Genome gene flow. Medical search. Frequent questions

Our results reveal discordant species divergence dates between mitochondrial and nuclear genomes, with a high frequency of conflicting trees throughout the nuclear genome suggesting that some sea turtle species frequently hybridized in the past. (fmach.it)
Nuclear genome comprises genetic material inherited from both parents, while mitochondrial genome carries only maternal lineage. (earth.com)
To understand potential gene flow across the rift, we sequenced the more than 2 billion base pairs that make up entire nuclear genome as well as the more than 16,000 base pairs that make up the entire mitochondrial genome. (earth.com)
Analysis of the nuclear genome suggests male-mediated gene flow might have occurred as recently as a thousand years ago. (earth.com)
While the nuclear genome is a mix of genetic information from both mother and father, the mitochondrial DNA (mtDNA) is passed directly from mother to child without any contribution of DNA from the father. (eurekalert.org)
These patterns suggest that the nuclear genome of one ecotype can enter the seeds of the other via occasional pollen movements with sorting of nuclear groups in subsequent generations. (whiterose.ac.uk)

Among the topics considered by the journal are genome structure and function, comparative genomics, molecular evolution, genome-scale quantitative and population genetics, proteomics, epigenomics, and systems biology. (eurekalert.org)
In this study we use comparative genomics to uncover a gene with uncharacterized function (1700011H14Rik/C14orf105/CCDC198), which we hereby name FAME (Factor Associated with Metabolism and Energy). (lu.se)
Genome structure, comparative genomics, and bioinformatics. (lu.se)

There are two main variants of hybrid species genomes: allopolyploid, which have one full chromosome set from each parent species, and homoploid, which are a mosaic of the parent species genomes with no increase in chromosome number. (wikipedia.org)
That is, to what extent hybrids, with their combination of gene variants from both species, can successfully compete for food and territory. (phys.org)
Still, despite gene flow between species, we found that genetic variants associated with the cultivated trichome morphology continue to segregate. (lu.se)
Accurately resolve structural variants and repeat regions, and characterise base modifications (e.g. methylation), fusion genes, and haplotype phasing, with PCR-free nanopore sequencing data. (nanoporetech.com)
The technique allows subsequent reassembly of the genome sequence and identification of novel variants and genomic structures that would be missed by targeted sequencing approaches. (nanoporetech.com)
Effect of CYP2C9 and VKORC1 Gene Variants on Warfarin Response in Patients with Continuous-Flow Left Ventricular Assist Devices. (cdc.gov)
To characterize identified variants and genes functionally, we rely on a broad repertoire of functional genomics methods , including CRISPR-Cas9, synthetic oligonucleotide libraries, and massively parallel reporter assays (MPRA). (lu.se)
NEW YORK (Reuters Health) - A new genome-wide association study has identified variants associated with worse albuterol response in African American and Puerto Rican children with asthma. (medscape.com)

Eosinophils in airway fluid were quantitated by flow cytometry. (cdc.gov)
In addition, in order to phenotypically anchor the gene expression data, changes in the heterogeneity of cell subtype populations and cell cycle phase were monitored using flow cytometry. (plos.org)
We make use of high-resolution, high-throughput flow cytometry, advanced imaging techniques, gene expression data as well as crosslinking data from population based registries. (lu.se)
Flow cytometry of Fanconi anemia cells cultured with nitrogen mustard and other clastogens demonstrates an arrest in G2/M. (medscape.com)

From portable, yet powerful Flongle and MinION devices, suitable for microbial genomes, through to the flexible GridION device and high-output PromethION devices, ideal for large eukaryotic genomes - scale your sequencing to match your specific whole-genome sequencing requirements. (nanoporetech.com)
Eukaryotic genomes are known to have garnered innovations from both archaeal and bacterial domains but the sequence of events that led to the complex gene repertoire of eukaryotes is largely unresolved. (darkenergybiosphere.org)
The organisation and evolution of the eukaryotic genomes. (lu.se)

A research team led by Yue-Chen Liu of China's Peking University analyzed the complete genomes of 32 tiger specimens, selected to be representative of all six potential subspecies, to confirm that tigers do indeed fall into six genetically distinct groups. (mongabay.com)
Launched in January 2018, LOEWE-TBG is set to systematically analyze complete genomes or all active genes. (rdworldonline.com)

Biologists used whole-genome sequences of 48 contemporary weedy rice plants to show how herbicide resistance evolved by gene flow from crop rice. (eurasiareview.com)
By comparing the sequences of mtDNA genomes from various regions of Europe with mitochondrial genomes from around the world, they made a very surprising observation regarding when sub-Saharan lineages appeared in Europe. (eurekalert.org)
The greater overlap offered by long reads enhances genome assembly by providing longer continuous, unambiguously assembled sequences, resulting in fewer contigs. (nanoporetech.com)
We developed a chromosome-scale reference genome for Canada lynx and used low-coverage whole genome sequences to better understand connectivity and gene flow between Maine and adjacent Canadian provinces. (umass.edu)

In this study, we generated whole genome resequencing data of the five globally distributed sea turtle species to estimate a calibrated phylogeny and the population size dynamics, and to understand the role of hybridization in shaping the genomes of these ancient species. (fmach.it)
Speciation with gene flow is a common pattern in marine species, and it raises questions whether current hybridization events should be considered as a part of these species' evolutionary history or a conservation issue. (fmach.it)
Eukaryote hybrid genomes result from interspecific hybridization, where closely related species mate and produce offspring with admixed genomes. (wikipedia.org)
Thus hybrid genomes are highly dynamic and may undergo rapid evolutionary change, including genome stabilization in which selection against incompatible combinations results in fixation of compatible ancestry block combinations within the hybrid species. (wikipedia.org)
The article summarizes how introgressed alleles or hybrid species can establish and how the resulting hybrid genomes evolve. (wikipedia.org)
Genetic exchange between species can impede the evolution of biodiversity because gene flow between diverging species counteracts their differentiation and hybridization between recently diverged species can lead to loss of genetic adaptations or species fusion. (wikipedia.org)
Such introgressive hybridization may enable neutral or selectively beneficial alleles to be transferred across species boundaries even in species pairs that remain distinct despite occasional gene flow. (wikipedia.org)
Here, we generate draft genome assemblies of 14 species representing the global cichlid diversity and integrate these into a new phylogenomic hypothesis of cichlid and teleost evolution that we time-calibrate with 58 re-evaluated fossil constraints and a new Bayesian model accounting for fossil-assignment uncertainty. (nature.com)
The drawings illustrate the 14 cichlid species used for whole-genome sequencing. (nature.com)
Despite the traditional view that species do not exchange genes by hybridisation, recent studies show that gene flow between closely related species is more common than previously thought. (phys.org)
A team of scientists from Uppsala University and Princeton University now reports how gene flow between two species of Darwin's finches has affected their beak morphology. (phys.org)
We wondered whether this evolutionary change could be explained by gene flow between the two species. (phys.org)
Scientists have sequenced the genomes of 16 Anopheles mosquito species from around the world. (sciencedaily.com)
Nora Besansky, O'Hara Professor of Biological Sciences at the University of Notre Dame and a member of the University's Eck Institute for Global Health, has led an international team of scientists in sequencing the genomes of 16 Anopheles mosquito species from around the world. (sciencedaily.com)
These results offer new insights into how these species are related to each other and how the dynamic evolution of their genomes may contribute to their flexibility to adapt to new environments and to seek out human blood. (sciencedaily.com)
To address these questions, researchers sequenced the genomes of 16 Anopheles species. (sciencedaily.com)
The researchers carried out interspecies gene comparisons with the Anopheles and other insects, to identify equivalent genes in each species and highlight potentially important differences. (sciencedaily.com)
Methods: We morphologically evaluated 155 herbarium specimens of three Mentha species and sequenced the genomes of a subset of 93 specimens. (lu.se)
Conclusions: Although hybridization, allopolyploidization, and human selection during cultivation can increase species richness (e.g., by forming hybrid taxa), we showed that unless reproductive barriers are strong, these processes can also result in mixing of genes between species and the potential loss of natural biodiversity. (lu.se)
It provides robust, genome-wide evidence for the origin and evolution of this charismatic megafauna species. (mongabay.com)
Cross-genome analyses now indicate that there are apparently no genetic barriers between species and that there has been gene flow among different rorqual species in the past. (rdworldonline.com)
However, the researchers could not detect traces of recent liaisons between the two species in their genomes. (rdworldonline.com)
Fontsere C, de Manuel M, Marques-Bonet T, Kuhlwilm M. Admixture in mammals and how to understand its functional implications: on the abundance of gene flow in mammalian species, its impact on the genome, and roads into a functional understanding. (upf.edu)
Further study is required to identify and conserve corridors which facilitate connectivity and gene flow between populations at the trailing edge and at the core of the species distribution. (umass.edu)
Here, through the enrichment of hydrothermal vent microorganisms, we recovered two circularized genomes of Heimdallarchaeum species that belong to an Asgard archaea clade phylogenetically closest to eukaryotes. (darkenergybiosphere.org)

Lung tissue gene expression was assessed using whole-genome mRNA microarrays. (cdc.gov)
We provide a searchable web resource for exploring differential mRNA expression and splice form usage between excitatory, PV, SST, and VIP neurons ( http://research-pub.gene.com/NeuronSubtypeTranscriptomes ). (jneurosci.org)

It also allows tentative dating of the specimen on the basis of "missing evolution" in its genome, detailed measurements of Denisovan and Neandertal admixture into present-day human populations, and the generation of a near-complete catalog of genetic changes that swept to high frequency in modern humans since their divergence from Denisovans. (nih.gov)
They say that their genomic research shows very little gene flow has occurred between tiger populations, but also that, despite the big cat's low genetic diversity, each subspecies has a unique evolutionary history. (mongabay.com)
This obstacle spurred researchers to examine the genomes of 100 Masai giraffes, trying to uncover whether populations on either side of the rift have interbred recently, a question with profound implications for conservation. (earth.com)
Interbreeding among different populations results in the exchange of genetic information - often called gene flow - and is generally considered to be beneficial because it can improve overall genetic diversity and help buffer small populations against disease and other threats," said Lan Wu-Cavener, assistant research professor of biology and a member of the research team. (earth.com)
This complex data presented a variety of computational and data storage challenges for our small team, but using the entire genome instead of a small portion allowed us to definitively investigate the extent of gene flow among these populations. (earth.com)
The course of human history has been marked by complex patterns of migration, isolation, and admixture, the latter a term that refers to gene flow between individuals from different populations. (news-medical.net)
In the article 'Evolutionary Genetics and Admixture in African Populations,' researchers from two institutes - Georgia Institute of Technology and Mediclinic Precise Southern Africa - reviewed how multiple demographic events have shaped African genomes over time (Pfennig, et al. (news-medical.net)
More recent demographic events that have occurred over the last 10,000 years have similarly resulted in admixture among modern humans, including gene flow among different click-speaking Khoe-San populations, the spread of pastoralism from eastern to southern Africa, and migrations of Bantu speakers across the continent. (news-medical.net)
They used data from the 1000 Genomes Project that were acquired from several admixed populations, including Colombians from Medellin, individuals with Mexican Ancestry from Los Angeles, Peruvians from Lima, and Puerto Ricans from Puerto Rico. (news-medical.net)
Salas said that it still remains unknown why there was genetic flow between the Africa and Europe in prehistoric times, but one possible scenario is that some bidirectional flow was promoted when the last glaciation pushed some Europeans southward, until the glacier receded and populations returned north. (eurekalert.org)
We investigated the differentiation of Spanish Basques from the rest of Iberian populations by means of a dense, genome-wide SNP array. (upenn.edu)
Genome-wide diversity was lower at the trailing edge, which suggests populations at the range periphery may already be showing genetic impacts of isolation. (umass.edu)
However, adaptive potential at some functional loci is weakened by available standing variation, particularly among peripheral populations where genome-wide diversity is low. (umass.edu)
It shows ancient contact and gene flow between the ancestors of the First Australians and now extinct populations of Neanderthals and Denisovans. (iflscience.com)
Speciation is the result of evolutionary processes that generate barriers to gene flow between populations, facilitating reproductive isolation. (cam.ac.uk)
We think that it was actually mixing or gene flow into the population from neighboring populations that helped recover the gene pool of the Willow Flycatchers in the San Diego area," said Ruegg. (northfortynews.com)

To delve into the genetic history of the animals, scientists sequenced their nuclear and mitochondrial genomes. (earth.com)
After identifying several gene blocks inherited together, or haplotypes, in the mitochondrial genome, researchers conducted a network analysis. (earth.com)

The potential for rapid adaptation or speciation makes hybrid genomes a particularly exciting subject in evolutionary biology. (wikipedia.org)
Speciation under gene flow is rare. (rdworldonline.com)
My work focusses on the impact of sex and gene flow on the processes of adaptation and speciation, and I use experimental speciation to study this. (cam.ac.uk)
Over the past decade, speciation genomics has provided better predictions on how barrier loci spread in the genome and how speciation-with-gene-flow can occur. (cam.ac.uk)

Homoeologous evolution of the allotetraploid genome of Poa annua L. (springer.com)
Two recent studies published in Genome Biology and Evolution examine patterns of admixture in two different regions of the world-;Africa and the Americas-;revealing how this process has shaped the genomes of modern humans. (news-medical.net)
To trace the evolution and ancestry of humans, scientists study the DNA sequence of the mitochondria, a specialized cellular structure that produces energy for the cell and carries genetic information that is separate from the rest of the genome that resides in the nucleus. (eurekalert.org)
In these networks, we study plant and insect trait evolution, and the role of trait diversification for gene flow and local adaptation. (lu.se)

Thus, Basques cannot be considered a genetic outlier under a general genome scope and interpretations on their origin may have to be revised. (upenn.edu)
This topical collection on " Gene Editing " aims to provide a forum for discussions on the latest technical developments in the fields of general genome engineering technologies, including (i) the establishment of cell culture systems, and (ii) the development of established and emerging organismal models by CRISPR/Cas9 or similar genome engineering tools. (mdpi.com)

This includes the foundational study on the first Aboriginal Australian genome from Western Australia and ancient DNA recovered from fossil remains from Lake Mungo. (iflscience.com)

New evidence from several archaeological sites, including the wreck of the Swedish warship Kronan , helped reveal how the prevalence of genes from three regions-the British and Irish Isles, the eastern Baltic and Southern Europe-varied across time and space. (smithsonianmag.com)
These results reveal numerous examples where neuron subtype-specific gene expression, as well as splice-isoform usage, can explain functional differences between neuron subtypes, including in presynaptic plasticity, postsynaptic receptor function, and synaptic connectivity specification. (jneurosci.org)
van der Valk T, Díez-Del-Molino D, Marques-Bonet T, Guschanski K, Dalén L. Historical genomes reveal the genomic consequences of recent population decline. (upf.edu)
These genomes reveal diverse mobile elements, including an integrative viral genome that bidirectionally replicates in a circular form and aloposons, transposons that encode the 5,000 amino acid-sized proteins Otus and Ephialtes. (darkenergybiosphere.org)
Gene expression and subcellular localization analyses reveal that FAME is a membrane-bound protein enriched in the kidneys. (lu.se)

Evidence for viral gene flow between Africa, the Middle East, virus that emerged in Austria in 2001: comparison with the South and Europe. (cdc.gov)
In a study published online today in Genome Research , researchers present the first genetic evidence for prehistoric gene flow between Africa and Europe, dating back as far as 11,000 years ago. (eurekalert.org)
In this study, an international team of researchers performed the largest analysis of complete mtDNA genomes belonging to haplogroup L (a lineage of sub-Saharan Africa origin) in Europe to date, aiming to untangle the history of genetic links between the two contents. (eurekalert.org)
This is important, because these age estimates might be influenced by older gene flow (SNPs with more than 10% minor allele frequency) and also by structure in Africa. (blogspot.com)

The date of admixture is consistent with a pattern of late Neandertals (including Vindija, the source of the Neandertal genome, and also a few in the Near East, such as Kebara, Amud, and Shanidar) becoming more similar to modern humans over time. (blogspot.com)
This does not speak of occasional admixture -which wouldn't have affected all Neandertal remains- but of thorough inter-deme gene flow. (blogspot.com)
Note, that the published admixture estimates of a few percent were genome-wide averages without MAF-filtration. (blogspot.com)
Dr. White and her colleagues analyzed the genomes of 1,441 children with asthma from the Study of African Americans, Asthma, Genes & Environments (SAGE II) and the Genes-Environments & Admixture in Latino Americans (GALA II) studies. (medscape.com)

Baird S.J.E., Petru ela J., Jaro I., krab nek P. & Mart nkov N. (2023): Genome polarisation for detecting barriers to geneflow. (muni.cz)
PALO ALTO, Calif. , Sept. 19, 2023 /PRNewswire/ -- Ganymede Bio , the cloud infrastructure provider purpose-built for the life sciences and manufacturing industries, and Kytopen , a leader in the development and commercialization of non-viral transfection tools for genome engineering, today announced a partnership to bring the power of cloud native, structured data to Kytopen's Flowfect ® platforms. (wkrn.com)

Traditionally, zoologists have viewed interspecific hybridization as maladaptive behaviour which can result in breaking up co-adapted gene complexes. (wikipedia.org)
This article reviews the evolutionary outcomes of interspecific hybridization and the properties of genomes of hybrid genomes. (wikipedia.org)

We present a DNA library preparation method that has allowed us to reconstruct a high-coverage (30×) genome sequence of a Denisovan, an extinct relative of Neandertals. (nih.gov)
Perhaps a case of hybrid vigor as MP Arabians and MP Neandertals mixed their genes and hit a kind of evolutionary jackpot. (blogspot.com)
Through the comparison of single nucleotide polymorphisms, we identify gene flow of FAME from Neandertals into modern humans. (lu.se)

A surprising finding was that the observed gene flow was substantial on most autosomal chromosomes but negligible on the Z chromosome, one of the sex chromosomes," says Fan Han, Uppsala University, who analysed these data as part of her Ph.D. thesis. (phys.org)
This explain why genes on the Z chromosome cannot flow from the medium ground finch to the cactus finch via these hybrid females, whereas genes in other parts of the genome can, because parents of the hybrid contribute equally. (phys.org)
S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. (cancerindex.org)
Prenatal Fanconi anemia diagnosis can be accomplished by demonstration of chromosome breaks in cells obtained in utero from chorionic villus biopsy, amniocentesis, or cord blood (by cordocentesis) or by identification of Fanconi anemia gene mutations in DNA extracted from fetal cells. (medscape.com)
correction of chromosome breakage or of impaired growth by a specific vector indicates that the cells have a mutation in that gene. (medscape.com)

Hybrids represent the merging of divergent genomes and thus face problems arising from incompatible combinations of genes. (wikipedia.org)

Far more imperiled than initially estimated, these towering creatures face geographic barriers that have limited their gene flow for over a millennium. (earth.com)

In the subset of VPA targeted genes, 114 were downregulated whilst 217 genes were upregulated. (plos.org)
In the subset of LiCl targeted genes, 73 were downregulated and 91 were upregulated. (plos.org)
ExperimentalDesign: We investigated ERh by immunohistochemistry in 353 stage II primary breast tumors from patients treated with 2 years adjuvant tamoxifen, and generated gene expres- sion profiles for a representative subset of 88 tumors. (lu.se)

Genomes of Africans contain mixtures of multiple ancestries, each of which has experienced different evolutionary histories. (news-medical.net)
of their genes than Africans do. (blogspot.com)

There were 3954 correlations and a total of 15 correlations for differentially expressed proteins (DEPs) and differentially expressed genes (DEGs) from proteomics and transcriptomics. (hindawi.com)

Historically, gene flow between wheat and its relatives may have contributed novel alleles to the bread wheat pangenome. (bris.ac.uk)

They looked at 48 new and 249 previously published ancient genomes and compared them to 16,638 genomes from modern humans. (smithsonianmag.com)
In the study, researchers from Brown University, the Universidad Nacional Autónoma de México, and the University of California-Merced analyzed how the resulting gene flow between modern humans redistributed archaic ancestry in admixed genomes. (news-medical.net)

Analysis of lung gene expression reveals a role for Cl- channels in diisocyanate induced airway eosinophilia in a mouse model of asthma pathology. (cdc.gov)
The genome reveals that this classification does match the evolutionary signals. (rdworldonline.com)
This resource, combining a unique new dataset and novel application of analysis methods to multiple relevant datasets, identifies numerous potential drug targets for manipulating circuit function, reveals neuron subtype-specific roles for disease-linked genes, and is useful for understanding gene expression changes observed in human patient brains. (jneurosci.org)

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. (cancerindex.org)

Whole-genome sequencing aims to provide complete analysis of an organism's genome. (nanoporetech.com)

We analyzed the whole genomes in a population and the phylogenetic framework and associated genomic classifications in conjunction with the morphological assessments. (lu.se)

In this study, we performed the first analysis of the levels and patterns of nucleotide variation in rice genomes under on-farm conservation in Yunnan during a 27-year period of domestication. (springer.com)
In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms. (genomeweb.com)
This study explores the use of a simple human neurosphere-based in vitro model to characterise the pharmacological and toxicological effects of LiCl and VPA using gene expression changes linked to phenotypic alterations in cells. (plos.org)
In a study published last week in the journal Cell , scientists examined nearly 300 ancient human genomes from Scandinavia that span a 2,000-year period, painting a picture of the region's genetic history. (smithsonianmag.com)
One avenue for better understanding the genetic architecture of African genomes is the study of ancient DNA: 'Going forward, analysis of ancient DNA is expected to become much more common. (news-medical.net)
In this study, we compared the genomes of nine diverse Methanomicrobiales strains, examined their pangenomes, reconstructed gene flow and identified genes putatively mediating their success across different habitats. (uncg.edu)
Sheela Turbek, a postdoctoral researcher in CSU's Department of Biology , led this study that sequenced the genomes of the Willow Flycatcher over a 100-plus year period, comparing DNA from museum specimens from the late 1800s to modern samples taken today. (northfortynews.com)

Methods for gene identification and analysis of gene structure: cloning, PCR, restriction mapping, in situ hybridisation, DNA sequencing. (lu.se)
Methods for analysis of gene expression: microarray, hybridisation, promoter analyses. (lu.se)

The researchers aren't sure why this is the case, but they say future studies with more genomes could shed light on the question, per Gizmodo . (smithsonianmag.com)
Much of our understanding of many such processes derives from the sequencing of the Anopheles gambiae genome in 2002, which was led by Notre Dame researchers and which has since facilitated many large-scale functional studies that have offered numerous insights into how this mosquito became highly specialized in order to live amongst and feed upon humans. (sciencedaily.com)
The researchers also used their genome-wide survey to look for evidence that different groups of tigers have adapted to the distinct environments in their geographic regions through the process of natural selection. (mongabay.com)
After the years-long effort of sequencing the historical genome, and comparing the historical results to modern samples, the researchers determined that the Willow Flycatcher had seen an increase in genetic variation over time. (northfortynews.com)

Pathogen-mediated natural selection may be responsible for the high differentiation previously reported for Basques at very specific genes such as ABO , RH , and HLA . (upenn.edu)

The quality of this genome allows a direct estimation of Denisovan heterozygosity indicating that genetic diversity in these archaic hominins was extremely low. (nih.gov)

Caicedo AL, Williamson SH, Hernandez RD et al (2007) Genome-wide patterns of nucleotide polymorphism in domesticated rice. (springer.com)
This suggests that ancient individuals with non-Scandinavian ancestry contributed proportionately less to the current gene pool in Scandinavia than expected based on the patterns observed in the archaeological record. (smithsonianmag.com)

This is very similar to the gene flows reported between Neanderthals, Europeans and Asians. (iflscience.com)

Using the bioinformatics tool MAGICTRICKS and reversible pharmacological inhibition, we found that primed genes required the transcriptional activities of NF-κB. (frontiersin.org)
Gene fusions derived by transcriptional readthrough are driven by segmental duplication in human. (upf.edu)

We used RNA sequencing coupled with chromatin immunoprecipitation sequencing to analyze primed microglial inflammatory gene expression and modifications to histone H3 lysine 4 trimethylation (H3K4me3) at the promoters of primed genes. (frontiersin.org)

In agreement with GSS activity localization in vivo , we identified six genes encoding arylsulfatase-like enzymes with a predicted C-terminal transmembrane domain, of which five showed GSS activity upon heterologous expression in insect cells. (nature.com)
We, therefore, tested the hypothesis that hypoxia would enhance or "prime" microglial pro-inflammatory gene expression in response to a later inflammatory challenge without programmatically increasing basal levels of pro-inflammatory cytokine expression. (frontiersin.org)
Expression changes in a core set of genes occurs independent of IgE in a mouse model of chemical-induced airway eosinophilia. (cdc.gov)
Treatment with VPA and LiCl resulted in the differential expression of 331 and 164 genes respectively. (plos.org)
To understand the molecular-genetic basis of functional specialization and identify potential drug targets specific to each neuron subtype, we performed a genome wide assessment of both gene expression and splicing across EXC, PV, SST and VIP neurons from male and female mouse brains. (jneurosci.org)
We used a genome-wide analysis which not only examined differential gene expression levels but could also detect differences in splice isoform usage. (jneurosci.org)
The main tool used in transcriptomics is total RNA sequencing, which is a powerful tool for analyzing gene expression changes in response to various environmental stresses [ 27 ]. (hindawi.com)
There's an excellent discussion of the article by Razib Khan, " The Basques may not be who we think they are ", Gene Expression 2/18/2010. (upenn.edu)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
Principles of gene expression. (lu.se)
Molecular mechanisms for regulation of gene expression at different levels: remodeling of chromatin, initiation of transcription, nuclear transport and signalling, and RNA interference. (lu.se)
Principles for regulation of gene expression through intercellular signalling. (lu.se)
Strategies for gene therapy and production of medicines via genetically-modified organisms (expression vectors and viral vectors). (lu.se)
An ERh gene expression profile was identified and was markedly different from the ERa signature. (lu.se)
Conclusion: Expression of ERh is an independent marker for favorable prognosis after adjuvant tamoxifen treatment in ERa-negative breast cancer patients and involves a gene expression program distinct from ERa. (lu.se)

With genome sequencing complete, scientists from around the world contributed their expertise to examine genes involved in different aspects of mosquito biology including reproductive processes, immune responses, insecticide resistance, and chemosensory mechanisms. (sciencedaily.com)

We provide evidence of a substantial gene flow, in particular from the medium ground finch to the common cactus finch," explains Sangeet Lamichhaney, one of the shared first authors and currently Associate Professor at Kent State University. (phys.org)

These groups have not interbred or traded genetic material for thousands of years, creating two separate gene pools isolated for an impressively long period. (earth.com)
We used over 200 contemporary samples from the Willow Flycatcher to scan the genetic material for specific regions of the genome associated with important environmental variables," said Turbek. (northfortynews.com)

The overarching aim of the Epigenetics common cause of gastric cancer, Pan-cancer genoMe and Group (EGE) is to advance the which is the third most common cause tranScriPtoMe analySiS and understanding of the role of epigenetic of cancer-related deaths worldwide. (who.int)
orthogonal exPeriMental changes and pathways induced by EGE investigated the impact of aSSeSSMent of ePigenetic environmental factors in cancer causation, both current H. pylori infection and driver geneS and their link to underpinning studies of etiology e , pigenetic memory of past (eradicated) environMental carcinogenS carcinogen evaluation, and prevention. (who.int)
One also needs to consider environmental factors, and gene by environment interactions, as well as interactions with other genes, and epigenetic effects. (medscape.com)

For the first time, scientists of the German Senckenberg Biodiversity and Climate Research Center, Goethe University and the University of Lund in Sweden have deciphered the complete genome of the blue whale and three other rorquals. (rdworldonline.com)
Our research highlights the enormous potential of genome sequencing to better understand biological processes and the fundamentals of biodiversity. (rdworldonline.com)

In the end, we were quite amazed that, by performing a stepwise genome-wide scan, seven regions including 14 genes stood out as the potential regions subject for selection," Luo said. (mongabay.com)

Complete genome analysis and molecular characterization of Usutu strains. (cdc.gov)
Gene ontology (GO) term enrichment analysis was used to highlight the most relevant GO terms associated with a given gene list following toxin exposure. (plos.org)
In addition, important genes related to osmoregulation, such as ion transport and carbonic anhydrase, were also detected in the correlation analysis for same trend DEPs_DEGs. (hindawi.com)
Nanopore technology delivers the most comprehensive whole-genome analysis available on a single platform. (nanoporetech.com)

Overexpression of chromatin remodeling and tyrosine kinase genes in iAMP21-positive acute lymphoblastic leukemia. (cancercentrum.se)

Computational methods allowed them to work out probable genetic ancestry and ancestral geographical origins through studies of gene flow. (sott.net)
Individuals of African ancestry represent only about 3% of everyone included in genome-wide association studies worldwide, he noted. (medscape.com)

This approach accelerates the processes of discovery, development, and manufacturing of gene-modified cell therapies, thereby propelling transformative advancements in healthcare. (wkrn.com)

Teaming up with cetacean specialist Professor Ulfur Arnason at University of Lund, Sweden, Lammers and his colleagues are the first to have sequenced the complete genome of the blue whale and other rorquals, including the humpback and the gray whale. (rdworldonline.com)

Gene technology: basic and applied molecular genetic methods. (lu.se)

In: Brush SB (ed) Genes in the fields: on-farm conservation of crop diversity. (springer.com)

However, the seed-transported chloroplast genomes are consistently shared by distinct ecotypes inhabiting the same region. (whiterose.ac.uk)

Here, we explored the phenotypic and genomic effects of interspecific gene flow following the widespread cultivation of Mentha spicata (spearmint), M. longifolia, and M. suaveolens. (lu.se)

However, mutations in specific Fanconi anemia genes can often be identified. (medscape.com)

Surprisingly, however, the majority of primed genes were not enriched for H3K4me3 acutely following hypoxia exposure. (frontiersin.org)
Surprisingly, the genomes show that rorquals have been hybridizing during their evolutionary history. (rdworldonline.com)

Until now, the lack of such genomic resources for other Anopheles limited comparisons to small-scale studies of individual genes with no genome-wide data to investigate key attributes that impact the mosquito's ability to transmit parasites. (sciencedaily.com)
Our partnership reflects their commitment to cutting-edge, outstanding practices in all areas-they are revolutionizing the field of cell and gene therapy manufacturing by introducing cloud data integration between instruments, thereby enabling a more interconnected and streamlined drug development process. (wkrn.com)

A genome-wide survey does not show the genetic distinctiveness of Basques ", Human Genetics , published online 1/16/2010. (upenn.edu)
And, more significantly, the progress achieved recently in human genomics research,1 the creation of genetically-modified foods2 and the gene therapy3 have added to the major bioethical issues the Region is likely to face in the near future. (who.int)

Anatomy11

Organisms46

Diseases4

Chemicals and Drugs14

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Psychiatry and Psychology4

Phenomena and Processes112

Disciplines and Occupations8

Anthropology, Education, Sociology and Social Phenomena4

Technology, Industry, Agriculture7

Humanities2

Information Science11

Health Care18

Geographicals25

Nuclear genome6

Comparative genomics3

Variants8

Cytometry4

Eukaryotic genomes3

Complete genomes2

Sequences4

Species25

MRNA2

Populations16

Mitochondrial2

Speciation4

Evolution4

General genome2

Aboriginal Australian1

Reveal5

Africa4

Admixture4

20232

Hybridization2

Neandertals3

Chromosome5

Divergent1

Barriers1

Subset3

Africans2

Proteomics1

Alleles1

Modern humans2

Reveals3

Proteins1

Organism's1

Phylogenetic1

Study7

Hybridisation2

Researchers4

Differentiation1

Archaic1

Patterns2

Neanderthals1

Transcriptional2

Promoters1

Expression15

Examine1

Evidence1

Genetic material2

Epigenetic3

Biodiversity2

Scan1

Analysis4

Chromatin1

Ancestry2

Processes1

Colleagues1

Molecular1

Diversity1

Distinct1

Interspecific1

Mutations1

Surprisingly2

Data2

Human2