AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaHumanitiesInformation ScienceHealth Care
Calcitonin Gene-Related PeptideCalcitoninBethanechol CompoundsBethanecholSubstance PNeuropeptide YNeuropeptidesCapsaicinNerve FibersVasoactive Intestinal PeptidePeptidesReceptors, CalcitoninGenomeGenome, BacterialReceptors, Calcitonin Gene-Related PeptideThyroid NeoplasmsGenome, ViralBase SequencePeptide FragmentsRNA, MessengerCalcitonin Receptor-Like ProteinAmino Acid SequenceFMRFamideGenome, PlantGenome, HumanMolecular Sequence DataGenesBlotting, SouthernOligopeptidesTranscription, GeneticGenome, MitochondrialPeptide LibraryCarnosineParathyroid Hormone-Related ProteinPeptide PHIBombesinSigma FactorYin-YangYY1 Transcription FactorQuality Indicators, Health CareKnowledge ManagementMedical TourismReceptors, sigmaAcademies and InstitutesNobel PrizeNational Human Genome Research Institute (U.S.)History, 20th CenturyHistory, 21st CenturyResearchPublications
CGRPReceptorsReceptorNeuropeptidesHormonesProteinsEukaryoticMammalianProteinAmino acidsGWASCharacterizationIntestinalChromosomeContractionsCancersExomeExpressionMoleculesNeuronsOrganisationHormoneSequence1993ResearchersFamilyVariantsVertebratesMigraine drugsBacteriaTreatmentsHereditaryGeneticBoneDiseasesDisordersStudySpecificParticipantsSignalTypeInhibitorResultsRelevanceTreatmentMultipleGroup
CGRP8
Receptors2
  • The Rhodopsin family accounts for ~68% of the Ciona GPCR repertoire wherein the LGR-like subfamily exhibits a lineage specific gene expansion of a group of receptors that possess a novel domain organisation hitherto unobserved in metazoan genomes. (biomedcentral.com)
  • Human epicardial adipose tissue expresses glucose-dependent insulinotropic polypeptide, glucagon, and glucagon-like peptide-1 receptors as potential targets of pleiotropic therapies. (harvard.edu)
Receptor6
  • Receptor activity modifying protein 3, also known as RAMP3, is a human gene. (wikipedia.org)
  • The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). (wikipedia.org)
  • RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. (wikipedia.org)
  • Another danger area covers the HTR1F gene encoding serotonin 1F receptor, likewise a target for brand-new migraine-specific medications. (terapiayrehabilitacionfisica.com)
  • BACKGROUND: Atogepant is a United States Food and Drug Administration-approved oral calcitonin gene-related peptide receptor antagonist for the preventive treatment of episodic migraine. (bvsalud.org)
  • In the moth Manduca and the cricket Acheta ,functional studies have shown that its cognate receptor (DH-R) is related to the mammalian CRF receptor. (silverchair.com)
Neuropeptides1
  • [ citation needed ] Because it is an amidated peptide, like many neuropeptides , it is believed to be responsible for the effect on appetite. (wikidoc.org)
Hormones2
  • We show that midgut-preferential RNA knockdown of the peptide hormones AstA or Dh31 respectively results in decreased or increased adult lifespan. (bioone.org)
  • In insects, salt and water balance is closely regulated by a series of peptide hormones that work independently and in concert. (silverchair.com)
Proteins1
  • The expression of autophagy-related proteins Beclin-1, LC3, SQSTM1/p62, and LAMP-1 was assessed by Western blot in C57BL/6 and BALB/c mice at 1, 3 and 5d post infection (p.i. (ijo.cn)
Eukaryotic5
  • GPCR based signal transduction is ubiquitous in eukaryotic genomes and forms the basis of detection of diverse environmental cues such as odorant molecules, amines, peptides, lipids, nucleotides and photons. (biomedcentral.com)
  • Chapters 8 and 9 introduced you to different components of eukaryotic gene structure and RNA molecules transcribed. (pressbooks.pub)
  • Introns were initially thought to be entirely a feature of the eukaryotic genome. (pressbooks.pub)
  • The discovery of eukaryotic split genes with introns and exons came as quite a surprise. (pressbooks.pub)
  • Go to the DNA Learning Center website and click on the Interactive Animation that outlines the experiments that led to the discovery that eukaryotic genes have non-coding regions. (pressbooks.pub)
Mammalian2
Protein4
  • A CH genome-wide association study identified 25 loci, including 19 not implicated previously in CH. Splicing, protein and expression quantitative trait loci were identified for CD164 and TCL1A. (bvsalud.org)
  • Proislet amyloid polypeptide (proIAPP, proamylin, proislet protein) is produced in the pancreatic beta cells (β-cells) as a 67 amino acid, 7404 Dalton pro-peptide and undergoes post-translational modifications including protease cleavage to produce amylin. (wikidoc.org)
  • What does this gene/protein do? (cancerindex.org)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
Amino acids1
  • ProIAPP consists of 67 amino acids , which follow a 22 amino acid signal peptide which is rapidly cleaved after translation of the 89 amino acid coding sequence. (wikidoc.org)
GWAS3
  • Migraine is a complex neurovascular disease with a range of severity and symptoms, yet mostly studied as one phenotype in genome-wide association studies (GWAS). (bvsalud.org)
  • To get more insight into the specific threat genes, researchers from the International Headache Genetics Consortium put together a large genetic dataset to conduct a genome-wide association study (GWAS), trying to find hereditary variations that were more common in those who had migraine in general, or one of the 2 main migraine types. (terapiayrehabilitacionfisica.com)
  • The COPD GWAS gene ADGRG6 instructs function and injury response in human iPSC-derived type II alveolar epithelial cells. (harvard.edu)
Characterization1
  • Recent advances have been made in the of host factors, polymorphisms, and candidate genes associated characterization of the immune response to low-molecular- with occupational asthma may improve our understanding of weight agents. (cdc.gov)
Intestinal4
  • These results indicate that the two intestinal secretory peptides antagonistically regulate adult lifespan and intestinal senescence through multiple pathways, irrespective of insulin, which implicates a complementary gradient distribution of each of the hormone-producing EEs, consistent with local requirements for cell activity along the posterior midgut. (bioone.org)
  • There are at least four distinct but related alkaline phosphatases: intestinal, placental, placentallike,and liver/bone/kidney (tissue non-specific). (antiviralbiologic.com)
  • The product ofthis gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form,that is expressed primarily in the placenta although it is closely related to the intestinal form ofthe enzyme as well as to the placental-like form. (antiviralbiologic.com)
  • Genome-Wide Association Study Identifies 4 Novel Risk Loci for Small Intestinal Neuroendocrine Tumors Including a Missense Mutation in LGR5. (harvard.edu)
Chromosome1
  • The DMD gene is one of the largest known gene in humans, spanning 2.6 million base pairs (bp) consisting of almost 0.1% of the human genome or about 1.5% of the entire X chromosome . (pressbooks.pub)
Contractions1
Cancers1
  • Data table showing topics related to specific cancers and associated disorders. (cancerindex.org)
Exome2
  • Challenges and recommendations to increasing the use of exome sequencing and whole genome sequencing for diagnosing rare diseases in Brazil: an expert perspective. (cdc.gov)
  • In a whole-genome sequencing in 17 Esophageal Squamous Cell Carcinoma cases and whole-exome sequencing in 71 cases, Song (2014), reported ASH1L alterations. (cancerindex.org)
Expression6
  • The effects of age and repetitive mechanical loading on systemic whole genome gene expression. (cdc.gov)
  • Surgical Outcomes of Thyroid Nodules Positive for Gene Expression Alterations Using ThyroSeq V3 Genomic Classifier. (cdc.gov)
  • We show that in combination with the preserved in the first intron, only the 121 kb upstream and 36 kb downstream regions, but not the 3 kb upstream region, allow for accurate expression of reporter gene in SYP expressing cells in the mouse. (brain-tumor-cancer-information.com)
  • 2. Molecular biology and genomics: The MMRRC has a range of facilities and resources for molecular biology and genomics research, including DNA sequencing, microarray analysis, and gene expression studies. (coremarketplace.org)
  • We all found that these atp2a/serca body's genes are usually firmly conserved amid vertebrates and also present secondary as well as tissue-specific expression inside BMS-1 research buy embryos. (biotiny.com)
  • Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
Molecules1
  • The molecules acting through RAS predominantly ARBs and ACEI are found to be effective in various ongoing and completed clinical trials related to cognition, memory, Alzheimer's disease (AD), and pain. (hindawi.com)
Neurons1
  • These RAS peptides are present in astrocytes, glial cells, oligodendrocytes, and neurons of various areas of the brain [ 14 , 15 ] such as the basal ganglia, cerebral cortex, and hippocampus [ 16 ]. (hindawi.com)
Organisation1
  • The following, our company offers genome organisation inside Xenopus laevis and also tropicalis along with phylogeny of atp2a/serca body's genes within craniates. (biotiny.com)
Hormone1
  • Amylin, or islet amyloid polypeptide ( IAPP ), is a 37-residue peptide hormone . (wikidoc.org)
Sequence1
  • You should be able to draw /identify/annotate when given a gene sequence the elements of the gene above. (pressbooks.pub)
19931
Researchers5
  • Researchers have now conducted the largest genetic study of migraine to date, which involved analyzing the genomes of 102,084 people with migraine and those of 771,257 controls who do not have the condition. (medicalnewstoday.com)
  • The researchers identified two regions that contain genes that recently developed migraine drugs target. (medicalnewstoday.com)
  • In the largest genome study of migraine yet, researchers have more than tripled the variety of known hereditary risk factors for migraine. (terapiayrehabilitacionfisica.com)
  • A global consortium of leading migraine researchers recognized more than 120 areas of the genome that are connected to risk of migraine. (terapiayrehabilitacionfisica.com)
  • Researchers are also hopeful in using these peptides in drug design. (asianbestiary.org)
Family2
  • It is similar to α 1 antitrypsin and is affiliated to the Serpin gene family [ 17 ]. (hindawi.com)
  • Genomic Comparison of Closely Related Tanacetum-Family Plants. (or.jp)
Variants2
Vertebrates1
  • The genome of the protochordate Ciona intestinalis has a compact size with an ancestral complement of many diversified gene families of vertebrates and is a good model system for studying protochordate to vertebrate diversification. (biomedcentral.com)
Migraine drugs1
  • Dr. Matti Pirinen, a group leader from the Institute for Molecular Medicine Finland, University of Helsinki, who led the study, commented: "These two new associations near genes that are already targeted by effective migraine drugs recommend that there might be other possible drug targets among the new genomic areas, and supply a clear rationale for future hereditary research studies with even bigger sample sizes. (terapiayrehabilitacionfisica.com)
Bacteria1
  • In recent years the presence of intron-containing genes has been documented in archaea, bacteriophages, and even some bacteria. (pressbooks.pub)
Treatments1
  • The bat peptides could be used in treatments for many conditions where improved blood flow to damaged areas is needed such as in heart failure, hypertension and burns. (asianbestiary.org)
Hereditary1
  • Re-recognition of BMPR1A-related polyposis: beyond juvenile polyposis and hereditary mixed polyposis syndrome. (cdc.gov)
Genetic3
  • A multinational study that trawled the genomes of more than 100,000 people has trebled the tally of known genetic risk factors for migraine. (medicalnewstoday.com)
  • In addition to implicating tens of new regions of the genome for more targeted investigation, our study provides the first meaningful opportunity to evaluate shared and distinct genetic components in the two main migraine subtypes," says first author Heidi Hautakangas, Ph.D., from the Institute for Molecular Medicine Finland at the University of Helsinki. (medicalnewstoday.com)
  • Amongst the determined 123 genetic regions are 2 that contain target genes of just recently established migraine-specific drugs. (terapiayrehabilitacionfisica.com)
Bone1
Diseases3
  • Smoking demonstrates a dosage-dependent impact on risk of CH. CH associates with several smoking-related diseases. (bvsalud.org)
  • Pain-related diseases are the top leading causes of life disability. (iasp-pain.org)
  • In contrast, secondary Raynaud phenomenon, especially when associated with scleroderma-related diseases, often causes irreversible digital ischemia, resulting in the development of digital ulcers or even digital amputation. (medscape.com)
Disorders2
  • The review summarizes the recent advances in the brain RAS system highlighting its significance in pathophysiology and treatment of the central nervous system-related disorders. (hindawi.com)
  • A disease concept model for STXBP1-related disorders. (cdc.gov)
Study2
  • GISTs with NTRK Gene Fusions: A Clinicopathological, Immunophenotypic, and Molecular Study. (cdc.gov)
  • AMD presence and severity was determined using the Age-Related Eye Disease Study (AREDS) grading system. (qxmd.com)
Specific3
  • A particularly intriguing finding was the identification of genomic risk areas consisting of genes that encode targets for recently developed migraine-specific therapies. (terapiayrehabilitacionfisica.com)
  • It has also been suggested that NE cell specific silencer elements lay within the 2.6 kb upstream fragment of a binding site for RE-1 silencing transcription VX-222 factor (REST), a.k.a. neuron-restrictive silencer factor (NRSF), is located within the first intron of gene [30]. (brain-tumor-cancer-information.com)
  • This is evident at the subfamily level comparisons since Ciona GPCR sequences are significantly analogous to vertebrate GPCR subfamilies even while exhibiting Ciona specific genes. (biomedcentral.com)
Participants2
  • Using whole-genome sequencing of 45,510 Icelandic and 130,709 UK Biobank participants combined with a mutational barcode method, we identified 16,306 people with CH. Prevalence approaches 50% in elderly participants. (bvsalud.org)
  • Serious adverse events were observed in 3.4% of participants (none were treatment-related), and there were no deaths. (bvsalud.org)
Signal1
  • [2] [3] Once released from the signal peptide, it undergoes additional proteolysis and posttranslational modification (indicated by ^ ) . (wikidoc.org)
Type1
  • Identify when given a description/diagram of an alternately spliced gene which type it is. (pressbooks.pub)
Inhibitor1
  • Particularly, atp2a2/serca2 is plainly depicted from the neural-related cells, my spouse and i Dexamethasone Immunology & Inflammation inhibitor .electronic. (biotiny.com)
Results1
  • The results show that COVID-19-related international news flow had a complex and unequal pattern, with a few countries and media outlets occupying a prominent place in the network and three media groups played key but different roles in disseminating the news. (bvsalud.org)
Relevance1
  • An extreme example of splicing and of medical relevance is the human dystrophin gene. (pressbooks.pub)
Treatment1
  • Progress toward treatment and prevention of age-related macular degeneration (AMD) requires imaging end points that relate to vision. (qxmd.com)
Multiple1
  • Development of asthma is multifactorial and depends on the interactions among multiple susceptibility genes and environmental factors. (msdmanuals.com)
Group1
  • This gene encodes a member of the trithorax group of transcriptional activators. (cancerindex.org)