• As Type C retroviruses, replicating murine leukemia viruses produce a virion containing a spherical nucleocapsid (the viral genome in complex with viral proteins) surrounded by a lipid bilayer derived from the host cell membrane. (wikipedia.org)
  • From 5' to 3' (typically displayed as "left" to "right"), the genome contains gag, pol, and env regions, coding for structural proteins, enzymes including the RNA-dependent DNA polymerase (reverse transcriptase), and coat proteins, respectively. (wikipedia.org)
  • The encoded proteins are trafficked to the plasma membrane, where they assemble into progeny virus particles. (wikipedia.org)
  • The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. (lookformedical.com)
  • Proteins synthesized by HUMAN IMMUNODEFICIENCY VIRUSES such as the HIV-1 and HIV-2 . (lookformedical.com)
  • Different strains of mice may have different numbers of endogenous retroviruses, and new viruses may arise as the result of recombination of endogenous sequences. (wikipedia.org)
  • Species of GAMMARETROVIRUS , containing many well-defined strains, producing leukemia in mice. (lookformedical.com)
  • Using a pair of black mice from the Granby farm, Little develops the C57BL and C57BR strains. (jax.org)
  • The strain is now valued as a source of embryonic stem cells for making knockout mice. (jax.org)
  • The viral genome is a single stranded, positive-sense RNA highly folded, molecule of around 8000 nucleotides. (wikipedia.org)
  • The murine leukemia viruses (MLVs or MuLVs) are retroviruses named for their ability to cause cancer in murine (mouse) hosts. (wikipedia.org)
  • L. C. Dunn breeds Strain 129, which later proves to have a high incidence of testicular cancer. (jax.org)
  • Replicating MLVs have a positive sense, single-stranded RNA (ssRNA) genome that replicates through a DNA intermediate via the process of reverse transcription. (wikipedia.org)
  • Among the latter MLVs are amphotropic viruses (Gr. amphos, "both") that can infect both mouse cells and cells of other animal species. (wikipedia.org)
  • different populations of wild mice (mus musculus domesticus) in los angeles and ventura counties were observed over their lifespan in captivity for expression of infectious murine leukemia virus (mulv) and murine mammary tumor virus (mmtv) and for the occurrence of cancer and other diseases. (liverpool.ac.uk)
  • only three haplotypes are found in laboratory mice: ga, gb, and gc which are represented by balb/c, akr, and dba/2 prototypes respectively. (liverpool.ac.uk)
  • He was at the National Institute of Allergy and Infectious Diseases and had a Branch, or a Laboratory, consisting of a number of well known investigators, amongst which was Wally Rowe and, in his lab, Janet Hartley, who were pretty well known for work in some of the murine viruses. (nih.gov)
  • The integrated analyses of The Cancer Genome Atlas (TCGA) datasets and bioinformatics methods were adopted to discover gene expression, gene coexpression, and overall survival in patients with breast cancer. (bvsalud.org)
  • And up until I knew Bob from the Cancer Institute, I had been at the Public Health Service in Cincinnati and knew him more in terms of Adenoviruses and a variety of enteric viruses which his laboratory had been very instrumental in discovering, developing and, in fact, he supplied us with Adenovirus Type 3, which we used in disinfection studies and things like that. (nih.gov)
  • tcrg gene polymorphism was investigated by southern blot analysis on a panel of laboratory and wild mouse strains using a set of probes which identify all known tcrg-v and -c genes. (liverpool.ac.uk)
  • PMID- 214405 TI - Long-term T-cell-mediated immunity to Epstein-Barr virus in man. (nih.gov)
  • The results strongly suggest that the regression phenomenon is an in vitro expression of long-term T-cell-mediated immunity to EB virus which the large majority, if not all, infected individuals possess. (nih.gov)
  • PMID- 214407 TI - Antibodies to Herpes simplex virus types 1 and 2 in patients with squamous-cell carcinoma of uterine cervix in India. (nih.gov)