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  • genes
  • The onset of disease is influenced not only by your genes, but also by other natural and environmental external factors. (easydna.ie)
  • There are certain factors (perhaps the types of foods you eat or your lifestyle habits) which are known to be possible triggers for certain diseases by activating the disease-causing genes. (easydna.ie)
  • Variations in other genes, such as BARD1 and BRIP1 , also increase breast cancer risk, but the contribution of these genetic changes to a person's overall risk appears to be much smaller. (nih.gov)
  • Although each of these variations only slightly increases a person's risk, having changes in several different genes may combine to increase disease risk significantly. (nih.gov)
  • Our genetic heritage is determined by our DNA, which contain thousand of genes that provide instruction to the cells on how to operate. (hsaforamerica.com)
  • When mutated genes are inherited, genetic disease may develop. (hsaforamerica.com)
  • A Hcs locus, with high phenotypic effects, and various epistatic gene-gene interactions were identified in rats, suggesting a genetic model of predisposition to hepatocarcinogenesis with different subset of low-penetrance genes, at play in different subsets of population, and a major locus. (uniss.it)
  • Maybe there are people who are interested in publishing their genetic information on the web to make it available, but those people don't have the opportunity," Though Greshake acknowledges that there are services that allow people to test their own genes and discover inherent predispositions, they are often expensive, or difficult to access. (wikipedia.org)
  • Human leukocyte antigen class II genes are more frequent in patients with Kikuchi disease, suggesting a genetic predisposition to the proposed autoimmune response. (wikipedia.org)
  • heritable
  • NAFLD is a heritable and complex trait, the genetic component of which has been explored by a myriad of studies that used different approaches illustrated in Figure 1 . (e-cmh.org)
  • coronary
  • The result is enhanced shear stress on vessel walls, and repeated nicotine exposure contributes to accelerated health problems that are a function of chronic vascular injury such as coronary artery disease, acute cardiac ischemic events, and hypertension Studies have shown that nicotine exposure contributes to stroke, peptic ulcer disease, and esophageal reflux. (wikipedia.org)
  • cholesterol
  • Although altered lipid metabolism has been extensively implicated in the pathogenesis of Alzheimer disease (AD) through cell biological, epidemiological, and genetic studies, the molecular mechanisms linking cholesterol and AD pathology are still not well understood and contradictory results have been reported. (le.ac.uk)
  • CONCLUSIONS: Genetic predisposition to increased blood cholesterol and triglyceride lipid levels is not associated with elevated LOAD risk. (ox.ac.uk)
  • subset
  • In addition to the genetic defects in dystrophin or other cytoskeletal proteins, a subset of dilated cardiomyopathy is linked to enteroviral infection in the heart, especially coxsackievirus B. Enterovirus infections are responsible for about 30% of the cases of acquired dilated cardiomyopathy in humans. (wikipedia.org)
  • Symptoms
  • Once the disease becomes established, its genetic underpinnings may allow more rapid progression of damage or severity of symptoms. (beltina.org)
  • Part of the encyclopedia is a disease dictionary including not only recommendation how to prevent each disease but also its initial symptoms, causes and useful advices about treatment for given illness. (beltina.org)
  • This in turn may lead to a number of symptoms or complications: Fluid retention in the abdomen (ascites) in more advanced disease Enlarged spleen in more advanced disease Oesophageal varices in more advanced disease Hepatic encephalopathy, including coma in extreme cases in more advanced disease. (wikipedia.org)
  • Kikuchi disease is a self-limiting illness which has symptoms which may overlap with Hodgkin's lymphoma leading to misdiagnosis in some patients. (wikipedia.org)
  • Humans
  • This decellularized valve tissue provides a scaffold with the remaining extracellular matrix (ECM) that can then be used for tissue engineering and valve replacement in humans inflicted with valvular disease. (wikipedia.org)
  • doctors
  • Doctors believe genetic influences underlie many if not all health conditions that develop over time, such as HYPERTENSION (high BLOOD PRESSURE ), ATHEROSCLEROSIS , OSTEOARTHRITIS , RENAL FAILURE , LIVER disease, and type 2 DIABETES . (beltina.org)
  • Many doctors and researchers believe knowing of genetic predispositions gives an individual the opportunity to engage in lifestyle modifications to prevent health problems from developing. (beltina.org)
  • chronic
  • Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease whose prevalence has reached global epidemic proportions. (e-cmh.org)
  • Abstract: BACKGROUND: Depression and chronic pain are the two most important causes of disability (Global Burden of Disease Study 2013). (duhnnae.com)
  • progresses
  • As the disease progresses the patient exhibits more serious problems, becoming subject to mood swings and unable to perform complex activities such as driving. (wikipedia.org)
  • As the disease progresses, vision deteriorates, sometimes rapidly. (wikipedia.org)
  • factors
  • Changing and taking control of these external factors can decrease your chances of developing the disease. (easydna.ie)
  • These include other genetic factors (sometimes called modifiers) as well as lifestyle and environmental factors. (nih.gov)
  • The Coriell Personalized Medicine Collaborative explains genetic and nongenetic risk factors for complex diseases. (nih.gov)
  • Most degenerative disease is the result of lifestyle and environmental factors in combination with your particular genetic risks. (hsaforamerica.com)
  • Genetic Predisposition - the tendency to develop a health condition as a consequence of the interaction between genetics and lifestyle factors. (beltina.org)
  • These genetic elements influence the effects of environmental factors such as cigarette smoking, physical activity and inactivity, exposure to chemical toxins, ALCOHOL consumption, and nutrition (lack of certain NUTRIENTS or excesses of other nutrients) in the development of disease processes. (beltina.org)
  • Hence, knowledge of the disease pathogenesis and predisposing factors is crucial for understanding the disease biology and making decisions on diagnostic or therapeutic interventions, the latter being the main goal of Precision Medicine. (e-cmh.org)
  • Although shared socio-demographic risk factors (e.g. gender, deprivation) might explain the co-morbidity of these three conditions, we hypothesised that these three long-term, highly prevalent conditions co-occur and may be due to shared familial risk, and/or genetic factors. (duhnnae.com)
  • Several risk factors have been proposed, including autoimmune diseases, infections and genetic predisposition. (wikipedia.org)
  • however, it is believed to involve a combination of genetic and environmental factors. (wikipedia.org)
  • While the cause is unknown, it is believed to occur due to a combination of genetic, environmental, and hormonal factors. (wikipedia.org)
  • Several sources suggest that keratoconus likely arises from a number of different factors: genetic, environmental or cellular, any of which may form the trigger for the onset of the disease. (wikipedia.org)
  • SYNDROME
  • Unlike GENETIC DISORDERS that encode for specific disturbances of structures and functions that inevitably produce a disease state (such as DOWN SYNDROME ), genetic predisposition for a condition does not make that condition certain. (beltina.org)
  • Classically recognized white dot syndromes include: Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) Birdshot chorioretinopathy Multiple evanescent white dot syndrome (MEWDS) Acute zonal occult outer retinopathy (AZOOR) Multifocal choroiditis and panuveitis (MCP) Punctate inner choroiditis (PIC) Serpiginous choroiditis Specific characteristics regarding the white dots and predicted etiology are presented of selected diseases. (wikipedia.org)
  • However, AZOOR may definitely be related to other diseases included in the white dot syndrome group. (wikipedia.org)
  • Variation
  • Pei L, Zhu H, Zhu J, Ren A, Finnell R, Li Z. Genetic variation of infant reduced folate carrier (A80G) and risk of orofacial defects and congenital heart defects in China. (labome.ru)
  • abnormalities
  • Abnormalities in liver enzyme tests are usually present and elevated gamma-glutamyl transferase and alkaline phosphatase (ALP) are found in early disease. (wikipedia.org)
  • The accumulation is due to various genetic and biochemical abnormalities. (wikipedia.org)
  • gene
  • If you have a family history of breast and ovarian cancer and are looking for a clinical result to confirm if you have the disease causing variant in the gene or not then you need to order a complete BRCA 1 and 2 test. (easydna.ie)
  • Single-gene diseases such as cystic fibrosis or Huntington's disease occur whenever the gene itself occurs. (hsaforamerica.com)
  • Unless you have a single-gene disease, the results will only show risks, and will not tell you for sure whether you will get the disease. (hsaforamerica.com)
  • To date, no clear genetic defect has been found to point to a single gene cause. (wikipedia.org)
  • makeup
  • Whilst you cannot alter your genetic makeup, you can alter conditions in your environment. (easydna.ie)
  • After receiving his results, he posted them on Github, hoping to find other users willing to share their personal genetic makeup. (wikipedia.org)
  • polymorphisms
  • Lu P, Chen M, Wu X, Gu J, Liu Y, Gu R. Genetic polymorphisms of UGT1A7 and cancer risk: evidence from 21 case-control studies. (labome.ru)
  • This research revealed parts of the IL12 signaling cascade, particularly IL12A and IL12RB2 polymorphisms, to be important in the aetiology of the disease in addition to the HLA region. (wikipedia.org)
  • environmental
  • An environmental Gram negative alphabacterium - Novosphingobium aromaticivorans has been associated with this disease with several reports suggesting an aetiological role for this organism. (wikipedia.org)
  • occur
  • Although the disease is relatively benign in the early stages, when severe clinical forms, including nonalcoholic steatohepatitis (NASH), cirrhosis and even hepatocellular carcinoma, occur, they result in worsening the long-term prognosis. (e-cmh.org)
  • Elevations in bilirubin occur in advanced disease. (wikipedia.org)
  • normally
  • Once initiated, the disease normally develops by progressive dissolution of Bowman's layer, which lies between the corneal epithelium and stroma. (wikipedia.org)
  • pathogenesis
  • In this review, we focused on the genetic component of NAFLD, with special emphasis on the role of genetics in the disease pathogenesis and natural history. (e-cmh.org)
  • scleroderma
  • It has been noted that clinical diagnosis of BXO can be "almost unmistakable," though there are other dermatologic conditions such as lichen planus, localized scleroderma, leukoplakia, vitiligo, and the cutaneous rash of Lyme disease can have a similar appearance. (wikipedia.org)
  • In June 2004, Broadway's wife, Dianne, died after 14 years of battling scleroderma, a rheumatic disease of the connective tissues. (wikipedia.org)
  • specific
  • Imagine the value of being able to know which specific diseases you should be screened for during medical check-ups. (easydna.ie)
  • you could start making the right lifestyle changes, planning specific health screening and blood tests and work together with a genetic councellor towards a tailored program for disease prevention. (easydna.ie)
  • A genetic predisposition results from specific genetic variations that are often inherited from a parent. (nih.gov)
  • certain
  • Genetic predisposition towards certain human behaviors is scientifically investigated by attempts to identify patterns of human behavior that seem to be invariant over long periods of time and in very different cultures. (wikipedia.org)
  • E. O. Wilson's book on sociobiology and his book Consilience discuss the idea of genetic predisposition to behaviors The field of evolutionary psychology explores the idea that certain behaviors have been selected for during the course of evolution. (wikipedia.org)
  • DISORDERS
  • It is a widely explored treatment option for many central nervous system (CNS) disorders including neurodegenerative diseases, stroke, traumatic brain injury, spinal cord injury, and acute management of neurotoxin consumption (i.e. methamphetamine overdoses). (wikipedia.org)
  • infection
  • In addition to yield, BPMV can reduce grain quality through protein and oil content, reduced seed quality and performance (discolored appearance, low germination and seedling vigor), delayed plant maturation, and the predisposition to other stresses and diseases (such as infection of Phomopsis fungus decreasing germination of seed and seedling vigor). (wikipedia.org)
  • Kaposi's Sarcoma caused by Human herpesvirus 8 (HHV8), also called Kaposi's sarcoma-associated herpesvirus (KSHV) Legionnaires' Disease (Legionella pneumophila) Microsporidium Mycobacterium avium complex (MAC) (Nontuberculosis Mycobacterium) Mycobacterium tuberculosis Pneumocystis jirovecii, previously known as Pneumocystis carinii f. hominis Pseudomonas aeruginosa Salmonella Staphylococcus aureus Streptococcus pneumoniae Streptococcus pyogenes Toxoplasma gondii Since opportunistic infections can cause severe disease, much emphasis is placed on measures to prevent infection. (wikipedia.org)
  • In epidemiology, a risk factor is a variable associated with an increased risk of disease or infection. (wikipedia.org)
  • Secondary lactose intolerance is due to injury to the small intestine such as from infection, celiac disease, inflammatory bowel disease, or other diseases. (wikipedia.org)
  • disorders
  • Available types of predictive medicine through health care professionals include: Newborn screening: Newborn screening is conducted just after birth to identify genetic disorders that can be treated early in life. (wikipedia.org)
  • This testing of infants for certain disorders is one of the most widespread uses of genetic screening - all US states currently test infants for phenylketonuria and congenital hypothyroidism. (wikipedia.org)
  • Upregulation of PHACTR1 by transforming growth factor (TGF)-β has been described in breast cancer cell lines, potentially pointing to a connection with the TGF-β signaling pathway, which is also implicated in genetic predisposition to migraine9 and has a key role in Marfan and Loeys-Dietz syndromes, two inherited connective tissue disorders causing aortic dissection. (wikipedia.org)
  • It is one of several genetic disorders known to be highly prevalent among the Afrikaner population. (wikipedia.org)
  • Lists of child and adult mental disorders can be found in the International Statistical Classification of Diseases and Related Health Problems, 10th Edition (ICD-10), published by the World Health Organization (WHO) and in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), published by the American Psychiatric Association (APA). (wikipedia.org)
  • Many psychopathological disorders in children involve genetic and physiological mechanisms, though there are still many with out any physical grounds. (wikipedia.org)
  • prevalent
  • Additionally, new tests from Genetic Technologies LTD and Phenogen Sciences Inc. comparing non-coding DNA to a woman's lifetime exposure to estrogen can now determine a woman's probability of developing estrogen positive breast cancer also known as sporadic breast cancer (the most prevalent form of breast cancer). (wikipedia.org)
  • cause
  • There are many factors that can cause this kind of damage, including exposure to harsh chemicals and genetic predisposition, but by far the most common cause is sun exposure. (skinsite.com)
  • Known contraindications include: Hypersensitivities to doxepin, other TCAs, or any of the excipients inside the product used Glaucoma A predisposition to developing urinary retention such as in benign prostatic hyperplasia Use of monoamine oxidase inhibitors in last 14 days Its use in pregnant and lactating women is advised against, although the available preclinical (based on animal studies) evidence suggests it is unlikely to cause any deleterious effects on fetal development. (wikipedia.org)
  • Some diseases and conditions are caused by dysfunction in the intestinal epithelium, and some diseases and conditions cause problems with these cells, which then leads to further complications. (wikipedia.org)
  • Many of these pathogens do not cause disease in a healthy host that has a normal immune system. (wikipedia.org)
  • citation needed] Children with a predisposition to psychopathology may cause higher stress in the relationship with their mother, and mothers who suffer from psychopathology may also cause higher stress in the relationship with their child. (wikipedia.org)
  • symptoms
  • Families of alcoholics suffer the same symptoms of the disease as the alcoholic Kronenwetter, Excessive use of alcohol claims at least , lives each year, either through accidents or health problems. (ivujoz.tk)
  • Bean pod mottle virus Table of Contents Description and Importance Symptoms Disease Cycle and Pathogenesis Agronomic Impact Management Strategies Genetic Resistance Cultural Tactics Chemical Tactics Description and Importance BPMV is the viral pathogen that causes the disease Bean Pod Mottle in soybeans and other legumes such as snap peas. (wikipedia.org)
  • treatment
  • Specialized nutrition plans are essential components in the treatment of many disease and health care conditions. (md-update.com)
  • People with diabetes can benefit from education about the disease and treatment, good nutrition to achieve a normal body weight, and exercise, with the goal of keeping both short-term and long-term blood glucose levels within acceptable bounds. (diabeteshelpcare.com)
  • Genetic screening of newborns and children in the field of predictive medicine is deemed appropriate if there is a compelling clinical reason to do so, such as the availability of prevention or treatment as a child that would prevent future disease. (wikipedia.org)
  • significantly
  • Predictive medicine is a field of medicine that entails predicting the probability of disease and instituting preventive measures in order to either prevent the disease altogether or significantly decrease its impact upon the patient (such as by preventing mortality or limiting morbidity). (wikipedia.org)
  • possible
  • Some prefer the term risk factor to mean causal determinants of increased rates of disease, and for unproven links to be called possible risks, associations, etc. (wikipedia.org)
  • risk
  • however, only few genetic risk loci for hand OA have been identified. (nottingham.ac.uk)
  • The average survival at 5 years is much higher if the diagnosis is made in the early stages of the disease (stage I). For this reason, to know the epidemiology and risk factors is an important weapon that we can use for 'prevention' and consequently the reduction of incidence and mortality. (imedpub.com)
  • Predictive Risk Testing: Testing that is conducted to determine the probability of developing a specific disease not the presence of the disease. (wikipedia.org)
  • It is often used to determine if an individual is at higher than average or lower than average risk of developing a disease over a given period of time. (wikipedia.org)
  • develop
  • There are two basic types of alcoholics, those who inherit a predisposition to compulsive drinking, and those who develop a problem from long-continued stress or long-term social drinking. (ivujoz.tk)
  • He has founded two biotechnology companies, Sideromics LLC and Recognyz System Technology, founded to develop treatments for the health effects experiences by persons with rare diseases. (wikipedia.org)
  • clinical
  • To overcome the confounding effects of genetic complexity, MS genetic research needs to take advantage of clinical and epidemiological information to better homogenize study samples. (ox.ac.uk)
  • early
  • Although proteomics and cytomics allow for the early detection of disease, much of the time those detect biological markers that exist because a disease process has already started. (wikipedia.org)
  • primary
  • Regarding aetiology of maxillary displaced canines, different theories have been proposed, two primary theories are: the guidance theory and the genetic theory.6 The guidance theory7 suggests that the eruption of the canine is influenced by presence, size, shape and positioning of the maxillary lateral incisor while genetic theory8 suggests that the impaction is due to a genetic predisposition. (thefreelibrary.com)
  • Lactose intolerance is a consequence of lactase deficiency, which may be genetic (primary hypolactasia and primary congenital alactasia) or environmentally induced (secondary or acquired hypoalactasia). (wikipedia.org)
  • diet
  • Management is typically by decreasing the amount of lactose in the diet, taking lactase supplements, or treating the underlying disease. (wikipedia.org)
  • presence
  • There are genetic, cultural, and chemical options which should be used together in an integrated pest management plan, in addition to managing the vector presence as well. (wikipedia.org)
  • Available
  • Genetic Resistance Partial resistance to BPMV is available in some soybean varieties meaning there is less yield reductions, lower rates of green stem and seed mottling. (wikipedia.org)
  • health care
  • Current genetic testing guidelines supported by the health care professionals discourage purely predictive genetic testing of minors until they are competent to understand the relevancy of genetic screening so as to allow them to participate in the decision about whether or not it is appropriate for them. (wikipedia.org)
  • already
  • Inadequate care of these women already underdeveloped, especially during pregnancy, leads them in turn to deliver underweight babies who are vulnerable to further malnutrition and disease. (wikipedia.org)