (lu.se)
  • In subgroup analyses stratified by ethnicity, we also observed rs10830963 to be associated with significantly increased risk of GDM in all genetic models in the Chinese population. (viamedica.pl)
  • In an F 2 cross, the observed LD blocks are often very large, due to limited number of recombination events happened in the F 1 individuals, though the recombination rate in yeast is relatively high. (frontiersin.org)
  • Racial Differences in the Association of Endometriosis and Uterine Leiomyomas With the Risk of Ovarian Cancer Obstet Gynecol. (usc.edu)
  • Based on the machine-learning principle, the proposed method gives powerful and flexible genome-wide search for various patterns of gene-gene interaction. (biomedcentral.com)
  • There were few significant SNV-thiazide diuretic interaction associations on TG concentrations and for either diuretic on cholesterol concentrations. (escholarship.org)
  • Using average nucleotide identity to improve taxonomic assignments in prokaryotic genomes at the NCBI. (cdc.gov)
  • Jihye Kim received an American Association for Cancer Research Scholar-in-Training Award for the work she will be presenting at the AACR Annual Meeting in Chicago, Absolute risk prediction models for pancreatic cancer. (harvard.edu)
  • The prediction of trait values using detected QTL was good according to cross validation, because the specific F 2 population share similar LD patterns, but such prediction would not perform as superior in another population with different LD pattern. (frontiersin.org)