• Lathrop sends mice that developed tumors to Leo Loeb at the University of Pennsylvania , who publishes pioneering papers on cancer. (jax.org)
  • Species of GAMMARETROVIRUS , containing many well-defined strains, producing leukemia in mice. (lookformedical.com)
  • Disease is commonly induced by injecting filtrates of propagable tumors into newborn mice. (lookformedical.com)
  • L. C. Strong breeds a Bagg albino with an albino from Little 's stock and starts the first of many tumor-prone strains, called the A strain, known for mammary and lung tumors. (jax.org)
  • The concept of precision cell therapy targeting tumor-specific mutations is appealing but requires surface-exposed neoepitopes, which is a rarity in cancer. (bvsalud.org)
  • B cell receptors (BCR) of mature lymphoid malignancies are exceptional in that they harbor tumor-specific-stereotyped sequences in the form of point mutations that drive self-engagement of the BCR and autologous signaling. (bvsalud.org)
  • Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus. (lookformedical.com)
  • Here, we use a BCR light chain neoepitope defined by a characteristic point mutation (IGLV3-21R110) for selective targeting of a poor-risk subset of chronic lymphocytic leukemia (CLL) with chimeric antigen receptor (CAR) T cells. (bvsalud.org)
  • The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. (lookformedical.com)
  • He is known for his groundbreaking work on HIV/AIDS and the human genome. (wikipedia.org)
  • He was a founder chairman and CEO of Human Genome Sciences, a company that pioneered the application of genomics to drug discovery. (wikipedia.org)
  • External envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene. (lookformedical.com)
  • Transmembrane envelope protein of the HUMAN IMMUNODEFICIENCY VIRUS which is encoded by the HIV env gene. (lookformedical.com)
  • Proteins synthesized by HUMAN IMMUNODEFICIENCY VIRUSES such as the HIV-1 and HIV-2 . (lookformedical.com)
  • Effect of host strain and H-2 type on spontaneous regression of murine leukemia. (jax.org)
  • Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. (lookformedical.com)
  • different populations of wild mice (mus musculus domesticus) in los angeles and ventura counties were observed over their lifespan in captivity for expression of infectious murine leukemia virus (mulv) and murine mammary tumor virus (mmtv) and for the occurrence of cancer and other diseases. (liverpool.ac.uk)
  • only three haplotypes are found in laboratory mice: ga, gb, and gc which are represented by balb/c, akr, and dba/2 prototypes respectively. (liverpool.ac.uk)
  • The present findings suggest that the detection of immune complexes in unfractionated samples of late tumour-bearer serum using a C1q-binding assay is masked by the increasing production of tumour-specific antibodies and by a shift from complement fixing to non-complement-fixing tumour-specific antibodies. (nih.gov)
  • liver tumors from interspecific hybrid, transgenic mice containing the sv40 early region linked to a mouse major urinary protein enhancer/promoter were analyzed for loss of heterozygosity to identify chromosomal regions which potentially contain genetic loci involved in multistep tumorigenesis. (liverpool.ac.uk)
  • AB - Peripheral blood mononuclear cells from donors of known serological status with respect to EB virus were exposed to the virus in vitro and then cultured at various cell concentrations. (nih.gov)
  • The results strongly suggest that the regression phenomenon is an in vitro expression of long-term T-cell-mediated immunity to EB virus which the large majority, if not all, infected individuals possess. (nih.gov)
  • CONCLUSION: Breast cancer cells transfected with cyclin D1b can induce the differentiation of macrophages into a tumor-associated macrophage-like phenotype, which promotes tumor metastasis in vitro and in vivo. (bvsalud.org)
  • The integrated analyses of The Cancer Genome Atlas (TCGA) datasets and bioinformatics methods were adopted to discover gene expression, gene coexpression, and overall survival in patients with breast cancer. (bvsalud.org)
  • Characterization of sera from different stages of tumour growth. (nih.gov)
  • AB - Antibody activity to Herpes simplex virus type-1 (HSV-1) and type-2 (HSV-2) was measured by the indirect hemagglutination (IHA) test in sera from 124 women with squamous-cell carcinoma of the uterine cervix, 46 women with non-cervical cancer and 116 matched normal women. (nih.gov)
  • src These could explain the "perinuclear" location of pp60 claimed by Rohrschnieder, since Kasamatsue found antibodues against the proteins in random tumor antisera, but not in normal sera, THE EARLY REGION OF ADENOVIRUS Presentations foa focused on the transcription, Splicing and regulation of ths region and, in the words of no less than Phil Sharp, "bewildering", and certainly provided no d information beariang directly on the main topic of the meeting. (nih.gov)
  • PMID- 214407 TI - Antibodies to Herpes simplex virus types 1 and 2 in patients with squamous-cell carcinoma of uterine cervix in India. (nih.gov)
  • It appears to be a polymorphic protein, variant from species to species, barely detectable (if at all) in normal ac cells (except for undifferentiated EC cells), induced by SV4O transformation and, it turns, out , by other forms of oncogeneisis, as well: Jay has found t what is proabaly the a same protein in a host of m neoplastic cells by using antibodies raised against various MCAinduced tumors. (nih.gov)
  • Isolated fractions were examined for their capacity to bind [125I]C1q as a measure of immune complex levels, and for their ability to bind soluble tumour-specific antigen as well as to react with antigens expressed at the surface of viable hepatoma cells. (nih.gov)
  • Elevated levels of circulating immune complexes in unfractionated serum were directly detectable during early tumour development although, following serum fractionation, immune complexes were identified at both early and late stages of tumour growth. (nih.gov)
  • In this study, we analyzed the clinicopathological and genetic characteristics of LS-associated GBMs and concurrent porokeratosis, as well as evaluated the tumor immune microenvironment (TIME) of LS-associated GBMs. (bvsalud.org)
  • However, the role of cyclin D1b in inducing macrophage differentiation toward tumor-associated macrophage-like cells remains unknown. (bvsalud.org)
  • Stevenson: Before we get started on that, maybe we could go back in time and kind of pick up where Bob Huebner got started with virus cancer type investigations. (nih.gov)
  • We were doing work on enteric viruses in water and sewage and, at that time, I was also collecting fecal specimens from Albert Sabin's polio vaccine experiments to determine what quantities of Poliovirus were in feces, and we were using his vaccine strains in his volunteers as some indication of what you could find in raw feces. (nih.gov)
  • Do you recall when Bob got interested in tumor viruses for the first time? (nih.gov)
  • They were ubiquitous and they hung around for a long time and they had qualities that some of the other DNA viruses he was aware of did not. (nih.gov)
  • Well, it was right about that time that Charlotte Friend came up with her virus. (nih.gov)
  • He is known for his groundbreaking work on HIV/AIDS and the human genome. (wikipedia.org)
  • He was at the National Institute of Allergy and Infectious Diseases and had a Branch, or a Laboratory, consisting of a number of well known investigators, amongst which was Wally Rowe and, in his lab, Janet Hartley, who were pretty well known for work in some of the murine viruses. (nih.gov)
  • And up until I knew Bob from the Cancer Institute, I had been at the Public Health Service in Cincinnati and knew him more in terms of Adenoviruses and a variety of enteric viruses which his laboratory had been very instrumental in discovering, developing and, in fact, he supplied us with Adenovirus Type 3, which we used in disinfection studies and things like that. (nih.gov)
  • OBJECTIVE: Tumor-associated macrophages (TAMs) of the M2 phenotype are frequently associated with cancer progression. (bvsalud.org)