Genetically sensitive mice. Medical search. Frequent questions

UCSF researchers previously reported that they had developed a bioassay for infectious prions in genetically engineered (or transgenic) mice. (scienceblog.com)
In the current study, the researchers report that this bioassay for infectious prions in genetically engineered (or transgenic) mice may detect up to 10,000-fold more prions than standard bioassay in normal mice. (scienceblog.com)
Transgenic mice challenged with orally administered Salmonella typhimurium , a murine enteric pathogen that is less sensitive in vitro to the bactericidal activity of cryptdins than to HD-5, were markedly resistant to salmonellosis compared to wild-type mice. (the-scientist.com)
In this present work, we rescued Pts -/- mice by transgenic introduction of human PTS cDNA under the control of the dopamine β-hydroxylase promoter to examine regional differences in the sensitivity of dopaminergic neurons to BH4-insufficiency. (fujita-hu.ac.jp)
We expect to develop a biomarker profile to show who might be at risk," she said, noting that her lab is conducting studies using transgenic mouse models genetically altered for obesity. (uga.edu)
Using transgenic mouse models that have been genetically altered for obesity-those having a body mass index of 30 or higher-have provided Murph with important information relating to the initiation and progression of breast cancer and have emerged as powerful tools for preclinical research. (uga.edu)

The neurons in the brain of one strain contained an optically sensitive protein that triggers neuronal activity when exposed to light. (vumc.org)

However, when the knockout mice become obese with age, they develop fasting hyperglycemia and glucose intolerance, while neither fasting hyperglycemia nor glucose intolerance is evident in the aged knockout mice without obesity, suggesting that both the genetic defect in glucose-induced insulin secretion and the acquired insulin resistance due to environmental factors are necessary to develop diabetes in Kir6.2 knockout mice. (diabetesjournals.org)
The drugs had a similar effect on genetically obese mice. (scienceupdate.com)
Not all obese mice develop breast cancer but some will, and the differences in biomarkers in obese mice with breast cancer as compared to the non-cancer group might confirm the likelihood of developing breast cancer. (uga.edu)
Our study of 250 female obese mice that have been bred and given birth to multiple litters will show that roughly 50 percent of them spontaneously contracted breast cancer by 12 to 18 months of age," she said. (uga.edu)
In her research, Murph is specifically looking at fragments of microRNA material in the obese mice involved in the regulation of cancer gene expression. (uga.edu)

Developed by a team from Northwestern University, US, led by Yevgenia Kozorovitskiy and John A. Rogers, the implant uses the sci-fi-esque technique called optogenetics - using light to stimulate genetically targeted neurons - where the mice had modified neurons with a gene from light-sensitive algae. (cosmosmagazine.com)
Then, they put the mice in different chamber, and, employing a technique called optogenetics, used an optical fiber implanted in the brains of the mice to reactivate the engram established in the previous location. (giantfreakinrobot.com)

A study in mice and rat brains reveals how general anesthesia dampens high frequency brain activity by weakening synapses. (oist.jp)
To corroborate his unit's findings, Takahashi reached out to Dr. Takayuki Yamashita, a researcher from Nagoya University who conducted experiments on synapses, called cortico-cortical synapses, in the brains of living mice. (oist.jp)
We find that in patDp/+ mice delay eyeblink conditioning-a form of cerebellum-dependent motor learning-is impaired, and observe deregulation of a putative cellular mechanism for motor learning, long-term depression (LTD) at parallel fibre-Purkinje cell synapses. (nature.com)
The team also experimentally prevented LTP from forming on these synapses during aggression training, and found that aggression-training no longer led to an increase in aggressive behaviors in these mice. (scitechdaily.com)
Administration of supplemental testosterone to the non-aggressive mice caused both the appearance of aggressive behavior and LTP at the amygdala-hypothalamic synapses. (scitechdaily.com)

Methods: Human lung cancer cell lines H460 and A549 were genetically transformed to express red fluorescent protein (RFP). (elsevierpure.com)
Their observations, published in Nature Neuroscience , were enabled by the use of a genetically encoded fluorescent label discovered by Stephanie Rudolph, who was a post-doctoral fellow at Harvard Medical School at the time of the study. (medicalxpress.com)

The experimenters utilized optogenetics , developing custom-designed viruses to infect only the fast-spiking interneurons of either the prefrontal or barrel cortex in mice with genetically engineered, light-sensitive cation channels. (scientificamerican.com)
Optogenetics involves introducing a genetically modified virus into the brain of a subject, which is able to "infect" certain classes of neurons with a light-sensitive receptor. (alphr.com)

Here, we have targeted expression of synapto-pHluorin, a pH-sensitive protein that reports synaptic vesicle fusion, to olfactory sensory neurons in mouse. (nih.gov)
This bioassay, which has a time lag that makes it impractical for the rapid detection of prions in large-scale testing in tissue, involves injecting brain tissue from cattle with BSE into mice genetically engineered to over-express bovine prion protein. (scienceblog.com)
The expression of the bovine prion protein makes the mice highly sensitive to bovine prions from infected cattle. (scienceblog.com)
The team made the discovery by genetically labelling the cells with a coloured marker protein before injecting them into mice with damaged leg muscles. (thenakedscientists.com)
Dr. Zoghbi found that normalizing MeCP2 levels in a mouse model can reverse disease-like features of the human MECP2 duplication syndrome, a disorder that is usually found in boys and results from excess MeCP2 protein. (aap.com.au)
The experiment used genetically modified mice that had a light sensitive protein, usually found in the eye, embedded in the membrane of the presynaptic neurons in one area of the brain (purple circle). (oist.jp)
MIT neuroscientist Susumu Tonegawa led the project in which the first step was to genetically engineer mice that expressed a specific protein, ChR2, in hippocampus neurons that help form memories. (giantfreakinrobot.com)
The ChR2 protein is light-sensitive, which means that light causes the cells that house the protein to activate, allowing the researchers to promote the encoding of new memories. (giantfreakinrobot.com)
To track down which cells anthrax targeted, the researchers looked at mice genetically altered so that a protein called CMG2, to which anthrax toxins bind, was absent from their endothelial cells. (nbcnews.com)
The researchers next tested mice that were missing the CMG2 protein from their heart cells. (nbcnews.com)
Those mice survived the doses of lethal toxin much better than their litter mates that had the protein, which pointed to anthrax's effects on the heart muscle as the way that it kills. (nbcnews.com)
Based on our findings on 6-pyruvoyltetrahydropterin synthase (PTS) gene-disrupted (Pts -/- ) mice, we suggested that the amount of tyrosine hydroxylase (TH) protein in dopaminergic nerve terminals is regulated by the intracellular concentration of BH4. (fujita-hu.ac.jp)
In a study of mice, NIH researchers showed that a protein encoded by a gene called Shisa7 (green) may boost the nerve calming effects of valium and other benzodiazepines by sticking to GABA type A neurotransmitter receptors (red). (nih.gov)
Electrical recordings showed that Shisa7 hastened receptor responses to the transmitter GABA and nearly doubled the size of responses made in the presence of Valium (a.k.a. diazepam), suggesting the protein made the receptor more sensitive to benzodiazepines. (nih.gov)

mitochondrial dysfunction, whether genetically or pharmacologically induced, may impair urea production and result in hyperammonemia. (medscape.com)

UCSF-led researchers have developed a highly sensitive, automated test for detecting prions (PREE-on) that they report significantly improves the accuracy and speed of detecting the various forms of the infectious agent, which causes a set of neurodegenerative diseases, in cattle, sheep, deer and elk. (scienceblog.com)
Researchers from University College London and King's College London have just reported in journal Science on a new light-based technique that restores muscle movement in mice with injured motor neurons. (medgadget.com)
This technique enabled the researchers to follow the progress of the same mouse over a period of time by using a sensitive camera that could pick up the increasing intensity of the coloured stem cells as they grew. (thenakedscientists.com)
Led by Wu, the researchers focused on a teardrop-shaped cluster of neurons near the very center of the brain - called the medial septum - which they showed to be particularly active during social encounters between two unfamiliar mice. (sflorg.com)
The researchers randomly treated 24 male mice trapped at five sites in Huntingdon County, Pa. (vetscite.org)
The trapping sites were innovatively positioned to represent a large grid and mice were electronically tagged so researchers could keep precise track of where the animals were being recaptured. (vetscite.org)
Researchers also found that all mice at the separate untreated sites made significantly less contacts with other mice during the same time that the testosterone treatment significantly increased contacts. (vetscite.org)
A group of steroids found in female mouse urine goes straight to the male mouse's head, according to researchers at Washington University School of Medicine in St. Louis. (vetscite.org)
The researchers were able to make mice remember things that never actually happened. (giantfreakinrobot.com)
After performing all these neat genetic tricks on the mice, researchers then put them into a safe chamber, allowing them to encode memories of that space as comfortable and harmless. (giantfreakinrobot.com)
While the mice were busy remembering that first, safe space, researchers shocked their feet. (giantfreakinrobot.com)
The researchers put the rodents back into the first chamber, the safe one, but the mice froze in fear. (giantfreakinrobot.com)
When the mice were put back into the shock chamber, they also experienced fear, but the researchers claim that the fear expressed by the mice when they had their memory of the first space activated and were then put back into it was even greater. (giantfreakinrobot.com)
Researchers used lab mice to analyze their response to gentle touches. (cbsnews.com)
Mice given the neuron-activating chemical were observed to have fewer signs of stress, leading researchers to believe the sensation was both calming and pleasurable. (cbsnews.com)
A new mouse study, published by U-M researchers in the American Journal of Respiratory and Critical Care Medicine, shows that bacteria in healthy lungs may play an important role in helping ward off disease. (umich.edu)
Next, the researchers repeatedly played high-frequency sounds without the shock, and noticed that the mice stopped showing signs of fear. (alphr.com)
To examine the brains of these mice, they used three complementary approaches, which are commonly employed by neuroscientists and medical researchers worldwide. (medicalxpress.com)
To do this, Wenyan Han, Ph.D., an NINDS post-doctoral fellow worked with other researchers in the Lu lab to systematically examine Shisa proteins in mouse neurons. (nih.gov)
Caltech researchers have discovered that hard-wired neural circuits governing aggression in mice are strengthened following their victories in aggressive encounters. (scitechdaily.com)
Now, a team of Caltech researchers has discovered that hard-wired neural circuits governing aggression in mice are strengthened following their victories in aggressive encounters, and has identified a learning mechanism operating in the hypothalamus-a brain region traditionally viewed as the source of instincts, rather than learning. (scitechdaily.com)

The lab has even found that these cells, harvested from mouse placentas, will travel to the damaged hearts of male mice after being artificially implanted in their tails. (smithsonianmag.com)
Twenty-five other male mice received sham implants, while mice at three separate sites received neither treatment. (vetscite.org)
In 2005, he found that female mice or their odors cause male mice to sing. (vetscite.org)
Like a champion fighter gaining confidence after each win, a male mouse that prevails in several successive aggressive encounters against other male mice will become even more aggressive in future encounters, attacking faster and for longer and ignoring submission signals from his opponent. (scitechdaily.com)
Although all of the male mice tested were genetically identical, about 25 percent never showed aggression and also were "immune" to the behavioral changes caused by aggression training. (scitechdaily.com)

Neuroscientists have found that mice possess a biological clock nearly identical to that of humans with the exception that it is tuned for a nocturnal lifestyle. (vumc.org)
To tease out the effects of lung microbes compared with gut microbes on lung immunity, the research team looked at 40 healthy, genetically identical mice, comparing bacterial populations in their lungs, tongues and lower intestines. (umich.edu)
The authors found that even though the mice were genetically identical to each other, the bacteria in their lungs varied greatly. (umich.edu)
The authors further found that such behavioral heterogeneity among genetically identical mice is due to naturally occurring variations in serum testosterone levels: the non-aggressive mice had, on average, lower levels of testosterone than their aggressive siblings. (scitechdaily.com)

Neurons that project to the ventral tegmental area (in blue) - a brain region associated with pleasure and reward - receive, in turn, projections from neurons in the spinal cord (in red) that themselves receive touch input, revealing a direct skin-to-brain circuit for pleasurable touch in mice. (innovations-report.com)

2022. Comparison of gelatin flavors for oral dosing of C57BL/6J and FVB/N mice. (awionline.org)
2022. Effects of hair removal creams on mouse skin. (awionline.org)
2022. Improving well-being and survival in the 6-OHDA lesion model of Parkinson´s disease in mice: Literature review and step-by-step protocol. (awionline.org)
2022. Refinement of handling and dosing methods for rats and mice. (awionline.org)

To elucidate differences in the functions of these two proteins, comprehensive survival studies with Xpa −/− , Xpc −/− and wild-type control female mice in a pure C57BL/6J background were done. (aacrjournals.org)

These cells were then transplanted into nude mice to check that the same effect was seen in vivo. (animalresearch.info)
Tumours were grown subcutaneously for each cell line and harvested and minced for surgical orthotopic implantation on the left lung of nude mice. (elsevierpure.com)

Genetically encoded probes show great promise in permitting functional imaging of specified neuronal populations in the intact nervous system, yet their in vivo application has been limited. (nih.gov)
Targeted expression of synapto-pHluorin in mouse will permit the analysis of previously inaccessible neuronal populations and chronic imaging from genetically identified neurons in vivo. (nih.gov)

The scientists did this by exposing the mice to high and low-pitched sounds. (alphr.com)
The scientists found that when the high-pitched sound was subsequently played without the shock, the mice would freeze in fear. (alphr.com)
One criticism of exposure therapy is that inured fears can relapse a few weeks after treatment, and the scientists indeed noted that neural pathways for high-pitched sounds in the mice remained strengthened - even though they'd stopped showing surface-level signs of fear. (alphr.com)
NIH mouse study could prompt scientists to rethink how benzodiazepines work. (nih.gov)
In a study of mice, scientists discovered that both may need the assistance of a 'sticky' gene, named after a mythological figure, called Shisa7. (nih.gov)
I'm still trying to figure out what the benefit of this genetic mod could possibly be: in Japan, scientists have bred mutant mice (always a good idea) to have no fear of cats . (techyum.com)

In fact, this variation in lung bacteria could be one of the reasons behind problems with reproducing experiments in mice. (umich.edu)
RESULTS: Experiments in Xenopus laevis oocytes expressing murine ENaC confirmed proteolytic ENaC activation by a combination of plg and uPA which stimulated amiloride-sensitive currents with concomitant cleavage of the ENaC Î³-subunit at the cell surface. (bvsalud.org)
Osorno, Rudolph and their colleagues carried out their experiments on adult mice. (medicalxpress.com)

Her thesis work focused on interrogating hippocampal microcircuits with a hybrid genetically-encoded voltage indicator. (stanford.edu)
Using this system, we identified JEDI-2P, an indicator that is faster, brighter, and more sensitive and photostable than its predecessors. (stanford.edu)

It is closely related to murine leukemia viruses, which cause a wide variety of cancers as well as immunological and neurological diseases in mice. (meassociation.org.uk)
METHODS: Activation of amiloride-sensitive currents by uPA and plg were studied in Xenopus laevis oocytes expressing murine ENaC. (bvsalud.org)

This is mainly for mice and rats, so they become "fearless" and in a way "stunned" so they are easier to catch. (techyum.com)

Fig. 2: SomArchon enables single-cell voltage imaging in multiple brain regions of awake mice, using a simple wide-field imaging setup. (nature.com)

The mice had new motor neurons, that were generated from embryonic stem cells, grafted onto the injured nerves. (medgadget.com)
The neurons were engineered to depolarize when illuminated via a light-sensitive ion channel that was genetically introduced into the cells. (medgadget.com)
We were able to show that the injected cells increased their own numbers, contributed to existing muscle and also produced entirely new muscle in these mice," points out Blau. (thenakedscientists.com)
In tests involving lab mice, which were surgically operated on to simulate a heart attack, she and her research team discovered something astonishing: heart cells with DNA that doesn't match the mother's own. (smithsonianmag.com)
The mystery cells belong to unborn mice. (smithsonianmag.com)
During pregnancy the fetal mouse cells cross the placenta into the mother's body, joyriding through her blood vessels until cardiac damage happens, at which point they sense inflammation and make a beeline for her wounded heart. (smithsonianmag.com)
On a nearby computer screen, Chaudhry pulls up highly magnified video footage of these fugitive fetal mouse cells in a petri dish. (smithsonianmag.com)
ATP-sensitive K+ channels (K(ATP) channels) are present in many cells and regulate a variety of cellular functions by coupling cell metabolism with membrane potential. (diabetesjournals.org)
To determine the physiological roles of K(ATP) channels directly, we have generated two kinds of genetically engineered mice: mice expressing a dominant-negative form of Kir6.2 specifically in the pancreatic beta-cells (Kir6.2G132S Tg mice) and mice lacking Kir6.2 (Kir6.2 knockout mice). (diabetesjournals.org)
At the heart of this intriguing lead was a line of mice the team genetically engineered so the animals's Mrgprb4 touch-sensitive cells would fire when illuminated with blue light. (innovations-report.com)
These types of touch cells had not previously been linked to any specific social behavior, but when Dr. Elias and Foster activated these cells by shining blue light on the mice, the duo could hardly believe the dorsiflexion responses they were seeing. (innovations-report.com)
To test whether medial septum cells were involved in animals' ability to remember new individuals, the team genetically modified these cells to be sensitive to a pair of custom drug compounds - one to activate the cells, and one to switch them off. (sflorg.com)
The technique inserts genes that express optically sensitive proteins into target cells in order to make the cells respond to light. (vumc.org)
Results showed that both sets of mice were similarly sensitive to anthrax, which meant that anthrax wasn't killing the mice via damage to endothelial cells. (nbcnews.com)
Similarly, mice without CMG2 in their liver cells fared better when exposed to edema toxin than mice that expressed CMG2, showing that the edema toxin affects the liver. (nbcnews.com)
Finally, we used single nuclei RNA sequencing to learn the molecular identity of candelabrum cells and how they relate genetically to other neuron types of the cerebellar cortex. (medicalxpress.com)
They also highlight these cells' unique molecular make-up and prove that they are highly sensitive to synaptic inputs. (medicalxpress.com)
We demonstrate that JEDI-2P can report light-evoked responses in axonal termini of Drosophila interneurons and the dendrites and somata of amacrine cells of isolated mouse retina. (stanford.edu)
RESULTS: The newly developed assay is very sensitive with a limit of detection of 100 RD cells/1 million L20B/mL. (cdc.gov)
We were the first to describe that the hormone-sensitive lipase (HSL) is expressed in beta-cells, controlling break down of triglycerides. (lu.se)
We showed how insulin deficiency in Friedreich's ataxia is likely to evolve, and that a mouse model for Huntington's disease develops diabetes due to loss of beta-cells. (lu.se)
We have taken a major interest in how mitochondria are genetically regulated, given their pivotal role in cellular energy metabolism and control of insulin secretion from beta-cells. (lu.se)
The biological properties and clinical potential of stem cells elicit that are generated must not be unduly sensitive to small fluctu- continued scientific, commercial, and public interest. (lu.se)

Here we report alterations in motor behaviour and cerebellar synaptic plasticity in a mouse model (patDp/+) for the human 15q11-13 duplication, one of the most frequently observed genetic aberrations in autism. (nature.com)
To examine which cerebellar synaptic alterations might contribute to motor deficits in autism, we studied cerebellar synaptic function and plasticity as well as motor coordination and learning in a mouse model for the human 15q11-13 duplication. (nature.com)
In contrast to the axonal origin of voltage-sensitive dye signals, hVOS signals represent predominantly post-synaptic responses. (stanford.edu)
Genetically eliminating Shisa7 from neurons reduced the number of GABA A receptors and decreased the strength of electrical currents generated by synaptic GABA A receptor responses. (nih.gov)

Our plan was to raise the testosterone levels in wild mice and measure the disease risk they posed to the population," said Grear, who presented the team's findings at the annual meeting of the Ecological Society of America in Milwaukee, Wis. (vetscite.org)

Using genetically-engineered mice, Dr. Zoghbi and her team learned that the brain is acutely sensitive to MeCP2 levels. (aap.com.au)
Using either deep brain stimulation or intense presymptomatic training of a Rett syndrome mouse model, her team showed that many symptoms can be normalized. (aap.com.au)
Most notably in their mouse studies, they for the first time teased out a full pathway that begins with neurons in the skin that respond to gentle stroking and run all of the way to pleasure centers of the brain. (innovations-report.com)
Each device was fitted between the skull and skin of the mice and connected to a minuscule, flexible filament-like probe with an LED on it, which bed through the skull into the brain. (cosmosmagazine.com)
Using the tiny, battery-free brain implant device, the team were able to program and deprogram mice to socially interact with each other in real-time. (cosmosmagazine.com)
In a study published in Nature , the Stanford team was able to observe for the first time how the mouse brain forms a memory of a new acquaintance and demonstrated the ability to selectively dampen or enhance these social memories with targeted drugs. (sflorg.com)
Medial septum neurons (magenta) in the center of a mouse brain slice. (sflorg.com)
He probes the male mouse's reaction to chemical signals from female mice to advance understanding of pattern recognition and learning in the much more complex human brain. (vetscite.org)
A new study, carried out in mice, shows how the use of genetically modified viruses and low-frequency light can be used to wipe fearful associations from the brain. (alphr.com)
Under conventional one-photon microscopy, SomArchon enables the routine population analysis of around 13 neurons at once, in multiple brain regions (cortex, hippocampus, and striatum) of head-fixed, awake, behaving mice. (nature.com)

non-temperature-sensitive, mouse-virulent strains ( 10-12 ). (cdc.gov)
The project involved genetically engineering two strains of mice. (vumc.org)
Tackenberg is currently testing whether strains of mice that suffer from seasonal affective disorder respond to this new approach. (vumc.org)

The study in Science Translational Medicine , part of the Science family of journals, found that five out of eight cancer types in mice responded to fasting alone: Just as with chemotherapy, fasting slowed the growth and spread of tumors. (sciencedaily.com)
In mice, the study found that fasting cycles without chemotherapy could slow the growth of breast cancer, melanoma, glioma and human neuroblastoma. (sciencedaily.com)
Like us, mice live in social groups, and need to be able to quickly remember if another animal is a family member, a former aggressor, a potential mate, and so on," added Xiaoting Wu, PhD, a postdoctoral researcher in Malenka's laboratory and the lead author of the new study. (sflorg.com)
The study was done using mice. (vumc.org)
By targeting a genetically-encoded hybrid voltage sensor (hVOS) to identify neurons activated during the presentation of sound, the properties and function of these neurons become accessible to study in slices of mouse ventral cochlear nucleus. (stanford.edu)
The study genetically-engineered mice so that MRGPRB4+ neurons would glow when activated. (cbsnews.com)
A third study evaluated muscle growth in mice genetically modified to lack traditional androgen receptors. (recmalabs.be)
But a new study in mice shows that bacteria in healthy lungs may play an important role in helping ward off disease. (umich.edu)
In this study, we examined AA effects on metabolism in wild-type (WT) mice and GLUT10 G128E mice fed with a normal diet (CD) or HFD, as we previously showed that GLUT10 G128E mice are highly sensitive to HFD-induced T2DM 9 . (researchsquare.com)
A study by Zhang et al suggests that those children who are genetically predisposed to asthma may be at an even higher risk if they are overweight beyond infancy. (medscape.com)

Fasting also extended survival in mice bearing a human ovarian cancer. (sciencedaily.com)
For example, a mouse is elderly at 3 years, a human is elderly at 80 years, and ginkgo trees show little effect of age even at 667 years. (wikipedia.org)
genetically modified mice to produce defensin HD-5, a human intestinal antimicrobial peptide. (the-scientist.com)
This non-germline genetically engineered mouse model mimics human proneural glioblastoma on histopathological, molecular, and treatment response levels. (nih.gov)
It may also explain why certain hair-covered areas of the human body are more sensitive to touch or associated with pleasure. (cbsnews.com)
Biochemical and pathological changes in DPS-rescued mice were similar to those in human malignant hyperphenylalaninemia and DRD. (fujita-hu.ac.jp)
Human hair removal brands such as Nair™ are sometimes used in research to remove hair from mice before surgery, imaging, and other procedures.1,3 While the use of these depilatory creams in rodent research is relatively. (awionline.org)
We have previously showed that genetic polymorphisms in glucose transporter 10 (GLUT10) gene are associated with a T2DM intermediate phenotype in non-diabetic population, and GLUT10 G128E mice (carrying human orthologous GLUT10 G128E variant) are highly sensitive to HFD-induced metabolic dysregulation. (researchsquare.com)
Genetically modified L20B (Mouse) and RD (Human Rhabdomyosarcoma) cell lines are commonly used in poliovirus research, surveillance, and diagnostics. (cdc.gov)
We evaluated specificity of the assay with five human and four mouse cell lines, as well as monkey and rat cell lines. (cdc.gov)
The assay showed no cross-reactivity with genomic DNA from human, mouse, rat, or monkey cell lines. (cdc.gov)

This could be used to implant optically sensitive proteins in SCN neurons that could be activated by an implanted LED. (vumc.org)
The discovery of C-fibers activated by histamine suggested that itch has its own dedicated sensory pathway, but itching is often accompanied by painful burning, tingling, or stinging sensations, and itch-sensitive C-fibers (or pruriceptors) also express certain pain-sensing membrane proteins, so some of them may transmit both pain and itch signals. (proto.life)

And later, the research team, led by then graduate student Melanie Schaffler , observed these same mice voluntarily going to the same spot in the research chamber where the animals previously had been illuminated. (innovations-report.com)
To find out, his team exposed the healthy mice to a commonly used antibiotic, ceftriaxone. (umich.edu)
After confirming that the lung microbiome exists and can be altered by the environment and antibiotics in healthy mice, Dickson and his team looked for a link between the bacteria and the lungs' immune state. (umich.edu)

When they tried them on healthy mice, the mice lost weight. (scienceupdate.com)

No reaction was recorded when the low-pitched sound was played, and an investigation into brains' of the mice found that - amongst those exposed to electric shocks - specific auditory pathways had become stronger. (alphr.com)

Thus, Kir6.2G132S Tg mice and Kir6.2 knockout mice provide a model of type 2 diabetes and clarify the various roles of K(ATP) channels in endocrine pancreatic function. (diabetesjournals.org)
Therefore, we first used a genetically predisposed mouse model to investigate whether AA effects on metabolism might be influenced by particular genetic and diet. (researchsquare.com)

XMRV is a virus that is closely related to viruses known to cause cancer and other diseases in laboratory mice. (meassociation.org.uk)
We've known for a while that our laboratory mice vary in their gut bacteria," says Dickson. (umich.edu)

Triple mutant astrocytes and allografts were sensitive to radiation, but expressed Mgmt and were resistant to temozolomide. (nih.gov)
Additionally, Xpc -deficient mice exhibited a strong increase in mutant frequency in lung compared with Xpa −/− mice, whereas in both models mutant frequency is increased in liver. (aacrjournals.org)

When the mice were anesthetized using isoflurane, high frequency transmission was strongly reduced whilst there was less effect on low frequency transmission. (oist.jp)

JEDI-2P can also optically record the voltage dynamics of individual cortical neurons in awake behaving mice for more than 30min using both resonant-scanning and ULoVE random-access microscopy. (stanford.edu)

In genetically susceptible individuals, these interactions can lead the patient with asthma to symptoms of breathlessness, wheezing, cough, and chest tightness. (medscape.com)
Also, more atten- tion should be devoted to sensitive groups, toxicological mechanisms and interactions as most workplace exposures are mixtures. (cdc.gov)

Female reproductive organs are highly sensitive to fat in the body. (uga.edu)
Dickson used novel, highly sensitive techniques to measure the bacterial DNA in the lungs and showed that it was not because of contamination. (umich.edu)

First, they confirmed that the mice indeed had naturally occurring bacteria in their lungs. (umich.edu)

The molecule - called SeNBD - is smaller than existing light-sensitive treatments, which means it can pass through the cell's defences more easily. (scitechdaily.com)

Using a voltage-sensitive dye we recorded glutamate receptor-independent signals arising predominantly from axons. (stanford.edu)
Imaging with a voltage sensitive dye provided a contrasting global view of signals arising predominantly from unmyelinated axons creating a potential method for studying type II auditory nerve or DCN parallel fibers. (stanford.edu)
These mice are special in that we can label or tag specific pathways that convey certain signals to the amygdala, so that we can identify which pathways are really modified as the mice learn to fear a particular sound," Jun-Hyeong Cho, co-author of the research, told The Guardian , adding: "It is like a bundle of phone lines […] Each phone line conveys certain auditory information to the amygdala. (alphr.com)

For example, multiple cycles of fasting combined with chemotherapy cured 20 percent of mice with a highly aggressive type of children's cancer that had spread throughout the organism and 40 percent of mice with a more limited spread of the same cancer. (sciencedaily.com)

We concluded that dopaminergic nerve terminals projecting to the lateral region of the striatum are the most sensitive to BH4-insufficiency. (fujita-hu.ac.jp)

They've taken away the rodents' ability to smell and react to cats, producing mice that see kitty and want to play. (techyum.com)
the mice do not need to learn how to lunge and attack when confronted with other mice they deem a threat-they just react. (scitechdaily.com)

The median survival of Xpc −/− mice showed a significant decrease, whereas the median survival of Xpa −/− mice did not. (aacrjournals.org)

Treatment of nephrotic wild-type mice with amiloride inhibited urinary uPA activity, prevented urinary plasmin formation and sodium retention. (bvsalud.org)
We investigated the impacts of AA on high-fat diet (HFD)-induced metabolic dysregulation in wild type (WT) and GLUT10 G128E mice. (researchsquare.com)
Xpc −/− mice displayed a significant increase in lung tumors and a trend toward increased liver tumors compared with Xpa -deficient or wild-type mice. (aacrjournals.org)

Imaging Voltage Globally and in Isofrequency Lamina in Slices of Mouse Ventral Cochlear Nucleus. (stanford.edu)
We then used a genetically-encoded hybrid voltage sensor (hVOS) to image voltage from a specific population of neurons. (stanford.edu)
Thus, SomArchon reports both spikes and subthreshold voltage dynamics in awake, behaving mice. (nature.com)
Genetically encoded voltage indicators are emerging tools for monitoring voltage dynamics with cell-type specificity. (stanford.edu)

In nephrotic mice lacking uPA (uPA-/- ), urinary plasmin formation from plg was suppressed and urinary uPA activity absent. (bvsalud.org)

Interestingly, despite the severe defect in glucose-induced insulin secretion, Kir6.2 knockout mice show only a very mild impairment in glucose tolerance. (diabetesjournals.org)
The DPS-rescued (Pts -/- , DPS) mice showed severe hyperphenylalaninemia. (fujita-hu.ac.jp)

A sensitive procedure of selective tumour fluorescence labelling would allow simple and high-resolution visualisation of the tumour for precise surgical navigation. (elsevierpure.com)
After the procedure, the mice no longer appeared fearful of high-pitched sounds, and there was no relapse. (alphr.com)

Transgenic6

Neurons in the brain1

Obese5

Technique called optogenetics2

Synapses5

Fluorescent2

Optogenetics2

Protein14

Pharmacologically1

Researchers21

Male mice5

Identical4

Pleasurable1

20224

C57BL1

Nude mice2

Populations2

Scientists6

Experiments3

Indicator2

Murine2

Rats1

Awake mice1

Cells23

Synaptic4

Testosterone levels1

Brain10

Strains3

Study10

Human11

Proteins2

Team3

Healthy mice1

Found1

Model2

Laboratory2

Mutant2

Frequency1

Optically1

Interactions2

Highly sensitive2

Naturally1

Light1

Signals3

Organism1

Striatum1

React2

Survival1

Wild-type3

Voltage4

Absent1

Severe2

Procedure2