• The purpose of this study was to identify genomic factors predictive of the occurrence of interstitial lung disease (ILD) in RA by performing a genome-wide association study of genetic variants, including single nucleotide polymorphisms (SNPs). (bvsalud.org)
  • The aim of the present study was to identify the genomic factors predictive of susceptibility to joint destruction in patients with RA by performing a genome-wide association study of genetic variants, including single nucleotide polymorphisms (SNPs). (bvsalud.org)
  • Shared genetic susceptibility between trigger finger and carpal tunnel syndrome: a genome-wide association study. (ox.ac.uk)
  • Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. (ox.ac.uk)
  • in rheumatoid arthritis: a genome-wide association study replication and meta-analysis. (who.int)
  • Variations in dozens of genes have been studied as risk factors for rheumatoid arthritis. (medlineplus.gov)
  • Multitrait genome association analysis identifies new susceptibility genes for human anthropometric variation in the GCAT cohort. (broadinstitute.org)
  • Genetic polymorphisms in the methylenetetrahydrofolate reductase and thymidylate synthase genes and risk of hepatocellular carcinoma. (snpedia.com)
  • Genetic polymorphisms located near the PRL and NFIA genes represent examples of genetic susceptibility factors specific for anti-CCP-negative RA. (ox.ac.uk)
  • Genetic variation in VEGF family genes and breast cancer risk: a report from the Shanghai Breast Cancer Genetics Study. (snpedia.com)
  • Even the role of MHC genes remains to be fully defined, and may involve interactive genetic effects. (biomedcentral.com)
  • In addition, stochastic genetic or physiologic events may contribute to the low penetrance of susceptibility genes. (biomedcentral.com)
  • This situation parallels developing paradigms for other autoimmune disorders, in which many different genes each appear to contribute a small amount to overall risk for disease, and where severity and specific phenotypic subtypes are subject to genetic effects. (biomedcentral.com)
  • Also, in the last year, another GWAS revealed the presence of new genes that may be potentially implicated in the development of CV disease in the general population. (bancoadn.org)
  • The causal genes, variants and haplotypes involved within many of these regions have yet to be identified. (biomedcentral.com)
  • A total of 1278 Caucasian patients with RA from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS) cohort receiving tumour necrosis factor (TNF) antagonists (infliximab, adalimumab and etanercept) were genotyped for 34 single nucleotide polymorphisms (SNPs), spanning the genes NLRP3, MEFV and CARD8. (uea.ac.uk)
  • By investigating SNP profiles associated with a disease trait, researchers would be able to reveal relevant genes. (biomedcentral.com)
  • Researchers hypothesize that many common diseases in humans are not caused by one genetic variation within a single gene, but are determined by complex interactions among multiple genes. (biomedcentral.com)
  • Then, it will just be a matter of time before physicians can screen individuals for susceptibility to a disease by analyzing their DNA samples for specific SNP patterns, and further design some experiments to target the genes that implicate the disease. (biomedcentral.com)
  • Predisposition to vitiligo and its associated autoimmune diseases may be related to single nucleotide polymorphisms (SNPs) of genes, such as rs12150220, rs2670660, rs6502867, and rs8182352 of the NLRP1 gene on chromosome 17p13.2, which is also named NALP1 (NACHT, LRR, and PYD Domains-Containing Protein 1) [ 8 - 12 ]. (oncotarget.com)
  • But exactly how a person's genes, the regulation of these genes and how the resulting proteins interact to cause disease is not widely understood. (uchicagomedicine.org)
  • Future therapies can target this pathway to tune the m6A level of disease susceptible genes without replacing the genetic code that alters the functioning of m6A. (uchicagomedicine.org)
  • Our paper provides some examples where genetic variations of immune traits change m6A levels in specific genes, suggesting possible paths from genotypic to phenotypic variations. (uchicagomedicine.org)
  • The genetic study showed promising results in "silencing" the genes that translate into tau protein, the primary component behind dementia. (medicaldaily.com)
  • Rheumatoid Arthritis Network and Coordinated Project, Klareskog L, Alfredsson L, Dunussi-Joannopoulos K, Clark JD, Padyukov L. Variants within STAT genes reveal association with anticitrullinated protein antibodynegative rheumatoid arthritis in 2 European populations. (who.int)
  • Rat models are frequently used for finding genes contributing to the arthritis phenotype. (medscape.com)
  • As a result, the linkage between the autoimmune experimental arthritis phenotype and the genomic region, that is, the quantitative trait locus, can cover several hundred genes. (medscape.com)
  • Thus, to find genes contributing to experimentally induced arthritis, we consider the CGC application to be a helpful tool in facilitating the evaluation of large amounts of textual information. (medscape.com)
  • Animal models provide a valuable tool for finding genes contributing to the susceptibility to and severity of RA. (medscape.com)
  • The interactions of multiple single nucleotide polymorphisms (SNPs) are highly hypothesized to affect an individual's susceptibility to complex diseases. (biomedcentral.com)
  • We want to investigate whether the single nucleotide polymorphisms (SNPs) of the Ang2 gene can predict the risk of rheumatoid arthritis (RA). (medsci.org)
  • We will examine association between 1400 markers within the PAR1 and PAR2 (on the Biobank Axiom® Array) and the risk of coronary artery disease, inflammation-immunity related disorders (asthma, rheumatoid arthritis, type 1 diabetes and inflammatory bowel disease), hypertension, type II diabetes, obesity and chronic kidney disease and/or related physiological traits. (ukbiobank.ac.uk)
  • These findings demonstrate for the first time that type 1 diabetes-associated genetic variants that restore immune tolerance to islet antigens also result in functional changes in the gut immune system and resultant changes in the microbiota. (biomedcentral.com)
  • Dysbiosis of the gut microbiota has been described in multiple inflammatory and immune-mediated diseases including rheumatoid arthritis, ulcerative colitis, Crohn's disease ankylosing spondylitis, and type 1 diabetes (T1D). (biomedcentral.com)
  • Type 1 diabetes (T1D) is a heritable polygenic autoimmune disease in which both genetic and environmental factors contribute to pathogenesis. (biomedcentral.com)
  • This meta-analysis demonstrates that within the Caucasian population, the NLRP1 rs12150220 polymorphism may correlate with a decreased risk of vitiligo-associated autoimmune diseases, especially autoimmune Addison's disease, type 1 diabetes, or systemic lupus erythematosus. (oncotarget.com)
  • Genetics in rheumatoid arthritis (RA) has moved from the finding of HLA-shared epitope decades ago toward the understanding of the role of HLA in RA and the findings of ∼100 additional genetic risk variants for disease susceptibility as well as several risk variants for severe disease. (musculoskeletalkey.com)
  • It is hoped that this treatment may prove effective, which would further support the host genetics approach as a method for identifying and building evidence for candidate treatment targets for infectious diseases. (phgfoundation.org)
  • Identifying links between genetics and susceptibility to disease can pave the way for potential treatments, researchers noted. (chkd.org)
  • It is likely though that genetics will be important for understanding these diseases. (biomedcentral.com)
  • When it comes to the study of genetics and polygenic human disease, however, the experiments have already been done, and we must make do with interpreting the results as they exist in the human population. (biomedcentral.com)
  • This requires a group of skills that are rarely found in one individual, and this naturally leads to collaborations among scientists with expertise in clinical disease definition, disease pathogenesis, and molecular and statistical genetics. (biomedcentral.com)
  • Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS) (2014). (uea.ac.uk)
  • In a new paper published in Nature Genetics , University of Chicago researchers discovered that a form of RNA chemical modification, N6-Methyladenosine (m6A), plays an important role in human disease heritability. (uchicagomedicine.org)
  • We do not yet know the mechanisms of the genetic variants that are associated with common diseases," said Xin He, PhD, Assistant Professor of Human Genetics and co-senior author of the paper. (uchicagomedicine.org)
  • 7.Bogunia-Kubik K, Wysoczańska B, Piątek D, Iwaszko M, Ciechomska M, Świerkot J. Significance of polymorphism and expression of miR-146a and NFkB1 genetic variants in patients with rheumatoid arthritis. (pmjournal.ir)
  • Copy number variants (CNVs) account for a major proportion of human genetic polymorphism and have been predicted to have an important role in genetic susceptibility to common disease. (ox.ac.uk)
  • A single nucleotide polymorphism, PTPN22 R620W , is one of the strongest genetic risk factors for multiple autoantibody associated human autoimmune diseases. (frontiersin.org)
  • We conducted a meta-analysis of four independent European SLE case collections for associations between SLE sub-phenotypes and MHC single-nucleotide polymorphism genotypes, human leukocyte antigen (HLA) alleles and variant HLA amino acids. (cdc.gov)
  • 13 Our study substantially expands this work by not only analysing imputed classical human leukocyte antigen (HLA) alleles, but also examining variant HLA amino-acid positions in conjunction with single-nucleotide polymorphism (SNP) genotypes across the extended MHC region (chromosome 6: 26-34 Mb). (cdc.gov)
  • Genetic polymorphism. (bvsalud.org)
  • Discovery of common and rare genetic risk variants for colorectal cancer. (broadinstitute.org)
  • Disease-modifying antirheumatic drugs in rheumatoid arthritis patients with a history of colorectal cancer]. (pgrn.de)
  • Streptococcus pyogenes (group A Streptococcus [GAS]) causes a range of pyogenic, toxigenic, and immunologic diseases with varying degrees of severity, from pharyngitis and impetigo to necrotizing fasciitis and streptococcal toxic shock syndrome ( 1 ). (cdc.gov)
  • Despite this stable rate, GAS disease increased, and multiorgan dysfunction and hypotension signaled an increase in GAS severity. (cdc.gov)
  • In their latest analysis, the COVID-19 Host Genomics Initiative (HGI ) have built upon previous research to reveal 13 new genomic regions associated with COVID-19 disease susceptibility and severity. (phgfoundation.org)
  • The COVID-19 Host Genomics Initiative (COVID-19 HGI) is an international network of researchers collaborating to map host genetic factors that affect COVID-19 susceptibility and disease severity. (phgfoundation.org)
  • The course of the disease and its severity can vary over time, even in the same individual. (ndnr.com)
  • The prevalence and severity of periodontal disease in diabetics has been shown to be greater than that of the population as a whole 3-4 , where the effects of periodontal disease in these individuals are aggravated by metabolic and histopathological changes, characteristics of diabetes, as well as vascular changes, defective immunological responses and a delayed process of healing 1,5-7 . (bvsalud.org)
  • Clinical disease activity index (CDAI) and modified health assessment questionnaire (mHAQ) scores at the administration of biologic treatment and after 12 months of tocilizumab and etanercept therapy were measured and compared to radiographical parameters between the groups. (bvsalud.org)
  • The combination of genetic risk factors into a Genetic Risk Scores creates a fairly good predictive model, but its clinical applicability is yet limited. (musculoskeletalkey.com)
  • The difficulty of precisely defining the clinical phenotype, as well as underlying genetic heterogeneity, complicates the problem. (biomedcentral.com)
  • A role for the microbiota in T1D etiology is suggested by studies that demonstrate changes in the microbial communities prior to clinical disease onset. (biomedcentral.com)
  • A recent longitudinal study of Finnish children at risk of T1D found a drop in bacterial diversity prior to the development of clinical disease [ 6 ]. (biomedcentral.com)
  • MicroRNAs in rheumatoid arthritis: From pathogenesis to clinical impact. (pmjournal.ir)
  • "Russian Journal of Immunology" is a scientific and educational journal in the field of fundamental and clinical immunology, the purpose of which is to promote the scientific achievements of fundamental and clinical immunology for various fields of medicine, publish reviews, lectures, articles by leading domestic and foreign experts in the field of fundamental and experimental immunology, clinical immunology, allergology, immunodiagnosis and immunotherapy of infectious, allergic, autoimmune and oncological diseases. (rusimmun.ru)
  • However, during the later stages of the disease, LTβR deletion exacerbated clinical symptoms of EAE. (rusimmun.ru)
  • Although genetic variation within the major histocompatibility complex (MHC) is associated with SLE, its role in the development of clinical manifestations and autoantibody production is not well defined. (cdc.gov)
  • Our aim was to discover genetic loci within the MHC region that are associated with specific clinical and/or immunological manifestations within SLE cases and hence to find evidence of genetic variants that may drive specific forms of the disease. (cdc.gov)
  • Abstract: Introduction: To determine whether the PTPN22 (protein tyrosine phosphatase nonreceptor 22)/CSK (c-src tyrosine kinase) pathway is implicated in the susceptibility and clinical heterogeneity of Henoch-Schönlein purpura (HSP) in the largest series of Caucasian HSP patients ever assessed for genetic studies. (unican.es)
  • The diagnosis of hemochromatosis is based on clinical features of the disease. (medscape.com)
  • Replication of GWAS Coding SNPs Implicates MMEL1 as a Potential Susceptibility Locus among Saudi Arabian Celiac Disease Patients. (nih.gov)
  • Role of HIF1A, VEGFA and VEGFR2 SNPs in the Susceptibility and Progression of COPD in a Spanish Population. (snpedia.com)
  • SNPs in NLRP3 showed association with RA susceptibility and EULAR response to anti-TNF in the BRAGGSS cohort, and in monocytes but not B cells, in eQTL analysis of 283 healthy controls. (uea.ac.uk)
  • CARD8 SNPs were associated with RA susceptibility and DAS28 improvement in response to anti-TNF and eQTL effects in monocytes and B cells. (uea.ac.uk)
  • CONCLUSIONS: This study found evidence of modulation of the NLRP3-inflammasome in patients with RA prior to receiving infliximab and some evidence of association for SNPs at NLRP3 and CARD8 loci with RA susceptibility and response to anti-TNF. (uea.ac.uk)
  • The SNPs associated with susceptibility/response are not the main eQTL variants for either locus, and the associations with treatment response require replication in an independent cohort. (uea.ac.uk)
  • Researchers often use SNPs as genetic markers in disease studies. (biomedcentral.com)
  • MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease. (broadinstitute.org)
  • Other gene variants had been previously linked to an increased risk of interstitial lung disease (a group of diseases that cause scarring of the lungs), further highlighting the role of lung-related pathways in severe COVID-19 cases. (phgfoundation.org)
  • Multiple sclerosis (MS) is the most common disabling neurological disease of young adults with symptom onset generally occurring between the ages of 20 to 40 years. (nih.gov)
  • Marburg variant MS (also known as malignant MS) causes swift and relentless symptoms and decline in function, and may result in significant disability or even death shortly after disease onset. (nih.gov)
  • Failure to confirm influence of methyltetrahydrofolate reductase (MTHFR) polymorphisms on age at onset of Huntington disease. (snpedia.com)
  • Conversely, genetic inactivation of LTβR delayed EAE onset. (rusimmun.ru)
  • A a predisposing variant for early onset breast cancer? (cancervic.org.au)
  • Predictive risk factors before the onset of familial rheumatoid arthritis: the Tatarstan cohort study. (cdc.gov)
  • In addition, there were no differences in the allele or genotype frequencies when HSP patients were stratified according the age at disease onset, sex, presence of arthralgia/arthritis, nephritis or gastrointestinal manifestations. (unican.es)
  • The A allele over rs11137037 was associated with longer duration between disease onset and blood sampling ( p = 0.003). (medsci.org)
  • A number of studies that have been carried out believe that diabetes has a big influence on the onset and progression of periodontal disease which, in turn, also influences glycemic control and that there exists, therefore, a bidirectional relationship between the two diseases in which diabetes predisposes the establishment of periodontal disease and the latter has a negative influence on the metabolic control of diabetes 1-2 . (bvsalud.org)
  • Morning stiffness that lasts for 30 minutes or more is another hallmark symptom of RA, per the Arthritis Foundation. (everydayhealth.com)
  • This is of main importance to improve our understanding of the pathogenesis of the atherosclerotic disease in RA. (bancoadn.org)
  • 17.Wang D, Li Y, Liu Y, Shi G. The role of autoreactive T cell in the pathogenesis of rheumatoid arthritis and implications for T cell targetedvaccine therapy. (pmjournal.ir)
  • Identification of follicular helper Tcells as a novel cell population potentially involved in the pathogenesis of Rheumatoid Arthritis. (pmjournal.ir)
  • BACKGROUND: The NLRP3-inflammasome, implicated in the pathogenesis of several inflammatory disorders, has been analysed in rheumatoid arthritis (RA). (uea.ac.uk)
  • abstract = "BACKGROUND: The NLRP3-inflammasome, implicated in the pathogenesis of several inflammatory disorders, has been analysed in rheumatoid arthritis (RA).METHODS: Relative gene expression of NLRP3-inflammasome components was characterised in PBMCs of 29 patients receiving infliximab. (uea.ac.uk)
  • People with rheumatoid arthritis often report that their joint pain and stiffness is worse when getting out of bed in the morning or after a long rest. (medlineplus.gov)
  • In addition to causing joint pain and stiffness, rheumatoid arthritis can lead to long-term complications that significantly affect quality of life. (team-noir.net)
  • Three variants in the IL23R gene have been shown to protect against Crohn's disease and ulcerative colitis . (wikidoc.org)
  • Our group has demonstrated the influence of genetic polymorphisms located in the HLA region as well as the influence of other polymorphisms located outside this region in the development of subclinical atherosclerosis and CV events in RA patients. (bancoadn.org)
  • Since atherosclerosis share many similarities with autoimmune diseases such as RA, the purpose of our project will be to assess the potential influence of these polymorphisms, found by GWAS, in the susceptibility to subclinical atherosclerosis and CV events in patients with RA. (bancoadn.org)
  • Hypothesising that the co-occurrence of trigger finger and carpal tunnel syndrome might be explained by shared germline predisposition, we aimed to identify a specific genetic locus associated with both diseases. (ox.ac.uk)
  • When there are more than two different variants of a gene at a certain locus, multiple alleles, a type of genetic diversity, appear. (microbenotes.com)
  • MS is a chronic disease that affects people differently. (nih.gov)
  • Rheumatoid arthritis (RA) is a chronic autoimmune condition in which your immune system mistakes the linings of your joints as foreign and attacks them. (everydayhealth.com)
  • Rheumatoid arthritis (RA) is a common chronic autoimmune disease leading to joint destruction. (bvsalud.org)
  • Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by inflammation and damage to the joints. (team-noir.net)
  • Juvenile rheumatoid arthritis (JRA) is the most common chronic rheumatologic disease in children and is one of the most common chronic diseases of childhood (see the image below). (medscape.com)
  • Clearly, DH is a chronic disease, but in some patients it has a continuous and more severe character, while in others it seems to be more sporadic and relapsing-remitting in nature. (ndnr.com)
  • Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune. (pmjournal.ir)
  • C is a Protective Factor for Chronic Obstructive Pulmonary Disease: A Case Control Study. (cdc.gov)
  • In the last decade, an increasing awareness was directed to the role of Vitamin D in nonskeletal and preventive roles for chronic diseases in different fields. (vitamindwiki.com)
  • Different studies showed the positive effect of Vitamin D in supporting the immune system and preventing different chronic and infectious diseases. (vitamindwiki.com)
  • 1] Imbalance and malnutrition can compromise the immune system and increase the risk of preventable chronic diseases. (vitamindwiki.com)
  • 1] In last decades, the prevalence of chronic diseases such as diabetes mellitus, obesity, cardiovascular diseases, and hypertension increased significantly, especially in industrial countries. (vitamindwiki.com)
  • Rheumatoid arthritis (RA) is an autoimmune disease characterised by chronic inflammation of the joints. (medscape.com)
  • If omics-based assays were applied with appropriate study designs, thorough validation of the markers, and careful interpretation of study results then a bioinformatics database could be built of the human response to different chemical exposures and associated chronic diseases. (who.int)
  • The disease-protective allele of rs62175241 was associated with increased expression of long non-coding RNA DIRC3 and its transcriptional target, IGBP5, an antagonist of IGF-1 signalling. (ox.ac.uk)
  • It is potentially a great example of a phenomenon termed 'balancing selection' -- where the same allele has different effect on different diseases. (chkd.org)
  • Past research has found that survivors of the bubonic plague pandemic in the Middle Ages, known as Black Death, carried a variant -- or allele -- in a gene known as ERAP2. (chkd.org)
  • The mutant or variant allele may have an intermediate influence on phenotype or be either dominant or recessive. (microbenotes.com)
  • Atherosclerosis in the coronary arteries, which supply blood to the heart, can result in coronary artery disease. (shyfamag.com)
  • Atherosclerosis in the arteries that supply the limbs, typically the legs, can result in peripheral artery disease. (shyfamag.com)
  • Atherosclerosis is a widespread condition and is considered one of the most common causes of cardiovascular disease worldwide. (shyfamag.com)
  • We compared the efficacy of tocilizumab and etanercept in inhibiting radiographic progression of joint destruction in rheumatoid arthritis. (bvsalud.org)
  • COVID-19 can have severe effects on even apparently low-risk individuals, and it has become clear that host factors affecting the risk of infection and disease progression include genomics. (phgfoundation.org)
  • These data suggest that reduced diversity and/or a change in metabolic function of the gut microbiota may be associated with disease progression in T1D. (biomedcentral.com)
  • Estimating cross-population genetic correlations of causal effect sizes. (broadinstitute.org)
  • To identify putative causal variants and establish their biological relevance, we did fine-mapping analyses and expression quantitative trait loci (eQTL) analyses, using fibroblasts from healthy donors (n=79) and tenosynovium samples from patients with carpal tunnel syndrome (n=77). (ox.ac.uk)
  • Although we don't know the exact mechanism influencing disease risk, carriers of alleles that provide more protection against respiratory disease seem to have an increased risk of autoimmune disease," he said in a university news release. (chkd.org)
  • Introduction of disease protective alleles at the Idd3 and Idd5 loci ( IL2 , Ctla4 , Slc11a1 , and Acadl ) resulted in significant alterations in the NOD microbiome. (biomedcentral.com)
  • The different variants of a gene located at the same location on homologous chromosomes are known as alleles or allelomorphs. (microbenotes.com)
  • Other forms of genetic diversity that might be mistaken with numerous alleles include pseudoalleles and isoalleles. (microbenotes.com)
  • Replication of Associations of Genetic Loci Outside the HLA Region With Susceptibility to Anti-Cyclic Citrullinated Peptide-Negative Rheumatoid Arthritis. (ox.ac.uk)
  • OBJECTIVE: Genetic polymorphisms within the HLA region explain only a modest proportion of anti-cyclic citrullinated peptide (anti-CCP)-negative rheumatoid arthritis (RA) heritability. (ox.ac.uk)
  • PMID 17301261 ] Dietary folate intake, MTHFR genetic polymorphisms, and the risk of endometrial cancer among Chinese women. (snpedia.com)
  • PMID 21245770 ] Vascular endothelial growth factor gene polymorphisms and rheumatoid arthritis. (snpedia.com)
  • PMID 22925497 ] The relation of vascular endothelial growth factor (VEGF) gene polymorphisms on VEGF levels and the risk of vasoocclusive crisis in sickle cell disease. (snpedia.com)
  • The periods of disease inactivity between MS attacks are referred to as remission. (nih.gov)
  • Treatment of rheumatoid arthritis (RA) is aimed at long-term remission and inhibition of joint destruction by different biologic drugs. (bvsalud.org)
  • Relapse rates in patients with rheumatoid arthritis in stable remission tapering or stopping antirheumatic therapy: interim results from the prospective randomised controlled RETRO study. (pgrn.de)
  • Despite the recent advent of biological agents enabling some RA patients to achieve disease remission with minimal symptoms, a marked proportion of patients remain treatment-refractory and suffer from progressive joint destruction, functional deterioration or even premature mortality [ 3 - 5 ]. (medsci.org)
  • Future studies are needed that focus on the functional understanding of the found genetic variants as well as on the development of methods that can encompass with the complexity of RA development. (musculoskeletalkey.com)
  • METHODS: The Rheumatoid Arthritis Consortium International densely genotyped 186 autoimmune-related regions in 3,339 anti-CCP-negative RA patients and 15,870 controls across 6 different populations using the Illumina ImmunoChip array. (ox.ac.uk)
  • Recent advances in genotyping techniques, statistical methods, and the organization of large patient cohorts have facilitated explosive progress in this field, and our understanding of the genetic architecture of human autoimmunity is rapidly expanding. (hindawi.com)
  • Recently, many methods have been proposed to identify SNP interaction patterns associated with diseases. (biomedcentral.com)
  • Additionally, this study's methods of statistical analysis lay the foundation for other teams to take a similar approach to understand other diseases. (uchicagomedicine.org)
  • Conclusion: PPFIBP2 could be a useful genetic marker for occurrence of interstitial pneumonia in RA patients and might help to identify the risk of ILD occurrence before RA treatment, thereby improving patient outcomes. (bvsalud.org)
  • Both of these conditions frequently co-occur, often in patients with rheumatoid arthritis. (ox.ac.uk)
  • This research strategy aimed to establish genetic markers of CV risk will be useful to indentify a subgroup of patients with RA and high risk for CV events. (bancoadn.org)
  • Antimodified protein antibody response pattern influences the risk for disease relapse in patients with rheumatoid arthritis tapering disease modifying antirheumatic drugs. (pgrn.de)
  • Prediction of disease relapses by multibiomarker disease activity and autoantibody status in patients with rheumatoid arthritis on tapering DMARD treatment. (pgrn.de)
  • Less severe elevations of homocysteine levels are more commonly observed as a result of heterozygous mutations of these enzymes, dietary deficits of folate or vitamin B 12 , or in patients with liver disease or decreased renal function [ 6 ]. (biomedcentral.com)
  • Chest radiography and echocardiography may be helpful in the evaluation of patients with hemochromatosis and cardiac disease. (medscape.com)
  • Replication of PTPRC as Genetic Biomarker of Response to TNF Inhibitors in Patients with Rheumatoid Arthritis. (who.int)
  • Mera-Varela A, Ferreiro-Iglesias A, Perez-Pampin E, Porto-Silva M, Gómez-Reino JJ, Gonzalez A. Ultrasonographic assessment of the entheses in HLA-B27 positive patients with Rheumatoid Arthritis, a matched case only study. (who.int)
  • No influence was found between genetic polymorphisms of osteoprotegerin in patients with diabetes and periodontitis. (bvsalud.org)
  • In particular, we are interested in papers describing novel genetic associations with autoimmune disease, genetic factors which predict disease outcome, or disease phenotype and papers which characterize the molecular or biological function of a known autoimmune disease risk variant. (hindawi.com)
  • 19.Aune TM, Crooke PS, Patrick AE, Tossberg JT, Olsen NJ, Spurlock CF. Expression of long non-coding RNAs in autoimmunity and linkage to enhancer function and autoimmune disease risk genetic variants. (pmjournal.ir)
  • Alterations in this gene may be associated with several diseases, including rheumatoid arthritis, celiac disease, and multiple sclerosis. (wikipedia.org)
  • While LTα is crucial for the formation and maintenance of secondary lymphoid organs, its overproduction is observed in autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. (rusimmun.ru)
  • Initially, LTα was considered pathogenic in the development of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, as demonstrated by the resistance of mice with genetic LTα inactivation to EAE induction. (rusimmun.ru)
  • The CGC application ranks gene candidates for 37 rat genomic regions associated with autoimmune experimental arthritis phenotypes. (medscape.com)
  • It is a type of cardiovascular disease that involves the hardening and narrowing of the arteries, which are the blood vessels responsible for carrying oxygen-rich blood from the heart to the rest of the body. (shyfamag.com)
  • The data from this project will help to improve understanding of the role of the sex chromosomes in susceptibility to common disorders with a potential to develop stratified approaches to prediction and therapy. (ukbiobank.ac.uk)
  • Disease-protected strains exhibited a restoration of immune regulatory pathways within the gut which could also be reestablished using IL-2 therapy. (biomedcentral.com)
  • Orthotopic liver transplantation is the only therapeutic option when end-stage liver disease progresses despite iron-reduction therapy. (medscape.com)
  • Recent findings, obtained by genome-wide association studies (GWAS), have disclosed the association of several genetic variants with the increase of cIMT, presence of carotid plaques and increase of serum levels of C-reactive protein in the general population. (bancoadn.org)
  • Seeing m6A's association with the heritability of disease contributes to a larger understanding within the scientific community that posttranscriptional regulation plays an important role in common diseases. (uchicagomedicine.org)
  • Upon identification of the most T1D-associated variant, we investigated the correlation between its genotype and SLC11A1 expression overall or with splice isoform ratio using 42 PAXgene whole blood samples from healthy donors by quantitative PCR (qPCR). (biomedcentral.com)
  • Regression analyses were performed to test for association between genotype and susceptibility and treatment response (disease activity score across 28 joints (DAS28) and EULAR improvement criteria) at 6 months, with secondary expression quantitative trait loci (eQTL) analyses. (uea.ac.uk)
  • The human sex chromosomes remain a fairly unexplored part of the human genome in terms of their role in complex disease as they have been excluded from genome wide association studies. (ukbiobank.ac.uk)
  • To this end, we wish to examine common variants on the pseudoautosomal regions of the sex chromosomes associate with the risk of common diseases. (ukbiobank.ac.uk)
  • Diet quality and genetic association with body mass index: results from 3 observational studies. (broadinstitute.org)
  • Association between single nucleotide variants of vascular endothelial growth factor a and the risk of thyroid carcinoma and nodular goiter in a Han Chinese population. (snpedia.com)
  • Here, we have conducted association analysis of this candidate gene region, and then investigated potential correlations between the most T1D-associated variant and RNA expression of the SLC11A1 gene and its splice isoform. (biomedcentral.com)
  • We considered P ≤ 0.005 as evidence of association given that we tested nine variants in total. (biomedcentral.com)
  • No evidence of disease association was obtained at any of the loci using the family collections ( P TDT ≥ 0.13). (biomedcentral.com)
  • 8.Liu F, Liang Y, Zhao Y, Chen L, Wang X, Zhang C. Meta-analysis of association of microRNAs genetic variants with susceptibility to rheumatoid arthritis and systemic lupus erythematosus. (pmjournal.ir)
  • CYP2A6 associates with respiratory disease risk and younger age of diagnosis: a phenome-wide association Mendelian randomization study. (cdc.gov)
  • Association of TERT (rs2736098 and rs2736100) genetic variants with elevated risk of hepatocellular carcinoma: a retrospective case-control study. (cdc.gov)
  • To address this we undertook a large, direct genome-wide study of association between CNVs and eight common human diseases. (ox.ac.uk)
  • 4 Genetic association studies of SLE have been successful in identifying multiple loci. (cdc.gov)
  • 5 - 11 However, relatively few studies have investigated the genetic association with specific SLE sub-phenotypes. (cdc.gov)
  • WEDNESDAY, March 8, 2023 (HealthDay News) -- Some people may have a gene that helps protect them from respiratory diseases like COVID-19 -- and helped their ancestors fight the plague. (chkd.org)
  • Objective: Genetic polymorphisms might serve as useful prognostic markers for the timely diagnosis of RA. (bvsalud.org)
  • Physical findings are important to provide criteria for diagnosis and to detect abnormalities suggestive of alternative etiologies, as well as to indicate disease subtypes. (medscape.com)
  • Rheumatoid arthritis: early diagnosis and treatment. (pmjournal.ir)
  • The Serum level of CD226 and not CD226 genotypes could be considered as an independent risk factor for the prediction of RA within healthy individuals and also for RA disease activity. (cusabio.com)
  • The aim of this project is to examine whether genetic variation between PAR1 and PAR2 is associated with complex polygenic disorders and physiological traits. (ukbiobank.ac.uk)
  • This same gene variation may be linked to an increased risk of autoimmune disease, including rheumatoid arthritis and inflammatory bowel disease, according to British researchers. (chkd.org)
  • They looked for links between variation in the ERAP2 gene and risk of autoimmune disease and infection. (chkd.org)
  • Many studies focus on genetic variation's role in transcription (turning DNA into messenger RNA), whereas our study demonstrates that genetic variation is also involved in m6A mediated post-transcription regulation such as translation (turning messenger RNA into proteins). (uchicagomedicine.org)
  • These studies indicate that in the steady state, NOD mice harbor a "diabetes-permissive" microbiota, and major perturbations in the microbiota can both reduce and accelerate disease. (biomedcentral.com)
  • Knowledge of the genetic basis of disease provides us with a unique window into human pathophysiology, which will facilitate improved diagnostic and therapeutic strategies and enable personalized medicine. (hindawi.com)
  • Endogenous factor and pathophysiology of rheumatoid arthritis: an autoimmune disease from decades. (pmjournal.ir)
  • However, the future challenges are largely going to involve understanding the genetic underpinnings of common disorders that are generally 'sporadic', in the sense that they do not exhibit a high degree of familial recurrence. (biomedcentral.com)
  • Estimating influenza disease burden from population-based surveillance data in the United States. (cdc.gov)
  • This study prompted the Centers for Disease Control and Prevention (CDC) to add iGAS to the Active Bacterial Core surveillance (ABCs) program. (cdc.gov)
  • This study was undertaken to replicate the associations of anti-CCP-negative RA with non-HLA genetic polymorphisms demonstrated in a previous study. (ox.ac.uk)
  • The new study found that humans now have the same variants, which is associated with protection against infections such as pneumonia and COVID. (chkd.org)
  • To study this, researchers looked at infection, autoimmune disease and parental longevity across participants in three large genetic studies. (chkd.org)
  • The second one uses a genome wide study on Parkinson disease (data acquired by using Illumina HumanHap300 SNP chips). (biomedcentral.com)
  • The third one chooses the rheumatoid arthritis study from Wellcome Trust Case Control Consortium (WTCCC) using Affymetrix GeneChip 500K Mapping Array Set. (biomedcentral.com)
  • For example, according to Xin He, the same methodology could be used to study brain tissue to see if m6A plays a role in neuropsychiatric diseases. (uchicagomedicine.org)
  • Because of the virus's genetic variability, it is difficult to properly implement effective prophylactic programs, such as vaccinations, according to a study published in International Journal of Molecular Sciences . (pharmacytimes.com)
  • [ 2 ] RA has a very complex genetic basis, and the combination of genetic and environmental causative factors makes it hard to study. (medscape.com)
  • The disease is two to three times more common in women than in men, which may be related to hormonal factors. (medlineplus.gov)
  • It is generally accepted that DH affects more men than women, particularly in adulthood, suggesting that hormonal factors may modify the course of the disease. (ndnr.com)
  • Individuals with a neurodegenerative disease called spinocerebellar ataxia 11 (SCA11) have mutations in a gene called TTBK2. (hum-molgen.org)
  • The U.S. National Library of Medicine has more on gene variants . (chkd.org)
  • However, having a close relative with rheumatoid arthritis likely increases a person's risk of developing the condition. (medlineplus.gov)
  • Sleep restriction increases the risk of developing cardiovascular diseases by augmenting proinflammatory responses through IL-17 and CRP. (who.int)
  • A new nomenclature, juvenile idiopathic arthritis (JIA), is being increasingly used to provide better definition of subgroups. (medscape.com)