• C. elegans muscle age is a data set of fluorescence 20X microscopy images of C. elegans nematodes stained with phalloidin to visualize actin in muscles at different ages (1,2,4, and 8). (cellimagelibrary.org)
  • We study the molecular events that give rise to the sensation of touch and temperature using C. elegans nematodes as a model system. (stanford.edu)
  • Teymuras Kurzchalia , a professor at the Max Planck Institute of Molecular Cell Biology and Genetics in Germany and co-author of the new study, described nematodes as stretching the boundaries of life. (zmescience.com)
  • The explosion of knowledge on the last few decades associated with the advancing of internet and computers led to advent of a new discipline in genetics: genomics. (bvsalud.org)
  • Here is discussed the transition from genetics to genomics and some of the main factors that were responsible for this progress. (bvsalud.org)
  • mathematical models, Genetics, Genomics. (bvsalud.org)
  • As C. elegans feeds on bacteria (microbivory), the intestine of worms isolated from the wild is usually filled with a large number of bacteria. (wikipedia.org)
  • Bleaching is a common method in the laboratory to clean C. elegans of contaminations and to synchronize a population of worms. (wikipedia.org)
  • Many experiments on aging have been performed on worms belonging to the species C. elegans . (elifesciences.org)
  • Caenorhabditis elegans - Taxon details on World Register of Marine Species (WoRMS). (wikimedia.org)
  • Now, Hilbert and Kim show that a signal that influences how C. elegans explores in response to chemicals in its environment is expressed differently in male and hermaphrodite worms. (elifesciences.org)
  • The sensory neurons that release DAF-7 are found in both sexes of C. elegans but the specific way that the male worms express this signal encourages them to search for mates. (elifesciences.org)
  • Knockdown of the C. elegans IMPACT homolog impt-1 activated the ISR pathway and increased lifespan and stress resistance of worms in a gcn-2 -dependent manner. (biomedcentral.com)
  • In a previous study , the researchers showed that C. elegans worms could be coaxed to enter cryptobiosis through desiccation (completely drying the animal of all its water) and freezing. (zmescience.com)
  • As determined by microarray analysis (a method, which allows the identification of C. elegans genes that are differentially expressed in response to different bacteria), 14 immune defence genes were up-regulated when C. elegans was grown on B. megaterium, while only two were up-regulated when fed with Pseudomonas sp. (wikipedia.org)
  • Although some of the genes are known to be important for C. elegans lifespan extension, the precise underlying mechanisms still remain unclear. (wikipedia.org)
  • Because the genes in C. elegans are related to those in higher organisms, the results from our studies should help us to understand how germ cells function in humans as well. (yale.edu)
  • We established conditions for RNA interference (RNAi) in C. elegans to target multiple genes simultaneously in a high-throughput setting. (biomedcentral.com)
  • We used this assay to examine the redundancy of duplicated genes in the genome of C. elegans that correspond to single orthologs in S. cerevisiae or D. melanogaster and identified 16 pairs of duplicated genes that have redundant functions. (biomedcentral.com)
  • By purifying and analysing mitochondria from different cell types, we show that PINK-1 and PDR-1 are required to set heteroplasmy differences between major somatic tissue groups in C. elegans and that removal of these genes equalises ΔmtDNA heteroplasmy across the organism. (biorxiv.org)
  • We have identified a large number of proteins/genes that are differentially expressed in C. elegans when exposed to Shigella using both proteomic and transcriptomic approaches. (edu.au)
  • Each chemosensory neuron type in C . elegans expresses multiple chemoreceptors that are likely tuned to different odorants, a subset of which can be behaviorally discriminated [ 27 , 28 ]. (plos.org)
  • Here, we show that C. elegans males exhibit an altered, male-specific expression pattern of daf-7 in the ASJ sensory neuron pair with the onset of reproductive maturity, which functions to promote male-specific mate-searching behavior. (elifesciences.org)
  • C. elegans has far fewer neurons and neuron-neuron connections, making it a great starting point," they say. (discovermagazine.com)
  • What's more, in C. elegans every neuron receives inputs from dozens of others. (discovermagazine.com)
  • Powerful genetics and advanced genomic resources make high-throughput forward genetics and single neuron profiling possible. (ist.ac.at)
  • Since then, with the help of a growing number of investigators, knowledge about the biology of "the worm" has accumulated at a steadily accelerating pace to the extent that C. elegans is now probably the most completely understood metazoan in terms of anatomy, genetics, development, and behavior. (cshlpress.com)
  • Nematode Caenorhabditis elegans ( C. elegans ) is a extensively used as a powerful model organism for physiological, cell division, molecular biology and many other researches ( 25 ), and provide a perfect model to study the interaction between intestine and other organic systems ( 26 , 27 ). (frontiersin.org)
  • His joint discovery of messenger RNA, and, in more recent years, his development of gene cloning, sequencing and manipulation techniques along with his work for the Human Genome Project have led to his standing as a pioneer in the field of genetics and molecular biology. (webofstories.com)
  • These efficiencies make C. elegans by far one of the best metazoan to genome edit, eradicating limitations to the use and adoption of this facile system as a mannequin for understanding animal biology. (stjosephs-hospital.com)
  • We address these questions in vivo with unprecedented cell specificity and comprehensiveness, utilizing innovative methods to investigate how genome structure and organization influences gene expression specifically in the C. elegans germ line. (yale.edu)
  • We found that the conserved PTEN-induced putative kinase (PINK1/PINK-1) and the E3 ubiquitin-protein ligase parkin (PDR-1), which are required for mitochondrial autophagy (mitophagy), underlie stereotyped differences in heteroplasmy of a deleterious mitochondrial genome mutation (ΔmtDNA) between major somatic tissues types in Caenorhabditis elegans . (biorxiv.org)
  • In many crops, genome engineering techniques have enabled researchers and breeders to take advantage of a vast knowledge base of plant physiology, pathology, and genetics. (frontiersin.org)
  • We have previously established that the spontaneous, genome-wide rate of gene duplication in C. elegans is two orders of magnitude higher than the point mutation rate [ 8 ]. (biomedcentral.com)
  • CRISPR genome modifying has revolutionized genetics in quite a few organisms. (stjosephs-hospital.com)
  • Chronis, N., Zimmer, M. & Bargmann, C.I. Microfluidics for in vivo imaging of neuronal and behavioral activity in Caenorhabditis elegans . (nature.com)
  • Here we report that the behavioral defects in the C. elegans egl-2 mutant are caused by a gain-of-function ( gf ) mutation in an eag-like K + channel. (jneurosci.org)
  • In 1965 Sydney Brenner chose the free-living nematode Caenorhabditis elegans as a promising model system for a concerted genetic, ultrastructural, and behavioral attack on the development and function of a simple nervous system. (cshlpress.com)
  • Here, we show that the behavioral response of Caenorhabditis elegans to bacterially produced medium-chain alcohols switches from attraction to avoidance when presented in the background of a subset of additional attractive chemicals. (plos.org)
  • To do this, we use a combination of quantitative behavioral analysis, genetics, in vivo electrophysiology, and heterologous expression of ion channels. (stanford.edu)
  • In C. elegans , thousands of individually transcribed loci encoding the piRNA class of small noncoding RNAs are clustered into two sharply demarcated regions on a single chromosome. (yale.edu)
  • Contained in the nematode Caenorhabditiselegans one injection into every of the 2 gonad arms of an grownup hermaphrodite exposes tons of of meiotic germ cells to modifying mixtures, allowing the restoration of a number of indels or small precision edits from every successfully injected animal. (stjosephs-hospital.com)
  • The chemotactic guidance factor encoded by the Caenorhabditis elegans unc-6 locus, whose mammalian homolog is Netrin, is perhaps the best known of the cell migration guidance factors. (johnshopkins.edu)
  • We have found that the C. elegans homolog of Lgl, LGL-1, has a role in polarity but is not essential. (biologists.com)
  • The decline of aging C. elegans male's mating behavior is correlated with the increased excitability of the cholinergic circuitry that executes copulation. (elifesciences.org)
  • It is also possible to analyze the underlying factors that contribute to behavior in C. elegans , because it has a relatively simple and well-defined nervous system. (elifesciences.org)
  • We are studying germ cell regulation primarily using the model organism C. elegans, a nematode, because of the large number of germ cells it contains, and because of the many experimental advantages it offers. (yale.edu)
  • By complementing genetics with biochemistry, the group's research aims at gaining insights into neurological processes and molecular mechanisms that are usually conserved from C. elegans to man. (ist.ac.at)
  • A C. elegans messenger RNA expressed in Xenopus oocytes encodes an avermectin-sensitive glutamate-gated chloride channel. (nih.gov)
  • We show that the Caenorhabditis elegans egl-2 gene encodes an eag K + channel and that a gain-of-function mutation in egl-2 blocks excitation in neurons and muscles by causing the channel to open at inappropriately negative voltages. (jneurosci.org)
  • de Bono, M. & Maricq, A.V. Neuronal substrates of complex behaviors in C. elegans . (nature.com)
  • Neuroendocrine regulation of diverse behaviors of Caenorhabditis elegans is under the control of the DAF-7/TGF-β ligand that is secreted from sensory neurons. (elifesciences.org)
  • Our results suggest that regulation of gene expression in sensory neurons can function in the integration of a wide array of sensory information and facilitate decision-making behaviors in C. elegans . (elifesciences.org)
  • Modern machine-learning based modelling should then enable a simulation of C. elegans' impressive breadth of brain states and behaviors," say the team. (discovermagazine.com)
  • In C. elegans , different protocols of DR elicit different degrees of lifespan extension and stress resistance by often distinct and complementary mechanisms [ 7 ]. (biomedcentral.com)
  • Caenorhabditis elegans - Taxon details on Animal Diversity Web (ADW). (wikimedia.org)
  • This chapter will introduce the diversity of kinases in C. elegans , and compare them to those of fungi and other metazoans, as well as to preliminary results from analysis of the C. briggsae kinome. (wormbook.org)
  • Remarkably, 14 of these redundant gene pairs were duplicated before the divergence of C. elegans and C. briggsae 80-110 million years ago, suggesting that there has been selective pressure to maintain the overlap in function between some gene duplicates. (biomedcentral.com)
  • Our results substantiate the use of a forward-genetics approach for studying sleep behaviours in mice, and demonstrate the role of SIK3 and NALCN in regulating the amount of NREMS and REMS, respectively. (nature.com)
  • The ecology of C. elegans can only be fully understood in the light of the multiple interactions with the microorganisms, which it encounters in the wild. (wikipedia.org)
  • In contrast, C. elegans strains that are cultivated in laboratories for research purposes have lost the natural associated microbial communities and are commonly maintained on a single bacterial strain, Escherichia coli OP50. (wikipedia.org)
  • Most of the studies on C. elegans are based on the N2 strain, which has adapted to laboratory conditions. (wikipedia.org)
  • Attribution: This strain was provided by the C. elegans Reverse Genetics Core Facility at the University of British Columbia, which is part of the international C. elegans Gene Knockout Consortium, which should be acknowledged in any publications resulting from its use. (umn.edu)
  • Now I'd got this culture, C. elegans , it had been isolated in Bristol and a strain had also been isolated in France where a man called Nigon had worked on it, that was called the Bergerac strain. (webofstories.com)
  • C. elegans is a well-established model organism in different research fields, yet its ecology however is only poorly understood. (wikipedia.org)
  • They have a short development cycle only lasting three days with a total life span of about two weeks.C. elegans were previously considered a soil-living nematode, but in the last 10 years it was shown that natural habitats of C. elegans are microbe-rich, such as compost heaps, rotten plant material, and rotten fruits. (wikipedia.org)
  • In these studies, C. elegans was exposed to various soil bacteria, either isolated in a different context or from C. elegans lab strains transferred to soil. (wikipedia.org)
  • In recent years, C. elegans (a soil-dwelling nematode) has become an attractive animal model to study host-pathogen interactions. (edu.au)
  • The neural circuit for touch sensitivity in Caenorhabditis elegans . (nature.com)
  • In contrast, the DNA damage accumulation and sensitivity of smc-5 mutant strains to replication impediments are suppressed by mutations in the C. elegans BRCA1/BARD1 homologs, brc-1 and brd-1. (uni-koeln.de)
  • Spatiotemporal patterns of declines in amphibian populations from chytridiomycosis and population genetics data on B. dendrobatidis provide increasing evidence that the pathogen has been recently introduced in many areas ( 4 , 5 ). (cdc.gov)
  • The host microbe interactions of C. elegans are closely studied because of their orthologs in humans. (wikipedia.org)
  • In C. elegans , bimodal responses to CO 2 are determined by the dauer arrest decision. (wormatlas.org)
  • Hilbert and Kim showed that the biological sex in combination with multiple other inputs - including the animal's past diet and age - regulate how the DAF-7 signal is expressed in C. elegans . (elifesciences.org)
  • The past few years have seen the completion of two major long-term projects that provide new insights into C. elegans development and lay important groundwork for future investigation: completion of the cell lineages of both sexes, from zygote to adult, and description of the complete anatomy at the level of electron microscope resolution, providing a complete "wiring diagram" of cell contacts in the animal. (cshlpress.com)
  • Beneficial bacteria can have a positive effect on the lifespan, generate certain pathogen resistances, or influence the development of C. elegans. (wikipedia.org)
  • Wnt signaling has been demonstrated to regulate diverse cell processes throughout the development of the Caenorhabditis elegans embryo. (nih.gov)
  • Increased understanding of plant genetics and the development of powerful and easier-to-use gene editing tools over the past century have revolutionized humankind's ability to deliver precise genotypes in crops. (frontiersin.org)
  • The effect of microbes on C. elegans can vary from beneficial to lethal. (wikipedia.org)
  • Furuta, T, Arur S . sart -3 functions to regulate germline sex determination in C. elegans . (mdanderson.org)
  • Our results demonstrate that we can excite specific neurons expressing ChR2 while simultaneously monitoring G-CaMP fluorescence in several other neurons, making it possible to rapidly decipher functional connections in C. elegans neural circuits. (nature.com)
  • This leads to translation of an alternative and functional open reading frame of the ATF4 gene ( atf-5 in C. elegans ) [ 20 , 21 ]. (biomedcentral.com)
  • By exhaustively mapping these functional connections between neurons, this large-scale initiative aims to reverse engineer a complete simulation of the C. elegans brain. (discovermagazine.com)
  • Reverse engineering C. elegans will provide a Rosetta-stone-like translation between the language of annotated connectomes and functional properties," say Halpern and colleagues. (discovermagazine.com)