• Up to now, several single-nucleotide polymorphisms (SNPs) have been identified in the APOA1 gene located on the long arm of chromosome 11 [ 16 ]. (biomedcentral.com)
  • The focus is on various techniques for identifying the various Single Nucleotide Polymorphisms (SNPs). (routledge.com)
  • Polymorphism studies document the affect SNPs, and their expressions have upon the functionality of the enzymes, proteins. (routledge.com)
  • The aim of this study was to identify any impact of CYP2A13 single-nucleotide polymorphisms (SNPs) on CYP2A13 expression in human lung. (aspetjournals.org)
  • To date, more than 20 single-nucleotide polymorphisms (SNPs) have been identified in CYP2A13 (Zhang et al. (aspetjournals.org)
  • We performed genotyping of 19 single nucleotide polymorphisms (SNPs) by Sequenom MassARRAY. (hindawi.com)
  • Previous study found that single nucleotide polymorphisms (SNPs) in nucleotide excision repair (NER) are associated with progression-free survival, including ERCC1, ERCC6, POLD2, POLE, and XPA [ 15 , 16 ]. (hindawi.com)
  • The authors analyzed 18 single nucleotide polymorphisms (SNPs) -- genetic variants affecting a single DNA building block -- in 10 genes previously implicated in mathematical performance. (sciencedaily.com)
  • We have shown that genetic and non-genetic factors, such as single nucleotide polymorphisms (SNPs), exercise, diet, obesity, and age alter the epigenetic pattern in human tissues affecting type 2 diabetes. (lu.se)
  • Their initial analysis identified 130 suggestive single-nucleotide polymorphisms (SNPs) for African Americans and 369 suggestive SNPs for European Americans related to LTPA-related energy expenditure. (medscape.com)
  • The Q353 allele of the factor VII gene polymorphism is associated with decreased factor VII and could be protective against cardiovascular disease. (who.int)
  • Some of these polymorphisms are linked to increased susceptibility to various diseases especially cancers, cardiovascular diseases, immune disorders, neurological pathologies. (routledge.com)
  • Different genotypes of several genetic polymorphisms of certain genes, at least in part, might be accounted for susceptibility to COVID-19 infection. (degruyter.com)
  • Sequence variations that affect CYP2A13 expression may contribute to interindividual differences in susceptibility to tobacco-related tumorigenesis. (aspetjournals.org)
  • CYP2A13 genetic polymorphisms may be associated with interindividual differences in susceptibility to tobacco-related tumorigenesis, because the resultant variations in CYP2A13 expression and metabolic activity can significantly alter the extent of NNK metabolic activation in human lung. (aspetjournals.org)
  • So far, the studies which explore the relationship between the E2F1 polymorphisms and ovarian cancer susceptibility are rare. (hindawi.com)
  • The amino acid variation S326C of human OGG1 disrupts Ser-326 phosphorylation site and affects susceptibility to a variety of cancers [9]. (deepdyve.com)
  • Conclusion s : The present study suggests that the SLC6A4 rs140701 polymorphism variant may be associated with susceptibility to PD, and 5-HTTLPR polymorphism may be a predictor of response to sertraline in the treatment of PD. (researchsquare.com)
  • In addition, ATM gene variants can allow cells to die inappropriately, particularly affecting cells in a part of the brain involved in coordinating movements (the cerebellum). (medlineplus.gov)
  • In a previous study Lambert et al 3 sequenced the transcription factor LBP-1c / CP2 / LSF gene, which lies within the chromosome 12 AD locus, in order to identify any genetic variants that may modify the risk of developing AD. (bmj.com)
  • These genetic variants can affect the safety and efficacy of certain drugs. (medscape.com)
  • Specifically, the authors found that genetic variants of ROBO1 in young children are associated with grey matter volume in the right parietal cortex, which in turn predicts mathematical test scores in second grade. (sciencedaily.com)
  • The main objective of this investigation was to approach, for the first time, the study of genetic variants in several polygenic profiles and their role in elite endurance and professional football performance by comparing the allelic and genotypic. (researchgate.net)
  • A study of genetic variants, genetic risk score and DNA methylation of PNPLA3 and TM6SF2 in alcohol liver cirrhosis. (cdc.gov)
  • NEW YORK (Reuters Health) - Several genetic variants influence the development and regulation of the capacity to perform leisure-time physical activity, according to a genome-wide analysis. (medscape.com)
  • The novel loci included variants in the regions of ENO1, MPP5 and ATP6V1D, which might affect LTPA by way of glycolytic pathways and the neuromuscular junction. (medscape.com)
  • A recent study suggested that the A allele of the 3′UTR biallelic polymorphism in the LBP-1c / CP2 / LSF gene was associated with reduced AD risk. (bmj.com)
  • found a biallelic polymorphism (Ala−9Val) in the mitochondrial targeting sequence (MTS) of human MnSOD in a Japanese population and reported a significant positive association between the MnSOD allele and Parkinson's disease. (nature.com)
  • In this study, we evaluated whether the single-nucleotide polymorphism (SNP) rs198585630 of 5-HT 1A receptor is associated with cognitive alterations in rats after microwave exposure with a frequency of 2.856 GHz and an average power density of 30 mW/cm 2 . (frontiersin.org)
  • This result nucleotide with a Safety and Health Act of 1970 (OSH Act), is known as the no observed adverse effect level frequency greater than which mandates standards and regulations to (NOAEL). (cdc.gov)
  • The disorder of lipid metabolism and genetic predisposition are major risk factors for coronary artery disease (CAD). (biomedcentral.com)
  • Several genetic polymorphisms affect the metabolism of these vitamins. (unboundmedicine.com)
  • therefore, genetic differences in oxidative metabolism can significantly impact the levels of active drug circulating in a patient. (medscape.com)
  • CYP2D6 is among the most promiscuous of these enzymes, involved in the metabolism of approximately 20% of drugs in clinical use, and displays large individual-to-individual variability in activity due to genetic polymorphisms. (medscape.com)
  • Certain common changes (polymorphisms) in the CYP2C9 and VKORC1 genes account for most of the variation in warfarin metabolism due to genetic factors. (medlineplus.gov)
  • Polymorphisms in other genes, some of which have not been identified, have a smaller effect on warfarin metabolism. (medlineplus.gov)
  • Several CYP2C9 gene polymorphisms decrease the activity of the CYP2C9 enzyme and slow the body's metabolism of warfarin. (medlineplus.gov)
  • We hypothesized that individuals bearing genetic polymorphisms for genes related to quercetin metabolism , benzo[a]pyrene metabolism , oxidative stress and DNA repair differ in their response to DNA protective effects of increased antioxidant intake. (bvsalud.org)
  • Individual drug metabolism rates are influenced by genetic factors, coexisting disorders (particularly chronic liver disorders and advanced heart failure), and drug interactions (especially those involving induction or inhibition of metabolism). (msdmanuals.com)
  • This is built upon the premise of existence of linkage disequilibrium between causal polymorphisms and the molecular markers used in the analysis (Meuwissen et al. (nature.com)
  • African Americans with a common genetic variation are at increased risk for developing Alzheimer's disease, while European Americans with the same variation are not, according to a study led by researchers at Rush University Medical Center. (eurekalert.org)
  • The common polymorphisms of the gene ABCG2 coding the efflux transporter BCRP and the gene SLCO1B1 coding the influx transporter OATP1B1 are associated with the interindividual variation in the effectiveness and tolerability of the cholesterol-lowering statins. (helsinki.fi)
  • The main goal of the first project is to understand the role of natural and sexual selection in the evolution and maintenance of genetic variation at loci coding for melanin-based colour traits by combining disciplines of behavioural ecology, genetics and population genetics. (unil.ch)
  • In this regard, comprehensive studies of the impact of amino acid variation on protein PTMs will be helpful for further understanding of how genetic polymorphisms are involved in regulating biological and pathological processes and providing instructive information for drug development of various related diseases. (deepdyve.com)
  • DNA variation in a gene called ROBO1 is associated with early anatomical differences in a brain region that plays a key role in quantity representation, potentially explaining how genetic variability might shape mathematical performance in children, according to a new study. (sciencedaily.com)
  • DNA variation in a gene called ROBO1 is associated with early anatomical differences in a brain region that plays a key role in quantity representation, potentially explaining how genetic variability might shape mathematical performance in children, according to a study published October 22nd in the open-access journal PLOS Biology by Michael Skeide of the Max Planck Institute for Human Cognitive and Brain Sciences, and colleagues. (sciencedaily.com)
  • As a result, it is an open question how genetic variation could give rise to differences in mathematical ability. (sciencedaily.com)
  • With the advancement of pharmacogenomic technologies, genetic variation has been identified to contribute to individual response to antidepressants. (researchsquare.com)
  • There is a substantial variation among individuals within a population due to genetic and environmental factors, including the Q192R polymorphism, which affect the efficiency of substrate hydrolysis. (cdc.gov)
  • variation in a single at the historical boundaries of the Occupational that did not cause an adverse effect. (cdc.gov)
  • We investigated the correlation between CYP3A5 genetic polymorphisms and the adverse events in patients with UC. (blogspot.com)
  • The authors reported correlation between the frequency of the Del allele of the ACE Ins/Del polymorphism and prevalence and mortality rates of COVID-19 in 33 countries (25 European, three north-African and five Middle East countries). (degruyter.com)
  • If data of Asian and European countries were used for analysis, it seems that we would observe no correlation between the ACE Ins/Del polymorphism and the prevalence of COVID-19 infection or the mortality due to COVID-19. (degruyter.com)
  • Besides clinical factors of age, sex, smoking stage, histology, and grade, many genetic polymorphisms also were considered correlation with prognosis in cancer patients. (hindawi.com)
  • Then, we analyzed the correlation between these gene polymorphisms and response to sertraline drug. (researchsquare.com)
  • The individuals with the APOA1 -75 A allele were likely to have a lower risk of CAD as a result of its effect on higher serum concentrations of ApoA1 and HDL-C. (biomedcentral.com)
  • They found that the A allele of a G/A polymorphism located in the 3′UTR was associated with sporadic AD in samples diagnosed predominantly by clinical, rather than pathological, criteria. (bmj.com)
  • In this study, we investigated the genetic association of the MnSOD allele with schizophrenia and TD in a Japanese sample through case-control studies. (nature.com)
  • 11] The International Society of Psychiatric Genetics finds genetic testing to be most beneficial after an inadequate response or adverse reaction to treatment with an antidepressant or antiphychotic. (medscape.com)
  • The review assessed treatment response using the Hamilton Rating Scale for Depression (21 and 24-item HAM-D) or the Montgomery Asberg Depression Rating Scale (MADRS), and response rates in relation to SERTPR (s/s, s/l and l/l genotypes) and STin2 (10/10 and 10/12 genotypes) polymorphisms. (york.ac.uk)
  • 2001 ), involves the use of genomic information to predict the genetic merit of untested genotypes. (nature.com)
  • 2011 ). This methodology has revolutionized plant breeding, allowing breeders to perform accurate selections of superior genotypes in early stages, skipping breeding phases, reducing costs associated with field trials and phenotyping, and increasing the rate of genetic gain per unit of time (Crossa et al. (nature.com)
  • Researchers led by Professor Caroline Dean have uncovered the genetic basis for variations in the vernalization response shown by plants growing in very different climates, linking epigenetic mechanisms with evolutionary change. (jic.ac.uk)
  • These modifications affect gene expression and are behind epigenetic memory. (jic.ac.uk)
  • More research is needed to determine exactly how these polymorphisms contribute to epigenetic memory, as the mechanism itself is still not fully understood. (jic.ac.uk)
  • Thus, we selected three widely-studied polymorphism loci (rs3213172, rs3213173, and rs3213176) to find a novel marker for the risk prediction of ovarian cancer. (hindawi.com)
  • A UK study indicated that physical activity may attenuate the cumulative effect of 12 of these loci, but replication studies are lacking. (lu.se)
  • Therefore, we tested whether the aggregate effect of these loci is diminished in adults of European ancestry reporting high levels of physical activity. (lu.se)
  • Genetic polymorphisms in low penetrance genes are responsible for the alterations in the gene expression of critical signal transduction proteins and metabolic enzymes. (routledge.com)
  • This book collates the reviews on the roles played by polymorphisms in critical metabolic, signal transduction, cell cycle or DNA repair genes either directly or indirectly in the disease mechanisms. (routledge.com)
  • Metabolic gene polymorphisms might modify the effect of toxins on the outcome of pregnancy and development afterwards. (biomedcentral.com)
  • Overall, the findings "suggest that human LTPA may be regulated by the genetic factors through 1) homeostasis and neural reward system, both of which are under the constant control of the nervous system, (and) 2) the structural and metabolic constraints exerted on the capacity to actually perform LTPA," the researchers conclude. (medscape.com)
  • Genetic polymorphisms of CYP2D6 have been shown to affect response to tamoxifen, opioid analgesics, antidepressants, and antipsychotics, for example. (medscape.com)
  • The Impact of the CYP2D6 and CYP1A2 Gene Polymorphisms on Response to Duloxetine in Patients with Major Depression. (cdc.gov)
  • This review examined the relationship between clinical response to selective serotonin re-uptake inhibitors in patients with depression and genetic polymorphisms (SERTPR and STin2) in the serotonin transporter gene. (york.ac.uk)
  • Studies that assessed the relationship between treatment response and genetic polymorphism of the serotonin transporter gene were eligible for inclusion. (york.ac.uk)
  • The aim of the present study was to examine the association of serotonin-related gene polymorphisms with PD risk. (researchsquare.com)
  • Abundant evidence has shown that serotonin-related gene polymorphisms played an important role in the clinical effects of antidepressants. (researchsquare.com)
  • Certain VKORC1 gene polymorphisms decrease the amount of functional VKORC1 enzyme available to help activate clotting proteins. (medlineplus.gov)
  • Pharmacogenomic studies focusing on candidate gene polymorphisms implicated in antidepressant response, especially in the serotonergic pathway. (researchsquare.com)
  • Genetic architecture of well-being: cumulative effect of serotonergic polymorphisms. (cdc.gov)
  • Genetic polymorphisms are important determinants of phenotypic variations and may modulate the risk to or even cause various diseases including genetic disorders and multifactorial diseases. (routledge.com)
  • Consequently, amino acid variations through changing the type of residues of the target sites or key flanking residues could directly or indirectly influence PTM of protein and bring about a detrimental effect on protein function. (deepdyve.com)
  • 7] analyzed amino acid variations of 15 different PTMs and indicated that about 4.5% of amino acid variations may affect protein function through disruption of PTMs, and the mutation of 238 PTMs sites in human proteins was causative of disease. (deepdyve.com)
  • The study found that African Americans with this polymorphism are 30 percent more likely to develop Alzheimer's disease dementia than the African American without the genetic polymorphism. (eurekalert.org)
  • The finding that regulators of the melanocortin system can pleiotropically affect the expression of suites of correlated phenotypic traits has important implications with regard to the existence of behavioural syndromes. (unil.ch)
  • This project is original, since the interest in melanin-based colour traits and genetic colour polymorphism has recently grown. (unil.ch)
  • Furthermore, we recently proposed a new genetic mechanism to explain why melanin-based colour traits are frequently associated with several individual attributes. (unil.ch)
  • The net selection effect of herbicides on herbicide-resistance traits in weeds is conditioned by the fitness benefits and costs associated with resistance alleles. (bioone.org)
  • Genotypic data from 86,930 markers and three traits with different genetic architecture (fruit firmness, fruit weight, and total yield) were evaluated. (nature.com)
  • Estimating the direct effects of the genetic liabilities to bipolar disorder, schizophrenia, and behavioral traits on suicide attempt using a multivariable Mendelian randomization approach. (cdc.gov)
  • According to the authors, the results suggest that genetic variability might shape mathematical ability by influencing the early development of the brain's basic quantity processing system. (sciencedaily.com)
  • adverse effect of a concern for individual variability in response to The use of epidemiologic data in standard hazardous agent using hazard identification, hazardous substances. (cdc.gov)
  • Additionally, people who have more than one polymorphism in a gene or polymorphisms in multiple genes associated with warfarin sensitivity have a lower tolerance for the drug's effect or take even longer to clear the drug from their body. (medlineplus.gov)
  • Genetic polymorphisms also serve as important genetic, population and evolutionary markers that allow the study of genetic and evolutionary aspects of individuals, populations and organisms and aid in tracing the evolutionary and parental lineages. (routledge.com)
  • The aims of this study were to assess folate, vitamin B12 and homocysteine status in distinct Brazilian individuals after the initiation of folic acid fortification by Brazilian authorities and to investigate the effects of RFC1 A80G, GCPII C1561T and MTHFR C677T polymorphisms on folate, vitamin B12 and Hcy levels in these populations. (unboundmedicine.com)
  • Fitness costs play an important evolutionary role preventing the fixation of adaptive alleles and contributing to the maintenance of genetic polymorphisms within populations. (bioone.org)
  • Type 2 diabetes is a multifactorial disease, and combinations of genetic and non-genetic factors such as age, obesity, and physical inactivity increase disease risk. (lu.se)
  • A protein coded by a variant gene may be dysfunctional, which can affect the efficiency and safety of the substrate drug individually. (helsinki.fi)
  • In this study we have typed for the 3′UTR polymorphism in a series of necropsy confirmed AD cases and age matched non-demented controls to see if we could confirm an association between this polymorphism and sporadic AD, and thus give further support for the role of this genetic variant as a risk factor in AD. (bmj.com)
  • Pharmacogenetic testing is being evaluated for routine implementation, and it has been reported that over 90% of the population has at least one actionable genetic variant. (medscape.com)
  • A genetic risk score (GRS) was calculated by summing the BMI-associated alleles of each genetic variant. (lu.se)
  • Investigating the role of cell membrane proteins has increased over the last decade, as drugdrug interactions and genetic polymorphisms have been found to cause changes in drug pharmacokinetics and dynamics. (helsinki.fi)
  • These include lead's ability to inhibit or mimic the actions of calcium (which can affect calcium-dependent or related processes) and to interact with proteins (including those with sulfhydryl, amine, phosphate, and carboxyl groups) [ATSDR 2010]. (cdc.gov)
  • The polymorphisms affect chemical modifications to histone proteins which DNA is wrapped around. (jic.ac.uk)
  • The objective of the present study was to investigate the effect of two polymorphisms (-75 G/A and +83 C/T) of APOA1 on lipid profiles and the risk of CAD. (biomedcentral.com)
  • The in vitro method developed in this study remains in the research team as a tool to investigate the polymorphisms of the SLCO1B1-gene, the inhibition of the transporter and possible drug interactions. (helsinki.fi)
  • The aim of this study was to investigate the effect of 3 and 6 mg of caffeine per kg of body mass (mg/kg) on whole-body substrate oxidation during an incremental cycling exercise test in healthy active women. (researchgate.net)
  • The aim was to investigate CKM polymorphism on injury incidence in high-performance football players. (researchgate.net)
  • Genetic polymorphism occurs in several genes that code drug metabolizing enzymes or drug transporters. (helsinki.fi)
  • Mean V T corrected for TSPO genotype was significantly lower in patients compared to controls, especially in patients in whom CNI dose had been reduced because of nephrotoxic side effect. (springer.com)
  • FVIIc levels with the 10 bp insertion polymorphism were not significantly different. (who.int)
  • Genetic factors levels vary significantly in the general pop- contribute significantly to the development ulation and are influenced by environmental of these diseases. (who.int)
  • Statistical analysis of 34 biologically relevant genetic polymorphisms revealed that six significantly influenced the outcome of the intervention. (bvsalud.org)
  • Genetic polymorphisms lead to individual differences. (frontiersin.org)
  • A combination of four genetic differences (polymorphisms) between the two varieties is responsible for the requirement for a longer period of cold. (jic.ac.uk)
  • Chronic microwave exposure can induce cognitive deficits, and 5-HT system is involved in this effect. (frontiersin.org)
  • And the research on the effect of microwave radiation on cognitive function has lasted for decades, but it is still controversial and the associated mechanisms remain unclear. (frontiersin.org)
  • I have also studied the effect of genetic polymorphisms on cognition, as well as the impact of various types of cognitive training interventions. (bbk.ac.uk)
  • Third, in addition to hereditary factors that can affect the prevalence, fatality and mortality of a disease, various environmental and social factors are also involved. (degruyter.com)
  • There was no significant effect of gender, age, SNP GPX-1 and SNP GPX-4 on the prevalence of age-related nuclear, cortical and posterior sub-capsular cataract. (aaem.pl)
  • Interaction of Val66Met BDNF and 5-HTTLPR polymorphisms with prevalence of post-earthquake 27-F PTSD in Chilean population. (cdc.gov)
  • However, this locus accounts for less than half the genetic variance. (bmj.com)
  • Folate and vitamin B12 are essential nutrients, whose deficiencies are considerable public health problems worldwide, affecting all age groups. (unboundmedicine.com)
  • After a multivariate analysis, Hcy levels were predicted by variables such as folate, vitamin B12, gender, age and RFC1 A80G polymorphism, according to the groups studied. (unboundmedicine.com)
  • Recently, genetic polymorphisms in vitamin D-binding protein have received great attention because they largely affect bioavailable 25(OH)D concentrations. (unboundmedicine.com)
  • This finding suggests that the serum total 25(OH)D concentrations would not be comparable among different gene polymorphisms and thus may be inappropriate as an index of vitamin D status. (unboundmedicine.com)
  • The authors hypothesized that genetic polymorphisms affecting histamine degradation would explain the diversity of responses to additives. (nih.gov)
  • I explore problems such as how frequency-dependent processes within and between species maintains diversity, whether genetic polymorphisms or species in ecological communities. (lu.se)
  • N-linked glycosylation affects asparagine (N), and O-linked glycosylation occurs on the hydroxyl group of either serine (S) or threonine (T) [3]. (deepdyve.com)
  • It typically occurs in young adults, and women are more likely to be affected than men[3]. (researchsquare.com)
  • Genotype analyses of RFC1 A80G, GCPII C1561T and MTHFR C677T polymorphisms were performed by PCR-RFLP. (unboundmedicine.com)
  • The CT genotype of E2F1 gene rs3213172 polymorphism is associated with an increased risk of ovarian cancer, and E2F1 gene rs3213172 polymorphism may be a novel marker for the risk prediction of ovarian cancer. (hindawi.com)
  • The impor- objectives of determining the frequencies tance of FVII in normal haemostasis is il- of these gene polymorphisms in the popula- lustrated by the severe bleeding diathesis tion and clarifying the genotype association associated with low plasma levels of the of the R353Q and 0/10 bp insertion poly- protein [ 3 ]. (who.int)
  • It has been estimated that genetic risk factors explain approximately 20 %-60 % of CAD cases [ 12 ]. (biomedcentral.com)
  • Genetic polymorphisms of ataxia telangiectasia mutated affect lung cancer risk. (medlineplus.gov)
  • The present study is aimed at exploring whether rs3213172, rs3213173, and rs3213176 polymorphisms of the E2F1 gene confer risk for ovarian cancer. (hindawi.com)
  • E2F1 gene rs3213173 and rs3213176 polymorphisms confer no risk to ovarian cancer risk. (hindawi.com)
  • The present study is to explore whether E2F1 gene polymorphisms confer risk for ovarian cancer. (hindawi.com)
  • ABSTRACT Factor VII gene polymorphisms may contribute to elevations in factor VII coagulant (FVIIc) levels that have been associated with cardiovascular risk. (who.int)
  • She took up a postdoctoral research position at the Brain Dynamics Centre based within the Westmead Millennium Institute, with a focus on the genetic and brain markers of risk for mental health. (edu.au)
  • in particular, genetic markers of risk, and integrating these genes with core brain and body measures including magnetic resonance imaging (MRI), electroencephalography (EEG), and electrocardiography (ECG). (edu.au)
  • Smoking during pregnancy is a well-known risk factor for adverse birth outcomes such as spontaneous abortion [ 4 ], low birth weight, and preterm birth [ 5 ] that, in turn might affect children's development. (biomedcentral.com)
  • Increasing the number of participants and including dietary, health, and pesticide exposure data from the accompanying questionnaires of this ongoing large population study will allow us to identify genetic and environmental risk factors for low PON1 status, the role of pesticide exposure, and allow us to counsel the most at-risk subgroup about their individual pesticide vulnerability. (cdc.gov)
  • workplace dard is adopted, and lack of consideration of ge- to as the threshold dose) then no adverse effect atmosphere netic information in risk assessments, the OSH would be observed. (cdc.gov)
  • it was found that the orthodontic treatment can be considered as a risk factor of EARR, mostly affecting the upper incisors. (bvsalud.org)
  • Good patient and parental education should include tactful genetic counseling and an explanation of the multisystem nature of the disease. (medscape.com)
  • To their surprise, the brains of the healthy donors who had the polymorphism displayed biomarkers that are known to play a role in neurodegenerative brain disease. (eurekalert.org)
  • SSRIs are often the first choice in the pharmacologic treatment of depression, which, according to the Centers for Disease Control and Prevention (CDC), affects approximately 5% of the U.S. population. (medscape.com)
  • The genetic profile that is needed to identify talents has been studied extensively in recent years. (researchgate.net)
  • The historical approach to setting OELs has in- genetic information extensively, but to date such factors have not volved investigators observing workers as well transmitted between been used to protect workers by incorpora- as conducting laboratory and animal studies. (cdc.gov)
  • I combine classical population biological studies in nature with field and laboratory experiments, quantitative genetic approaches, measurements of selection and phylogenetic comparative methods. (lu.se)
  • We therefore studied the association of two polymorphisms - R353Q polymorphism at codon 353 involving the catalytic region and the 10 base pair (bp) insertion polymorphism involving the promoter region - with FVIIc levels in 176 healthy Tunisians. (who.int)
  • CIENCIASMEDICASNEWS: The effect of CYP3A5 genetic polymorphisms on adverse events in patients with ulcerative colitis treated with tacrolimus. (blogspot.com)
  • The adverse effect of food additives on ADHD symptoms was moderated by histamine degradation gene polymorphisms HNMT T939C and HNMT Thr105Ile in 3- and 8/9-year-old children and by a DAT1 polymorphism (short versus long) in 8/9-year-old children only. (nih.gov)
  • The BMD is defined as the maximum period that would not could be defined by certain genetic polymor- likelihood estimate of exposure that provides result in adverse health effects phisms as hypersusceptible. (cdc.gov)
  • The evolution, maintenance and adaptive function of genetic colour polymorphism in birds. (unil.ch)
  • The factors that could affect MS analysis are also discussed, such as biological sample cleanup and peptide ionization efficiency. (degruyter.com)
  • Even if you have a biological or genetic predisposition to low levels of PA, we can always find a PA program that will work for you," Dr. Enyon said. (medscape.com)
  • [ 7 , 8 ] The recognition that DS is associated with trisomy 21 helped in understanding the genetic basis of this association. (medscape.com)
  • In this study, we focus on evaluating association between DNA repair polymorphisms of EXO1, RPA1, and prognosis in lung cancer patients whom received platinum-based chemotherapy. (hindawi.com)
  • We explored the association between prenatal exposure to SHS and neurodevelopment at 24 months of age considering genetic polymorphism and breastfeeding in 720 mothers and their offspring enrolled in the Korean multicenter birth cohort study (Mothers and Children Environmental Health, MOCEH). (biomedcentral.com)
  • The SLC6A4(rs140701, rs3813034, 5-HTTLPR and STin2), 5-HTR1A rs6295, 5-HTR2A rs6313 and COMT rs4680 gene polymorphisms were genotyped and assessed for the potential association. (researchsquare.com)
  • A few studies have investigated the association between the 5-HTT linked polymorphic region (5-HTTLPR), 5-HTR1A rs6295, 5-HTR2A rs6313, COMT rs4680 polymorphisms and PD[8-16]. (researchsquare.com)
  • ATG can exert various effects on the immune system, including T-cell depletion in the blood and peripheral tissues, down-modulation of adhesion molecules and chemokine receptors, 7 and possibly a direct effect on hematopoietic stem cells. (haematologica.org)
  • The 5-HT 1A receptors can influence the activity of cholinergic, glutamatergic and GABAergic neurons in the cerebral cortex and hippocampus to affect the declarative and non-declarative memory. (frontiersin.org)
  • Thus, the aim of the present study was to evaluate the influence of the time of the day on the effect of caffeine on the. (researchgate.net)
  • The influence of the rs8111989 polymorphism in the muscle-specific creatine kinase gene (CKM) on injury incidence is unknown. (researchgate.net)
  • MAOA uVNTR Polymorphism Influence on Older Adults Diagnosed with Diabetes Mellitus/Systemic Arterial Hypertension. (cdc.gov)
  • Does the Time of Day Play a Role in the Acute Effect of p-Synephrine on Fat Oxidation Rate during Exercise in Women? (researchgate.net)
  • Background: A number of studies have shown that genetic factor plays an important role in etiology of panic disorder (PD). (researchsquare.com)
  • A meta-analysis showed genetic factors explain approximately 43% of the variance in the PD[4], indicating an important role in the pathological PD. (researchsquare.com)
  • While changes in specific genes, particularly CYP2C9 and VKORC1 , affect how the body reacts to warfarin, many other factors, including sex, age, weight, diet, and other medications, also play a role in the body's interaction with this drug. (medlineplus.gov)
  • There is a gap between the presence of abnormal brain pathology and the early signs of AD, suggesting that other factors (genetic or environmental) may play an important role in the development of AD. (medscape.com)
  • Investigators need to examine the potential role and implications of using genetic information in standard setting. (cdc.gov)
  • In this review, we focus primarily on inherited genetic factors and their role in occupational health standard setting. (cdc.gov)
  • Dr. Simin Liu from Brown University, in Providence, Rhode Island, and colleagues examined the role of genetic factors in affecting LTPA in their genome-wide analysis of data from the Women's Health Initiative, the Jackson Heart Study and the Framingham Heart Study. (medscape.com)
  • The relationships between the Arterial and venous thrombosis, which clinical presentation and FVII levels and the clinically manifest as stroke, myocardial in- associated molecular genetic defects lack farction or pulmonary embolism are a ma- apparent consistency [ 7,10 ]. (who.int)
  • almost half the population are carriers of this polymorphism. (eurekalert.org)
  • This motivated us to evaluate the effect of training population sizes and composition, as well as the impact of marker density and sequencing depth on phenotype prediction for the species. (nature.com)
  • The polymorphisms associated with warfarin sensitivity often differ by population and ethnic background. (medlineplus.gov)
  • We conclude that genotyping for relevant polymorphisms enables selecting subgroups among the general population that benefit more of DNA damage -modulating effects of micronutrients . (bvsalud.org)
  • I also strive to understand how natural and sexual selection interact and affect population divergence, reproductive isolation and ultimately speciation and biodiversity. (lu.se)
  • Recent studies have shown that transporters can mediate drug-drug interactions, and transporter genes are subject to genetic polymorphism which may affect pharmacokinetic parameters of a drug, such as absorption, distribution, and excretion. (helsinki.fi)
  • For example, a few studies investigated that 5-HTTLPR, intron 2 (STin2), 5-HTR1A rs6295, 5-HTR2A rs6313 and COMT rs4680 polymorphisms associated with antidepressant response[17-26]. (researchsquare.com)
  • Ataxia-telangiectasia should be considered among the immunodeficiency diseases, cancer-prone genetic disorders, chromosomal instability syndromes, disorders with abnormal radiosensitivity, syndromes with possible DNA-repair/processing defects, and (as is now evident) the progeroid syndromes. (medscape.com)
  • I read with great interest the study by Delanghe and his colleagues entitled "COVID-19 infections are also affected by human ACE1 D/I polymorphism" that was published in Clinical Chemistry and Laboratory Medicine [ 1 ]. (degruyter.com)
  • Impact of multiple genetic polymorphisms on effects of a 4-week blueberry juice intervention on ex vivo induced lymphocytic DNA damage in human volunteers. (bvsalud.org)
  • 1, 2020 The causes of 40% of all cases of certain medulloblastomas -- dangerous brain tumors affecting children -- are hereditary. (sciencedaily.com)