• Optimizing the Targeting of Mouse Parvovirus 1 to Murine Melanoma Selects for Recombinant Genomes and Novel Mutations in the Viral Capsid Gene. (nih.gov)
  • The binding energy of capsid subunits on the genome is moderate (~7k B T 0 , with k B the Boltzmann constant and T 0 = 298 K, the room temperature), while the energy barrier separating the complexes and the virions is high (~ 20k B T 0 ). (cea.fr)
  • Depending on the size of the capsid enclosing the genome, three principles of viral nucleic acids import are discussed. (uzh.ch)
  • Second, the genome is injected from a capsid that is docked to the pore complex, and third, import factors are recruited to cytosolic capsids to increase capsid affinity to the pore complex, mediate translocation and allow disassembly in the nucleoplasm. (uzh.ch)
  • Each virion comprises a viral envelope and associated matrix enclosing a capsid, which itself encloses two copies of the single-stranded RNA genome and several enzymes. (wikipedia.org)
  • It is not clear how much extra DNA can be inserted into the genome, but as is evident from the electronmicrograph, capsid size may not be a limiting factor, as the particle sizes of His1 vary considerably in length (and so probably for His2, although negative-stain EM of these particles is much more difficult). (wikipedia.org)
  • The identification of several putative viral gene products including a DNA ligase and a viral antibiotic peptide is a powerful tool for the investigation of the phylogenetic relatedness of this evolutionary and ecologically relevant eukaryotic virus. (springer.com)
  • Applications include viral discovery from a complex background and improved sensitivity and coverage of rapidly evolving strains or variants in a gene family. (hindawi.com)
  • By comparing these gene lists, the researchers determined the core genome to be less tolerant of mutagenesis than the overall genome. (asm.org)
  • By comparing the genomes of mouse with human, the scientists were able to show that the binding sites for gene regulatory factors are very often not in the same place between the two species. (redorbit.com)
  • We utilized CRISPR/Cas9 to target the noncoding control region and the late gene open reading frame of the JCPyV genome. (harvard.edu)
  • For example, Sequin can be used to transfer annotations between highly similar HIV genomes that have identical gene content. (biomedcentral.com)
  • In the case of papillomaviruses, gene clusters match well our knowledge on viral biology and life cycle, illustrating the potential of our approach. (biomedcentral.com)
  • For the less known TuMV, our results trigger new hypotheses about viral evolution and gene interaction. (biomedcentral.com)
  • The viral eukaryogenesis hypothesis depicts a model of eukaryotic evolution in which a virus, similar to a modern pox virus, evolved into a nucleus via gene acquisition from existing bacterial and archaeal species. (wikipedia.org)
  • The lysogenic virus then became the information storage center for the cell, while the cell retained its capacities for gene translation and general function despite the viral genome's entry. (wikipedia.org)
  • Our cells have potent immune sensors that can detect the presence of viral nucleic acid in the cytosol. (prolekare.cz)
  • We hypothesized that this catastrophic uncoating might also expose viral genomes for sensing by nucleic acid pattern recognition receptors (PRRs). (prolekare.cz)
  • Despite the presence of numerous cytosolic PRRs that recognize pathogen nucleic acids, it is often viral transcripts or progeny genomes, as opposed to incoming genomes, that are detected [ 7 , 8 , 9 ]. (prolekare.cz)
  • The aim of this study was to investigate the frequency of viral nucleic acid detection in the myocardium of human immunodeficiency virus (HIV)-infected children to determine whether an association exists with the development of heart disease. (onlinejacc.org)
  • These data suggest that the presence of viral nucleic acid in the myocardium is common in HIV-infected children, and may relate to the development of myocarditis, DCM or CHF and may contribute to the rapid progression of HIV disease. (onlinejacc.org)
  • Why Viral Nucleic acid (Genome) is unique? (microbeonline.com)
  • Viral capsids: mechanical characteristics, genome packaging and delivery mechanisms. (nih.gov)
  • The main functions of viral capsids are to protect, transport and deliver their genome. (nih.gov)
  • This review focuses on the mechanical properties of viral capsids in general and the elucidation of the biophysical aspects of genome packaging mechanisms and genome delivery processes of double-stranded DNA bacteriophages in particular. (nih.gov)
  • In this way we directly connect the wealth of existing osmotic pressure data for DNA in the bulk with the DNA encapsidation curves within small viral capsids. (springer.com)
  • Here, we use timeresolved small-angle X-ray scattering to uncover the nonequilibrium self-assembly dynamics of icosahedral viral capsids packaging their full RNA genome. (cea.fr)
  • Concurrent with stimulating signaling, TRIM21 recruits p97/VCP, a AAA+ ATPase with segregase and unfoldase activity, and the proteasome, resulting in premature disassembly and degradation of viral capsids. (prolekare.cz)
  • A single locus was considered representative of the history of the whole genome and of the species. (biomedcentral.com)
  • The movement of mobile elements among species by horizontal transposon transfer (HTT) influences the evolution of genomes through the modification of structure and function. (biomedcentral.com)
  • A non-autonomous Helitron independently annotated as BmHel-2 from Bombyx mori and the MITE01 element from Ostrinia nubilalis was predicted in the genomes of 24 species in the insect Order Lepidoptera. (biomedcentral.com)
  • In many instances, the comparison of haplotype variants in a species or sophisticated computer algorithms are relied upon to predict the myriad of variant Helitron integrations in or among genomes. (biomedcentral.com)
  • Over the last century, the elucidation of viral oncogenic roles in many cancer types has provided fundamental knowledge on carcinogenetic mechanisms and established a basis for the early intervention of virus-related cancers. (springer.com)
  • Shlomai A, de Jong YP, Rice CM. Virus associated malignancies: the role of viral hepatitis in hepatocellular carcinoma. (springer.com)
  • This unusual genome provides proof that integration of an RNA virus into a DNA virus may have occurred between two unrelated virus groups at some point in evolution - something that has not been observed before. (sott.net)
  • Lead author Kenneth M Stedman said, "As more viral metagenomic data are generated and analyzed, additional evidence of recombination between RNA and DNA virus groups will likely be discovered. (sott.net)
  • In dengue fever patients, urine samples contain dengue virus (DENV) genomes and virus antigens were present in renal biopsies. (mdpi.com)
  • The structure of a rigorously conserved RNA element within the SARS virus genome. (mja.com.au)
  • Combining virus-enhanced immunogenicity with direct delivery of immunomodulatory molecules would represent a novel treatment modality for melanoma, and would require development of new viral vectors capable of targeting melanoma cells preferentially. (nih.gov)
  • Toward improved utility of the cell line for research in virus transmission, we present an annotated assembly of the C6/36 genome. (jcvi.org)
  • Expression of virally encoded CXCL10 within the brain protected mice from death and correlated with increased infiltration of T lymphocytes, enhanced IFN-γ secretion, and accelerated viral clearance when compared with mice infected with an isogenic control virus, MHV. (jimmunol.org)
  • Examples of low-copy viral RNA samples include the following: HIV controllers (capable of controlling the virus in the absence of antiretroviral therapy) ( 18 ), dengue virus (DENV) clinical samples collected after peak viremia ( 19 ), and West Nile virus (WNV) surveillance samples ( 20 ). (pubmedcentralcanada.ca)
  • The state and expression of the hamster polyomavirus genome in a large panel of virus-induced lymphomas have been investigated. (asm.org)
  • Unfortunately, however, a large number of the complete virus genomes submitted to GenBank lack annotations, severely limiting the usefulness of the data. (biomedcentral.com)
  • To illustrate the applicability of the method, we have chosen two viral datasets, namely papillomaviruses and Turnip mosaic virus (TuMV) isolates, largely dissimilar in genome, evolutionary distance and biology. (biomedcentral.com)
  • This work identified the areas of the human genome that put pressure on the AIDS virus, and the regions of the virus that serve to escape human control. (elifesciences.org)
  • An organism where the virus is integrated into the genome? (biostars.org)
  • I would definitely do the short experiment of adding your virus genome to the human genome and then aligning all reads and redoing the MACS analysis. (biostars.org)
  • Using the host+viral leads to a bunch of false positives from the host which look nothing like peaks on the genome browser and almost nothing from the virus which is where I actually see good peaks. (biostars.org)
  • Widespread Genome Reorganization of an Obligate Virus Mutualist. (usda.gov)
  • Bovine viral diarrhea virus (BVDV) is a pathogen found worldwide in calves. (biomedcentral.com)
  • A new isolate of bovine viral diarrhea virus, named JL-1, was isolated from the spleen of a sick cow with diarrhea using MDBK cell culture. (biomedcentral.com)
  • Bovine viral diarrhea virus (BVDV), the etiological agent of bovine viral diarrhea/mucosal disease, is widespread and one of the most economically important diseases of cattle. (biomedcentral.com)
  • The BVDV 1a and BVDV2a were the main subtypes in modified live virus (MLV) and killed viral vaccines. (biomedcentral.com)
  • 2,226 entries of viral genomes (1,524 distinct virus strains) in the database. (techylib.com)
  • Here, the authors use block-based reconstruction method and provide a 3.5 Å cryo-EM structure of sindbis virus that identifies a conserved hydrophobic pocket near the viral membrane that is stabilized by an unknown pocket factor. (nature.com)
  • This work demonstrates how a virus can amend host-viral dynamics by modulating acquisition of nutrients from the environment. (pnas.org)
  • We identify in the genome of a phytoplankton virus, which infects the small green alga Ostreococcus tauri , a host-derived ammonium transporter. (pnas.org)
  • The so-called SOSIP trimers not only reproduce the antigenic properties of the native viral spike but also display the same degree of immature glycans as presented on the native virus. (wikipedia.org)
  • Viral eukaryogenesis is the hypothesis that the cell nucleus of eukaryotic life forms evolved from a large DNA virus in a form of endosymbiosis within a methanogenic archaeon. (wikipedia.org)
  • The virus exits the host cell by budding, and tubule-guided viral movement. (wikipedia.org)
  • The virus exits the host cell by monopartite non-tubule guided viral movement. (wikipedia.org)
  • The virus exits the host cell by cell to cell movement, and monopartite non-tubule guided viral movement. (wikipedia.org)
  • The complete genomes are available from , along with the complete genome for dozens of other similar, unclassified virus strains. (wikipedia.org)
  • Transfection of the reaction products recovered virus recombinants with insertions, and mapping of these located regions of the His2 genome that were non-essential. (wikipedia.org)
  • All four complete genomes, as well as several additional "unclassified" virus genomes, are available online. (wikipedia.org)
  • All eight complete genomes, as well as several additional "unclassified" virus genomes, are available at Viral replication is cytoplasmic. (wikipedia.org)
  • A genome-wide association study that linked common genetic variants to salivary gland carcinoma risk has been retracted, according to Retraction Watch. (genomeweb.com)
  • For their newly reported work, the team queried metagenomic datasets from multiple BAL samples, and were able to construct additional complete redondovirus genomes. (genengnews.com)
  • Metagenomic analysis of human diarrhea: viral detection and discovery. (biomedcentral.com)
  • The rapid spread of Helitrons among animal lineages by HTT is facilitated by shuttling in viral particles or by unknown mechanisms mediated by close organism associations (e.g. between hosts and parasites). (biomedcentral.com)
  • In live, attenuated vaccines, such contaminants are not inactivated, and endogenous retroviruses by their very nature as Mendelian transmitted genomes are particularly difficult to eliminate. (cdc.gov)
  • However, the association between disease symptoms from appearance of DENV genome in urine, renal injury (occurrence rate of 2.9-13.3% of dengue patients) and haemolytic uraemic syndrome in the pathogenesis of dengue fever is unclear [ 1 , 2 ]. (mdpi.com)
  • Here, a BVDV isolate was isolated and its pathogenesis and complete genome were studied. (biomedcentral.com)
  • The result of pathogenesis of JL-1 strain showed that all infected calves developed clinical signs of elevated rectal temperatures, decreased leucopenia, and viral discharge. (biomedcentral.com)
  • Episomal amplification or chromosomal integration of the viral genome: alternative pathways in hamster polyomavirus-induced lymphomas. (asm.org)
  • Evidence for infectivity came from the detection of viral DNA in newly emerged leaves and the precise excision of the viral genome from the multimeric clones in inoculated leaves. (canterbury.ac.nz)
  • Lab experiments had already discovered that sizeable portions of the Zika genome could successfully resist to the attack of degrading enzymes. (news-medical.net)
  • Dr Eddy Rubin, Director of the U.S. Department of Energy Joint Genome Institute and Director of the Genomics Division at Lawrence Berkeley National Laboratory in Berkeley added, "This study using a comparative genomics strategy discovered important human specific properties of the regulatory network in human ES cells. (redorbit.com)
  • As a consequence, nowadays the focus of molecular epidemiology studies has turned from the viral to the human genome. (hindawi.com)
  • The most common type of genetic variation found in the human genome is a single nucleotide polymorphism, or SNP for short: a SNP is produced when a single nucleotide - an A, C, G or T - is replaced by a different nucleotide. (elifesciences.org)