He cited breeding experiments in nasturtium and Drosophila, in which a distinct, mutant phenotype is lost with successive outcrossings, and recovered with inbreeding of offspring. (wikipedia.org)
By outcrossing, he argued, the breeder selects for modifying factors that attenuate the mutant phenotype, and by inbreeding and limiting the gene pool of modifiers, the dominance of the mutation is recovered. (wikipedia.org)
Strains2
Fine mapping of a major QTL influencing morphine preference in C57BL/6 and DBA/2 mice using congenic strains. (jefferson.edu)
One of the first INBRED MOUSE STRAINS to be sequenced. (uchicago.edu)
Quantitative trait3
Bessa?h T, de Yebenes EG, Kirkland K, Higley MJ, Buono RJ, Ferraro TN, Contreras D. Quantitative trait locus on distal chromosome 1 regulates the occurrence of spontaneous spike-wave discharges in DBA/2 mice. (jefferson.edu)
Analysis of a quantitative trait locus for seizure susceptibility in mice using bacterial artificial chromosome-mediated gene transfer. (jefferson.edu)
A novel quantitative trait locus implicates Msh3 in the propensity for genome-wide short tandem repeat expansions in mice. (uchicago.edu)
Gene2
Food-associated estrogenic compounds induce estrogen receptor-mediated luciferase gene expression in transgenic male mice. (knaw.nl)
Identification of five mouse mu-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon. (jefferson.edu)
Transgenic1
This strain is commonly used as genetic background for transgenic mouse models. (uchicago.edu)
Laboratory1
Additionally, it will consider how immunological measurement, interpreted in the light of paradigms from laboratory mouse immunology, can define individual variation relevant to ecological and epidemiological studies of infectious disease in the natural environment LY2090314 1, 6. (clinical-research-informatics.com)
Human3
The glossary features nearly 250 terms explained in an easy-to-understand way by leading scientists and professionals at the National Human Genome Research Institute. (genome.gov)
Animal models (e.g., mice, rats, zebrafish and others) are sufficiently like humans in their anatomy, physiology or response to a pathogen that researchers can extrapolate the results of animal model studies to better understand human physiology and disease. (genome.gov)
Of the 5379 expected proteins in prototype UPEC strain CFT073, only six proteins met all of our founded criteria: (1) surface exposure (expected and shown), (2) induction during growth in human being urine, (3) high manifestation in experimentally infected mice Minocycline hydrochloride and (4) high manifestation in ladies with UTI, (5) immunogenicity, and (6) pathogen-specificity. (morainetownshipdems.org)
Cancer1
Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model. (uchicago.edu)
Models1
Immunoglobulin G subclasses confer protection against Staphylococcus aureus bloodstream dissemination through distinct mechanisms in mouse models. (uchicago.edu)
Treatment1
PPARγ level is determined by IF assay in 3×Tg-AD mice, 3×Tg-AD mice with RSG treatment, 3×Tg-AD-KO mice, 3×Tg-AD-KO mice with GW9662 stimulation. (medchemexpress.com)
Deficient1
Female but Not Male Mice Deficient in Soluble IgM Are Susceptible to Chemically Induced Glomerular Injury. (ucdenver.edu)
Sequence2
The set represents ~36,000 full length genes and EST clusters derived from sequence clusters in Build 74 of the Mouse Unigene Database. (nih.gov)
The completed genome sequence, linkage maps, and ES-cell technologies make the laboratory mouse a highly genetically tractable organism for comparative genomic study and disease modeling. (medscape.com)
Profiles1
Below are the most recent publications written about "Mice, Inbred BALB C" by people in Profiles. (ucdenver.edu)
National Human Gen2
The glossary features nearly 250 terms explained in an easy-to-understand way by leading scientists and professionals at the National Human Genome Research Institute. (genome.gov)
The NIH Exposure Biology Workshop was co-sponsored by partner institutions in the GEI--the NIEHS and the National Human Genome Research Institute (NHGRI). (nih.gov)
Mutant2
He cited breeding experiments in nasturtium and Drosophila, in which a distinct, mutant phenotype is lost with successive outcrossings, and recovered with inbreeding of offspring. (wikipedia.org)
By outcrossing, he argued, the breeder selects for modifying factors that attenuate the mutant phenotype, and by inbreeding and limiting the gene pool of modifiers, the dominance of the mutation is recovered. (wikipedia.org)
Common1
Haldane showed that, contrary to Fisher's argument, despite a decreased intensity of selection for dominance in self-fertilized populations, dominance is often more common in inbred than in outbred plant species. (wikipedia.org)
Development1
The International HapMap Project ( https://hapmap.ncbi.nlm.nih.gov ) characterized patterns of single nucleotide polymorphism (SNP) across individuals from diverse ethnic backgrounds, identified over 3.1 million SNPs, [ 15 , 16 ] and paved the way for the development of SNP genotyping arrays and the genome-wide association studies (GWASs) that followed. (medscape.com)