Genetic variation among populations. Medical search. Frequent questions

Whole genome sequencing has led to the increasing reintegration of this gene-based view with population genetics, and also with the requirement for statistical methodology, the two subjects that Fisher pioneered a century ago. (cam.ac.uk)
A study by Pedersen and colleagues published in the February issue of GENETICS examines variation in whole exome sequences of 18 Greenlandic Inuit individuals, showing the power this unique population could have for identifying rare genetic variants linked to diseases. (genestogenomes.org)
Human population genetics. (up.ac.za)
We performed a population genetics survey based on CNVs derived from the BovineHD SNP array data of eight distinct cattle breeds. (usda.gov)

Despite these obese-specific variants, overall viral genetic diversity did not differ significantly between obese and lean hosts. (bvsalud.org)
The study found that Greenlandic Inuit have fewer genetic variants overall than other human populations tested so far, but the variants they do carry occur at higher frequencies. (genestogenomes.org)
To explore this idea, the authors estimated how much of the genetic variation in the Greenlandic population is likely to alter protein function, including potential loss-of-function alleles and variants that alter the amino acid sequence of a protein. (genestogenomes.org)
Sequencing the DNA of each animal allows the researchers to peg physiological and behavioral characteristics (phenotypes, in the vernacular) to specific genetic variants. (jax.org)
Pharmacogenomics provides an example of how prevalence of gene variants affecting drug response can differ among different populations. (cdc.gov)
Effective use of pharmacogenetics to increase the safety and efficacy of drug treatment will require research in diverse populations to ensure accurate identification of all relevant variants. (cdc.gov)
Replication studies identify several genetic variants in Arabs with obesity- linked diabetes. (who.int)
There's also genetic variation within dengue virus types, with some variants showing higher levels of virulence. (cdc.gov)

Human populations from Africa are the most genetically diverse of all because their ancestors were the source for all other groups that migrated out of Africa to populate the rest of the world. (genestogenomes.org)
Pedersen and colleagues show that the Greenlandic Inuit population has recently undergone a prolonged bottleneck of around 20,000 years, making it one of the historically smallest and most isolated human populations. (genestogenomes.org)
Also, because most human populations have migrated many times throughout their history and mixed with nearby groups, ethnicity estimates based on genetic testing may differ from an individual's expectations. (medlineplus.gov)
The frequencies exhibit considerable variation in different geographic locations, reflecting the underlying genetic and ethnic diversity of human populations [3]. (who.int)

The common variant/common disease model predicts that most risk alleles underlying complex health-related traits are common and therefore old and found in multiple populations, rather than rare or population-specific. (blogspot.com)
Accordingly, there is widespread interest in assessing the population structure of common alleles. (blogspot.com)
For all animals, we assessed MHC-DRB diversity and, across populations, we compared the number of unique MHC-DRB alleles and their distributions. (datadryad.org)
Wild individuals possessed more MHC-DRB alleles than did captive individuals, and overall, the wild population had more unique MHC-DRB alleles that were more evenly distributed than did the captive population. (datadryad.org)
Crossing over (genetic recombination) and random segregation during meiosis can result in the production of new alleles or new combinations of alleles. (wikipedia.org)
Potentially harmful recessive alleles can be hidden from selection in the heterozygous individuals in populations of diploid organisms (recessive alleles are only expressed in the less common homozygous individuals). (wikipedia.org)
Genetic predisposition to higher CRP (weighted score based on alleles of four CRP SNPs associated with higher circulating CRP) was not significantly associated with CRC-specific mortality (HR per CRP-score unit 0.95, 95% CI 0.86, 1.05) or all-cause mortality (HR 0.98, 95% CI 0.90, 1.07). (ox.ac.uk)
However, the extent to which standing genetic variation in thermal tolerance alleles influence dynamic stress responses vs. preparatory processes is unknown. (frontiersin.org)
Once new alleles arise, meiosis and sexual reproduction combine different alleles in new ways to increase genetic variation. (utah.edu)
Just like with disease alleles, the process of mutation creates these more neutral variations. (utah.edu)
The purging of deleterious alleles and admixture between populations are crucial determinants of the fate of some invasions [18] , [19] . (plos.org)
Variations, also called alleles, of MC1R control freckle number. (utah.edu)

HapMap, Perlegen) or in which a relatively small number of genes and/or populations were sampled. (blogspot.com)
The aim of this study was to examine the structure of common variation ascertained in major U.S. populations by resequencing the exons and flanking regions of 3,873 genes in 154 chromosomes from European, Latino/Hispanic, Asian, and African Americans generated by the Genaissance Resequencing Project. (blogspot.com)
This is likely due to the high supply rate of de novo variation and common evolutionary adaptations to the ferret host regardless of obesity status, which we show are mediated by variation in the hemagglutinin (HA) and polymerase genes (PB2 and PB1). (bvsalud.org)
citation needed] Ultimately, genetic variation is caused by variation in the order of bases in the nucleotides in genes. (wikipedia.org)
Examination of DNA has shown genetic variation in both coding regions and in the noncoding intron region of genes. (wikipedia.org)
Association of genetic variations in the Wnt signaling pathway genes with myocardial infarction susceptibility in Chinese Han population. (omicsdi.org)
We investigated the possible correlation between genetic variations in Wnt pathway genes and MI risk. (omicsdi.org)
Our study provided the first evidence of the association between polymorphisms in the Wnt pathway genes and MI susceptibility in Chinese Han population. (omicsdi.org)
We hypothesized that genetic variation of inflammatory pathway genes plays a role in tobacco-related carcinogenesis and is modified by tobacco smoking. (omicsdi.org)
Variation in genes can be used to infer relationships between organisms. (binghamton.edu)
We observed greater variation in lower thermal limits, with CT min ranging from 1.81 to 8.60°C, while CT max ranged from 38.74 to 40.64°C. We identified 151 and 99 distinct genes associated with CT min and CT max , respectively, and there was strong support that these genes are involved in both dynamic responses to thermal stress and preparatory processes that increase thermal resistance. (frontiersin.org)
Mutation creates variations in protein-coding portions of genes that can affect the protein itself. (utah.edu)
Multiple genes control hair texture, and different variations in these genes are found in different populations. (utah.edu)
Straight hair in Asians is mostly caused by variations in two genes-different genes from the ones that influence hair texture in Europeans. (utah.edu)
Certain common changes (polymorphisms) in the CYP2C9 and VKORC1 genes account for most of the variation in warfarin metabolism due to genetic factors. (medlineplus.gov)
These results suggest that genetic variations in TNF, TGFB1, PTGS1 and PTGS2 genes contribute to DA susceptibility. (cdc.gov)

To elucidate the genetic structure of the Tsushima population, we genotyped 101 individuals from the Tsushima Islands and 43 individuals from Honshu and Kyushu using 10 microsatellite loci, and performed population genetic analyses on the genotype data. (bioone.org)
PVWMH had more extensive genetic overlap with small vessel ischemic stroke, and unique associations with several loci implicated in ischemic stroke. (ox.ac.uk)
This problem was resolved, in part, by identification of loci containing a variable number of tandem repeats, which provided enough genetic variability to permit tracking of specific strains ( 10 - 12 ). (cdc.gov)
Genetic variation within a population is commonly measured as the percentage of polymorphic gene loci or the percentage of gene loci in heterozygous individuals. (wikipedia.org)
All of previously reported populations in Korea were sampled and seven loci from six enzymes were analyzed. (e-kjpt.org)
We assessed population genetic structure and levels of differentiation based on 1,376 samples from 31 localities throughout the Peruvian and Brazilian Amazon and Central America using 5-8 microsatellite loci. (nih.gov)
Description of protein loci and genetic divergence between Atlantic and Mediterranean populations = Anàlisi de la variabilitat genètica en el lluç europeu, Merluccius merluccius. (udg.edu)
We examined the genetic population structure of the european hake (Merluccius merluccius) using electrophoretically detectable population markers in 35 protein loci. (udg.edu)
The Nei genetic distance, D, (based on 33 loci) between samples from these two groups ranged from 0.002 to 0.006. (udg.edu)
There is need to investigate and document genetic variation at loci of pharmacogenetic relevance among different SSA populations since this information could be used to inform drug efficacy, safety and recommended dosage [ Reference Dandara 6 - Reference Masimirembwa and Hasler 8 ]. (cambridge.org)
To test our hypotheses, we measured the critical thermal minimum (CT min ) and critical thermal maximum (CT max ) of 100 lines of the Drosophila Genetic Reference Panel (DGRP) and used GWAS to identify loci that explain variation in thermal limits. (frontiersin.org)

She did her PhD work on the evolutionary consequences of genetic conflict in fruit flies at the University of Georgia. (genestogenomes.org)
Reproductive strategy affects population dynamics and genetic parameters that can, in turn, affect evolutionary processes during the course of biological invasion. (plos.org)
Evolutionary processes and genetic attributes of invasive populations may underpin their success in becoming established in a new range [1] - [3] . (plos.org)
Despite its importance in evolutionary biology, studies of the pattern of disease resistance in natural populations are rare. (lu.se)
article{c34f0f78-02b4-4f39-a3c2-3d18e368d937, abstract = {{Despite its importance in evolutionary biology, studies of the pattern of disease resistance in natural populations are rare. (lu.se)
I am an evolutionary ecologist studying the genetic architecture, adaptations, and evolutionary dynamics of wild animal populations. (lu.se)

Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis. (ox.ac.uk)
The scientific world originally embraced C.C. Little's inbred mouse because it was a way to reduce the daunting complexity of biology and focus on a single genetic trait, such as coat color or cancer susceptibility. (jax.org)
Genetic variation may explain differences in disease susceptibility among the population. (cdc.gov)
The results show that a major factor influencing offspring susceptibility is family identity, suggesting heritable variation in pathogen resistance. (lu.se)

citation needed] Genetic variation will result in phenotypic variation if variation in the order of nucleotides in the DNA sequence results in a difference in the order of amino acids in proteins coded by that DNA sequence, and if the resultant differences in amino-acid sequence influence the shape, and thus the function of the enzyme. (wikipedia.org)
We studied the associations between the stem quality, phenology, and genetic structure by genotyping the phenotypic variation at 15 genomic SSR makers of 208 mature European beech trees in four artificially established stands in Lithuania. (mdpi.com)
Genetic and phenotypic variation. (up.ac.za)

To address this lacuna, we used amplified fragment length polymorphism (AFLP) to assess the genetic variability of field and laboratory populations. (unl.edu)
We found high levels of polymorphism for all of the Amazonian populations (mean RS = 7.62, mean HO = 0.742), and low levels for the Belize and Guatemalan populations (mean RS = 4.3, mean HO = 0.457). (nih.gov)
Besides single nucleotide polymorphism (SNP), copy number variation (CNV) which comprise insertions, deletions and duplications of genomic sequence, is a new informative type of genetic variations. (usda.gov)

In this study, a reciprocal North Carolina II design and maximum-likelihood methods were implemented to investigate the genetic basis of variation for 15 floral and vegetative traits in four populations of the annual plant Amsinckia spectabilis (Boraginaceae) differing in mating system. (bioone.org)
Compared to the three partially selfing populations, we found significantly lower levels of nuclear variance for several traits in the nearly completely self-fertilizing population. (bioone.org)
Furthermore, for 11 of 15 traits we did not detect nuclear variation to be significantly greater than zero. (bioone.org)
We also found high maternal variance in one of the partially selfing populations for several traits, and little dominance variance in any population. (bioone.org)
This finding is evidenced through both LD score correlation and de novo variant analysis, indicating that multiple types of genetic risk for ASDs influence a continuum of behavioral and developmental traits, the severe tail of which can result in diagnosis with an ASD or other neuropsychiatric disorder. (ox.ac.uk)
To understand better these traits of potential importance for speciation, we performed quantitative genetic analysis of both seminal receptacle length and sperm length in two divergent populations. (syr.edu)
Since pathways implicated in different diseases reveal surprising insights into shared genetic bases underlying apparently unrelated traits, we hypothesize that there are common genetic components involved in the clustering of MetS traits. (biomedcentral.com)
With the aim of identifying these common genetic components, we have performed a genetic association study by integrating MetS traits in a continuous MetS score. (biomedcentral.com)
Copy number variations (CNVs) comprise large insertions, deletions, and duplications of genomic regions, which contribute to variations in traits among individuals. (usda.gov)
Combining ability and heterosis were determined in a population obtained from the full diallel crossing of four differentcotton genotypes (G. hirsutum and G. barbadense) for agro morphological traits and yield. (researchgate.net)
The GCA: SCA ratios for thestudied traits were higher than one indicating the presence of additive genetic effects for most of the characteristicsstudied, except for sympodia branch length. (researchgate.net)
In 2004 JAX Professor Gary Churchill, together with JAX Professor Elissa Chesler when she was at Oak Ridge National Laboratory and dozens of other leading laboratory mouse experts around the world (known collectively as the Complex Traits Consortium), devised the Collaborative Cross: a mouse population established with eight different founder strains, including standard inbred strains but also some wild-type mice. (jax.org)
My main research goals are to understand how natural and sexual selection shapes phenotypes in wild populations, why some populations are more evolvable than others and how the genetic architecture of traits constrain or facilitate evolution. (lu.se)

You want to download Divergent pattern between phenotypic and genetic variation in Scots pine - 746 unrelated genotyped Pinus sylvestris from 24 different populations across Northern Europe from the SND research data catalogue. (gu.se)
In contrast, populations of the intermediate form are highly divergent (G(subscript)ST, 54%), with genetic diversity apportioned between populations (D(subscript)ST, 0.121) rather than within (H(subscript)S, 0.105). (edu.au)
Our results revealed the overall CNV diversity among cattle populations and provided evidence for divergent selection for lineage-specific CNVs. (usda.gov)

Self-fertilization is expected to reduce genetic diversity within populations and consequently to limit adaptability to changing environments. (bioone.org)
Lower levels of genetic diversity were found in the small form (H(subscript)T,0.192) compared with the large form (H(subscript)T, 0.254), although both forms apportioned this diversity within populations (H(subscript)S, 0.122 and 0.164, respectively) rather than between D(subscript)ST, 0.070 and 0.090, respectively). (edu.au)

We found that both phenotypes have shared but also distinct genetic architectures, consistent with both different underlying and related pathophysiology. (ox.ac.uk)
Cognitive-behavioral phenotypes of Williams syndrome are associated with genetic variation in the GTF2I gene, in a healthy population. (bvsalud.org)

This might reflect the prediction that very small populations see increases in deleterious variation since natural selection is less effective in small groups. (genestogenomes.org)
The Effect of an Extreme and Prolonged Population Bottleneck on Patterns of Deleterious Variation: Insights from the Greenlandic Inuit. (genestogenomes.org)

Differences between populations resulting from geographic separation is known as geographic variation. (wikipedia.org)
Thanks to this shared heritage, small differences between populations can serve as powerful tools for unearthing discoveries that will help us all. (genestogenomes.org)

The AFLP results showed greater genetic variability between populations from Missouri and Mississippi (both USA), and relatively low variability within Missouri populations. (unl.edu)
The most highlighted impact of genomics is the inter-population variation, particularly the African genomic diversity, which could provide tools for improved understanding of individual variability in disease and pharmacology [ Reference Masimirembwa and Matimba 3 ]. (cambridge.org)

Here we analyse genome-wide data to show that some Amazonian Native Americans descend partly from a Native American founding population that carried ancestry more closely related to indigenous Australians, New Guineans and Andaman Islanders than to any present-day Eurasians or Native Americans. (nature.com)
Figure 2: A model of population history that can explain the excess affinity to Oceanians observed in Amazonian populations. (nature.com)
The Bayesian clustering analysis revealed five population clusters: northeastern Amazonian Brazil, southeastern and central Amazonian Brazil, western and central Amazonian Brazil, Peruvian Amazon, and the Central American populations. (nih.gov)

Magdalena P. Bartkowska and Mark O. Johnston "Quantitative Genetic Variation in Populations of Amsinckia spectabilis That Differ in Rate of Self-Fertilization," Evolution 63(5), 1103-1117, (1 May 2009). (bioone.org)
When compared to much larger populations, the patterns of variation differ in specific ways. (genestogenomes.org)
Though genetic patterns differ subtly between groups, the deeper similarities show how closely humanity is connected. (genestogenomes.org)
The polymorphisms associated with warfarin sensitivity often differ by population and ethnic background. (medlineplus.gov)

Efforts to increase the diversity of populations participating in genomic research will help to prevent healthcare disparities in genomic medicine in the future. (cdc.gov)

The frequency distributions of private and common single nucleotide polymorphisms (SNPs) were measured, and the extent to which common SNPs were shared across populations was analyzed using several different estimators of population structure. (blogspot.com)
Most SNPs that were common in one population were present in multiple populations, but SNPs common in one population were frequently not common in other populations. (blogspot.com)
Moreover, SNPs that were common in two or more populations often differed significantly in frequency from one another, particularly in comparisons of African Americans versus other U.S. populations. (blogspot.com)
These tests evaluate large numbers of individual variations (single nucleotide polymorphisms or SNPs) across a person's entire genome. (medlineplus.gov)
In ethnic groups with a smaller range of genetic variation due to the group's size and history, most members share many SNPs, and it may be difficult to distinguish people who have a relatively recent common ancestor, such as fourth cousins, from the group as a whole. (medlineplus.gov)

Genetic diversity was lower in the Tsushima population than in three geographic populations on the main islands: heterozygosity was 0.189-0.364 in the former, compared to 0.457-0.747 in the latter. (bioone.org)

During viral replication in a host, the negative sense single stranded RNA genome of IAV accumulates genetic diversity that may have important consequences for viral evolution and transmission . (bvsalud.org)
A high mutation rate caused by the lack of a proofreading mechanism appears to be a major source of the genetic variation that contributes to RNA virus evolution. (wikipedia.org)
Genetic recombination also has been shown to play a key role in generating the genetic variation that underlies RNA virus evolution. (wikipedia.org)
Little is known, however, about the way the evolution of self-fertilization changes the amount or pattern of the components of genetic variation in natural populations. (bioone.org)
Finally, more recent evolution has been driven by population disjunction, limited gene flow, and bottleneck and/or associated founder effects.From this study it is apparent that the genus Geleznowia consists of at least two taxa and a series of hybrid derivatives. (edu.au)
Without mutation there would be no variation, and without variation there would be no evolution. (utah.edu)

Our results suggest that restricted gene flow or inbreeding may have reduced genetic diversity in the Tsushima population, which has been geographically isolated from the main-island populations since the formation of Tsushima Strait. (bioone.org)
Given the need for comparative studies of functional genetic diversity, we investigated whether MHC diversity differs between populations which are open, that is experiencing gene flow, versus populations which are closed, that is isolated from other populations. (datadryad.org)
Therefore, loss of genetic diversity in lemurs, owing to small founder populations or reduced gene flow, can be mitigated by managed breeding efforts. (datadryad.org)
Natural selection, genetic drift, and gene flow can all contribute to geographic variation. (wikipedia.org)
An understanding of A. darlingi's population structure and contemporary gene flow patterns is necessary if vector populations are to be successfully controlled. (nih.gov)

The authors speculate this difference may be due to compensatory variation elsewhere in the genome since type 2 diabetes is a multigenic trait with many underlying contributing factors. (genestogenomes.org)
Intraspecific trait variation within natural populations (i.e. intra-population trait variation, IPTV) is the basic source for selection and can have significant ecological consequences. (osti.gov)
However, the reciprocal influences of variation in environmental conditions and phenotypic trait expression in spreading plant populations are not clearly defined. (osti.gov)
A study of identical twins concluded that hand clasping has a strong genetic basis (most twins share the trait), but it doesn't fit a predictable inheritance pattern. (utah.edu)

The intermediate form displays a stronger self-pollination mechanism than the small form.Patterns of genetic variation were analysed using both allozymes and randomly amplified polymorphic DNA (RAPDs). (edu.au)

and,(3) an intermediate form exhibiting mixed morphological characters.The patterns of morphological, reproductive and genetic variation within and between populations of these three forms were investigated. (edu.au)
Its hybrid origin is supported by the high level of genetic diversity between the intermediate form populations, as well as its strong autogamous tendencies and mixed morphological characteristics. (edu.au)
A review of morphological variation together with the genetic data presented here suggest that the populations of hake from these areas are subdivided into two different stocks: the North-Atlantic stock and the Mediterranean stock. (udg.edu)

Variation and recombination can be facilitated by transposable genetic elements, endogenous retroviruses, LINEs, SINEs, etc.[citation needed] For a given genome of a multicellular organism, genetic variation may be acquired in somatic cells or inherited through the germline. (wikipedia.org)

Many methods, including pulsed-field gel electrophoresis (often used for outbreak analysis), detect too few genetic differences between isolates to be useful in tracking the microdynamics of strains. (cdc.gov)
citation needed] Genetic variation can also be identified by examining variation at the level of enzymes using the process of protein electrophoresis. (wikipedia.org)
New technology now allows scientists to directly sequence DNA, which has identified even more genetic variation than was previously detected by protein electrophoresis. (wikipedia.org)
Genetic variation in Asaum misandrum, a woodland herb in Korea, was investigated based on allozyme analysis with starch gel electrophoresis. (e-kjpt.org)

Since most studies are carried out on non-African populations (Asians and Caucasians), a smaller portion of the overall human genome's diversity is interrogated and results from replication studies do not always concur. (cambridge.org)

Overall genetic variation of A. misandrum population showed considerably high levels of genetic variation within the species (A = 2.05, P = 71.4, HE = 0.294). (e-kjpt.org)
Although it showed moderate genetic diversity level, most habitats of the species were scattered and discontinuous. (e-kjpt.org)
Many insect species are undergoing rapid population decline in recent decades due to anthropogenic changes to natural landscapes and climate. (lu.se)

ABSTRACT We evaluated the distribution of ABO and Rhesus (Rh) D blood groups in the population of Poonch district in Azad Jammu and Kashmir. (who.int)

Figure 1: South Americans share ancestry with Australasian populations that is not seen in Mesoamericans or North Americans. (nature.com)
What is genetic ancestry testing? (medlineplus.gov)
Genetic ancestry testing, or genetic genealogy, is a way for people interested in family history (genealogy) to go beyond what they can learn from relatives or from historical documentation. (medlineplus.gov)
Variations in the Y chromosome can be used to explore ancestry in the direct male line. (medlineplus.gov)
Genetic ancestry testing has a number of limitations. (medlineplus.gov)
Genetic ancestry testing is offered by several companies and organizations. (medlineplus.gov)
On a larger scale, combined genetic ancestry test results from many people can be used by scientists to explore the history of populations as they arose, migrated, and mixed with other groups. (medlineplus.gov)

This event was distinct from the earlier expansions from the Caucasus region that contributed to the wider Levantine populations. (nature.com)

Factors contributing to the high levels of genetic diversity found within populations of A. misandrum include population maintenance via wide distribution range from Korea to Japan and primarily outcrossing breeding system. (e-kjpt.org)

In contrast, sucrase-isomaltase deficiency , a metabolic disease that prevents infants from digesting a certain sugar, is very rare in most populations but affects about 5-10% of people in Greenland. (genestogenomes.org)
Objective To characterise a population-based cohort of patients with Gaucher disease (GD) in Israel relative to the general population and describe sociodemographic and clinical differences by disease severity (ie, enzyme replacement therapy [ERT] use). (bmj.com)
Conclusions Establishing a population-based cohort of patients with GD is essential to understanding disease progression and management. (bmj.com)
The electronic health record (EHR) data enabled the examination of a large, population-based cohort of patients with Gaucher disease (GD). (bmj.com)
Here, a phylogenetic tree visualizes the genetic affinity between Lyme disease bacteria isolated from ticks in Binghamton region (white circles/nodes) and bacteria reported from elsewhere according to the bacteria's ospC gene DNA sequences. (binghamton.edu)
Keolu Fox explores the links between human genetic variation and disease in underrepresented populations. (ted.com)
Pharmacogenomics in SSA populations will probe the widest genetic diversity and improve the chances of identifying novel and relevant mechanisms of disease and for targeted therapies to sub-populations. (cambridge.org)
In contrast to variations that cause disease, there are many more examples of variations that are neither good nor bad, but just different-like blood types and eye color. (utah.edu)
In addition to offering some insights into disease prevalence, population genetic differences must be considered in developing genomic medicine. (cdc.gov)
Recognizing the impact of geospatial science in public health research, in 2015, GRASP formed a team of geospatial epidemiologists responsible for applying geospatial and temporal epidemiologic and spatial statistical methods to investigate the relationship between geographic variations of disease and environmental, demographic, behavioral, socioeconomic, genetic, and infectious risk factors. (cdc.gov)
This review summarizes the major pathological factors linking obesity to diabetes, focussing on current epidemiological data related to obese diabetic patients in the Arab world, the etiology of the disease and the genetic determinants of diabetes and obesity. (who.int)
Further genome-wide association studies in obese and diabetic Arab populations could add to our understanding of the pathophysiology, prevention and reversal of this disease. (who.int)

Our study provides the first insight into the consequences of host obesity on viral genetic diversity and adaptation, suggesting that host factors associated with obesity alter the selective environment experienced by a viral population , thereby impacting the spectrum of genetic variation . (bvsalud.org)
A variety of factors maintain genetic variation in populations. (wikipedia.org)
Almost all genetic risk factors for autism spectrum disorders (ASDs) can be found in the general population, but the effects of this risk are unclear in people not ascertained for neuropsychiatric symptoms. (ox.ac.uk)
Despite the sample size limitation of our study, this strategy can be useful to find genetic factors involved in the etiology of other disorders that are defined in a dichotomized way. (biomedcentral.com)
As a complex condition, MetS results from a complex interplay between many genetic and environmental factors. (biomedcentral.com)
An ectotherm's thermal tolerance is determined by both fixed genetic factors and plastic changes in behavior, morphology, physiology, and gene expression. (frontiersin.org)
Conversely, African Americans have a lower prevalence of other diseases, such as melanoma and acute lymphoblastic leukemia, due to protective genetic factors. (cdc.gov)

However, virtually nothing is known of its genetic variation, in natural or domesticated populations. (unl.edu)
Natural selection can also maintain genetic variation in balanced polymorphisms. (wikipedia.org)
This process of natural selection can lead to significant changes in the appearance, behavior, or physiology of individuals in a population, in just a few generations. (utah.edu)
Females were sampled at random from natural populations immediately prior to parturition with equal exposure of pathogens for all lizards once in captivity. (lu.se)

The patterns of genetic variation in any group of organisms, including humans, are closely tied to its size and history. (genestogenomes.org)
Which of the following scenarios would most likely result in the microevolution of a population of humans? (pearson.com)

Autosomal DNA analyses suggest that the North Lebanese Mountain Maronite community possesses an ancestral Fertile Crescent genetic component distinct from other populations in the region. (nature.com)
The population comprises about 2,500 cattle and is considered one of the ancestral populations of the modern Holstein breed. (frontiersin.org)

Differential cultural adaption by populations from the North Lebanese Mountains are clearly aligned with the L1b haplotype STR haplogroup clusters, indicating pre-existing and persistent cultural barriers marked by the transmission of L1b lineages. (nature.com)

Genetic variation and recombination by transposable elements and endogenous retroviruses sometimes is supplemented by a variety of persistent viruses and their defectives which generate genetic novelty in host genomes. (wikipedia.org)

HIV), damage in the RNA genome appears to be avoided during reverse transcription by strand switching, a form of genetic recombination. (wikipedia.org)
This signature is not present to the same extent, or at all, in present-day Northern and Central Americans or in a ∼ 12,600-year-old Clovis-associated genome, suggesting a more diverse set of founding populations of the Americas than previously accepted. (nature.com)
In order to trace the origins and migratory patterns that may have led to the genetic isolation and autosomal clustering in some of these communities we analyzed Y-chromosome STR and SNP sample data from 6327 individuals, in addition to whole genome autosomal sample data from 609 individuals, from Mount Lebanon and other surrounding communities. (nature.com)
38,000), we find genome-wide genetic links between ASDs and typical variation in social behavior and adaptive functioning. (ox.ac.uk)
The National Human Genome Research Institute (NHGRI) wants to ensure that all populations are knowledgeable about the science underpinning the Human Genome Project and genomics research, and have the opportunity to participate in various ways, such as becoming research scientists, research participants and policy makers. (genome.gov)
The role of African genome diversity and the opportunities for pharmacogenomics research are highlighted and will enable discovery of novel genetic mechanisms and validation of established markers. (cambridge.org)

Host obesity impacts genetic variation in influenza A viral populations. (bvsalud.org)
Although influenza B viruses have shown more antigenic stability than influenza A viruses, antigenic variation does occur. (cdc.gov)
If they become ill with influenza, such members of high-risk groups (see Groups at Increased Risk for Influenza-Related Complications) are more likely than the general population to require hospitalization. (cdc.gov)

These CNV results provide a new glimpse of diverse selections during cattle speciation, domestication, breed formation, and recent genetic improvement. (usda.gov)

The genotype data allow evaluation of genetic variance across landscapes and thus shed light on the degree of genetic-environmental association and the recolonization history of Scots pine in Scandinavia. (gu.se)

Reproductive strategy can also influence the adaptive potential of invasive populations. (plos.org)

This type of testing identifies genetic variations in mitochondrial DNA. (medlineplus.gov)

The multiple sources of genetic variation include mutation and genetic recombination. (wikipedia.org)
It's useful to think of mutation as a process that creates genetic variation. (utah.edu)
We often refer to a mutation as a thing-the genetic variation itself. (utah.edu)

An additive genetic effect of GABRA2 rs279871 , NPY rs16147 and TPMT rs1142345 in the MetS score variation was also found. (biomedcentral.com)

Random mutations are the ultimate source of genetic variation. (wikipedia.org)

METHODS: We investigated the association between pre-diagnostic high-sensitivity CRP concentrations and CRP genetic variation associated with circulating CRP and CRC-specific and all-cause mortality based on data from 1,235 individuals with CRC within the European Prospective Investigation into Cancer and Nutrition cohort using multivariable-adjusted Cox proportional hazards regression. (ox.ac.uk)

However, a major problem with the first 2 approaches has been a lack of genetic diversity to track strains. (cdc.gov)
Furthermore, over time, antigenic variation (antigenic drift) within a subtype may be so marked that infection or vaccination with one strain may not induce immunity to distantly related strains of the same subtype. (cdc.gov)

Within Central America there was low non-significant differentiation, except for between the populations separated by the Maya Mountains. (nih.gov)

Association between WNT-1-inducible signaling pathway protein-1 (WISP1) genetic polymorphisms and the risk of gastric cancer in Guangxi Chinese. (omicsdi.org)

Finally, a Bayesian clustering analysis showed that the Tsushima population is apparently differentiated from the main-island populations and comprises two genetic clusters. (bioone.org)
We detected a large amount of population structure in Amazonia, with three population clusters within Brazil and one including the Peru populations. (nih.gov)

The results can be very useful in understanding the process of adaption to the environment of each individual in the population. (wikipedia.org)

Crossing these animals shuffles the genetic deck to yield populations of mice with greater genetic diversity than is present in the entire human race. (jax.org)

Polyploidy is a condition wherein organisms have three or more sets of genetic variation (3n or more). (wikipedia.org)
In biology , cloning is the process of producing similar populations of genetically identical individuals that occurs in nature when organisms such as bacteria , insects or plants reproduce asexually . (wikiquote.org)

Variation and population genetic structure in the Western Australian endemic genus Geleznowia Turcz. (edu.au)

Anatomy8

Organisms28

Diseases6

Chemicals and Drugs16

Analytical, Diagnostic and Therapeutic Techniques and Equipment49

Psychiatry and Psychology5

Phenomena and Processes110

Disciplines and Occupations15

Anthropology, Education, Sociology and Social Phenomena4

Technology, Industry, Agriculture5

Humanities1

Information Science9

Named Groups10

Health Care41

Geographicals16

Genetics4

Variants8

Human populations4

Alleles12

Genes16

Loci11

Evolutionary6

Susceptibility4

Phenotypic variation3

Polymorphism3

Traits13

Divergent3

Diversity within populations2

Phenotypes2

Deleterious Variation2

Differences between populations2

Variability2

Amazonian3

Differ4

Genomic research1

SNPs5

Geographic populations1

Evolution6

Gene flow5

Trait4

Polymorphic1

Morphological3

Germline1

Electrophoresis4

Asians1

Species3

ABSTRACT1

Ancestry7

Caucasus1

Levels of genetic diversity1

Disease12

Factors7

Natural4

Humans2

Ancestral2

Differential1

Transposable elements1

Genome6

Influenza3

Speciation1

Genotype data1

Adaptive potential1

Mitochondrial1

Mutation3

Additive genetic1

Source of genetic1

Cohort1

Strains2

Central America1

Polymorphisms1

Clusters2

Adaption1

Greater genetic1

Organisms2

Endemic1