• Furthermore, an unfortunate association of factors such as tumor genetic complexity, overestimation of biomarker and drug potentials, as well as a poor understanding of tumor microenvironment in diagnosis and prognosis leads to the current levels of treatment failure regarding a vast majority of cancer types. (biomedcentral.com)
  • This study is looking at the effectiveness of combining a PARP inhibitor called niraparib and an immunotherapy called dostarlimab for treating people with an inherited BRCA mutation (found with genetic testing) or a tumor mutation (found through tumor testing) who have breast, pancreatic, ovarian, fallopian tube or primary peritoneal cancer that is metastatic or advanced and cannot be removed by surgery (unresectable). (facingourrisk.org)
  • Li Q J,Wang D R.Rad17 and its significance in tumor[J].Journal of International Oncology,2011,38(5):336-338. (nefu.edu.cn)
  • According to Darwinian evolutionary theory, evolutionary process can be attributed to the presence of genetic mutations between parental and offspring generations [ 7 ]. (biomedcentral.com)
  • Researchers have identified several hundred mutations in the ATM gene that cause ataxia-telangiectasia. (diff.org)
  • disorder have mutations in both copies of the ATM gene in each cell. (diff.org)
  • protein allows mutations to accumulate in other genes, which may cause cells to grow and divide in an uncontrolled way. (diff.org)
  • this protein prevents efficient repair of DNA damage, leading to the accumulation of mutations in other genes. (diff.org)
  • Gene mutation. (kawasaki-m.ac.jp)
  • As a result, plasticity may evolve or canalization may occur within a given epoch depending on the relative mutation rate of genic and epigenetic contributions to phenotype, highlighting the importance of genetic conflict on the evolution of plasticity. (rockefeller.edu)
  • Progress in microenvironment genetic studies represents a formidable opportunity for the development of new selective drugs because stromal cells have lower mutation rates than malignant cells, and should prove to be good targets for therapy. (biomedcentral.com)
  • 4. Gohlke G,Scholz C J,Kneitz S,et al.DNA methylation mediated control of gene expression is critical for development of crown gall tumors[J].PLoS Genetics,2013,9(2):e1003267. (nefu.edu.cn)
  • According to the transcriptome database of Halostachys caspica under the salt stress, the DNA damage repair gene DMC1 of H. caspica was cloned and named HcDMC1 . (nefu.edu.cn)
  • Brenner made significant contributions to work on the genetic code, and other areas of molecular biology while working in the Medical Research Council Laboratory of Molecular Biology in Cambridge, England. (academicinfluence.com)
  • Genetic polymorphism at codon 546 of the human RAD17 contributes to the risk for esophageal squamous cell carcinoma. (kawasaki-m.ac.jp)
  • DDR increased the expression level of pathogenesis-related ( PR ) genes and the total salicylic acid (SA) content and promoted mitogen-activated protein kinase signaling cascades, including the WRKY signaling pathway in Arabidopsis. (ppjonline.org)
  • For effective association of the 9-1-1 complex with DNA, RAD17-RFC is also needed. (wikipedia.org)
  • percent of the United States population carries one mutated copy of the ATM gene in each cell. (diff.org)
  • Jiang R S,Liu M,Li C,et al.Cell cycle checkpoint protein Rad17[J].Chinese Journal of Cell Biology,2008,30(4):417-420. (nefu.edu.cn)
  • Transcriptome analysis further revealed that defense-and SA-related genes were upregulated by DDR. (ppjonline.org)
  • Cells that are missing one copy of the ATM gene produce half the normal amount of ATM protein. (diff.org)
  • Gene signature driving invasive mucinous adenocarcinoma of the lung. (kawasaki-m.ac.jp)
  • The development of malignant mesothelioma in very few of the population exposed to asbestos and its frequent occurrence in some families may be significant in terms of genetic predisposition. (bvsalud.org)
  • This disease, which has limited treatment options and has a poor prognosis, revealing a genetic predisposition, if any, may prolong survival with early diagnosis and effective treatment. (bvsalud.org)
  • Linkage studies in the 1990s led to the discovery of several predisposition genes associated with many rare familial cancer syndromes, thus providing fundamental insights into various pathways of carcinogenesis [ 4 ]. (biomedcentral.com)
  • 13. cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster. (nih.gov)
  • HR-directed repair corrects DSB defects in an error-free manner using a mechanism that retrieves genetic information from a homologous, undamaged DNA molecule. (diff.org)
  • thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. (utsouthwestern.edu)
  • A cellular system can be described as a web of relationships amongst genes, proteins, and other macromolecules. (biomedcentral.com)
  • Serine/threonine-protein kinase ATR, also known as ataxia telangiectasia and Rad3-related protein (ATR) or FRAP-related protein 1 (FRP1), is an enzyme that, in humans, is encoded by the ATR gene. (wikipedia.org)
  • The protein encoded by this gene belongs to the PI3/PI4-kinase family. (utsouthwestern.edu)
  • Large-scale studies have revealed networks of various biological interaction types, such as protein-protein interaction, genetic interaction, transcriptional regulation, sequence homology, and expression correlation. (biomedcentral.com)
  • To study more complex relationships involving multiple biological interaction types, we assembled an integrated Saccharomyces cerevisiae network in which nodes represent genes (or their protein products) and differently colored links represent the aforementioned five biological interaction types. (biomedcentral.com)
  • Examples of network themes include a pair of protein complexes with many inter-complex genetic interactions - the 'compensatory complexes' theme. (biomedcentral.com)
  • Moreover, we performed a series of genome-wide CRISPR knockout genetic screens to identify genetic determinants of the cellular sensitivity to ATM inhibition in wildtype and BRCA2-knockout cells, and validated the top hits from multiple screens. (nih.gov)
  • In BRCA2-knockout cells, DNA repair genes (including RAD17, MDC1, and USP28) were essential for survival upon ATM inhibitor treatment, which was not the case in wild-type cells. (nih.gov)
  • Boettcher M*, Covarrubias S*, Biton A*, Blau J, Wang H, Zaitlen N, McManus MT (2019) Tracing cellular heterogeneity in pooled genetic screens via multi-level barcoding. (umh.de)
  • Genetic Variants in CD44 and MAT1A Confer Susceptibility to Acute Skin Reaction in Breast Cancer Patients Undergoing Radiation Therapy. (cdc.gov)
  • The number and properties of genetic variants that account for the remaining 75% of inherited risk are largely unknown. (biomedcentral.com)
  • Analyses of risk attributable to such alleles in the known breast cancer susceptibility genes (e.g. (biomedcentral.com)
  • If most cancer susceptibility is related to fundamental processes of cellular control, rare alleles might turn out to be the more important component and should be detectable by linkage analysis and/or the candidate gene re-sequencing approach [ 5 , 6 ]. (biomedcentral.com)
  • Via extensive analyses of genetic databases, we have characterized the DNA-repair capacity of glioblastoma with respect to patient survival. (oncotarget.com)
  • Genolet O, Monaco AA, Dunkel I, Boettcher M, Schulz EG (2021) Identification of X-chromosomal genes that drive sex differences in embryonic stem cells through a hierarchical CRISPR screening approach. (umh.de)
  • Failure to repair these defects can result in chromosomal instabilities leading to dysregulated gene expression and carcinogenesis. (diff.org)
  • Human PGCs show unique transcription patterns involving the simultaneous expression of both pluripotency genes and germline-specific genes, with a subset of them displaying developmental stage-specific features. (uth.edu)
  • 12. Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit. (nih.gov)
  • We provide a valuable list of common genes which regulate the response to multiple ATM inhibitors. (nih.gov)
  • 9. Precise localization of the FHIT gene to the common fragile site at 3p14.2 (FRA3B) and characterization of homozygous deletions within FRA3B that affect FHIT transcription in tumor cell lines. (nih.gov)
  • We developed a novel bioassay employing gene-disrupted clones of the chicken DT40 B-lymphocyte line, which are designed to be deficient in several specific DNA repair pathways. (nih.gov)
  • Fredebohm J, Wolf J, Hoheisel JD, Boettcher M (2013) Depletion of RAD17 sensitizes pancreatic cancer cells to gemcitabine. (umh.de)
  • Germ cells are vital for transmitting genetic information from one generation to the next and for maintaining the continuation of species. (uth.edu)
  • We used Affymetrix microarrays (U133Plus 2.0) to analyze activation and PPARg-induced gene expression changes. (gsea-msigdb.org)