• The kit generates high-yield, similar-sized libraries that lead to performance improvements in sequence uniformity and overall read depth. (qiagen.com)
  • Sequence data can be used to identify variants across different samples, as well as to compare with multiple genomes - from consensus reference genomes to one of many genomes that have been uploaded from around the world. (qiagen.com)
  • Sequencing of 16 M. persicae cDNA libraries generated 26,669 expressed sequence tags (ESTs). (nih.gov)
  • Entrez is NCBI's primary text search and retrieval system that integrates the PubMed database of biomedical literature with 38 other literature and molecular databases including DNA and protein sequence, structure, gene, genome, genetic variation and gene expression. (nih.gov)
  • Sequence alterations are abundant in cancer genomes but the proportion of fragments in cell-free DNA (cfDNA) that harbor tumor-specific (somatic) mutations is often low 8 , 9 , making it difficult to detect bona fide variants amidst background noise from sequence changes introduced in library construction and sequencing. (nature.com)
  • The firm's Accuracy and Content Enhanced (ACE) technology augments exome- and whole-genome sequencing by targeted capture of regions that are difficult to sequence, it said. (genomeweb.com)
  • For the future direction, we need the in-depth genome sequence information and analysis for most of the mammals, including human to fully understand genome variation of economic traits, genetic susceptibility to diseases, and pharmacogenomics of drug response. (springer.com)
  • Sequence analysis showed that these "young" Alu insertions represented gene conversion events of pre-existing ancient Alu elements or independent parallel insertions of older Alu elements in the same genomic region. (ojp.gov)
  • Most of the unread genome just belonged to centromeric regions, these are special sections of chromosomes that are necessary for cell division, and they usually consist of tandem repeating DNA sequence units. (vechnayamolodost.ru)
  • According to an approximate estimate, the version of the human nuclear genome, which has been constantly replenished and improved since 2001, did not contain about 8% of the genomic DNA sequence. (vechnayamolodost.ru)
  • While we were doing this article for two years, some of these genes were gradually added to the reference sequence of the genome, which confirmed the validity of our approach. (vechnayamolodost.ru)
  • Since 2001, the composition of the genome has been updated several times, most recently in 2019?Yes, but there were still pieces of genomic DNA sequences that could not be "stuck" into the whole sequence, into the contig. (vechnayamolodost.ru)
  • Toxicogenomics is the application of genomic technologies (e.g., transcriptomics, proteomics, metabolomics, genome sequence analysis) to study the effects of environmental chemicals on human health and the environment. (epa.gov)
  • It is estimated that there are some 3 million SNPs in the human genome (definition #1), with one occurring about every 100-300 base pairs along the more than 3 billion base pair sequence. (science20.com)
  • The Human Genome Project, being a public effort, had an official policy of releasing all sequence data to public databases within 24 hours of completion, thereby making the information freely available to anyone who carried a copy of the 'human genome' in their cells. (science20.com)
  • We conclude that Pool-Seq data can be easily combined across different library preparation methods, but sufficient sequence coverage is key to reliable results. (datadryad.org)
  • A short, fossilized femur from a 38-year-old Neandertal, which sat untouched in a museum in Zagreb, Croatia, could lead to the first full genome sequence of Homo sapiens 's closest relative and help scientists understand what is special about humans, say teams that published analyses of two partial sequences of Neandertal DNA in this week's issues of Science and Nature . (scientificamerican.com)
  • Going forward, Rubin plans to construct a library of sequence fragments so that future researchers can compare human sequences with Neandertal sequences easily. (scientificamerican.com)
  • We developed TS-REX, a database/software system that supports the analysis of tissue and cell type-specific transcription factor-gene networks based on expressed sequence tag abundance of transcription factor-encoding genes in UniGene EST libraries. (lu.se)
  • Options: -m N N is a positive integer for weight match in genome sequence alignment. (cdc.gov)
  • N will be used as weight mismatch in genome sequence alignment. (cdc.gov)
  • Without this option, the ssw_test will do genome sequence alignment. (cdc.gov)
  • For modeling and analysis - such as in cancer research, for example, which is what we do here - by far the most important parts of the human genome assembly are the parts that code for protein ( transcribed regions and their ORFs ), along with their adjacent regulatory sequences . (bcgsc.ca)
  • We sequenced the causative agent of COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), from 43 clinical samples we collected, along with another 79 genome sequences available from Colombia. (cdc.gov)
  • A genome-wide survey for N-terminal signal sequences using bioinformatic tools (Psortb 2.0 and SignalP 3.0) combined with a strategy of the subtraction of lipoproteins and proteins containing multiple transmembrane domains yielded 116 secretory proteins. (cdc.gov)
  • strain CF27, new sequences were generated, and an update assembly and functional annotation were undertaken, followed by a comparative analysis with other Acidithiobacillus species whose genomes are publically available. (frontiersin.org)
  • Little wonder, then, that discussions about genome sequences and comparisons thereof can leave otherwise interested audiences more frustrated than enlightened. (science20.com)
  • In a broad sense, a genome can be considered as the collective set of genes, non-coding DNA sequences, and all their variants that are located within the chromosomes of members of a given species. (science20.com)
  • Thus, even though humans and chimpanzees are about 98% identical in terms of their DNA sequences, there is still such as thing as a 'human genome' and a 'chimpanzee genome' rather than a continuum with humans and chimps at two mildly divergent extremes. (science20.com)
  • Because the DNA sequences of even close family members are not identical, it can also be said that each individual carries a unique genome consisting of the DNA in his or her chromosomes. (science20.com)
  • Two independent research groups reported draft sequences of the human genome in February 2001: the publicly-funded and internationally collaborative Human Genome Project and the private company headed by J. Craig Venter known as Celera Genomics . (science20.com)
  • Comparing the similar sequences of Neandertal and human DNA, Rubin's group determined that the two genomes are at least 99.5 percent identical. (scientificamerican.com)
  • Phylogenetic analysis of loci from whole-genome shotgun sequences, mitochondrial and apicoplast genomes, revealed that CHN_HEN01 represents a distinct lineage (C). Retrospective examination of epidemiologic data revealed associations between lineage and the geographical distribution of US infections plus strong temporal associations. (cdc.gov)
  • The prediction of transcription factor binding sites in genomic sequences is in principle very useful to identify upstream regulatory factors. (lu.se)
  • Current diagnostic PCR assays target a variety of SARS CoV-2 genes and the vast majority target sequences in regions of the SARS CoV-2 genome that are highly conserved. (who.int)
  • Repetitive DNA sequences make up more than 50% of our genomes. (lu.se)
  • Some viruses have an RNA genome so the genes are made of RNA that may function directly without being copied into RNA. (wikipedia.org)
  • In line with the hypothesis that phase variation evolved as an adaptation to colonize diverse hosts, computational comparisons of all 27 to date completely sequenced and annotated meningococcal genomes retrieved from public databases showed that contingency genes are indeed enriched for genes involved in host interactions. (uni-wuerzburg.de)
  • In silico comparison of cDNA libraries identified aphid genes with tissue-specific expression patterns, and gene expression that is induced by feeding on Nicotiana benthamiana. (nih.gov)
  • Researchers used Canberra-based independent software vendor (ISV) Ronin's web application to process, analyse, and categorise the animal's genome data to build a picture of the location of its specific genes. (arnnet.com.au)
  • BioSystems currently contains biological pathways from the Kyoto Encyclopedia of Genes and Genomes (KEGG) and the EcoCyc ( Escherichia coli K-12 MG1655) subset of the BioCyc databases and is designed to accommodate other data in the future. (nih.gov)
  • New findings do not support a recent analysis of the rough draft of the human genome that suggests that bacterial genes have been laterally transferred into the human genome. (jcvi.org)
  • The deepest branching species in the genus, Y. ruckeri , causative agent of red mouth disease in fish, has the smallest genome (3.7 Mb), although it shares the same core set of approximately 2,500 genes as the other members of the species, whose genomes range in size from 4.3 to 4.8 Mb. (biomedcentral.com)
  • Genome to genome variation in islands with genes encoding functions such as ureases, hydrogeneases and B-12 cofactor metabolite reactions may reflect adaptations to colonizing specific host habitats. (biomedcentral.com)
  • He was at the origins of the introduction of DNA analysis into forensic medical examination in our country, participated in the discovery of genes key to Alzheimer's disease, was one of the first in Russia to start working with ancient DNA and sequenced the mitochondrial genome of a mammoth. (vechnayamolodost.ru)
  • And when we started mapping these active promoter genes, we found that in addition to thousands of signals at sites of known genes, many signals are mapped to different genomic sites where no genes are marked by the reference genome. (vechnayamolodost.ru)
  • CF27 exhibits a large number of genomic islands (mostly containing genes of unknown function), suggesting that a large number of genes has been acquired by horizontal gene transfer over time. (frontiersin.org)
  • In this study, we compared the genomes of nine diverse Methanomicrobiales strains, examined their pangenomes, reconstructed gene flow and identified genes putatively mediating their success across different habitats. (uncg.edu)
  • Assessing which genes are active in a given tissue at a specific time, and determining the relative degree of gene activity are essential steps in understanding how the genome as a whole functions within the tissue or cell under investigation. (the-scientist.com)
  • The term "transcriptome" refers to the set of genes that are expressed or transcribed from genomic DNA in a particular cell or tissue. (the-scientist.com)
  • Genomics studies all of a person's genes-also known as the genome-and looks at how someone's genes work together. (medlineplus.gov)
  • The Human Genome Project has already fueled the discovery of more than 1,800 disease genes . (medlineplus.gov)
  • However, when applying this concept to genomes of multicellular organisms such as mammals, one has to deal with a large number of false positive predictions since many transcription factor genes are only expressed in specific tissues or cell types. (lu.se)
  • To characterize identified variants and genes functionally, we rely on a broad repertoire of functional genomics methods , including CRISPR-Cas9, synthetic oligonucleotide libraries, and massively parallel reporter assays (MPRA). (lu.se)
  • The leading genome research centers and scientists have publicly recognized that these are the core enabling goals for the next decade genomics research. (springer.com)
  • The National Human Genome Research Institute (NHGRI) has echoed this need through its vision for genomics research (Collins et al. (springer.com)
  • The recent development of second generation sequencing platforms (reviewed by Mardis [ 7 , 8 ] and Shendure [ 7 , 8 ]) offers an opportunity to change the direction of microbial genomics, enabling the rapid genome sequencing of large numbers of strains of both pathogenic and non-pathogenic strains. (biomedcentral.com)
  • Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants. (genomeweb.com)
  • They combined multiple lines of evidence from molecular dating, comparative genomic analyses, and phylogeography to examine how the rearing of pigs allowed for novel Streptococcus suis lineages, some of which are capable of zoonotic spillover. (news-medical.net)
  • New DNA sequencing technologies have enabled detailed comparative genomic analyses of entire genera of bacterial pathogens. (biomedcentral.com)
  • Given the importance of meta-analyses combining data sets, we determined the influence of different genomic library preparation protocols on the consistency of allele frequency estimates. (datadryad.org)
  • It facilitates cost-efficient large-scale whole-genome sequencing (WGS) analyses. (lu.se)
  • These kits are single-box solutions for sequencing the entire viral genome. (qiagen.com)
  • The kits include reagents to reverse transcribe the RNA into cDNA, primers to specifically enrich for the viral genome and Unique Dual Indices (UDIs) for sequencing. (qiagen.com)
  • The QIAseq DIRECT SARS-COV-2 Kit is a single-box solution for generating whole genome libraries that are sequencing-ready and compatible with all Illumina platforms. (qiagen.com)
  • Although next-generation sequencing (NGS) has become a vital tool, library preparation remains a key bottleneck in the NGS workflow. (qiagen.com)
  • Our results reconstruct the early evolutionary history of SARS-CoV-2 in Colombia and highlight the advantages of genome sequencing to complement COVID-19 outbreak investigations. (cdc.gov)
  • Sequencing libraries were built from purified genomic DNA using the Ion Xpress Plus gDNA library preparation protocol. (nih.gov)
  • To assess within-host genetic changes in meningococci, we further used ultra-deep whole-genome sequencing of throat-blood strain pairs isolated from four patients suffering from invasive meningococcal disease. (uni-wuerzburg.de)
  • The BioProject database is a searcheable collection of complete and incomplete (in-progress) large-scale molecular projects including genome sequencing and assembly, transcriptome, metagenomic, annotation, expression and mapping projects. (nih.gov)
  • We analyzed whole-genome sequencing data from 2,511 individuals in the Pan-Cancer Analysis of Whole Genomes (PCAWG) study as well as 489 individuals from four prospective cohorts and found distinct regional mutation type-specific frequencies in tissue and cell-free DNA from patients with cancer that were associated with replication timing and other chromatin features. (nature.com)
  • With the ongoing developments of high throughput sequencing machines and advancement of modern bioinformatics tools at unprecedented pace, the target goal of sequencing individual genomes of living organism at a cost of $1,000 each is seemed to be realistically feasible in the near future. (springer.com)
  • The completion of the first human genome drafts (Yamey 2000 ) was just a start of the modern DNA sequencing era which resulted in further invention, improved development toward new advanced strategies of high-throughput DNA sequencing, so called the " high-throughput next generation sequencing " (HT-NGS). (springer.com)
  • During this period, tremendous success has been achieved in the fields of decoding of human genome, technological advancement of new era of human genome applications, toward personalized genomes and discovery of rare variants, leveraging genome sequencing to impact on cancer researches and mammalian evolution and population structure. (springer.com)
  • Here we describe the deployment of new sequencing technology to extensively sample eight genomes from the Yersinia genus of the family Enterobacteriaceae. (biomedcentral.com)
  • CDC used whole genome sequencing (WGS) analysis to link one case to contaminated opened powdered formula from the patient's home and the other to contaminated breast pump equipment. (medscape.com)
  • Nevertheless, complete genome sequencing, though conducted primarily under definition #1, has revealed two major sources of variation among individuals. (science20.com)
  • Sequencing pools of individuals (Pool-Seq) is a cost-effective method to determine genome-wide allele frequency estimates. (datadryad.org)
  • Whole genome sequencing analysis was used to link one case of Cronobacter sakazakii infection in a full-term infant to an opened can of powdered infant formula, and another unrelated fatal case in a premature infant to contaminated breast pump equipment. (cdc.gov)
  • This document specifies the minimum requirements for generating and analysing whole genome sequencing (WGS) data of bacteria obtained from the food chain. (iso.org)
  • In the next few years, using advances in DNA sequencing that's occurring, there's no question that we're going to have a Neandertal genome. (scientificamerican.com)
  • Our DNA services includes whole genome, whole exome or targeted library preparation and sequencing on Illumina platforms. (lu.se)
  • Title : Purification of Cyclospora cayetanensis oocysts obtained from human stool specimens for whole genome sequencing Personal Author(s) : Qvarnstrom, Yvonne;Wei-Pridgeon, Yuping;Van Roey, Erik;Park, Subin;Srinivasamoorthy, Ganesh;Nascimento, Fernanda S.;Moss, Delynn M.;Talundzic, Eldin;Arrowood, Michael J. (cdc.gov)
  • Advancements in embryo culture, blastocyst biopsy techniques, 24-chromosome aneuploidy screening platforms, and improved genomic coverage of new sequencing platforms, such as next-generation sequencing, have made PGT safe and accessible for all patients who undergo in vitro fertilization. (medscape.com)
  • [ 2 ] This technique has evolved throughout the years and is now largely performed by biopsy of the blastocyst trophectoderm cells with analysis using techniques such as next-generation sequencing (NGS) and comparative genomic hybridization (CGH) to test for aneuploidy. (medscape.com)
  • One of the most frequently demanded and fastest growing services at CTG is the sequencing of customer-prepared NGS libraries. (lu.se)
  • In Australia, integration of genomic sequencing METHODS into the response to COVID-19 has al owed clusters and outbreaks to be identified and transmission chains to COVID-19 cases notified to the Tasmanian Department of be rapidly detected. (who.int)
  • I recently wrote an article about the oldest fossils of life on Earth, and I'm writing about genome sequencing this week. (medscape.com)
  • Here, we report a comprehensive secretome (600 proteins) of this species, which was identified using a multipronged strategy based on genetic/genomic, proteomic, and bioinformatic approaches. (cdc.gov)
  • Without the activity of enzymes and proteins, the genetic information in the genome would not be able to be expressed and translated into functional proteins. (proprofs.com)
  • An audio definition of SNPs is available from the National Human Genome Research Institute's Talking Glossary of Genetic Terms. (medlineplus.gov)
  • How scientists locate SNPs in the genome is explained by the University of Utah Genetic Science Learning Center. (medlineplus.gov)
  • This included 29 published reference genomes and collection isolates from 15 countries spread across the five continents above. (news-medical.net)
  • Employing the DNA blot analysis only one COMT-encoding gene was found in the rat genome. (lu.se)
  • A reporter-gene-fusion-based genomic library that was custom-generated in this study enabled the detection of 23 secretory proteins. (cdc.gov)
  • In each species DNA has been 'added' by horizontal gene transfer in the form of plasmids and genomic islands. (biomedcentral.com)
  • The level of gene conversion between Alu elements suggests that it has had a significant influence on the single nucleotide diversity within the genome. (ojp.gov)
  • The new library includes 4 guide RNAs per gene and is half the size of the company's current three-module CRISPR 150K Human Genome-Wide Knockout Library. (genomeweb.com)
  • The reduced library size enables researcher to study how cells respond to the disruption of each gene across the entire human genome in a single screening experiment. (genomeweb.com)
  • While the plenty of investigators have slogged through experiments and data using RNAi-with an array of useful data resulting-newly developed genome editing technology is poised to provide faster and cheaper solutions for a better understanding of gene function and smarter identification of drug targets for complex diseases. (genengnews.com)
  • These newly developed libraries provide comprehensive coverage of the human genome, with several guide RNAs selected per gene, using the latest algorithms to enhance knockout efficiency-leading to increased screening capabilities over RNAi and CRISPR pooled libraries. (genengnews.com)
  • The new whole human genome library is available in gene families including the druggable genome, transcription factors, G-protein coupled receptors, kinases, and immunology and immuno-oncology targets, among others. (genengnews.com)
  • Most strains slowly increased gene content whereas one, Methanocorpusculum labreanum, evidenced genome downsizing. (uncg.edu)
  • Suppliers of Whole-organism cDNA Libraries Suppliers of Tissue-specific cDNA Libraries The questions of gene function, interaction, and regulation are central to the science of molecular biology. (the-scientist.com)
  • The definition normally excludes regions of the genome that control transcription but are not themselves transcribed. (wikipedia.org)
  • Mutations in other regions of the genome may also be informative for known VOI/VOC detection. (who.int)
  • Together with Senior Graphics Editor Jen Christiansen, we've looked at everything from the evolution of the genomes of SARS-Cov-2 strains to how pets contribute to the bacterial flora in your home . (bcgsc.ca)
  • To further investigate the genomic diversity among this group and to help characterize lineages of the plague organism that have no sequenced members, we present here the genomes of two isolates of the "classical" antiqua biovar, strains Antiqua and Nepal516. (asm.org)
  • A total of 219 French patient isolates and environmental strains were compared using a mixed-genome micro-array. (biomedcentral.com)
  • Using a combination of genome engineering and bacteriophage genetics, we have assembled a five-phage cocktail that minimizes the emergence of phage resistance and cross-resistance to multiple phages, and which efficiently kills the M. tuberculosis strains tested. (bvsalud.org)
  • The study dataset comprised 3,070 genomic isolates of S. suis samples derived from previously existing published data and collected and sequenced as a part of this project. (news-medical.net)
  • PCR-based screening of over 500 Alu insertion loci resulted in the recovery of a few "young" Alu elements that also resided at orthologous positions in non-human primate genomes. (ojp.gov)
  • The panel consists of approximately 550 primers for creating 425 amplicons, covering the entire SARS-CoV-2 viral genome. (qiagen.com)
  • Viruses consist of nucleic acid (viral genome) and a limited number of proteins that facilitate entry into a host cell, replication of the genome and production of virions. (qiagen.com)
  • The size of the entire SARS-CoV-2 genome is under 30 kb and can be mixed with host RNA when isolating from a human sample, making it challenging to reconstruct the whole viral genome. (qiagen.com)
  • A groundbreaking initiative to unify genomic datasets from across Canada into a national library will drive innovations in personalized treatments for diseases like cancer, and OICR will be a major contributor. (oicr.on.ca)
  • The project will build on Canada's global leadership in genomic research, which until now has been limited by the lack of a national approach to capture, store and access genomic data. (oicr.on.ca)
  • Canada has several different projects and platforms that collect genomic information and patient data, but we do not have a consolidated infrastructure to connect all this information in an ethical and sustainable way," says Dr. Mélanie Courtot, a Principal Investigator and Director of Genome Informatics at OICR. (oicr.on.ca)
  • This work will be supported by Overture, a data management software suite developed by OICR Genome Informatics that is driving genomic research in Canada and around the world. (oicr.on.ca)
  • The University of Sydney's Tasmanian Devil Genome project is a great example of how Australian researchers are using cloud technology and open data, to share insights with the global academic community to accelerate research outcomes," said Iain Rouse, AWS country director for Public Sector in Australia and New Zealand. (arnnet.com.au)
  • The Assembly resource provides access to genome assemblies for both submitted data and NCBI RefSeq assemblies. (nih.gov)
  • However, there were no genomic data on the Yersinia species with more limited virulence potential, frequently found in soil and water environments. (biomedcentral.com)
  • In this report, we reviewed some of the recent and ongoing activities regarding the use of genomic data in risk assessment, inside and outside of the U.S. Environmental Protection Agency (EPA). (epa.gov)
  • We also identified research needs, recommendations, and issues for future consideration when using genomic data in risk assessments. (epa.gov)
  • We undertook an integrated analysis of genomic and epidemiological data to investigate a large health-care- associated outbreak of coronavirus disease 2019 (COVID-19) and to better understand the epidemiology of COVID-19 cases in Tasmania, Australia. (who.int)
  • Genomic clusters were determined and integrated with epidemiological data to provide additional information. (who.int)
  • 9 Genomic data enhance national Health between 2 March and 15 May 2020 were included surveil ance data by clarifying the source of infection in in the analysis. (who.int)
  • Linear eukaryotic chromosomes contain specialized protective structures at the chromosome ends, called telomeres, which are essential for maintaining genome stability. (ubc.ca)
  • Eukaryotic genomes are composed of both nuclear and mitochondrial DNA. (proprofs.com)
  • The information graphic showing the history of the human genome assembly is part of my series of designs created for the Scientific American Graphic Science page. (bcgsc.ca)
  • In March 2022, a flurry of publications announced the first ever complete assembly of a human genome. (bcgsc.ca)
  • Because the human genome - a human genome - is complete. (bcgsc.ca)
  • You've probably already heard - and have been hearing for the last 15 years - that the human genome has been sequenced. (bcgsc.ca)
  • 92% of the human genome is euchromatic. (bcgsc.ca)
  • Miten Generating high-quality reference human genomes using Promethion nanopo. (slideshare.net)
  • The Menlo Park, Calif.-based startup is focused on delivering medical interpretation of human genomes for research and, eventually, clinical applications. (genomeweb.com)
  • Year 2011 is celebrated as the 10th anniversary since the human genome was first sequenced ( www.nature.com/natureconferences/hg10years/index.html ). (springer.com)
  • And the reason for this interview was the receipt of the most complete version of the human genome. (vechnayamolodost.ru)
  • The most complete human genomeRecently, an article was published in Science: The Telomere-to-telomere (T2T) consortium published the full version of the human genome. (vechnayamolodost.ru)
  • What exactly from the human genome have you sequenced?The role of our group's employees is to participate in the analysis of centromeric alpha-like DNA repeats. (vechnayamolodost.ru)
  • Arrayed functional screening with high quality modified synthetic sgRNA libraries simplifies development and enables scientists to rapidly screen in an unbiased manner for relevant phenotypes in any cell type, including human stem cells and primary cells," explained Abhi Saharia, Ph.D., director of product management. (genengnews.com)
  • The arrayed sgRNA libraries are designed to be ready-to-transfect into any human cell type and enable straightforward testing, assaying and analysis of complex phenotypes beyond cell viability. (genengnews.com)
  • And indeed, no one would ever mistake a chimpanzee genome for a human genome, in part because they differ in DNA amount and chromosome number (human chromosome 2 is a product of fusion of what remain as two separate chromosomes in other great apes). (science20.com)
  • The pieces are then sequenced directly, and researchers reassemble them by mapping them to similar sections in the human genome. (scientificamerican.com)
  • Each of these figures is a drop in the bucket considering the human genome is 3.2 billion base pairs long. (scientificamerican.com)
  • It can also help researchers understand the full potential of the human genome. (medlineplus.gov)
  • Christopher Douse explores the repetitive portion of the human genome, so-called 'genomic dark matter', and its role in human brain development and degeneration. (lu.se)
  • This award includes a $1.2 million grant to support his lab's exploration of the repetitive portion of the human genome, so-called 'genomic dark matter', and its role in human brain development and degeneration. (lu.se)
  • They conducted a population genomic analysis of over 3,000 bacterial samples derived from tonsil and nasal swabs from pigs and wild boar. (news-medical.net)
  • NEW YORK (GenomeWeb News) - Personalis said after the close of the market Thursday that it has gained an exclusive license to commercialize the Pharmacogenomics Knowledge Base (PharmGKB) and has launched its genome services for researchers. (genomeweb.com)
  • The Canadian Institutes of Health Research (CIHR) announced $15 million in funding to create a Pan-Canadian Genome Library , a first-of-its kind resource for researchers, healthcare professionals and others looking to find and treat diseases more effectively. (oicr.on.ca)
  • The firm said that its genome services, which are available to institutionally-based researchers and are not offered directly to consumers, support "case-control, family-based, or proband-only genome studies of disease, pharmacogenomics and cancer. (genomeweb.com)
  • What happened when genomic researchers targeted more diverse groups of people in their studies? (medlineplus.gov)
  • By increasing diversity in genomic studies, researchers can better tailor new treatments that benefit all populations. (medlineplus.gov)
  • We looked at which parts of the genome in the neurons of the cerebral cortex have active promoters, using a special chromatin marker, and thus scanned the entire genome. (vechnayamolodost.ru)
  • We found that typically no more than 1% of the variation in allele frequency estimates could be attributed to differences in library preparation. (datadryad.org)
  • However, despite the significant damage inflicted by M. persicae in agricultural systems through direct feeding damage and by its ability to transmit plant viruses, limited genomic information is available for this species. (nih.gov)
  • The genomic similarities described between species are usually based on comparing a few specific regions of DNA from a small number of representative individuals. (science20.com)
  • The given statement that the genome is able to express its own information without the activity of enzymes and proteins is FALSE. (proprofs.com)
  • The project will be led by Dr. Guillaume Bourque, Director of Bioinformatics at the McGill Genome Centre. (oicr.on.ca)
  • They occur almost once in every 1,000 nucleotides on average, which means there are roughly 4 to 5 million SNPs in a person's genome. (medlineplus.gov)
  • This approach lays the groundwork for non-invasive cancer detection using genome-wide mutation features that may facilitate cancer screening and monitoring. (nature.com)
  • Here, we considered whether identifying somatic mutations genome-wide could enable the detection of an increased number of circulating tumor DNA (ctDNA) alterations and increase the detection of early stage disease. (nature.com)
  • To address these challenges, we developed an approach, called GEnome-wide Mutational Incidence for Non-Invasive detection of cancer (GEMINI), that can identify a much larger number of somatic alterations in cfDNA (Fig. 1 ). (nature.com)
  • CoV-2 genome and can be targeted as a region for detection of VOC/VOI. (who.int)
  • This new library will provide a Canada-wide picture of diseases like cancer and the biology behind them, which will lead to new approaches to treating disease that are tailored to a person's unique biology. (oicr.on.ca)
  • The combination of a mixed-genome micro-array and statistical analysis using a Random Forest algorithm has identified virulence markers in a consistent way. (biomedcentral.com)
  • Analysis of the taxonomic composition of genomes of the Acidithiobacillia infers that they are chimeric in nature, supporting the premise that they belong to a particular taxonomic class, distinct to other proteobacterial subgroups. (frontiersin.org)
  • Genomic analysis provided useful additional information on COVID-19 in Tasmania, including evidence of a large health-care-associated outbreak linked to an overseas cruise, the probable source of infection in cases with no previously identified epidemiological link and confirmation that there was no identified community transmission from other imported cases. (who.int)
  • 4-6 Locally, genomic shown to be beneficial in investigating health-care- analysis has been used to analyse transmission routes, associated infections, 9,17 monitoring community trans- assign likely origins of infection, link outbreak cases and mission, 8-10 informing public health responses 9,10,18 and inform public health interventions and policies. (who.int)
  • Despite their key roles in greenhouse gas emissions and waste conversion to methane, little is known about the physiological and genomic bases for their widespread distribution and abundance. (uncg.edu)
  • While viral genomes can be comprised of RNA or DNA, SARS-CoV-2 is encoded by an RNA molecule. (qiagen.com)
  • The study suggests that the majority of Alu insertions in primate genomes are the products of unique evolutionary events. (ojp.gov)
  • Overall, these assays and approaches detect specific mutations or features such as insertions, deletions and point mutations in the SARS CoV-2 genome that are characteristic of a particular VOC/VOI using PCR. (who.int)
  • We compare all five currently sequenced Y. pestis genomes and the corresponding features in Yersinia pseudotuberculosis . (asm.org)
  • Yersinia genomes had a similar global partition of protein functions, as measured by the distribution of Cluster of Orthologous Groups families. (biomedcentral.com)
  • The sheer number of companies offering premade and custom cDNA libraries and products that facilitate their use serves as evidence of the tool's sustained power and efficacy. (the-scientist.com)
  • It's no exaggeration to say that we're at the dawn of a new genomic era in which the systematic study of repeats and their functions is possible," says Christopher Douse. (lu.se)
  • 8 Govindaraghavan S, Hennell JR, Sucher N. From classical taxonomy to genome and metabolome: towards comprehensive quality standards for medicinal herb raw materials and extracts. (thieme-connect.com)
  • 37,000 complete SARS-CoV-2 genomes made available through public databases, mainly GISAID ( https://www.gisaid.org ). (cdc.gov)
  • Install the software 1) Download the software from https://github.com/mengyao/Complete-Striped-Smith-Waterman-Library. (cdc.gov)
  • Genomic insights are an important component of the response to COVID-19, and continuing genomic surveillance is warranted. (who.int)
  • The company also said that it has optimized sample prep and library construction methods. (genomeweb.com)