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  • proteins
  • We determined that LDs isolated from C. trachomatis-infected cells were enriched in proteins related to lipid metabolism, biosynthesis and LD-specific functions. (duke.edu)
  • serovar
  • The aim of the present study was to provide a proteome analysis of Ct ocular serovar B (CtB) elementary bodies (EB) by shotgun proteomics. (arvojournals.org)
  • Dean, D. Recombination in the ompA gene but not the omcB gene of Chlamydia contributes to serovar-specific differences in tissue tro-pism, immune surveillance , and persistence of the organism. (barnardhealth.us)
  • We used the fast-chelating agent 2,2′-bipyridyl (BPDL) to homogeneously starve Chlamydia trachomatis serovar L2 of iron, starting at 6 or 12 h postinfection. (asm.org)
  • cervical
  • HIV is also present in cervical-vaginal concentration in a frequency twice higher among women with gonorrhea, three times greater in the presence of Chlamydia and four times greater if there is ulceration of cervix or vagina 9 . (scielo.br)
  • protein
  • 1991 . A single peptide from the major outer membrane protein of Chlamydia trachomatis elicits T cell help for the production of antibodies to protective determinants. (asmscience.org)
  • These observations point out to Chlamydia-mediated manipulation of LDs in infected cells, which may impact the function and thereby the protein composition of these organelles. (duke.edu)
  • Batteiger, B.E. Polymorphic membrane protein H has evolved in parallel with the three disease-causing groups of Chlamydia trachomatis. (barnardhealth.us)
  • C. trachomatis MOMP was expressed on the surface of E. coli cells (including "porin knockout" cells) after optimizing leader sequence, temperature and medium composition, and the protein was functionally reconstituted at the single-channel level to confirm it was folded correctly. (biomedcentral.com)
  • Here, we used IncD as a model to investigate Inc/Inc interaction in the context of Inc protein expression in C. trachomatis . (frontiersin.org)
  • Altogether our approach can be generalized to any Inc protein and will help to characterize the molecular mechanisms by which Chlamydia Inc proteins interact with themselves and/or host factors, eventually leading to a better understanding of C. trachomatis interaction with the mammalian host. (frontiersin.org)
  • We have shown that the C. trachomatis type III effector protein IncD, the host lipid transfer protein CERT and the ER resident protein VAPB interact at ER-Inclusion MCSs. (virginia.edu)
  • humans
  • The most important animal chlamydiosis of zoonotic character is caused by Chlamydia psittaci , which causes respiratory disease in birds and humans. (ugent.be)
  • species
  • The secreted effectors identified in C. trachomatis are more divergent in other species than are the other selected virulence factors. (asmscience.org)
  • Chlamydia species are the most common microbial cause of chronic conjunctivitis that among different species C. trachomatis is the major cause of chronic follicular conjunctivitis. (omicsonline.org)
  • C. trachomatis VS domains, and homologous regions in MOMPs from other species, could correspond to cysteine-rich surface-exposed loops in a porin β-barrel, and EB MOMP is oxidised and highly cross-linked, making the OM very stable. (biomedcentral.com)
  • Chlamydial plasmids are small, highly conserved, nonconjugative, and nonintegrative DNA molecules that are nearly ubiquitous in many chlamydial species, including Chlamydia trachomatis . (rupress.org)
  • vaccines
  • Animal models are indispensable for the study of C. trachomatis infections and the development and evaluation of candidate vaccines. (asm.org)
  • There are currently no vaccines available against C. trachomatis . (clinicaladvisor.com)
  • In order to develop effective C. trachomatis vaccines, it is important to identify those antigens that elicit a protective immune response and also to develop new and adequate methods and adjuvants for effective vaccine delivery as conventional methods have failed to induce protective immunity. (ugent.be)
  • urogenital
  • This review will present the current evidence regarding the management challenges for urogenital and anorectal chlamydia infections and provide some suggestions for where future research efforts are needed to address important knowledge gaps in this area and provide stronger evidence for the development of robust treatment guidelines. (biomedcentral.com)
  • genes
  • By comparing two fully sequenced genomes of Chlamydia trachomatis using competitive hybridization on DNA microarrays, a logarithmic correlation was demonstrated between the signal ratio of the arrays and the 75-99% range of nucleotide identities of the genes. (biomedcentral.com)
  • We also observed an increase in transcription of genes involved in DNA repair and neutralizing oxidative stress, indicating that Chlamydia employs an "all-or-nothing" strategy. (asm.org)
  • biology
  • IMPORTANCE By utilizing an experimental approach that monitors the immediate global response of Chlamydia trachomatis to iron starvation, clues to long-standing issues in Chlamydia biology are revealed, including how Chlamydia adapts to this stress. (asm.org)
  • Our approach combine cell biology, molecular biology, microbiology and confocal microscopy techniques together with the newly developed genetic tools for Chlamydia. (virginia.edu)
  • homologous
  • The chapter addresses the surprising finding that chlamydiae have the tools to naturally acquire and integrate homologous DNA into their genome as long as the DNA is donated by a related chlamydial strain. (asmscience.org)
  • The experimental studies demonstrate that chlamydiae can share DNA, can be transformed, and can incorporate introduced DNA into the genome via homologous recombination. (asmscience.org)
  • genetic
  • This chapter addresses the challenging aspects of the chlamydial system and points out some avenues that can be exploited, perhaps opening the door to technologies for routine genetic modification of chlamydiae. (asmscience.org)
  • inclusion membrane
  • One of our candidates led us to uncover that, in addition to vesicular trafficking, C. trachomatis hijacks the non-vesicular lipid transfer machinery at zone of close apposition (10-50 nm) between the ER and the inclusion membrane. (virginia.edu)
  • Figure 2 ER - Chlamydia Inclusion Membrane Contact Sites . (virginia.edu)
  • Part of the Chlamydia inclusion membrane makes close contact with the endoplasmic reticulum. (virginia.edu)