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  • intervention
  • This report highlights the strong linkages between FGS and HIV infection and also sends out a strong call for accelerating advocacy, policy and intervention collaboration between the HIV and Neglected Tropical Diseases communities. (id-hub.com)
  • Tract
  • Although the amount of HIV in the vagina declines in parallel with those in the plasma when antiretroviral therapy for HIV is started, HIV is still detected frequently in cervical samples from women with undetectable plasma viral loads, suggesting that low level viral replication in the female vaginal tract could lead to both inflammation and incomplete increases in CD4+ T cells. (clinicaltrials.gov)
  • Two classes of HIV medications, nonnucleoside analogue reverse transcriptase inhibitors and protease inhibitors are substantially lower in the female genital tract compared to plasma, whereas concentrations of another class, nucleos(t)ide analogue reverse transcriptase inhibitors are similar or higher to those found in plasma. (clinicaltrials.gov)
  • Thus, many widely used first-line three drug HIV therapies only achieve high concentrations of only two medications in the female genital tract. (clinicaltrials.gov)
  • Importantly, with the recent development of raltegravir (RAL), which achieves concentrations in the female genital tract higher than those in plasma, ART regimens that deliver high concentrations of 3 antiretroviral drugs to the female genital tract are now available. (clinicaltrials.gov)
  • The investigators hypothesize that cervical CD4+ T cell reconstitution is better and inflammatory markers are lower in HIV-infected women on a HIV-therapy including tenofovir (TDF) and emtricitabine (FTC) with RAL versus ritonavir (RIT)-boosted atazanavir (ATZ), and that this is due to therapeutic concentrations of 3 versus 2 antiretroviral drugs in the female genital tract. (clinicaltrials.gov)
  • In addition, ratios will be compared to the concentration of the drug in the genital tract. (clinicaltrials.gov)
  • Seminal biochemistry will also assess the impact of the syndrome on the genital tract glands and follow its evolution. (clinicaltrials.gov)
  • Infection
  • Schistosomiasis is a parasitic disease affecting more than 250 million people worldwide - despite the scale of infection and the existence of a cheap and effective treatment, this disease of poverty and its patients remain highly neglected. (id-hub.com)
  • This report highlights the strong linkages between FGS and HIV infection and also sends out a strong call for accelerating advocacy, policy and intervention collaboration between the HIV and Neglected Tropical Diseases communities. (id-hub.com)
  • HIV infection and number of sexual partners in past year were important risk factors for prevalent and incident genital warts respectively. (biomedcentral.com)
  • common
  • Genital warts are common in Nigeria and our results provide important parameters for monitoring the impact of future HPV vaccination programs in the country. (biomedcentral.com)
  • features
  • Genital warts can present with four morphologic features - condylomata acuminata, smooth or flat papular lesions, or keratotic warts. (biomedcentral.com)