ProteinsGeneticsLupusPeptidesImmuneOdds ratiosAsthmaCHAINSDifferencesCellsHumanPlay a roleMajorIncludeRiskMultipleDataCellDiseasePositiveAllelesHaplotypesHistocompatibilityHaplotypeCeliac diseaseConferLymphocyteHypersensitivityPhenotypePredispositionMolecular geneticMoleculesClinicalComparisonsRegionRoleFactorsStudiesAssociationCasesPresentSpecificEvidencePatients
Proteins2
- The similarity between antigens of Streptococcus pyogenes and multiple cardiac proteins can cause a life-threatening type II hypersensitivity reaction. (wikipedia.org)
- These genes code for proteins that are involved in cell-cell adhesions (CTNNA3), glutathione conjugation for xenobiotic metabolism (GST gene family), and immune system response (HLA gene family). (cdc.gov)
Genetics1
- In addition to influencing immune response patterns, many of these alleles are associated with susceptibility to a wide spectrum of autoimmune diseases, making the MHC an essential starting point for anyone wanting to understand the genetics of rheumatic diseases. (musculoskeletalkey.com)
Lupus3
- Lupus nephritis susceptibility loci in women with systemic lupus erythematosus. (musc.edu)
- CTLA-4 gene polymorphisms and systemic lupus erythematosus in a population-based study of whites and African-Americans in the southeastern United States. (musc.edu)
- In the case of systemic lupus erythematosus (SLE) and related illnesses, many of the HLA class II alleles are associated with the presence of specific autoantibodies or clinical phenotypes. (musculoskeletalkey.com)
Peptides2
- Recent observations raise the hypothesis that not only the drug/chemical, but also parts of the haptenated protein or peptides may constitute the important structural determinants for antigen recognition by the TCR. (frontiersin.org)
- The allelic variations among different HLA molecules are a major factor accounting for differences in the types of antigenic peptides to which an individual responds or in the types of T cells that are used in an immune response. (musculoskeletalkey.com)
Immune1
- The HLA molecules and their counterparts in rodents were subsequently shown to be directly responsible for immune response differences between individuals and for determining the likelihood of graft rejection. (musculoskeletalkey.com)
Odds ratios2
- Researchers reported prevalence odds ratios (PORs) for 943 comparisons in 82 different genes/serotypes. (cdc.gov)
- Based on the product of single gene variant odds ratios, the risk of developing asthma was assigned to genotype profiles, and the frequency of each profile was estimated for the general population. (cdc.gov)
Asthma4
- Epidemiological studies show that only a subset of workers exposed to diisocyanate s develop diisocyanate -induced occupational asthma ( diisocyanate asthma, DA), indicating that genetic susceptibility may play a role. (cdc.gov)
- Many common human diseases such as asthma, cancer, and cardiovascular disease are complex in nature, as they are influenced variably by environmental, physiologic, and genetic factors. (cdc.gov)
- This model was developed using data collected from molecular epidemiology studies of allergic asthma that examined variants in 16 susceptibility genes. (cdc.gov)
- Common diseases of a chronic inflammatory nature such as asthma, Alzheimer disease, and cardiovascular disease are complex in nature, as they are variably influenced by genetic inheritance as well as environmental, physical, and lifestyle factors. (cdc.gov)
CHAINS2
- A broad specificity HLA-DR antigen that is associated with HLA-DRB1 CHAINS encoded by DRB1*01:15 and DRB1*01:16 alleles. (musc.edu)
- HLA class II molecules consist of noncovalently associated α (32 kD) and β (28 kD) chains, both of which are encoded within the MHC. (musculoskeletalkey.com)
Differences3
- The genetic components most responsible for differences in individual disease risk are thought to be DNA variants (polymorphisms) that influence the expression or function of mediators involved in the pathological processes. (cdc.gov)
- Differences in the first sign(s) or symptom(s) were compared across diagnoses and between HLA-B27 status. (bvsalud.org)
- CONCLUSION: In this SpA population, MMs were the most prevalent initial symptoms, with differences across diagnoses and depending on the presence of the HLA-B27 antigen. (bvsalud.org)
Cells4
- During a streptococcal infection, mature antigen-presenting cells such as B cells present the bacterial antigen to CD4+T cells which differentiate into helper T2 cells. (wikipedia.org)
- During thymic selection, T cells that have not yet encountered their cognate antigen are considered naive T cells. (frontiersin.org)
- Due to the artificial nature of drug/chemical-T-cell epitopes, it is not clear whether thymic selection of drug/chemical-specific T cells is a common phenomenon or remains limited to few donors or simply does not exist, suggesting T-cell receptor (TCR) cross-reactivity with other antigens. (frontiersin.org)
- In each individual, T cells are generally restricted to recognize antigens presented by the person's own HLA molecules. (musculoskeletalkey.com)
Human2
- During this time, the perception of CD has changed from a rather uncommon enteropathy to a common multi- organ disease with a strong genetic predisposition that is associated mainly with human leukocyte antigen (HLA)-DQ2 and HLA-DQ8. (vdocuments.net)
- The MHC, one of the most gene-rich regions in the human genome, has identified more than 200 genes. (musculoskeletalkey.com)
Play a role1
- Environmental, genetic, and immunologic factors appear to play a role. (medscape.com)
Major2
- This graph shows the total number of publications written about "HLA-DR2 Antigen" by people in this website by year, and whether "HLA-DR2 Antigen" was a major or minor topic of these publications. (musc.edu)
- Interestingly, the recent data in RA indicate that the major HLA-DR associations are with anti-CCP antibody positive disease, suggesting that control of autoantibody responses may be a primary mechanism underlying these associations in RA as well. (musculoskeletalkey.com)
Include2
- Common mutations include point mutations of the BRAF and RAS genes and chromosomal rearrangements of RET / PTC and PAX8 / PPARG . (medscape.com)
- Protein network functions for the DA-associated genes from this review include: antigen processing, lymphocyte activation, cytokine production regulation, and response to oxidative stress. (cdc.gov)
Risk8
- PORs 4.38-4.97) and three studies on HLA-DR1 (decreased DA risk, POR 0.24). (cdc.gov)
- Incorporating the influence of genetic variation in the risk assessment process is often considered, but no generalized approach exists. (cdc.gov)
- The purpose of this study was to estimate the combinatorial contribution of multiple genetic variants to disease risk. (cdc.gov)
- We used a logistic regression model to help estimate the joint contribution that multiple genetic variants would have on disease risk. (cdc.gov)
- The present model provided an opportunity to estimate the relative change in risk associated with multiple genetic variants. (cdc.gov)
- This will facilitate identification of susceptible populations and help provide a framework to model the genetic contribution in probabilistic risk assessment. (cdc.gov)
- Applying the composite genetic contribution to the risk assessment process would allow for identifying the most genetically susceptible groups in the population. (cdc.gov)
- In light of this, a multiplicative gene-gene interaction model was developed to allow for estimating the combinatorial contribution of multiple genetic variants to disease risk. (cdc.gov)
Multiple1
- Multiple genetic and epigenetic mutations result in the activation of signaling pathways that precipitate thyroid cancer. (medscape.com)
Data1
- The purpose of this systematic literature review was to compile and meta-analyze the reported data on genetic susceptibility markers for DA. (cdc.gov)
Cell2
- HLA class I and class II molecules are cell surface glycoproteins, anchored to the membrane by hydrophobic transmembrane segments. (musculoskeletalkey.com)
- The polymorphisms associated with the "shared epitope" are located on the α-helical rim (DRB1 chain) of the peptide-binding cleft, where they may interact with either the bound peptide antigen or the T cell receptor. (musculoskeletalkey.com)
Disease2
- Thus, for genetic variants to significantly affect disease severity or incidence, they must act cumulatively. (cdc.gov)
- In AS patients, the absence of HLA-B27 seems to be related to an increase in the probability of starting the disease with cervical pain and peripheral manifestations. (bvsalud.org)
Positive1
- In PsA, the onset of arthritis and psoriasis was more prevalent in HLA-B27-negative patients, while initiation with axial manifestations was more predominant in HLA-B27-positive patients. (bvsalud.org)
Alleles11
- DNA-based techniques were used to type individual alleles of four polymorphic HLA genes (HLA-DR, -DQA1, -DQB1, and HLA-B), six microsatellites (all located between HLA-DR and HLA-B), and three single nucleotide polymorphisms on the TNF gene. (nih.gov)
- p values were corrected for comparisons of multiple HLA alleles (p(c)) by multiplication of the raw p value by the estimated number of HLA alleles present within the loci examined. (nih.gov)
- 2. Linkage disequilibrium between the HLA-B14 subdivisions and HLA-A, DR and properdin factor B alleles. (nih.gov)
- Role of HLA-DQB1 alleles in the risk, signs and symptoms, and severity of celiac disease in a Venezuelan population. (cdc.gov)
- Differential expression of predisposing HLA-DQ2.5 alleles in DR5/DR7 celiac disease patients affects the pathological immune response to gluten. (cdc.gov)
- Association between HLA alleles and risk of celiac disease in Iranian patients. (cdc.gov)
- We determined HLA alleles B , DRB1 , DQA1, and DQB1 , by sequence-based typing. (nih.gov)
- p -Values were corrected for comparisons of multiple HLA alleles. (nih.gov)
- In addition, the HLA-B*44 alleles were present in 6.2% (7/113) of patients, but were absent in TCE-tolerant workers. (nih.gov)
- Molecular genetic testing of first-degree relatives of a proband (including young children) to monitor those with known celiac disease-susceptibility alleles for early evidence of celiac disease in order to institute gluten-free diet early in the disease course. (nih.gov)
- Genomewide single-nucleotide polymorphism (SNP) analysis has identified over 30 additional susceptibility alleles. (clinicalgate.com)
Haplotypes5
- Surprisingly, our results did not support the hypothesis of a unique susceptibility gene being shared by all MHC susceptibility haplotypes. (nih.gov)
- On HLA-DR1 and -DR7-positive haplotypes IGAD1 mapped to the class II region, whereas on haplotypes carrying HLA-DR3 the susceptibility locus mapped to the telomeric end of the class III region, as reported previously. (nih.gov)
- The disease is featured by a variable combination of clinical signs, specific antibodies, HLA-DQ2 and HLA-DQ8 haplotypes, and enteropathy. (wjgnet.com)
- 17. Identification of HLA-B44 subtypes associated with extended MHC haplotypes. (nih.gov)
- Human Leukocyte Antigen DQ (HLA-DQ) genotypes and haplotypes and their association with phenotype in patients with celiac disease in India. (cdc.gov)
Histocompatibility1
- 9. Histocompatibility antigens in polymyalgia rheumatica and giant cell arteritis. (nih.gov)
Haplotype5
- DR1 haplotype is caused by a duplication in the 21-OH MHC gene region. (nih.gov)
- 11. Unusual functional and biochemical properties of DR molecules from the HLA-DR1, B14 haplotype. (nih.gov)
- 12. Defective antigen presentation and novel structural properties of DR1 from an HLA haplotype associated with 21-hydroxylase deficiency. (nih.gov)
- 14. HLA-B14 subtyping by semi-nested PCR-SSP and haplotype distribution in a Spanish population. (nih.gov)
- Human leukocyte antigen (HLA) haplotype DQ2 or DQ8 identified by molecular genetic testing of HLA-DQA1 and HLA-DQB1 . (nih.gov)
Celiac disease9
- HLA Genotyping in Romanian Adult Patients with Celiac Disease, their First-degree Relatives and Healthy Persons. (cdc.gov)
- Enhanced Extracellular Transfer of HLA-DQ Activates CD3 Lymphocytes towards Compromised Treg Induction in Celiac Disease. (cdc.gov)
- HLA-DQ genotype distribution and risk evaluation of celiac disease in Northwest China. (cdc.gov)
- Low-Risk Human Leukocyte Antigen Genes and Mild Villous Atrophy Typify Celiac Disease With Immunoglobulin A Deficiency. (cdc.gov)
- Genetic predisposition to celiac disease in Kazakhstan: Potential impact on the clinical practice in Central Asia. (cdc.gov)
- HLA-DQ genotypes relative risks for celiac disease in Arabs: A case-control study. (cdc.gov)
- HLA-DQB1*02 allele in children with celiac disease: Potential usefulness for screening strategies. (cdc.gov)
- Influence of HLA on clinical and analytical features of pediatric celiac disease. (cdc.gov)
- Celiac disease is a multifactorial disorder resulting from the interaction of HLA-DQA1 and HLA-DQB1 allelic variants known to be associated with celiac disease susceptibility, less well-recognized variants in non-HLA genes, gliadin (a subcomponent of gluten), and other environmental factors. (nih.gov)
Confer2
- The genes that confer actions, are likely to provide important information susceptibility to IDDM are located in the HLA region regarding the causes of IDDM and lead to approaches of chromosome 6. (nih.gov)
- Genetic factors influencing the immune response to abacavir might confer susceptibility. (nih.gov)
Lymphocyte2
- Protein network functions for the DA-associated genes from this review include: antigen processing, lymphocyte activation, cytokine production regulation, and response to oxidative stress. (cdc.gov)
- 10. Mixed lymphocyte reactions for individuals with phenotypic identity for specific HLA-B,DR determinants: the role of linkage disequilibrium and of specific DR and other class II determinants. (nih.gov)
Hypersensitivity2
- The similarity between antigens of Streptococcus pyogenes and multiple cardiac proteins can cause a life-threatening type II hypersensitivity reaction. (wikipedia.org)
- The study aimed to identify genetic susceptible biomarkers associated with the TCE-induced hypersensitivity dermatitis in genes located in the human leukocyte antigen (HLA) region. (nih.gov)
Predisposition2
- Familial predisposition to IgA deficiency (IgAD) suggests that genetic factors influence susceptibility. (nih.gov)
- The similarities in clinical manifestations and genetic predisposition suggest that these disorders share pathogenic mechanisms. (clinicalgate.com)
Molecular genetic1
- 7. Molecular genetic analysis of nonclassic steroid 21-hydroxylase deficiency associated with HLA-B14,DR1. (nih.gov)
Molecules1
- In addition, we compared and analyzed the structure character of amino acid residues of HLA molecules found in participants. (nih.gov)
Clinical1
- The spondyloarthritides are a group of overlapping disorders that share certain clinical features and genetic associations. (clinicalgate.com)
Comparisons1
- Researchers reported prevalence odds ratios (PORs) for 943 comparisons in 82 different genes/serotypes. (cdc.gov)
Region1
- A novel marker gene within the tumor necrosis factor region. (nih.gov)
Role3
- Epidemiological studies show that only a subset of workers exposed to diisocyanate s develop diisocyanate -induced occupational asthma ( diisocyanate asthma, DA), indicating that genetic susceptibility may play a role. (cdc.gov)
- Environmental, genetic, and immunologic factors appear to play a role. (medscape.com)
- The HLA system has a fundamental role in identifying the antigens introduced into the host with the vaccines and in the development of specific antibodies, and some HLA phenotypes have been associated with a less effective immunological response. (wjgnet.com)
Factors2
- This has studies of potential etiologic determinants, focusing been due, in part, to a failure to account for host on host and environmental risk factors and their inter- susceptibility in most studies. (nih.gov)
- Susceptibility to AS is determined largely by genetic factors, with B27 comprising less than one-half of the genetic component. (clinicalgate.com)
Studies2
Association1
- 13. Strong association between an HLA-DR antigen and thyroid carcinoma. (nih.gov)
Cases1
- 5. HLA antigens in 88 cases of rheumatic fever observed in Martinique. (nih.gov)
Present1
- During a streptococcal infection, mature antigen-presenting cells such as B cells present the bacterial antigen to CD4+T cells which differentiate into helper T2 cells. (wikipedia.org)
Specific1
- Activation of receptor tyrosine kinases (RET/PTC, TRK, MET), whether by rearrangement or gene amplification, appears to be specific for the transformation of thyroid follicular cells into papillary thyroid carcinomas. (medscape.com)