• Genetic alterations associated with the development of this syndrome and thus to cancers derived from it, have been located in STK11, also called LKB1, located on the short arm of chromosome 19 (19p13.3). (ivami.com)
  • Of the people who qualified for the study, 1,254 had at least 1 diagnosis of lumbar disc disease or lumbar disc herniation, along with the requisite genealogical data. (apta.org)
  • This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc. (celiac.com)
  • Brock the Boxers diagnosis was not a complete shock to his owner the breeder had explained to Andrian that Boxers had a genetic predisposition to heart problems, and at young age, a heart murmur had been detected. (dogslife.com.au)
  • Clinical practice guideline for the diagnosis and management of group a streptococcal pharyngitis: 2012 update by the infectious diseases society of america. (medscape.com)
  • Autoimmune diseases are difficult to diagnose and require a thorough examination of the patient's history, blood tests and physical examination for a definitive diagnosis. (thefreelibrary.com)
  • Little is known about how their risks vary with the patient's cancer site, carrier status for predisposing genetic mutations, or age at cancer diagnosis. (nih.gov)
  • Incidence of the disease has increased fivefold over the last 40 years (and 23 percent in the last decade), leaving about 450,000 young people with a diagnosis. (greatist.com)
  • Clinical presentation and pre-mortem diagnosis of variant Creutzfeldt-Jakob disease associated with blood transfusion: a case report. (cdc.gov)
  • Although altered lipid metabolism has been extensively implicated in the pathogenesis of Alzheimer disease (AD) through cell biological, epidemiological, and genetic studies, the molecular mechanisms linking cholesterol and AD pathology are still not well understood and contradictory results have been reported. (le.ac.uk)
  • With models, researchers can study the mechanisms of a disease and test therapies. (michaeljfox.org)
  • The cause of radiation sensitivity may be the insufficient repair and/or misrepair of the radiation-damaged genetic material of the cells ( DNA ), for instance due to defective repair mechanisms. (bfs.de)
  • Thus, the evidence linking cigarette smoke exposure with cardiovascular disease is clearly present, yet the exact components of cigarette smoke and the mechanisms responsible for this association have not been clearly elucidated. (onlinejacc.org)
  • This article updates the present clinical and experimental observations on the potential pathobiology and mechanisms involved in smoking-related cardiovascular disease ( Fig. 1 ). (onlinejacc.org)
  • The bold boxes and arrows in the flow diagram represent the probable central mechanisms in the complex pathophysiology of cigarette-smoking-mediated athero-thrombotic disease. (onlinejacc.org)
  • These findings have led to a better understanding of the underlying disease mechanisms. (plos.org)
  • NAFLD is a heritable and complex trait, the genetic component of which has been explored by a myriad of studies that used different approaches illustrated in Figure 1 . (e-cmh.org)
  • However, we treat numerous similar cases - most of which occurred after the patient had received the second vaccination "against" viral diseases. (marioninstitute.org)
  • A chemical compound or substance that inhibits oxidation - damage to cells' membranes, proteins or genetic material by free radicals (the same chemical reaction that causes iron to rust). (michaeljfox.org)
  • Variation in radiation sensitivity may be partly caused by changes in gene products (proteins), which ensure that the genetic material ( DNA ) is maintained and damage is repaired. (bfs.de)
  • Unlike Celiac disease, this condition doesn't respond to the elimination of gluten or similar proteins. (greatist.com)
  • A class of drugs used to treat mild to moderate dementia in Parkinson's disease. (michaeljfox.org)
  • Aggregation of the protein alpha-synuclein is found in Lewy bodies, a pathological hallmark of Parkinson's disease. (michaeljfox.org)
  • A class of drugs often effective in reducing the tremor of Parkinson's disease. (michaeljfox.org)
  • Some studies have linked oxidative damage to Parkinson's disease. (michaeljfox.org)
  • A medicine used to treat Parkinson's disease. (michaeljfox.org)
  • A movement disorder sometimes confused with Parkinson's disease that manifests in low, repetitive, involuntary, writhing movements of the arms, legs, hands, and neck that are often especially severe in the fingers and hands. (michaeljfox.org)
  • No validated biomarker of Parkinson's disease currently exists. (michaeljfox.org)
  • One of the cardinal clinical features of Parkinson's disease, the slowing down and loss of spontaneous and voluntary movement. (michaeljfox.org)
  • PARKINSON'S DISEASE is a progressive degenerative disease characterized mainly by the lack or difficulty of movement, because of muscle rigidity, the presence of tremors and a poor coordination. (botanical-online.com)
  • Parkinson's disease affects both men and women, but is more common in the former. (botanical-online.com)
  • It was named Parkinson's disease because it was discovered in the eighteenth century by an English physician named James Parkinson. (botanical-online.com)
  • Other HIV-related immune complex kidney diseases have also been described, including IgA nephropathy, membranous nephropathy, membranoproliferative glomerulonephritis, and other conditions such as post-infectious glomerulonephritis. (oncologynurseadvisor.com)
  • Other diseases include Phenylketonuria, autosomal dominant disease, hemophilia, muscular dystrophy and may include conditions like cleft lip, spina bifida and Down syndrome. (howstuffworks.com)
  • Streptococcal toxic-shock syndrome: spectrum of disease, pathogenesis, and new concepts in treatment. (medscape.com)
  • Streptococcus pyogenes causing toxic-shock-like syndrome and other invasive diseases: clonal diversity and pyrogenic exotoxin expression. (medscape.com)
  • In theory, two people could thus share a gene that is perfectly identical and yet show differences in their predisposition to a disease due to genetic differences concerning the regulation (overexpression or underexpression) of this same gene. (medicalxpress.com)
  • Single-gene diseases such as cystic fibrosis or Huntington's disease occur whenever the gene itself occurs. (hsaforamerica.com)
  • Unless you have a single-gene disease, the results will only show risks, and will not tell you for sure whether you will get the disease. (hsaforamerica.com)
  • We investigated the genetic architecture of AD in four publicly available independent datasets through genome-wide association, transcriptome-wide association, and gene-based and pathway-based analyses. (cdc.gov)
  • The disease gene may be transmitted either in an autosomal-dominant fashion or in an autosomal-recessive fashion, with limited penetrance. (medscape.com)
  • However, the disease gene has not yet been identified. (medscape.com)
  • Anyone who tests positive for a disease gene with this kit is advised to seek the opinions of a doctor or genetic counselor on what they can do to protect themselves from it, or in the very least how to manage it if it does develop. (stayinpink.com)
  • In early April 2017, the US Food and Drug agency approved a home testing kit by the company 23andMeb to test for 10 types of genetic-based diseases. (stayinpink.com)