Genetics mice inbred strains. Medical search. Frequent questions

The inbred C57BL/6J-mice (B6) and hybrid B6D2F1-mice demonstrated extensive permanent threshold shift and subsequent onset of AHL. (cdc.gov)
In this study we have increased the density of microsatellite markers 2- to 5-fold in each of several major RI sets that share C57BL/6 as a parental strain (AXB, BXA, BXD, BXH, and CXB). (nervenet.org)
The complex regulation of Na v s, together with the anatomical rostral shift of the DRG harboring injured fibers in C57BL/6 J mice, emphasize that caution is necessary and preliminary anatomical experiments should be carried out for gene and protein expression studies after SNI in mouse strains. (biomedcentral.com)
Similarly, we observed 70% protection when 10× LD50 EEEV FL93-939-infected C57BL/6 mice were treated prophylactically with BDGR-49 at 50 mg kg-1 per day. (bvsalud.org)
The chimeric mice are bred to C57BL/6J albino mice to generate F1 heterozygous animals. (mmrrc.org)
On rare occasions, for example when very few F1 mice are obtained from the chimera, F1 heterozygous mice are crossed to 129/SvEvBrd x C57BL/6 hybrid mice to yield additional heterozygous animals for the intercross to generate the F2 mice. (mmrrc.org)
exposure to organophosphate neurotoxicants combined with high circulating glucocorticoids in two inbred mouse strains, C57BL/6J and DBA/2J. (cdc.gov)

Quantitative Trait Loci and Candidate Genes for Neutrophil Recruitment in Sterile Inflammation Mapped in AXB-BXA Recombinant Inbred Mice. (genenetwork.org)
Evaluation of heritable determinants of blood and brain serotonin homeostasis using recombinant inbred mice. (genenetwork.org)
Note to the Reader Please cite this work as: Williams RW, Gu J, Qi S, Lu L (2001) The genetic structure of recombinant inbred mice: High-resolution consensus maps for complex trait analysis. (nervenet.org)

In the review, Chesler and colleagues focus on two reference populations based on the same eight founder strains. (jax.org)
Initially, the founder strains, which include five common laboratory and three wild-derived strains, were selected to establish the Collaborative Cross (CC), a panel of high diversity recombinant inbred strains. (jax.org)
The other population, Diversity Outbred (DO), is bred to produce individual mice whose genetics derive equally from the eight founder strains but in a random configuration. (jax.org)
We demonstrate that the genetic diversity of the CC, which derives from random mixing of eight founder strains, results in high phenotypic diversity and enhances our ability to map causative loci underlying complex disease-related traits. (jax.org)

Breeding of inbred strains is often towards specific phenotypes of interest such as behavioural traits like alcohol preference or physical traits like aging, or they can be selected for traits that make them easier to use in experiments like being easy to use in transgenic experiments. (wikipedia.org)
One of the key strengths of using inbred strains as a model is that strains are readily available for whatever study one is performing and that there are resources such as the Jackson Laboratory, and FlyBase, where one can look up strains with specific phenotypes or genotypes from among inbred lines, recombinant lines, and coisogenic strains. (wikipedia.org)
Nature Communications 7:10464 [Best reference on the BXD family of strains and the wide range of phenotypes that have been generated over the past 40 years. (genenetwork.org)
Harenza JL, Muldoon PP, De Biasi M, Damaj MI, Miles MF (2014) Genetic variation within the Chrna7 gene modulates nicotine reward-like phenotypes in mice. (genenetwork.org)
The strains are highly useful for trait correlation studies, as phenotypes from a CC panel can be compared across experiments and laboratories. (jax.org)
By maximizing the genetic diversity of mouse strains, researchers can identify the gene variants responsible for various phenotypes and behaviors. (spectrumnews.org)
In another study, researchers documented the various phenotypes and behaviors visible in Collaborative Cross strains. (spectrumnews.org)
These strains show a much wider variety of phenotypes, such as body length or level of anxiety, than those documented for BXD mice, an existing inbred lab strain 2 . (spectrumnews.org)

A hybrid between two inbred strains can be used to cancel out deleterious recessive genes resulting in an increase in the mentioned areas. (wikipedia.org)
In a study, researchers used 1,200 outbred mice, which are more similar to a natural population, to test a new cost-effective technique to search for specific genes linked with 66 different physical and behavioral traits. (sciencedaily.com)
Genome-wide association studies -- matching genes to diseases and other traits -- have been a big deal in human genetics for the past decade," said Abraham Palmer, PhD, professor of psychiatry at University of California San Diego School of Medicine. (sciencedaily.com)
That's because researchers have mostly been using crosses between inbred strains, making it impossible to pinpoint specific genomic regions or individual genes associated with a trait. (sciencedaily.com)
Next, the team will engineer mice that specifically lack these genes to determine if the associations are truly causal and to better understand the underlying mechanisms. (sciencedaily.com)
Human alcoholism studies of genes identified through mouse quantitative trait locus analysis. (colorado.edu)
Both groups scoured the human genomic sequence around chromosome 1p36, syntenic to the Sac locus on the distal end of mouse chromosome 4, in search of GPCR genes. (biomedcentral.com)
In the early 1980s, researchers began genetically manipulating mice by inserting genes from other species (including humans) during the earliest stages of embryonic cell division. (mentalfloss.com)
Scientists also began turning off specific genes during early development, creating 'knockout mice. (mentalfloss.com)
Researchers typically use inbred mouse strains, which have identical genes on each chromosome and whose genetics are well established. (spectrumnews.org)
Mice carrying mutations in single or multiple genes or other modifications can be created in one step by injecting the CRISPR/Cas9 system into zygotes (the cells formed by the union of egg and sperm that proceed to divide and create a living organism). (jax.org)
I thought that genetics was cool, and discovering new genes even cooler. (aai.org)
Analysis based on inferred haplotypes improves power, reduces false discovery, and provides information to identify and prioritize candidate genes that is unique to multifounder crosses like the CC. The number of expression QTLs discovered here exceeds all previous efforts at eQTL mapping in mice, and we map local eQTL at 1-Mb resolution. (jax.org)

Founding fathers: Using just eight strains of mice, the Collaborative Cross initiative is planning to generate thousands of strains of genetically diverse mice. (spectrumnews.org)
Researchers are creating a population of inbred lab mice, called the Collaborative Cross , with the potential to produce thousands of genetically diverse strains. (spectrumnews.org)
To address this issue, in 2004, researchers launched a project called the Collaborative Cross to create 1,000 inbred mouse strains from 5 lab strains and 3 derived from wild populations 4 . (spectrumnews.org)
Further breeding among the Collaborative Cross strains has the potential to produce unlimited numbers of genetically diverse mice. (spectrumnews.org)
The Collaborative Cross (CC) is a mouse recombinant inbred strain panel that is being developed as a resource for mammalian systems genetics. (jax.org)

Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease. (jax.org)
Genome-wide analysis of the incipient strains reveals high genetic diversity, balanced allele frequencies, and dense, evenly distributed recombination sites-all ideal qualities for a systems genetics resource. (jax.org)
John M. Hancock mostly deals with Genetics, Gene, Genome, Ribosomal RNA and Peptide sequence. (research.com)
His Genome study combines topics from a wide range of disciplines, such as International Knockout Mouse Consortium, Inbred strain, Replication slippage and Expressivity. (research.com)

The result was 'transgenic mice. (mentalfloss.com)
Animal models (especially differences between inbred mouse strains or transgenic mouse lines) can be indispensable for determining molecular mechanisms of gene regulation in the brain. (genewhisperer.com)

Previously, only large regions of a chromosome could be associated with a particular mouse trait or behavior. (sciencedaily.com)
High-resolution genetic mapping of the saccharin preference locus (Sac) and the putative sweet taste receptor (T1R1) gene (Gpr70) to mouse distal Chromosome 4. (biomedcentral.com)
The analysis was possible owing to the fact that the C-band on chromosomes 14 of the CBA/Kw strain and that of chromosome 18 of the KE strain show size polymorphism: while the CBA/Kw mice have a small sized C-band on chromosome 14, the KE mice show small C-bands on chromosome 18. (edu.pl)

Thus outbred strains of most laboratory animals are also available, where an outbred strain is a strain of an organism that is effectively wildtype in nature, where there is as little inbreeding as possible. (wikipedia.org)
Certain plants including the genetic model organism Arabidopsis thaliana naturally self-pollinate, which makes it quite easy to create inbred strains in the laboratory (other plants, including important genetic models such as maize require transfer of pollen from one flower to another). (wikipedia.org)
Laboratory mice have been at the center of biomedical research for almost a century. (jax.org)
Mice are one of the most commonly used laboratory organisms, widely used to study everything from autism to infectious diseases. (sciencedaily.com)
I also worked as a Genetics technician at Ipatimup diagnostics, an accredited and certified genetic diagnostics laboratory, where I implemented diagnostic tests for genetic disorders and performed routine forensic genetics analyses and parentage testing. (kolabtree.com)
Today, it's estimated that 95 percent of the world's lab mice are descended from mice born in the Jackson Laboratory. (mentalfloss.com)
Bar Harbor, Maine - Jackson Laboratory researchers have shown that using an electric current to deliver the CRISPR/Cas9 system, in order to engineer genetic changes in laboratory mice, is highly efficient and significantly improves the system's throughput. (jax.org)
His Computational biology study integrates concerns from other disciplines, such as Identifier, Phenomics and Laboratory mouse. (research.com)

His research combines quantitative genetics, genomics, analytical chemistry, and remote sensing to elucidate the genetic basis of complex trait variation in various crops. (genestogenomes.org)
Research in the Tellier lab is focused on population genetics/genomics theory bridging evolutionary and ecological processes and time scales. (genestogenomes.org)

The researchers also show that classic lab mouse strains have been selected for domesticity, by documenting wild-like behaviors in those bred from the wild-derived strains. (spectrumnews.org)

Two papers, published in the May issues of Nature Genetics and Nature Neuroscience , report the cloning of a candidate taste receptor gene, T1r3 , which is linked to the Sac locus that determines mouse sensitivity to sweet tastants. (biomedcentral.com)

Susceptibility of inbred and F1 hybrid strains to noise-induced hearing loss. (cdc.gov)
These mice provided some of the first evidence that susceptibility to cancer can be inherited, just like hair color. (mentalfloss.com)
For example, researchers tested 371 mice from 66 new strains for their susceptibility to the fungus Aspergillus fumigatus , which can also infect humans. (spectrumnews.org)

A strain is inbred when it has undergone at least 20 generations of brother x sister or offspring x parent mating, at which point at least 98.6% of the loci in an individual of the strain will be homozygous, and each individual can be treated effectively as clones. (wikipedia.org)
The final consensus maps are based on 1578 microsatellite loci and these maps have a cumulative length of approximately 1400 cM after adjustment for recombination frequencies of RI strains. (nervenet.org)
Recombinant inbred (RI) strains have been used to map a wide range of Mendelian loci and quantitative traits (Taylor, 1989). (nervenet.org)
Increased T1D disease risk from IL-2 pathway loci in the TwinsUK cohort of human subjects resulted in some similar microbiota changes to those observed in the NOD mouse. (biomedcentral.com)

The purpose of this study was to test the hypothesis that putative genotypes for age related hearing loss (AHL) may make mice more susceptible to noise induced hearing loss (NIHL). (cdc.gov)
Genotypes of more than 100 RI strains were extensively error checked and regenotyped. (nervenet.org)
A third advantage of RI strains is that genotypes generated by different groups using a variety of methods can be pooled to generate high-density linkage maps. (nervenet.org)

Oct. 2 Presentation by Brody Holohan, PhD, CIBM postdoctoral fellow (Center for Human Genetics, Marshfield Clinic Research Inst. (wisc.edu)
In 2015, he left his post as director of the Psychiatric Genetics Group at the University of Oxford's Wellcome Trust Centre for Human Genetics to join UCLA, where he became one of four directors of UCLA's Depression Grand Challenge. (genestogenomes.org)

Inbred strains (also called inbred lines, or rarely for animals linear animals) are individuals of a particular species which are nearly identical to each other in genotype due to long inbreeding. (wikipedia.org)

NIH acquires knockout mice. (mmrrc.org)
2014) Salty taste deficits in CALHM1 knockout mice. (monell.org)

Such strains are useful in the analysis of variance within an inbred strain or between inbred strains because any differences would be due to the single genetic change, or to a difference in environmental conditions between two individuals of the same strain. (wikipedia.org)
The authors conclude that the major differences observed for permanent threshold shift in the B6 and B6D2F1-mice and the minimal temporary threshold shifts in the CB and CBB6F1-mice support the hypothesis for a major genetic difference among these strains. (cdc.gov)
DO mice have profound trait differences between individual mice, providing a powerful genetic mapping platform to identify associations between the traits and specific genomic regions. (jax.org)
We profiled individual differences in alcohol consumption upon initial exposure and during 5 weeks of voluntary alcohol intake in female mice from 39 BXD recombinant inbred strains and parents using the drinking in the dark (DID) method. (northumbria.ac.uk)
Gender differences in methamphetamine-induced mRNA associated with neurodegeneration in the mouse nigrostriatal dopaminergic system. (omeka.net)
In this report female and male CD-1 mice were treated with a neurotoxic regimen of methamphetamine (MA) to compare gender differences in striatal dopamine depletion and concordant changes in mRNA markers of the transforming growth factor-beta injury response associated with neurodegeneration. (omeka.net)
No statistically significant differences between MA-treated female and male mice were obtained in mRNA levels for transforming growth factor-beta, transforming growth factor-beta type 2 receptor, activin-like kinase-5 or fibronectin. (omeka.net)
Laping Nicholas J, "Gender differences in methamphetamine-induced mRNA associated with neurodegeneration in the mouse nigrostriatal dopaminergic system. (omeka.net)

Neurobiology and genetics of of social behavior development, and neurobiology and genetics of autism and spectrum disorders. (upenn.edu)
Although progress with research methods has only recently made work with DO mouse populations readily feasible, DO studies have already successfully mapped complex traits related to cardiovascular function, addiction, metabolic syndrome, cancer, behavior and more. (jax.org)
For example, they report that the mouse gene Azi2 is associated with the effects methamphetamines have on body movements, and that mouse gene Zmynd11 is associated with anxiety-like behavior. (sciencedaily.com)

Unfortunately, a multitude of genetic backgrounds and experimental setups, together with inter-individual variation, complicates cross-study comparisons and a global understanding of the mouse microbiota landscape. (nih.gov)
Here, we investigate the variability of the healthy mouse microbiota of five common lab mouse strains using 16S rDNA pyrosequencing. (nih.gov)
Genetic distance correlates positively to microbiota distance, so that genetically similar strains have more similar microbiota than genetically distant ones. (nih.gov)
Here, we have performed an analysis of associations between the gut microbiota and T1D genetic risk using the non-obese diabetic (NOD) mouse model of T1D and the TwinsUK cohort. (biomedcentral.com)
In the inbred non-obese diabetic (NOD) mouse model of T1D, susceptible NOD mice were shown to harbor a distinct gut microbiota to a variety of T1D-protected inbred strains [ 8 ]. (biomedcentral.com)
These studies indicate that in the steady state, NOD mice harbor a "diabetes-permissive" microbiota, and major perturbations in the microbiota can both reduce and accelerate disease. (biomedcentral.com)

Mice homozygous for disruptions in this gene are essentially normal although their kidneys are smaller and more succeptible to injury. (jax.org)
The autosomal recessive nude gene in homozygous (sp/sp) mice causes the lack of fur and an abnormal thymus. (taconic.com)
The majority of the homozygous mutant mice exhibited retinal depigmentation spots in the fundus test. (mmrrc.org)
RT-PCR analysis revealed that the transcript was absent in the homozygous mutant mice. (mmrrc.org)

Heterozygous (sp/wt) mice carry only one copy of the nude mutation and have hair. (taconic.com)
Estimation of microsatellite mutation rates in recombinant inbred strains of mouse. (zju.edu.cn)

The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. (mmrrc.org)

Mulligan MK, Mozhui K, Prins P, Williams RW 2017 GeneNetwork: A Toolbox for Systems Genetics. (genenetwork.org)
Williams RW, Williams EG 2017 Resources for Systems Genetics. (genenetwork.org)

Research using inbred (genetically nearly identical) mice has provided countless biological insights and has been vital for medical progress, but translation to clinical application has been difficult and inconsistent. (jax.org)
Research with inbred mouse strains-that is, mice inbred for generations until their genetics are identical, or as nearly so as possible-has yielded countless biological discoveries and led to significant medical progress. (jax.org)
So he began to dream of mice strains that were identical and docile, 'like newly minted coins. (mentalfloss.com)
However, available strains are strikingly genetically identical to one another, greatly limiting the amount of genetic variation that researchers are able to study. (spectrumnews.org)
Our idea was to make mice that had identical genetic backgrounds but differed in only one phenotype: the ability to stimulate a mixed lymphocyte response. (aai.org)

A genetically diverse mouse population model in combination with a systems biology approach was utilized to identify transcriptional changes, INH-responsive metabolites, and gene variants that contribute to the liver response in genetically sensitive individuals. (nih.gov)
Several mice show remarkable resistance to infection, allowing the researchers to hone in on the gene variants responsible for resistance 3 . (spectrumnews.org)

Trends in Genetics. (knaw.nl)

Department of Genetics faculty, postdocs, students and collaborators published eleven papers during Jan. 28-Feb. 10, 2018. (unc.edu)

Genomes of individuals strains typically incorporate 45-55 recombinations between parental chromosomes. (nervenet.org)

Mar. 26 Presentation by Andrew Hasley, PhD, CIBM postdoctoral fellow (Dept. of Genetics, UW-Madison), Actually, Data Science CAN Be Accessible: Barriers to Inclusion of People with Disabilities in the Data Science Workforce Pipeline and Ideas for Lowering Them , Rm. (wisc.edu)

In Systems Genetics , Methods in Molecular Biology 1488:75-120 [An updated primer in using GeneNetwork for molecular analysis of mouse and human cohorts. (genenetwork.org)
In Systems Genetics , Methods in Molecular Biology 1488:3-29. (genenetwork.org)
Michael Gore is the chair of the plant breeding and genetics section, professor of molecular breeding and genetics for nutritional quality, Liberty Hyde Bailey professor, and international professor of plant breeding and genetics at Cornell University. (genestogenomes.org)

Combining rabies-virus tracing, optical clearing (CLARITY), and whole-brain light-sheet imaging, we mapped the monosynaptic inputs to midbrain dopamine neurons projecting to different targets (different parts of the striatum, cortex, amygdala, etc) in mice. (elifesciences.org)
classified dopamine neurons in the mouse brain into eight types based on the areas to which they project, and then mapped which neurons send input signals to each type. (elifesciences.org)
Striatal dopamine concentrations of MA-treated female mice were less depleted and significantly greater than that of identically treated males. (omeka.net)

doi: 10.1534/genetics.117.300211. (unc.edu)

One type of inbred strain that either has been altered, or naturally mutated so that it is different at a single locus. (wikipedia.org)
We provide two-locus correlograms that can be used to detect and correct for non-syntenic association and to reduce error rates in QTL mapping studies that exploit RI strains. (nervenet.org)

For this reason, researchers are increasingly focusing on mouse populations with high genetic diversity. (jax.org)
The JAX Genetic Diversity Initiative is a strategic effort to increase the awareness and availability of diversity mouse populations and associated tools across the research community. (jax.org)
Three international breeding sites began the work to produce hundreds of strains that maximized genetic diversity across strain panels. (jax.org)

Researchers quickly realized the value of using standardized mice strains, and the money began pouring in. (mentalfloss.com)
Researchers are also conducting experiments on many of the existing 'nearly inbred' strains of mice. (spectrumnews.org)
The researchers are currently working to further refine the technique and optimize it for a variety of inbred mouse strains. (jax.org)

June 14, 2022 A new study reveals that opioid analgesic fentanyl may induce autism-like behaviors in young male and female mice. (sciencedaily.com)

Inbred strains have been extensively used in research. (wikipedia.org)

Right here, we report the phenotype of mice bred to hold two copies of the BAC, which extra utterly recapitulate the phenotypic options of HGPS in pores and skin, adipose, skeletal, and vascular tissues. (eumorphia.org)
Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics. (research.com)
Phenotypic data provided by Lexicon Genetics, Inc. Full report available through MGI data link (includes genotyping information under "Genetics" on left side of screen). (mmrrc.org)
Level I phenotypic analysis is performed on mice from this generation. (mmrrc.org)

To test this hypothesis, we infected K18-hACE2 mice with SARS-CoV-2 USA-WA1/2020 (WA1) and, after 24 days, challenged with WA1, Alpha, or Delta. (bvsalud.org)

Alam G, Miller DB, O'Callaghan JP, Lu L, Williams RW, Jones BC 2016 MPTP neurotoxicity is highly concordant between the sexes among BXD recombinant inbred mouse strains. (genenetwork.org)

We now have been utilizing the Inbred Lengthy- and Quick-Sleep mouse strains (ILS, ISS) and a recombinant inbred panel derived from them, the LXS, to research the genetic underpinnings of acute ethanol tolerance which is taken into account to be a threat issue for alcohol use issues (AUDs). (eumorphia.org)
Intravenous cocaine self-administration in a panel of inbred mouse strains differing in acute locomotor sensitivity to cocaine. (unc.edu)

Nonetheless, inbred mouse strains have limitations, and findings in them often don't translate well to humans or for clinical applications. (jax.org)
Yet genomic studies in mice have lagged behind those in humans. (sciencedaily.com)
However, animal models are limited in revealing some of the most fundamental aspects of development, genetics, pathology, and disease mechanisms that are unique to humans. (genewhisperer.com)

Some inbred strains have been bred for over 150 generations, leaving individuals in the population to be isogenic in nature. (wikipedia.org)
The mice were backcrossed nine generations (N9). (taconic.com)

When investigated within diverse mouse populations, traits show a range similar to those observed in human populations, and they can be genetically mapped with high precision. (jax.org)
The CC, DO and founder mice as well as associated analysis tools will greatly improve mouse-based research into complex traits and disease and complement human genetic analyses. (jax.org)
As the authors conclude, "These diversity mice can be used to dissect complex traits at multiple levels by establishing heritability, identifying coregulation with other traits, finding interesting model strains, and making mechanistic genetic insights. (jax.org)
Recombinant inbred (RI) strains of mice are an important resource used to map and analyze complex traits. (nervenet.org)
Between 1909 and 1914, C.C. Little toiled in the biology labs of Harvard's Bussey Institute, using mice to learn how mammals inherit traits from their parents. (mentalfloss.com)
Sometimes, the traits that Little and his team found most useful were the ones that produced the least healthy mice. (mentalfloss.com)

Furthermore, the observed environmental and genetic effects have important consequences for experimental design in mouse microbiome research. (nih.gov)
Through the analysis of five separate colonies of T1D susceptible NOD mice, we identified similarities in NOD microbiome that were independent of animal facility. (biomedcentral.com)

For exam- ple, coxsackievirus B3 (CB3) infection of susceptible mice that genetic as well as environmental factors (such as results in inflammation of the heart (myocarditis) that infection) are necessary for the disease to develop (6). (cdc.gov)
However, a body of circumstantial evi- susceptible mice by stimulating elevated levels of proin- dence links diabetes, multiple sclerosis, myocarditis, and flammatory cytokines from mast cells during the innate many other autoimmune diseases with preceding infec- immune response. (cdc.gov)

This work also highlights the value of using a mouse diversity panel to investigate drug-induced responses across a diverse population. (nih.gov)
Chaum E, Winborn CS, Bhattacharya S 2015 Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population. (genenetwork.org)
Previously I worked at Ipatimup, Porto, Portugal, where I participated in several projects in the field of Population and Forensic Genetics. (kolabtree.com)
As a post-doc he joined Wolfgang Stephan's lab at LMU Munich (Germany), where he learned theoretical population genetics and worked on adaptation of wild tomato species (Solanum sp. (genestogenomes.org)
He now assumes the position of associate professor of population genetics at the Technical University of Munich. (genestogenomes.org)

Thanks to this increase in efficiency, Wang adds, "we may now be in a position to generate mouse models of human disease alleles with unprecedented efficiency and throughput. (jax.org)

The findings demonstrated the advantages of using inbred and F1 hybrid strains of mice which are genetically well defined, numerous and readily available. (cdc.gov)

Inbred strains of animals are frequently used in laboratories for experiments where for the reproducibility of conclusions all the test animals should be as similar as possible. (wikipedia.org)
Experiments using the first of these mice are published in the August issue of Genomic Research 1 , 2 , 3 . (spectrumnews.org)

This exceedingly high uniformity means that fewer individuals are required to produce results with the same level of statistical significance when an inbred line is used in comparison to an outbred line in the same experiment. (wikipedia.org)
Here we describe an experiment that uses partially inbred CC lines to evaluate the genetic properties and utility of this emerging resource. (jax.org)

Hayes SK, Hager R, Grencis RK (2014) Sex-dependent genetics effects on immune responses to parasitic nematodes. (genenetwork.org)
Disease-protected strains exhibited a restoration of immune regulatory pathways within the gut which could also be reestablished using IL-2 therapy. (biomedcentral.com)

New genetically diverse mouse populations mirror human genetic variation, providing a powerful new experimental platform to complement human data insights, particularly for complex trait and complex disease research. (jax.org)

Outstanding in vivo efficacy was observed in several lethal, subcutaneous infection mouse models using an 8-day dosing regimen. (bvsalud.org)
Last, we observed 100% therapeutic efficacy when mice, challenged with 10× LD50 VEEV TrD, were dosed at 48 hours after infection with BDGR-49 at 25 mg kg-1 per day. (bvsalud.org)
Mouse brain viral titers at 96 hours after infection were reduced to values near the limit of detection. (bvsalud.org)
This has motivated studies to assess protection conferred by earlier strains following infection or vaccination to each new VOC. (bvsalud.org)
Genetic factors are important in the development of be induced by injecting mice with heart proteins mixed with autoimmune disease, since such diseases develop in cer- adjuvant(s), which indicates that an active infection is not tain strains of mice (e.g., systemic lupus erythematosus or necessary for the development of autoimmune disease. (cdc.gov)

The GAMT knockout (KO) mouse mannequin presents biochemical alterations in bodily fluids, the mind, and muscle tissue, together with elevated GAA and decreased Cr and creatinine (Crn) ranges, that are just like these noticed in people. (eumorphia.org)
On the behavioral stage, solely restricted and gentle alterations have been reported, with a big a part of analyzed behaviors being unaffected in GAMT KO as in contrast with wild-type mice. (eumorphia.org)

We tested whether modulation of inhibition or excitation in the auditory cortex of male mice could evoke such a variety of effects in tone-evoked responses and in behavioral frequency discrimination acuity. (jneurosci.org)
In this study, we disrupted circadian rhythms in female and male mice using both environmental (i.e., shifting diurnal cycles) and genetic (i.e. (mdpi.com)
Alcohol consumption and preference, as well as food and water consumption, total caloric intake, and weight were assessed in adult female and male Clock Δ19/Δ19 mutant mice or wild-type (WT) litter-mates, housed under a 12-hour:12-hour light:dark (L:D) cycle or a shortened 10-hour:10-hour L:D cycle. (mdpi.com)

The Asian Mouse Mutagenesis Useful resource Affiliation (AMMRA) is a non-profit group consisting of main useful resource and analysis establishments with rodent experience from inside the Asia Pacific area. (eumorphia.org)

Anatomy2

Organisms16

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Chemicals and Drugs5

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

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Phenomena and Processes29

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Recombinant inbred mice3

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Phenotypes8

Genes13

Collaborative Cross5

Genome4

Transgenic2

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Genomics2

Wild-derived strains1

Nature Genetics1

Susceptibility3

Loci4

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Human genetics2

Genotype1

Knockout mice2

Differences8

Behavior3

Microbiota6

Homozygous4

Mutation2

Congenic1

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Identical5

Variants2

Trends in Genet1

Department of Genetics1

Genomes1

Postdoctoral Fellow1

Molecular3

Dopamine3

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Locus2

Genetic diversity3

Researchers3

Autism1

Extensively1

Phenotypic4

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Acute2

Humans3

Generations2

Traits6

Microbiome2

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Male3

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