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  • gene
  • We determined that a 10-nucleotide oligomer of peptide nucleic acid (PNA) targeting the start codon region of an essential gene acpP is able to cause complete growth inhibition of E. amylovora . (frontiersin.org)
  • PNAs
  • Further, PNAs have applications in analysis of biosensor chips for identification of nucleic acids [ 22 ]. (medsci.org)
  • The PNAs used in this study were created by Ly at Carnegie Mellon's Center for Nucleic Acids Science and Technology (CNAST), a leading center for PNA science. (healthcanal.com)
  • This study examined the use of Peptide Nucleic Acids (PNAs) technology to interrupt type IV secretion system (T4SS) effector protein expression in E. chaffeensis followed by intracellular complementation of the effector to determine its requirement for infection. (frontiersin.org)
  • The volume concentrates on modern developments encompassing topics in the wide range from G-quadruplexes via DNAzymes, catalysis at the DNA scaffold, and metal-mediated base pairs to peptide nucleic acids (PNAs) being thus of relevance, e.g., for chemistry and nanotechnology but also for molecular biology and (genetic) diagnostics. (springer.com)
  • nucleotides
  • Hi guys… I'm a post-graduate in the biological sciences, and I can humbly say that I possess more knowledge than most of you do on matters of evolutionary science and various theories and experiments designed to prove that life arose out of a random collision of amino acids and nucleotides. (atheistnexus.org)
  • molecule
  • The NAN enables both a small molecule drug and a nucleic acid - RNA or DNA - to be delivered to a cell. (eurekalert.org)
  • A slightly different version of the hypothesis is that a different type of nucleic acid , termed pre-RNA , was the first one to emerge as a self-reproducing molecule, to be replaced by RNA only later. (chemeurope.com)
  • A much shorter RNA molecule has been formed in lab with the ability to form peptide bonds , and it has been suggested that rRNA has evolved from a similar molecule . (chemeurope.com)
  • A self-assembling molecule synthesized in a laboratory may resemble the earliest form of information-carrying biological material, a transitional stage between lifeless chemicals and the complex genetic architectures of life. (atheistnexus.org)
  • By exploiting an HIV protein that readily traverses cell membranes, Carnegie Mellon University scientists have developed a new way to introduce a gene-like molecule called a peptide nucleic acid (PNA) directly into live mammalian cells, including human embryonic stem (ES) cells. (news-medical.net)
  • neurotoxic
  • The presence and concentration of neurotoxic amino acids were investigated in organisms from various trophic levels to examine the potential for biomagnification. (springer.com)
  • The findings of this study suggest that exposure to neurotoxic amino acids through seafood in the Arabian Gulf may be minor, yet the presence of BMAA in phytoplankton confirms the need for further monitoring of marine waters and seafood to protect human health. (springer.com)
  • researchers
  • Researchers at Carnegie Mellon University and Yale University have for the first time used a gene editing technique to successfully cure a genetic condition in a mouse before birth. (healthcanal.com)
  • Authoritative and cutting-edge, Non-Natural Nucleic Acids: Methods and Protocols aims to serve as a guide for researchers exploring their own inquiries and to provide a springboard for new endeavors. (kriso.ee)
  • researchers were part of a team that has uncovered what may be an important genetic risk factor for amyotrophic lateral sclerosis (ALS). (news-medical.net)
  • sequences
  • The beauty of this system is that it is programmable, modular, and has the ability to rapidly integrate diverse peptide sequences. (eurekalert.org)
  • Fitch WM, Upper K (1987) The phylogeny of tRNA sequences provides evidence for ambiguity reduction in the origin of the genetic code. (springer.com)
  • arrays
  • The materials presented in this chapter examine the recent developments in the field of peptide microarrays with special emphasis on the generation and applications of high-density arrays of peptides on glass slides. (springer.com)
  • Research
  • Nucleic Acids Research. (wisc.edu)
  • The delivery platform, featured in the paper by Rouge and her research team, combines synthetic peptides, surfactants, and nucleic acids to form a nanocapsule that allows time-appropriate, enzyme-specific co-release of a given pharmaceutical and an oligonucleotide (DNA or RNA). (eurekalert.org)
  • Their findings, published in Nature Communications , present a promising new avenue for research into treating genetic conditions during fetal development. (healthcanal.com)
  • While the study findings are significant, much more research is needed to refine the genetic engineering strategy, said Egan. (scitechdaily.com)
  • protein
  • Many studies have correlated characteristics of amino acids with crystallization propensity, as part of the effort to determine the factors that affect the propensity of protein crystallization. (biomedcentral.com)
  • The peptide array has come into focus as an emerging screening platform for large-scale protein detection and activity studies. (springer.com)
  • a stereochemical basis for the division between protein and non-protein amino-acids. (springer.com)
  • embryonic
  • Inheritance of mtDNA is further complicated by the genetic bottleneck which occurs during embryonic development in female foetuses [ 8 ]. (biochemistry.org)
  • fetal
  • New work by scientists at Carnegie Mellon University and Yale University has shown that it's possible to cure a genetic disorder in a fetal mouse. (labroots.com)
  • molecular
  • Unlike CRISPR, which uses molecular scissors to 'cut-and-paste' the desired genetic changes, the PNA system is designed to open up double-stranded DNA. (labroots.com)
  • modular
  • After ligation to the modular peptide-based BioShuttle carrier, which was utilized to facilitate the delivery of the functional modules into the cells' cytoplasm, the modules were scrutinized. (medsci.org)
  • disorder
  • If such a tool was created, it could help the 8 million children that are born every year with a birth defect or genetic disorder. (labroots.com)
  • study
  • Such a model is described in the present article and may be the first step in a new approach to the study of the evolution of the genetic code. (springer.com)
  • This study was reported in Nature Communications and opens up a new avenue for treating genetic disorders during development. (labroots.com)
  • Code
  • There are currently three major theories on the origin and evolution of the genetic code: the stereochemical theory, the coevolution theory, and the error-minimization theory. (springer.com)
  • The first two assume that the genetic code originated respectively from chemical affinities and from metabolic relationships between codons and amino acids. (springer.com)
  • This proposal is distinct from the stereochemical and the coevolution theories because they do not contemplate any ambiguity in the genetic code, and it is distinct from the error-minimization theory because ambiguity-reduction is fundamentally different from error-minimization. (springer.com)
  • Bollenbach T, Vetsigian K, Kishony R (2007) Evolution and multilevel optimization of the genetic code. (springer.com)
  • Di Giulio M (2008) An extension of the coevolution theory of the origin of the genetic code. (springer.com)
  • However, the idea of independent RNA life is older and can be found in Carl Woese's The Genetic Code . (chemeurope.com)
  • Considering how biological macromolecules first evolved, probably within a marine environment, it seems likely the very earliest peptides were not encoded by nucleic acids, or at least not via the genetic code as we know it. (mdpi.com)
  • diagnostics
  • Although innovation is clearly a driving force of technological revolutions in genetic diagnostics analysis and TRIZ can facilitate innovation, to my knowledge it has not been systematically applied to solve technical challenges there. (triz-journal.com)
  • The purpose of this paper is to determine whether the 40 Inventive Principles and 39×39 Contradictory Matrix are applicable to genetic diagnostics. (triz-journal.com)
  • cell
  • Brachet J (1946) Nucleic acids in the cell and the embryo. (springer.com)
  • We found that conjugation of cell penetrating peptide (CPP) to PNA is essential for the antimicrobial effect, with CPP1 [(KFF)3K] being the most effective against E. amylovora . (frontiersin.org)
  • Cells have to carry around a huge amount of genetic material, and usually that DNA is about 1000 times longer than the cell where it lives. (labroots.com)
  • diseases
  • A new drug delivery system that uses a synthetic-biological hybrid nanocapsule could provide a smart technology for targeted treatment of a variety of serious diseases at the genetic level. (eurekalert.org)
  • While Rouge feels her method has clear promise to reduce the negative side effects associated with chemotherapy for cancer patients, she is confident the technology could be applied to a number of other genetic and acquired diseases. (eurekalert.org)
  • Genetic diseases can be traced back to an error in a gene. (labroots.com)
  • correct
  • The hybrid offers a way to correct diseased cells at the genetic level - while at the same time leaving healthy cells alone - to increase the effectiveness of treatments and reduce unwanted side effects. (eurekalert.org)
  • Genetic conditions can often be detected during pregnancy using amniocentesis, but there are no treatment options to correct these genetic conditions before birth. (healthcanal.com)