• Enterovirus 71 (EV71) causes hand-foot-and-mouth disease (HFMD), for which there are currently no therapeutics. (ox.ac.uk)
  • From this study, we report two new, highly potent neutralizing antibodies, A9 and D6, against enterovirus 71 (EV71), the causative agent of HFMD. (ox.ac.uk)
  • Human infections with enteroviruses such as coxsackievirus A (CVA) are generally mild, but severe complications were more often reported for infections caused by enterovirus 71 (EV71) ( 1 , 2 ). (blogspot.com)
  • Monthly distribution of isolated enteroviruses revealed a major peak in summer-fall season and a small second peak in winter constituted totally by EV71. (omicsdi.org)
  • Enterovirus 71(EV71)-associated hand, foot and mouth disease (HFMD) decreased dramatically in Beijing from 2009 to 2019. (biomedcentral.com)
  • Phylogenetic and phylogeographic methods based on the EV71 genome were used to determine the evolution features, origin, and spatiotemporal dynamics. (biomedcentral.com)
  • Taken jointly these results first of all characterized the anti-EV71 antibody replies which are mostly against VP1 epitopes predicated on common enterovirus cross-reactive series. (healthyguide.info)
  • As a little non-enveloped positive-stranded RNA pathogen using a genome around 7 400 bases long enterovirus 71 (EV71) is certainly a member from the genus Enterovirus in the family members Picornaviridae which include poliovirus individual enterovirus A B C and D (HEV-A-D) and recently individual rhinovirus A B and C which infect human beings. (healthyguide.info)
  • Along with individual coxsackievirus (A2-8 A10 A12 A14 and A16) EV71 is certainly classified in to the types individual enterovirus A which is certainly made up of most causative agencies responsible for hands foot and mouth area disease (HFMD) predicated on its genome series1 2 EV71 and CA16 are main etiological agencies for HFMD an exanthematous and self-limited febrile disease. (healthyguide.info)
  • Within this research we portrayed the EV71 capsid protein and some BMN-673 8R,9S truncated VP1 protein to systematically analyze the web host antibody response to these protein and confirmed that individual anti-EV71 antibody replies are mostly turned on in response to VP1 especially to epitopes predicated on the normal enterovirus cross-reactive series. (healthyguide.info)
  • The genomic basis for these phe- noviruses and enteroviruses and the need to detect both notypic differences between similar viruses is not yet fully viruses in respiratory specimens. (cdc.gov)
  • There are three main viruses that have been studied and confirmed as the agents responsible for AHC, including enterovirus 70, coxsackievirus A24 variant (CA24v) and adenovirus 11. (wikipedia.org)
  • [ 3 ] which are small, nonenveloped RNA viruses, in which an icosahedral capsid encloses the single-stranded RNA genome. (medscape.com)
  • In relation to "CFS", the most-studied viruses have been the Epstein-Barr Virus (EBV) and the Human Herpes Virus-6 (HHV-6). (investinme.org)
  • In relation to "pure" ME, the most studied viruses (and for which there is extensive evidence) have been the enteroviruses, usually Coxsackie B (CBV). (investinme.org)
  • I believe that the main reason (ME)CFS patients are symptomatic is due to continuing inflammatory response toward viruses living within the cells, enteroviruses in most of the cases I see. (investinme.org)
  • We have clearly documented certain enterovirus infections triggering autoimmune responses in some patients…Can you imagine how we would feel if there are viruses surviving in our muscles, brains, hearts and gastrointestinal tracts triggering ongoing immune responses? (investinme.org)
  • Enteroviruses are common human viruses associated with various clinical syndromes, from minor febrile illness to severe, potentially fatal conditions (e.g., aseptic meningitis, paralysis, myocarditis, and neonatal enteroviral sepsis). (cdc.gov)
  • Like all other positive-strand RNA viruses, genome replication of enteroviruses occurs on rearranged membranous structures called replication organelles (ROs). (uu.nl)
  • ACBD3 knockout impaired replication of representative viruses from four enterovirus species and two rhinovirus species. (uu.nl)
  • Altogether, our data provide new insight into the central role of ACBD3 in recruiting PI4KB by enterovirus 3A and reveal the minimal domains of ACBD3 involved in recruiting PI4KB and supporting enterovirus replication.IMPORTANCE Similar to all other positive-strand RNA viruses, enteroviruses reorganize host cellular membranes for efficient genome replication. (uu.nl)
  • With sequencing technologies becoming cheaper and easier to use, more groups are able to obtain whole genome sequences of viruses of public health and scientific importance. (biomedcentral.com)
  • In contrast to most bacteria, fungi, or parasites, viruses are completely dependent on the host cell for their replication, hijacking the cell's biochemical machinery through the actions of viral genome-encoded factors. (genetex.com)
  • Several notifiable emerging viruses like influenza, Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), Ebola, Hendra, Nipah and Zika viruses have become the leading causes of epidemics and losses thereto in both human and animals. (benthamopen.com)
  • Notably, the majority of the emerging viruses enclose RNA genome and these are more prone for insertions/mutation in their genome, leading to evolving viral variants. (benthamopen.com)
  • Cross-reactivity: Diagnostic evaluation with human pathological samples confirm the specificity of the Kit against human respiratory viruses Enterovirus, Bocavirus, Adenovirus and Entero/Rhinovirus. (healthincode.com)
  • This review summarises CA antiviral action on the following viruses: influenza A virus (H1N1/H3N2/H7N9), hepatitis C virus (HCV) and hepatitis B virus (HBV), human immunodeficiency virus (HIV), infectious bronchitis virus (IBV), porcine reproductive and respiratory syndrome virus (PRRSV), herpes simplex virus (HSV)-1, enterovirus 71 (Ent 71), adenoviruses (AdenV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (archivepp.com)
  • Coronaviruses are ssRNA viruses, some of which can infect human lung epithelium via binding the ACE2 receptor. (tuni.fi)
  • These orphan viruses were initially termed ECHO, an acronym for enteric cytopathic human orphan virus, which was later simplified to echovirus. (medscape.com)
  • The analysis of viral sequences verified that single infection of human adenovirus was the leading cause of gastroenteritis among infants and children, which was detected in 23.2% of the patients, followed by a mixed infection of human adenovirus and other viruses, which was detected in 20.9% of patients. (biomedcentral.com)
  • A(H1N2) variant viruses and one human case of infection with an influenza A(H3N2) variant virus were reported officially.3 One additional human case of infection with an influenza A(H1N1)v virus was detected. (who.int)
  • The overall public health risk from currently known influenza viruses at the human-animal interface has not changed, and the likelihood of sustained human-to-human transmission of these viruses remains low. (who.int)
  • Human infections with viruses of animal origin are expected at the human-animal interface wherever these viruses circulate in animals. (who.int)
  • 1. What is the likelihood that additional human cases of infection with avian influenza A(H5) viruses will occur? (who.int)
  • Most human cases were exposed to A(H5) viruses through contact with infected poultry or contaminated environments, including live poultry markets. (who.int)
  • Since the viruses continue to be detected in animals and environments, further human cases can be expected. (who.int)
  • 2. What is the likelihood of human-to-human transmission of avian influenza A(H5) viruses? (who.int)
  • Even though small clusters of A(H5) virus infections have been reported previously including those involving healthcare workers, current epidemiological and virological evidence suggests that influenza A(H5) viruses have not acquired the ability of sustained transmission among humans, thus the likelihood is low. (who.int)
  • The nasopharyngeal swab tested negative for influenza, adenovirus, respiratory syncytial virus, human metapneumovirus, parainfluenza viruses 1-3 and rhinovirus. (who.int)
  • A combined nasopharyngeal/oropharyngeal swab and cerebrospinal fluid sample were negative by reverse transcription-polymerase chain reaction (RT-PCR) testing for enteroviruses and human parechovirus, as well as for a panel of common respiratory pathogens and encephalitic viruses by molecular methods ( 2 ). (cdc.gov)
  • It is not part of the International Committee on Taxonomy of Viruses classification of viruses (ie, it is not a species, genus, or family), which is based on the nature and structure of the viral genome. (msdmanuals.com)
  • Enteroviruses, along with rhinoviruses (see Common Cold) and human parechoviruses, are a genus of picornaviruses ( pico , or small, RNA viruses). (msdmanuals.com)
  • The genotypes HEV-1 to HEV-8 belong to the genus Orthohepevirus A of which at least HEV-1 to HEV-4 can infect humans. (nature.com)
  • The enterovirus genus of the picornavirus family includes a large number of important human pathogens such as poliovirus, coxsackievirus, enterovirus A71, and rhinoviruses. (uu.nl)
  • Coxsackievirus B is an RNA Enterovirus, which usually causes an asymptomatic or brief upper respiratory tract or gastroenteric infection. (medscape.com)
  • Coxsackievirus B was present in 24% of the 18,000 enteroviruses isolated and reported in the United States from 1970-1979. (medscape.com)
  • A committee sponsored by the National Foundation for Infantile Paralysis categorized EVs and other enteroviruses (ie, coxsackievirus group A and group B, polioviruses) together in 1957. (medscape.com)
  • We then sequenced whereas enteroviruses infect primarily the gastrointestinal the 5 untranslated region, capsid protein VP1, and protease tract and can spread to other sites such as the central ner- precursor 3CD regions of virus-positive samples. (cdc.gov)
  • While most of the approximately 100 species of enteroviruses primarily infect the gastrointestinal (GI) tract, EV-D68 has tropism for the respiratory tract. (medscape.com)
  • There are more than 200 virus species that can infect humans, not including many others that affect humanity by targeting plants and animals used by people. (genetex.com)
  • Enteroviruses can infect all tissues of the human body. (medscape.com)
  • All human infections caused by a new influenza subtype are required to be reported under the International Health Regulations (IHR, 2005).4 This includes any influenza A virus that has demonstrated the capacity to infect a human and its haemagglutinin gene (or protein) is not a mutated form of those, i.e. (who.int)
  • Rhinoviruses and enteroviruses are leading causes of onomy.asp) because of their high sequence homology ( 1 ). (cdc.gov)
  • However, some enteroviruses exhibit specifi c diversity of rhinoviruses circulating in humans. (cdc.gov)
  • Human rhinoviruses (HRVs) and enteroviruses (HEVs) ments the 2 previously known A and B lineages ( 6 - 8 ) (N.J. are leading causes of infection in humans. (cdc.gov)
  • In this study, we screened a large number of persons with acute respiratory diseases by using assays designed to Author affi liations: University of Geneva Hospitals, Geneva, Swit- overcome the diversity of both rhinoviruses and enterovi- zerland (C. Tapparel, S. Van Belle, L. Turin, S. Cordey, P. M. Soc- ruses circulating in humans. (cdc.gov)
  • [ 10 , 3 ] EV-D68 is acid-labile and behaves more like human rhinoviruses in its affinity for the respiratory tract. (medscape.com)
  • Human rhinoviruses (HRVs) are a highly prevalent cause of acute respiratory infection in children. (plos.org)
  • Hospitals in Illinois and Missouri reported an increased incidence of rhinovirus and enterovirus infection, with 30 of 36 isolates from the nasopharyngeal secretions of patients with severe respiratory illness identified as EV-D68. (medscape.com)
  • This highlights the importance of enterovirus surveillance for detection of the importation of new genotypes such as EV-C105, thus allowing a better understanding of the roles they play in disease. (who.int)
  • Human EV-D68 is a small nonenveloped virus with single-stranded positive-sense RNA genome of 7.5 kilobases. (medscape.com)
  • The virus enters human cells via endocytosis by binding the ACE2 receptor and releasing its positive-sense RNA genome. (news-medical.net)
  • The National Enterovirus Surveillance System (NESS) is a voluntary, passive surveillance system that has monitored trends in circulating enteroviruses since 1961. (cdc.gov)
  • Here we report on the identification of EV-C105 for the first time in New Zealand from a patient with mild lower respiratory tract symptoms during an admission to a hospital in Auckland through the national enterovirus surveillance system. (who.int)
  • Polymorphisms in Toll-like receptor 3 confer natural resistance to human herpes simplex virus type 2 infection. (cdc.gov)
  • [ 3 ] Enterovirus surveillance in the United States between 1970 and 2005 identified only 26 cases of EV-D68 infection. (medscape.com)
  • Hitherto reports confirm infection of humans through rotaviruses of animal origin, exclusively via direct transmission or through gene reassortments between animal and human strain of rotaviruses. (benthamopen.com)
  • Information about human parechovirus (HPeV) infection in animals is scant. (blogspot.com)
  • Despite the frequent infections and numerous HPeV genotypes detected in humans, information about HPeV infection in animals is scant. (blogspot.com)
  • Since the last risk assessment on 21 May 2021, one new laboratory-confirmed human case of influenza A(H5N6) virus infection was reported from China to WHO on 30 May 2021. (who.int)
  • Good quality serological investigations may be useful in differentiating infection from contamination in these cases and allow for better assessment of the risk of human infection. (who.int)
  • Fevrier M, Dorgham K, Rebollo A (2011) CD4 + T cell depletion in human immunodeficiency virus (HIV) infection: role of apoptosis. (virosin.org)
  • The New Zealand National Poliovirus and Enterovirus Identification Reference Laboratory at the Institute of Environmental Science and Research (ESR) Limited, National Centre for Biosecurity and Infectious Disease routinely receives untyped enterovirus clinical specimens or cell culture isolates from four major hospitals (based in Auckland, Waikato, Wellington and Christchurch) as part of the New Zealand enterovirus surveillance network. (who.int)
  • To understand the molecular basis for the possible pathogenetic mechanism of these CVA2 strains, we analyzed their complete genome sequences. (blogspot.com)
  • As part of an ongoing effort to generate complete genome sequences of hand, foot and mouth disease-causing enteroviruses directly from clinical specimens, two complete coding sequences and two partial genomic sequences of human bocavirus 1 (n=3) and 2 (n=1) were co-amplified and sequenced, representing the first genome sequences of human bocaviruses from Vietnam. (ox.ac.uk)
  • Imperial College London, London, UK (E. Zdobnov) has not been shown in natural human infections ( 18 ). (cdc.gov)
  • There are 57 variants of this virus, that each cause 5-10% of upper respiratory infections in humans. (wikipedia.org)
  • CI = 0--0.4) than infections with other enteroviruses. (cdc.gov)
  • NESS data allowed identification and description of a core group of consistently circulating enteroviruses that probably determine the disease burden associated with enterovirus infections. (cdc.gov)
  • Intro Picornaviruses are nonenveloped infections with a positive-sense single-stranded RNA genome. (palomid529.com)
  • Because many human being picornaviruses are thought to get into their website hosts by traversing the digestive tract epithelium, we possess been interested in the conversation between these infections and digestive tract epithelial cells. (palomid529.com)
  • Several viral infections in humans have been tracked to have animal-origin and conversely, reverse-zoonosis is also not unusual [ 1 Choudhary P, Minakshi P, Ranjan K, Basanti B. Zooanthroponotic transmission of rotavirus in Haryana State of Northern India. (benthamopen.com)
  • Despite significant advances in health care, outbreaks of infections by enteroviruses (EVs) continue to plague the Asia-Pacific region every year. (ox.ac.uk)
  • During the course of viral infections, the human body produces neutralizing antibodies which play a defining role in clearing the virus. (ox.ac.uk)
  • Members of the human herpesvirus (HHV) and human papillomavirus (HPV) families cause the most common primary viral infections of the oral cavity. (medscape.com)
  • Nonetheless, many other viral infections can affect the oral cavity in humans, either as localized or systemic infections. (medscape.com)
  • Three species of Chlamydia cause human disease, including sexually transmitted infections and respiratory infections. (msdmanuals.com)
  • Human enteroviruses (HEVs) are the most frequently reported cause of aseptic meningitis with or without CSF pleocytosis in childhood. (omicsdi.org)
  • Human enteroviruses (HEVs) are common causes of acute meningitis. (omicsdi.org)
  • BACKGROUND:Human enteroviruses (HEVs) are common causal agents of aseptic meningitis in young children. (omicsdi.org)
  • Tissue samples of heart, lung, spleen, and rectum, and nasopharyngeal and rectal swab specimens were positive for enterovirus by virus culture in a rhabdomyosarcoma cell line. (blogspot.com)
  • A total of 437 hospitalized patients were reported, and enteroviruses were detected in the specimens from 84 patients (19.2%) and were identified into 17 serotypes. (omicsdi.org)
  • To develop new and more effective indicators of waterborne pathogens it is important to better understand how both evolution and ecology interact with the genomes and natural history of waterborne pathogens and their indicators, if different from themselves. (nationalacademies.org)
  • State and federal public health laboratories have built capacity such that they now sequence more than 6000 influenza virus genomes and more than 5000 enteropathogenic bacterial genomes each year [ 11 ]. (biomedcentral.com)
  • The fundamental structure of the viral particle includes the DNA or RNA genome within a protein coat, or capsid. (genetex.com)
  • A9 destabilizes and damages the virus capsid that forms an outer protective covering around the genome of the virus, while also interfering with virus attachment to the host cells. (ox.ac.uk)
  • Comparative genomics of Pseudomonas fluorescens subclade III strains from human lungs. (cdc.gov)
  • Full Genome Analysis of Enterovirus D-68 Strains Circulating in Alberta, Canada. (cdc.gov)
  • The prominent gastroenteric virus is rotavirus, which is a double-stranded RNA virus with a segmented nature of genome enabling higher reassortment events and generates unusual strains with unique genomic constellations derivative of parental rotavirus strains. (benthamopen.com)
  • Molecular characterization of unusual bovine rotavirus A strains having high genetic relatedness with human rotavirus: Evidence for zooanthroponotic transmission. (benthamopen.com)
  • Because sequence analysis of the 5′-UTR amplicon showed that this enterovirus strain was closely related to other human enterovirus A strains, another set of consensus primers (5′-TGCCCACAYCARTGGATHAA-3′ and 5′-CCTGACCACTGNGTRTARTA-3′) specific for the viral protein 2-viral protein 3 region of human enterovirus A was used for typing. (blogspot.com)
  • One of the problems with eradicating a virus like polio is that it has a high probability to recombine with other co-circulating enterovirus strains. (healthfreedomohio.org)
  • These temporal dynamics were found to be most similar to those of human enterovirus species B variants. (ox.ac.uk)
  • They are classified into at least three species, HRV-A, HRV-B and HRV-C, which are characterized by sequencing the 5′ untranslated region (UTR) or the VP4/VP2 region of the genome. (plos.org)
  • Enterovirus C105 (EV-C105) is a member of the human enterovirus group C species and was first identified in the Democratic Republic of Congo in late 2010 in a faecal sample collected from a fatal acute flaccid paralysis patient during a poliomyelitis outbreak. (who.int)
  • Genome mapping of filaria vector species and benefit. (icmr.nic.in)
  • Arbovirus (arthropod-borne virus) is defined as any virus that is transmitted to humans and/or other vertebrates by certain species of blood-feeding arthropods, mostly insects (flies and mosquitoes) and arachnids (ticks). (msdmanuals.com)
  • Enteroviruses typically spread through the fecal-oral route, although some serotypes, like EV-D68, also spread via respiratory secretions. (medscape.com)
  • Our data provide direct evidence that enteroviruses use ER and then Golgi membranes to initiate RO formation, demonstrating the remarkable flexibility with which enteroviruses usurp cellular organelles.IMPORTANCE Enteroviruses are causative agents of a range of human diseases. (figshare.com)
  • GenBank currently has automatic prokaryotic and eukaryotic genome annotation pipelines but has no viral annotation pipeline beyond influenza virus. (biomedcentral.com)
  • Surprisingly, other than for influenza virus, NCBI GenBank does not currently have an automatic viral genome annotation pipeline. (biomedcentral.com)
  • Information from these notifications is critical to inform risk assessments for influenza at the human-animal interface. (who.int)
  • Bosphore SARS-CoV-2/Flu/RSV Panel Kit detects and discriminates 2019-nCoV (which is later renamed officially as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by WHO), RSV A&B and influenza A&B in human respiratory samples including nasopharyngeal, oropharyngeal swabs and saliva. (anatoliageneworks.com)
  • Thus, this molecular approach will add incrementally to our current knowledge of the HEV-genome organization and pathogenesis in chronic hepatitis E. (nature.com)
  • Therefore, to capture the heterogeneity of the HEV quasispecies, including recombination events and SNP that occur with very low frequencies, we developed new sequencing approaches for HEV genotype 3 based on the amplification of the near full-length genome of HEV by long-range PCR (lrPCR) followed by subsequent next-generation sequencing (NGS) and third-generation sequencing. (nature.com)
  • Widespread recombination within human parechoviruses: analysis of temporal dynamics and constraints. (ox.ac.uk)
  • Genomic inclusivity: In silico design based on 4,115 SARS-CoV-2 genomes (GISAID). (healthincode.com)
  • Here we report the development of a direct RT-PCR SARS-CoV-2 detection method that can reliably detect minute quantities of SARS-CoV-2 gRNA in nasopharyngeal swab samples as well as the presence of human genomic DNA. (medrxiv.org)
  • Efforts to increase laboratory participation in NESS should continue to allow for more complete and accurate surveillance for enteroviruses. (cdc.gov)
  • Enterovirus surveillance operates year-round and is based on reports from routine diagnostic services for patients. (who.int)
  • This previously unknown and unsuspected aspect of enterovirus replication provides an explanation for reports of enteroviral RNA detected in diseased tissue in the apparent absence of virus particles" (Journal of IiME 2009:3:1). (investinme.org)
  • Enteroviruses are associated with diverse clinical syndromes ranging from minor febrile illness to severe, potentially fatal conditions (e.g., aseptic meningitis, encephalitis, paralysis, myocarditis, and neonatal enteroviral sepsis) and could be linked with the development of some chronic diseases (e.g., type 1 diabetes and dilated cardiomyopathy) ( 1,2 ). (cdc.gov)
  • To investigate the molecular epidemiology of enteroviruses (EVs) among patients with sepsis-like illness and/or aseptic meningitis admitted to three major hospitals in West Bank, Palestine from 2012 to 2015. (omicsdi.org)
  • Molecular epidemiology of human enterovirus associated with aseptic meningitis in Shandong Province, China, 2006-2012. (omicsdi.org)
  • however, cases of pleurodynia secondary to other enteroviruses have been reported (eg, enteric cytopathogenic human orphan [ECHO] virus). (medscape.com)
  • To gain in-depth insights into the viral population and to perform detailed characterization of viral genomes, we used a new approach combining long-range PCR with next-generation and third-generation sequencing which allowed near full-length sequencing of HEV-3 genomes. (nature.com)
  • Molecular characterization of an outbreak of enterovirus-associated meningitis in Mossel Bay, South Africa, December 2015-January 2016. (omicsdi.org)
  • Molecular detection and genotyping of enteroviruses from CSF samples of patients with suspected sepsis-like illness and/or aseptic meningitis from 2012 to 2015 in West Bank, Palestine. (omicsdi.org)
  • An internal control based on the detection of human endogenous nucleic acid sequence (RNase P) present in human genome has been employed in order to check RNA extraction, PCR inhibition and sampling or application errors. (anatoliageneworks.com)
  • These methods allow the identification of insertions and SNPs in the HEV genome. (nature.com)
  • We present Viral Annotation Pipeline and iDentification (VAPiD), a portable and lightweight command-line tool for annotation and GenBank deposition of viral genomes. (biomedcentral.com)
  • We report on the first identification of Enterovirus C105 (EV-C105) in New Zealand from a 52-year-old male hospitalized with mild respiratory tract symptoms. (who.int)
  • Each week, all enterovirus identification results are reported to ESR and then collated and published nationally. (who.int)
  • 1 In addition, untyped enteroviruses are referred to ESR for further identification. (who.int)
  • Enterovirus genome replication occurs at virus-induced structures derived from cellular membranes and lipids. (figshare.com)
  • Echovirus 7 enters polarized Caco-2 intestinal epithelial cells by a clathrin-mediated endocytic procedure and after that techniques through the endosomal program before releasing it is genome into the cytoplasm. (palomid529.com)
  • These structural proteins are important to determine host range and tropism, and they play a crucial role in delivering the RNA genome into the cytoplasm of new host cells. (medscape.com)
  • Enterovirus detections by serotype with specimen type, collection date, and demographic information are reported monthly by participating laboratories to CDC, which summarizes the data and disseminates the results. (cdc.gov)
  • 3 In 2012, the virus was assigned as EV-C105 because subsequent sequencing showed that it had only 74.7% nucleotide and 82.5% amino acid identity to EV-109, thus satisfying the criteria for assignment of a new enterovirus serotype. (who.int)
  • Finished Annotated Genome Sequence of Burkholderia pseudomallei Strain Bp1651, a Multidrug-Resistant Clinical Isolate. (cdc.gov)
  • Nora Chapman et al from the Enterovirus Research Laboratory, Department of Pathology and Microbiology, University of Nebraska Medical Centre, have shown that human enteroviruses Coxsackie B can naturally delete sequence from the 5' end of the RNA genome and that this deletional mechanism results in long-term viral persistence, which has substantially altered the previously held view (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440640/?tool=pubmed). (investinme.org)
  • Association of TLR3-1377C/T gene polymorphisms and expression with susceptibility to enterovirus 71 encephalitis in children]. (cdc.gov)
  • Here, we revealed a role of a Golgi-residing protein, ACBD3, as a mediator of PI4KB recruitment upon enterovirus replication. (uu.nl)
  • Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: Glycemic effects of chlorogenic acid and caffeine. (archivepp.com)
  • Furthermore, we developed a targeted ultra-deep sequencing approach to assess the dynamics of clinically relevant mutations in the RdRp-region and to detect insertions in the HVR-domain in the HEV genomes. (nature.com)
  • Enterovirus neurovirulence is believed to result from direct cellular destruction. (medscape.com)
  • Together, these data establish the dual origin of enterovirus ROs and the chronology of their biogenesis at different supporting cellular membranes. (figshare.com)
  • The near full genome showed 96% nucleotide identity with the genotype 6 reference genome (AB252582). (blogspot.com)
  • The next closest genotype was EV-109 with 89% amino acid identity (GenBank accession number: ADK22861), another group C enterovirus. (who.int)
  • The exact mechanism of how enteroviruses recruit PI4KB was unclear. (uu.nl)