• Comparisons of levels and patterns of genetic diversity with the predictions of models based on archeological evidence suggest that the spread of early farmers from the Levant was probably the main episode in the European population history, but that both older and more recent processes have left recognizable traces in the current gene pool. (pnas.org)
  • For fixed population sizes, the probability of fixation for a new allele with selective advantage s can be approximated using the theory of branching processes. (wikipedia.org)
  • These results shed light on migratory events and adaptive processes of Greenlandic populations. (cam.ac.uk)
  • Further, my results show that, from a migration system perspective, mallard flyways/populations can hardly be delineated from a biological point of view. (wur.nl)
  • Other projects involve the study of human past populations' microbiome through dental calculus and recovering ancient pathogens from Central America. (utoronto.ca)
  • The overarching research topic in the department of Archaeogenetics is the use of novel scientific approaches from high throughput sequencing of ancient DNA from human populations and their pathogens to explore research questions related to human history, gene-culture coevolution, and adaptation to infectious disease. (zeit.de)
  • In turn, knowledge about human population history helps inform studies in medical genetics. (broadinstitute.org)
  • Importantly, the population genetic architecture of Jews helps to explain the observed patterns of health and disease-relevant mutations and phenotypes which continue to be carefully studied and catalogued, and represent an important resource for human medical genetics research. (springer.com)
  • A new paper in PLoS, Rapid Assessment of Genetic Ancestry in Populations of Unknown Origin by Genome-Wide Genotyping of Pooled Samples: Many association studies have been published looking for genetic variants contributing to a variety of human traits such as obesity, diabetes, and height. (scienceblogs.com)
  • Large-scale whole-genome sequencing of the Icelandic population. (nature.com)
  • High-accuracy HLA type inference from whole-genome sequencing data using population reference graphs. (nature.com)
  • Figure 1: A population-aware analytical framework for analyzing Genome STRucture in Populations (Genome STRiP). (nature.com)
  • At a higher level, there are two different paradigms in ancestry inference: global ancestry inference which tries to compute the genome-wide average of the population contributions and local ancestry inference which tries to identify the regional ancestry of a genomic segment. (frontiersin.org)
  • Ancestry estimation is a frequently encountered problem and has been used in a variety of applications such as tracing someone's geographic origin in forensic investigations, correcting for population stratification in genome-wide association studies and developing personalized approaches to treatment. (frontiersin.org)
  • GA inference involves estimating the proportion of ancestry contributed by different populations averaged across the entire genome. (frontiersin.org)
  • In contrast, in LA inference, we interpret each chromosome in an individual's genome as a mosaic of segments that originate from different ancestral populations and the goal is to find the ancestral population of origin at each position. (frontiersin.org)
  • The main goal of GA inference is to estimate the fraction of ancestry contributed by each population as averaged across the entire genome. (frontiersin.org)
  • The potential value of such extensively genotyped collections is illustrated by selection of genetically matched population controls in a genome-wide analysis of abacavir-associated hypersensitivity reaction. (nih.gov)
  • Mendel's Accountant (hereafter referred to as "Mendel") is a state-of-the-art forward-time population genetics model that tracks millions of individual mutations with their unique effects on fitness and unique location within the genome through large numbers of generations. (icr.org)
  • F. F. Gonzalez-Galarza, S. Christmas, D. Middleton, and A. R. Jones, "Allele frequency net: a database and online repository for immune gene frequencies in worldwide populations," Nucleic Acids Research , vol. 39, no. 1, pp. (hindawi.com)
  • We performed a survey of the global distribution of pharmacogenomic variants followed by a more focused study of pharmacogenomic allele frequency differences between the two Colombian populations. (frontiersin.org)
  • Because both the sampling location of an organism or self-reported ancestry in the case of humans can be uninformative for this purpose, the use of genetic markers can facilitate accurate and reliable ancestry inference by exploiting allele frequency differences across population groups. (frontiersin.org)
  • The availability of a textbook for a course in fisheries genetics would make the field of population genetics relevant and accessible to students and practitioners of fisheries science. (fisheries.org)
  • In the microfungi heterocaryosis, exhibiting fusion of the cytoplasm without using the recombination mechanism of the nucleus, forms a branch of genetics which has been greatly forwarded by Pontecorvo at Glasgow, and by Mather at Birmingham. (royalsocietypublishing.org)
  • With its uniquely comprehensive population data, deCODE is turning research on the genetic causes of common diseases into a growing range of products and services - in gene and drug discovery, DNA-based diagnostics, pharmacogenomics, bioinformatics, and clinical trials. (decode.com)
  • The ideal applicant should have completed a PhD in genetics, bioinformatics, and computer science or relevant neighboring disciplines, worked with large high-throughput sequencing or SNP datasets, and a profound interest in human history. (zeit.de)
  • Under the assumption of complete linkage, we derive a robust analytical approximation for the number of ancestral haplotypes and their distribution in a sample from the population. (nih.gov)
  • Dienekes points me to a new paper, European Population Genetic Substructure: Further Definition of Ancestry Informative Markers for Distinguishing Among Diverse European Ethnic Groups. (scienceblogs.com)
  • This pattern is consistent with a major, but variable component of shared Near East ancestry, together with variable degrees of admixture and introgression from the corresponding host Diaspora populations. (springer.com)
  • If your are new to population genetics, please read our DNA testing FAQ to learn how to retrace ancestry with DNA, which test to choose and how to interpret your results. (eupedia.com)
  • Our work focuses on two neighboring populations with distinct ancestry profiles: Antioquia and Chocó. (frontiersin.org)
  • A number of these pharmacogenomic variants also show anomalous effect allele frequencies within and between the two Colombian populations, and these differences were found to be associated with their distinct genetic ancestry profiles. (frontiersin.org)
  • In this mini review, I describe the numerous approaches that are currently available for both kinds of ancestry inference from population genomic datasets. (frontiersin.org)
  • Briefly stated, genetics is well suited to addressing scientific questions such as whether humans share ancestry with other forms of life, and what our population structure looked like as we separated from our evolutionary relatives. (biologos.org)
  • We will also develop explicit tree- and graph-based population-genetic models for common ancestry and admixture between different groups of samples to understand order and timing of historical events. (zeit.de)
  • Progressively more detailed population genetic analysis carried out independently by multiple research groups over the past two decades has revealed a pattern for the population genetic architecture of contemporary Jews descendant from globally dispersed Diaspora communities. (springer.com)
  • deCODE's pharmaceuticals group, based in Chicago, and deCODE's biostructures group, based in Seattle, conduct downstream development work on targets derived from deCODE's proprietary research in human genetics as well as contract service work for pharmaceutical and biotechnology companies. (decode.com)
  • This school aims to expose students and researchers from diverse backgrounds to the basics and the forefront of current research in population genetics. (icts.res.in)
  • To facilitate exploratory genetics research, we have assembled a DNA resource from a large number of subjects participating in multiple studies throughout the world. (nih.gov)
  • Using these findings, we have developed and validated an inexpensive allele-specific PCR assay to test for the presence of such population-enriched pharmacogenomic SNPs in Colombia. (frontiersin.org)
  • One approach is appropriate for low-coverage sequencing data, and incorporates population-level information on genotype frequencies and error rates pre-estimated by an ML method. (g3journal.org)